CN115429282A - Composite microneedle structure and nerve microelectrode - Google Patents
Composite microneedle structure and nerve microelectrode Download PDFInfo
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- CN115429282A CN115429282A CN202210880707.0A CN202210880707A CN115429282A CN 115429282 A CN115429282 A CN 115429282A CN 202210880707 A CN202210880707 A CN 202210880707A CN 115429282 A CN115429282 A CN 115429282A
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- 239000002131 composite material Substances 0.000 title claims abstract description 28
- 210000005036 nerve Anatomy 0.000 title description 4
- 230000001537 neural effect Effects 0.000 claims abstract description 14
- 210000000944 nerve tissue Anatomy 0.000 claims description 18
- 210000001519 tissue Anatomy 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 6
- 230000007547 defect Effects 0.000 abstract description 3
- 238000002513 implantation Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 4
- 239000004642 Polyimide Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/262—Needle electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a composite micro-needle structure and a neural microelectrode, wherein the composite micro-needle structure is used for implanting a microelectrode of neural tissue, the composite micro-needle structure comprises a hard needle and a soft needle, the front end of the hard needle is provided with a clamping groove structure, and the front end of the soft needle is provided with a clamping strip structure; the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the tissue, and then the hard needle is pulled out. According to the technical scheme provided by the invention, the soft needle can be brought into the neural tissue through the hard needle and then the hard needle is pulled out, so that the defect of adoption of a single hard needle or a single soft needle can be avoided, the soft needle and the hard needle can be well fixed, the soft needle is prevented from warping to a certain extent, the hard needle is convenient to pull out, and the tissue can be guaranteed to be damaged to a small extent.
Description
Technical Field
The invention relates to the field of brain-computer interface neural microelectrodes in biomedical engineering technology, in particular to a composite microneedle structure and a neural microelectrode.
Background
At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a polyimide electrode in a soft needle structure.
When the hard needle (rigid needle) is implanted, the hard needle cannot be adaptively deformed along with the expansion and contraction of blood vessels, and certain damage may be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like.
Disclosure of Invention
The invention mainly aims to provide a composite microneedle structure, which aims to bring a soft needle into nervous tissue through a hard needle and pull out the hard needle, so that the defect of adopting a single hard needle or a single soft needle can be avoided, the soft needle and the hard needle can be well fixed, the soft needle is prevented from warping to a certain degree, the hard needle is convenient to pull out, and the nervous tissue can be ensured to be damaged less.
In order to achieve the above object, the present invention provides a composite microneedle structure for a microelectrode to be implanted into a neural tissue, the composite microneedle structure including:
the front end of the hard needle is provided with a clamping groove structure; and
the front end of the soft needle is provided with a clamping strip structure;
the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the nerve tissue, and then the hard needle is pulled out.
Optionally, the hard needle and the soft needle are both of a structure with a narrow front end and a wide back end.
Optionally, the front end upper surface of hard needle sets up protruding chamber, protruding chamber upper end opening, two inside walls in protruding chamber are close to diapire department and all are equipped with the recess to form the draw-in groove structure.
Optionally, the front end of the hard needle is provided as a tip to enter nerve tissue.
Optionally, a stopper is disposed at a rear end of the slot structure, and two ends of the stopper in the extending direction are flush with two outer side walls of the convex cavity to form a closed structure.
Optionally, the lower surface of the front end of the soft needle is provided with a T-shaped bulge to form a clamping strip structure.
Optionally, both the lower surface of the hard needle and the upper surface of the soft needle are provided with smooth planes.
Optionally, the front end of the soft needle is provided with a tip, the side wall of the front section of the soft needle close to the tip is provided with a barb, and the tip of the barb inclines backwards.
Optionally, the clamping groove structure is a long and thin cylinder, the clamping strip structure is a hollow annular tube, and the inner diameter of the hollow annular tube is equal to the diameter of the long and thin cylinder.
The invention also provides a neural microelectrode, which comprises the compound microneedle structure, wherein the compound microneedle structure comprises: the front end of the hard needle is provided with a clamping groove structure; the front end of the soft needle is provided with a clamping strip structure; the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the nerve tissue, and then the hard needle is pulled out.
According to the technical scheme, the clamping groove structure is arranged at the front end of the hard needle, the clamping strip structure is arranged at the front end of the soft needle, and the clamping groove structure and the clamping strip structure can be matched with each other to realize clamping connection.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
Fig. 1 is a schematic perspective view of an embodiment of a composite microneedle structure provided in the present invention;
FIG. 2 is an enlarged view of the tip of FIG. 1 including a hard needle and a soft needle;
FIG. 3 is an enlarged view of the structure of the hard needle clamping groove in FIG. 1;
FIG. 4 is an enlarged schematic view of the forward end of the hard needle of FIG. 1;
FIG. 5 is a perspective view of the soft needle of FIG. 1;
FIG. 6 is an enlarged schematic view of the forward end of the soft needle of FIG. 5;
fig. 7 is a schematic cross-sectional view of the composite microneedle structure of fig. 1.
The embodiment of the invention is illustrated by reference numerals:
| reference numerals | Name (R) | Reference numerals | Name (R) |
| 100 | |
13 | |
| 1 | |
2 | |
| 11 | |
21 | |
| 12 | Convex |
22 | |
| 122 | Groove |
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indication is changed accordingly.
In addition, if there is a description of "first", "second", etc. in an embodiment of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
The invasive neural microelectrode is one of the nerve electrical activity sensing means with the highest resolution at present as a sensing device, and can record action potential of a nervous system or even a single neuron on the premise of not damaging the nervous system as much as possible. At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a polyimide electrode in a soft needle structure. When the hard needle (rigid needle) is implanted, the hard needle cannot be adaptively deformed along with the expansion and contraction of blood vessels, and certain damage may be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like.
In view of the above, the present invention provides a composite microneedle structure 100, which is convenient and safe for implantation of a microelectrode 100. Referring to fig. 1 to 7, an embodiment of a composite microneedle structure 100 according to the present invention is shown.
Note that, in the following embodiments, the up-down direction referred to by the composite microneedle structure 100 corresponds to the vertical direction, i.e., the gravity direction; the front-back direction and the left-right direction of the composite microneedle structure 100 correspond to the front-back direction and the left-right direction of the user, respectively.
Referring to fig. 1, the present invention provides a composite microneedle structure 100, where the composite microneedle structure 100 includes a hard needle 1 and a soft needle 2, a card slot structure 11 is disposed at a front end of the hard needle 1, and a card strip structure 21 is disposed at a front end of the soft needle 2; the card strip structure 21 can be clamped into the card slot structure 11, so that the hard needle 1 brings the soft needle 2 into the nerve tissue, and then the hard needle 1 is pulled out.
According to the technical scheme, the clamping groove structure 11 is arranged at the front end of the hard needle 1, the clamping strip structure 21 is arranged at the front end of the soft needle 2, the clamping strip structure 21 can be matched with the clamping groove structure 11 to be clamped, when the hard needle 1 enters the nervous tissue of a human body, the clamping strip clamped with the clamping groove of the hard needle 1 drives the soft needle 2 to enter the nervous tissue together, and then the hard needle 1 is pulled out, so that the defects of the single hard needle 1 or the soft needle 2 can be overcome, the soft needle 2 and the hard needle 1 can be well fixed, the soft needle 2 is prevented from warping to a certain degree, the hard needle 1 can be conveniently pulled out, and the damage to the nervous tissue can be guaranteed to be small.
In the technical scheme of the invention, the hard needle 1 is a michigan electrode, in the embodiment, the material of the clamping groove is not limited, and under different application requirements, the clamping groove and the clamping strip are made of materials with good biocompatibility and biodegradability or silicon materials, although other materials harmless to human nerves are also feasible. Hard needle 1 is fixed connection or integrated into one piece with draw-in groove structure 11, hard needle 1 also is fixed connection or integrated into one piece with draw-in groove structure 11 and soft needle 2 with card strip structure 21, when draw-in groove structure 11 with card strip structure 21 joint together, realizes that hard needle 1 and soft needle 2 move together in neural tissue.
In order to make the composite microneedle conveniently implant into the nervous tissue of the human body and maintain the structural performance of the microelectrode, referring to fig. 1, in this embodiment, the hard needle 1 is a michigan electrode, the michigan electrode is a three-dimensional electrode array assembled by a plurality of silicon needles with a plurality of recording channels, the surface is made into a process surface layer to form a structure similar to a cuboid, and in this embodiment, a section of elongated implantation section is arranged at the front end of the similar cuboid structure, so that the front end of the hard needle 1 is narrow and the rear end is wide. This design makes it possible to more conveniently invade the hard needle 1 into the nerve tissue of the human body. The soft needle 2 is made of SiN materials and has flexibility, the soft needle is inconvenient to penetrate into nerve tissues, the soft needle has a good prospect in the aspect of biocompatibility, and the shape of the soft needle 2 is the same as that of the hard needle 1 and is smaller than that of the hard needle 1, so that the soft needle can be conveniently clamped on the hard needle 1 and cannot fall off.
Further, in an embodiment, referring to fig. 7, in order to make the hard needle 1 and the soft needle 2 firmly clamped and not fall off during implantation, a convex cavity 12 is disposed on the upper surface of the front end of the hard needle 1, the upper end of the convex cavity 12 is open, and grooves 122 are disposed on two inner side walls of the convex cavity 12 near the bottom wall to form a clamping portion of the clamping groove structure 11, so that the clamping strip is clamped into the convex cavity 12 to realize clamping. The engaging portion of the slot structure 11 may be provided in a sectional manner, or may be provided in an integral manner without being divided.
Referring to fig. 3 and fig. 4, in a further embodiment, the front end of the hard needle 1 is configured to be similar to a tapered tip, and the front end of the hard needle 1 gradually decreases in the horizontal direction to form a tip, so that the resistance of the slot structure 11 is reduced when entering the nervous tissue, thereby facilitating the entry of the hard needle 1, and the hard needle 1 and the soft needle 2 are clamped by the slot structure 11 and the clamping strip structure 21, thereby facilitating the entry of the soft needle 2.
Further, in an embodiment, referring to fig. 3, a stopper 13 is disposed at a rear end of the slot structure 11, two ends of the stopper 13 in an extending direction are flush with two outer side walls of the convex cavity 12, the shape of the stopper 13 is not limited, the embodiment is preferably a rectangular parallelepiped shape, the height of the stopper 13 in the up-down direction is the same as the height of the convex cavity 12, and the left and right ends of the stopper 13 are hermetically connected with the left and right outer side walls of the convex cavity 12, so that the stopper 13 and the convex cavity 12 form a closed structure. When the clamping strip is clamped into the convex cavity 12, the stop block 13 can prevent the clamping strip structure 21 from sliding out of the clamping groove structure 11, and prevent the soft needle 2 from sliding out of the nerve tissue.
In order to enable the card strip structure 21 of the soft needle 2 to be matched with the card slot structure 11 of the hard needle 1 and to ensure that the card is firmly clamped, in this embodiment, referring to fig. 7, the size of the card strip structure 21 is matched with the shape of the card slot structure 11, the lower surface of the front end of the soft needle 2 is provided with an inverted "T" -shaped protrusion 22 along the front-back direction, that is, the lower surface of the front end of the soft needle 2 is formed with a strip-shaped protrusion 22, the cross section of the lower end of the protrusion 22 is widened and has a section similar to an inverted "T", and the length of the protrusion 22 in the left-right direction is the same as the depth of the recess 122, so that the protrusion 22 is just clamped into the recess 122 to realize the clamping and prevent the soft needle 2 from slipping out of the hard needle 1 in the moving process. The card strip structure 21 can also be a strip-shaped convex block protruding from the surface of the soft needle 2.
Further, in an embodiment, referring to fig. 1, the lower surface of the hard needle 1 and the upper surface of the soft needle 2 are both configured as smooth planes, and a smooth coating may be applied on the lower surface of the hard needle 1 and the upper surface of the soft needle 2, so that the hard needle 1 reduces resistance when driving the soft needle 2 to invade the nerve tissue, and simultaneously reduces damage to the nerve tissue.
Further, in an embodiment, please refer to fig. 5 and fig. 6, the front end of the soft needle 2 is a tip, which is designed to match with the tip of the front end of the hard needle 1, so that the shape of the soft needle is adapted when the soft needle is connected to the hard needle, and no resistance is added to the implantation, the side wall of the front section of the soft needle 2 near the tip is provided with a barb, the tip of the barb is inclined backwards, which is beneficial for the soft needle 2 to enter the nerve tissue under the driving of the hard needle 1, and after the hard needle 1 is pulled out, the soft needle 2 can be stabilized in the nerve tissue without any swing.
In order to enable the hard needle 1 and the soft needle 2 to be clamped more firmly and facilitate easy implantation of the compound microneedle into the nerve tissue, further, in the embodiment, the size of the clamping strip structure 21 is matched with the size of the clamping groove structure 11, specifically, the length of the clamping strip structure 21 in the front-back direction is slightly shorter than that of the clamping groove structure 11, so that when the hard needle 1 is implanted into the nerve tissue, the soft needle 2 can be driven to enter the nerve tissue without being clamped outside; the width of the clamping strip structure 21 in the left-right direction is slightly smaller than that of the clamping groove structure 11, so that the bulge 22 of the clamping strip structure 21 can be clamped into the convex cavity 12 of the clamping groove; the thickness of the card strip structure 21 in the up-down direction is substantially equal to the thickness of the card slot structure 11 in the up-down direction, or slightly smaller than the thickness, so that the card strip structure 21 can be tightly clamped with the card slot structure 11 and cannot fall off when being implanted into nervous tissue.
In this embodiment, the slot structure 11 is a slender cylinder, the clamping strip structure 21 is a hollow annular tube, the inner diameter of the hollow annular tube is equal to the diameter of the slender cylinder, the slot structure 11 of the slender cylinder can just be inserted into the clamping strip structure 21 of the hollow annular tube, and a second stopper is arranged at the rear end of the slot structure 11, the shape of the second stopper is not limited, and the second stopper can be annular or a bump, and can prevent the soft needle 2 from sliding out when being brought into the nervous tissue by the hard needle 1.
The invention also provides a neural microelectrode, which comprises the compound microneedle structure, wherein the compound microneedle structure specifically refers to the above embodiments, and the neural microelectrode adopts all the technical schemes of all the above embodiments, so that the neural microelectrode also has all the beneficial effects brought by the technical schemes of the above embodiments, and further description is omitted here.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structural changes made by using the contents of the present specification and the drawings, or any other related technical fields, which are directly or indirectly applied to the present invention, are included in the scope of the present invention.
Claims (10)
1. A composite microneedle structure for implanting a microelectrode of neural tissue, comprising:
the front end of the hard needle is provided with a clamping groove structure; and
the front end of the soft needle is provided with a clamping strip structure;
the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into nerve tissue, and then the hard needle is pulled out.
2. A composite microneedle structure according to claim 1, wherein the hard needle and the soft needle are each a structure having a narrow front end and a wide back end.
3. The composite microneedle structure of claim 2, wherein a leading end of said hard needle is configured as a tip for entering into nerve tissue.
4. The composite microneedle structure of claim 1, wherein a convex cavity is formed on the upper surface of the front end of the hard needle, the upper end of the convex cavity is open, and grooves are formed on the two inner side walls of the convex cavity near the bottom wall to form a clamping groove structure.
5. The composite microneedle structure of claim 4, wherein a stopper is disposed at a rear end of the slot structure, and left and right ends of the stopper are flush with two outer sidewalls of the protruding cavity.
6. The composite microneedle structure according to claim 1, wherein a lower surface of a front end of the soft needle is provided with a T-shaped projection in a front-rear direction to form a snap strip structure.
7. A composite microneedle arrangement according to claim 1, wherein both the lower surface of the hard needles and the upper surface of the soft needles are provided as smooth planes.
8. The compound microneedle structure of claim 1, wherein the front end of the soft needle is provided as a tip end, the side wall of the front section of the soft needle close to the tip end is provided with a barb, and the barb tip end is inclined backward.
9. The composite microneedle structure of claim 1, wherein the dimensions of said snap strip structure match the dimensions of said snap groove structure.
10. A neural microelectrode comprising the composite microneedle structure of any one of claims 1 to 9.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880707.0A CN115429282B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and nerve microelectrode |
| PCT/CN2022/126573 WO2024021326A1 (en) | 2022-07-25 | 2022-10-21 | Composite microneedle structure and neural microelectrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880707.0A CN115429282B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and nerve microelectrode |
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| CN115429282A true CN115429282A (en) | 2022-12-06 |
| CN115429282B CN115429282B (en) | 2024-02-06 |
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| WO (1) | WO2024021326A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115281682A (en) * | 2022-07-25 | 2022-11-04 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
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| WO2024021326A1 (en) | 2024-02-01 |
| CN115429282B (en) | 2024-02-06 |
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