DE102007049429A1 - Wound care articles comprising superabsorbent polymers in fiber and / or yarn form - Google Patents

Abstract

The invention relates to a wound care composition comprising a proportion of superabsorbent polymers, wherein said superabsorbent polymers are in fiber and / or yarn form (FIG. 1).

Description

The The invention relates to a wound care article according to the Preamble of claim 1.

One such wound care article is particularly suitable for recording of exudate from chronic wounds such. In diabetes, ulcer Cruris and similar diseases occur.

Of the Term "exudate" refers to an over the inflammatory Wound edema processes Blood plasma derived wound fluid. Just like the blood for the transport of nutrients and other messengers and thus for the supply of various Parts of the body is responsible, the exudate serves in a very similar way to the care of the wound bed and the healing processes taking place in it. To this multitude of functions to cope with it, it contains a wide range of components, which results in a specific weight that is slightly above whose water is lying. This is different from the transudate, which is derived from non-inflammatory processes and a significantly lower specific gravity with a low Cell and protein content has. In addition to the provision of nutrients for the fibroblasts and epithelial cells that coordinates Exudate the various processes of wound healing in time and place spatially due to its high content of growth factors and cytokines. These are mainly due to platelets, keratinocytes, Macrophages and fibroblasts formed. They affect the motility, Migration and proliferation of various wound healing involved cells. Thus, the migration of cells into the wound base as well as the supply of the newly formed granulation tissue through angiogenesis. The wound cleansing is also due to the exudate supported. It contains various serine, cysteine and aspartate proteases, as well as matrix metalloproteases, in their Activity strictly regulated irreversibly damaged Degrade tissue and thus the wound bed for the subsequent Prepare phases of healing.

ingredients of the physiological exudate are in particular salts, glucose, cytokines and growth factors, plasma proteins, proteases (especially matrix metalloproteases), Granulocytes and macrophages.

comes It does not lead to a significant progression within a few weeks the wound healing process according to the different phases of wound healing, This is the name of a chronic wound. You look at it but already more than three days of continuous exudative Phases as a complication and speaks of a pathological exudation, which can contribute to a chronicity of the wound. The basis lying causes are usually complex and can be quite be systemic nature. It is surprising, however the previously explained importance of the exudate for Wound healing does not cause complications of wound healing in a significantly altered composition and effect of the exudate.

Under Others by a shift in concentration of the individual components Exudate loses the normally healing exudate in chronic wounds its positive effect. In particular the Content of inflammatory cytokines and proteases is pathological Exudate significantly increased. The content of growth factors is reduced. A particularly serious difference results with regard to the activity of the zuvo Matrix metalloproteinases. In addition to the preparation of the wound bed are they also in the later conversion of granulation to scar tissue involved. These enzymes are usually called an inactive pre-enzyme formed and in their activation by appropriate inhibitors regulates (tissue inhibitors of metalloproteases, TIMPs), which at the same time have a positive effect on cell growth. In chronic exudate seems due to disorders in this regulatory system increases the activity of the proteases, possibly contributing to an active wound regression. The pathological exudate is in terms of the content of its components get out of the wound progression-promoting balance. This results in various complications that further Contribute to deterioration and chronicity of the wound.

One Wound care article of the type mentioned in particular serves to absorb said chronic exudate and so wound healing to promote.

However, the use of particulate superabsorbent polymers in wound care articles has a number of disadvantages:
Thus, these particles can not be brought close to the wound because they are not absorbable, so it is not excluded that particles get into the wound, remain there and lead to inflammation. For this reason, these particles must always be separated from the wound by a particle-tight sheath.

The Particles must always be in a carrier matrix be arranged, such. B. in a mat of an airlaid. Of the Proportion of superabsorbent materials in such a wound care article is thus always reduced by the proportion of airlaid, which is the maximum Absorption capacity affected.

Particles can not handle liquid flows direct or judge. In this way it can u. U. come to a Wundrandmazeration.

particle often have a high abrasiveness and can - at least in the dry state - an unpleasant skin sensation cause.

task the present invention is to provide a wound care article, which avoids the disadvantages mentioned.

These Tasks are performed by a wound care article with the characteristics of the submitted main claim. The dependent claims indicate preferred embodiments. It should be noted, that the stated ranges consistently include the respective limit values are to be understood.

Therefore a wound care article is provided, comprising at least one Proportion of superabsorbent polymers, said superabsorbent polymers Polymers in fiber and / or yarn form are present.

Superabsorbent polymers (SAP) are plastics that are able to absorb many times their own weight - up to 1000 times - in liquids. Chemically, this is a copolymer of acrylic acid (propenoic acid, C ₃ H ₄ O ₂ ) and sodium acrylate (sodium salt of acrylic acid, NaC ₃ H ₃ O ₂ ), wherein the ratio of the two monomers to each other may vary. In addition, a so-called core crosslinker (core-crosslinker, CXL) is added to the monomer solution, which connects the long-chain polymer molecules formed in places with each other by chemical bridges (they "crosslinked"). These bridges make the polymer water insoluble. When water or aqueous salt solutions penetrate into the polymer particles, they swell up and tighten this network at the molecular level, so that the water can no longer escape without help.

Superabsorbent polymers are usually in the form of granules or a powder, before, and are z. B. in this form for use in wound dressings from the WO03094813 , of the WO2007051599 and the WO0152780 the assignee of the present invention. The disclosure of the said writings is fully attached to the disclosure of this document.

The Wound dressing described therein may preferably be substantially flat material portion of absorbent material, the z. B. from an absorbent fleece of said fibers with distributed therein superabsorbent polymers. These are as described, preferably in the form of a granulate or a powder, However, also in the form of a bed, a Compacts, of a foam, in the form of fibers, of a fiber knit, or non-woven fabric and / or a fiber wadding present.

• i) So haben besagte Fasern oder Garne einen Dochteffekt. Auf diese Weise können sie bei Kontakt mit einer Flüssigkeit sehr viel schneller diese Flüssigkeit aufnehmen und binden als dies partikuläre superabsorbierende Polymere können.
• ii) überdies können die Flüssigkeitssströme lenken bzw. richten. Auf diese Weise kann z. B. eine Wundrandmazeration verhindert werden.
• iii) Sie können anders als partikulare superabsorbierende Polymere zu Vliesen, Geweben oder ähnlichem verarbeitet werden. Auf diese Weise kann z. B. die Hülle einer Wundauflage aus diesen Fasern oder Garnen gefertigt sein, und die superabsorbierenden Eigenschaften können so sehr viel näher an den Wundgrund gebracht werden.
• iv) Die Gefahr, dass superabsorbierende Materialien in der Wunde verbleiben, ist bei einem Gewebe aus superabsorbierenden Garnen sehr viel geringer als bei partikulären superabsorbierenden Polymeren. Auch dies trägt dazu bei, dass die superabsorbierenden Eigenschaften so sehr viel näher an den Wundgrund gebracht werden können
• v) Da in vielen Fällen auf ein gesondertes Trägermaterial verzichtet werden kann, kann der Anteil an superabsorbierenden Materialien in einem Wundpflegeartikel erheblich erhöht werden; im Extremfall kann er sogar einen Gewichtsanteil von 100% annehmen.
• vi) Besagte Fasern oder Garne bzw. die daraus hergestellten Produkte besitzen eine sehr viel höhere Weichheit und eine geringere Abrasivität als die entsprechenden partikulären superabsorbierenden Polymere.
• vii) Besagte Fasern oder Garne lassen sich zu einem Gefüge verarbeiten, ohne dass – wie es bei partikulären superabsorbierenden Polymeren erforderlich ist – ein Kleber oder ein Schweissverfahren verwendet werden muß. Dies hat sowohl in bezug auf die Reinheit des Produkts als auch in bezug auf die Pharmakologie und etwaige Allergenität erhebliche Vorteile.
• viii) Im Gegensatz zu partikulären superabsorbierenden Polymere läßt sich die Dimensionierung besagter Fasern oder Garne sehr viel genauer steuern und kontrollieren, was einerseits zu Verhinderung von Stäuben führt, wie sie bei Verwendung von partikulären superabsorbierenden Polymere häufig entstehen., und was andererseits die Produktqualität (Homogenität und Reproduzierbarkeit) wesentlich erhöht.
• ix) Aufgrund der fehlenden Ausbildung von Stäuben kann ggf. auch auf die Verwendung einer gesonderten Hülle verzichtet werden.
• x) Besagte Garne oder Fasern können in aus dem Stand der Technik bekannten Airlaids, die partikuläre superabsorbierenden Polymere enthalten, die Trägerfasern des Airlaids ersetzen, um so den Anteil an superabsorbierenden Materialien in einem Wundpflegeartikel und damit die gesamte Absorptionskapazität – zu erhöhen.

The use of superabsorbent polymers in fiber or yarn form proposed by the Applicant for the first time in the present context has a number of advantages over particulate superabsorbent polymers:

• i) Thus, said fibers or yarns have a wicking effect. In this way, upon contact with a liquid, they can absorb and bind this liquid much faster than particulate superabsorbent polymers can.
• ii) Moreover, the liquid streams can direct. In this way, z. B. a Wundrandmazeration be prevented.
• iii) Unlike particulate superabsorbent polymers, they can be made into nonwovens, fabrics or the like. In this way, z. For example, the sheath of a wound dressing may be made of these fibers or yarns, and the superabsorbent properties can be brought much closer to the wound base.
• iv) The risk of superabsorbent materials remaining in the wound is much lower for a web of superabsorbent yarns than for particulate superabsorbent polymers. This also contributes to the fact that the superabsorbent properties can be brought so much closer to the wound base
• v) Since in many cases can be dispensed with a separate carrier material, the proportion of superabsorbent materials in a wound care article can be significantly increased; in extreme cases, it can even assume a weight percentage of 100%.
• vi) Said fibers or yarns or the products made therefrom have a much higher softness and a lower abrasiveness than the corresponding particulate superabsorbent polymers.
• vii) Said fibers or yarns can be made into a structure without the need for an adhesive or a welding process, as is required with particulate superabsorbent polymers. This has considerable advantages both in terms of the purity of the product and in terms of pharmacology and possible allergenicity.
• viii) In contrast to particulate superabsorbent polymers, the dimensioning of said fibers or yarns can be controlled and controlled much more accurately, which on the one hand leads to the prevention of dusts, as often occur when using particulate superabsorbent polymers., And on the other hand the Product quality (homogeneity and reproducibility) significantly increased.
• ix) Due to the lack of formation of dusts may possibly be dispensed with the use of a separate shell.
• x) Said yarns or fibers can be substituted in prior art airlaids containing particulate superabsorbent polymers to replace the carrier fibers of the airlaid so as to increase the proportion of superabsorbent materials in a wound care article and thus the total absorbent capacity.

Any two- or three-dimensional arrangement of the fibers or yarns here conceivable. So the fibers or yarns can be addressed or undirected (Wirr-Warr), arranged in several layers or otherwise be.

Superabsorbent fibers of polyacrylates are z. They are marketed and sold by the company Technical Absorbents under the trade name "Oasis Super Absorbent Fiber." Like all superabsorbent polyacrylates, they have a very high absorption capacity for liquids, for example in the form of a nonwoven, an airlaid, a Fabric, an airlaid and / or a nonwoven DE 69807337 known

The However, said fibers of superabsorbent material are in usually very brittle, as the polyacrylate material used has a high brittleness. For this reason, can the fibers do not exceed a certain length and therefore not easily processed into a yarn.

The WO0106047 describes yarns having superabsorbent polymers. These yarns are based on a special manufacturing process in which the abovementioned superabsorbent fibers are mixed with supporting fibers of a stronger material and then spun into a yarn. In said supporting fibers are, for. For example, fibers of polyester, polypropylene, nylon, cotton, viscose or similar material. The yarn thus produced can then be made into a woven, scrim, knit and / or knitted fabric. Likewise, the fibers can also be processed with elastic fibers, such as spandex.

So far, however, only the use of such yarns for cables, especially underwater cables, described, such. B. in the EP1072698 from the same applicant as those discussed above WO0106047 ,

Prefers It is envisaged that the present in fiber form superabsorbent Polymers at least partially in the form of a batt, a fleece, an airlaid and / or a nonwoven.

For this are preferably fibers with mean lengths of 5-50 mm used. The preparation is carried out by known methods, such as z. As the carding or the airlaid process. It can the superabsorbent fibers are the sole constituent of each Be material. However, it is preferably provided that the wound care article moreover has a proportion of supporting fibers, which also in moist condition to ensure the integrity of the wound dressing, wherein said fibers are selected from the group comprising

• a) cellulose fibers,
• b) viscose fibers,
• c) alginate fibers, and / or
• d) polyester, polyolefine, polyurethane, polyvinyl alcohol or polymaid fibers, or mixtures or copolymers thereof

On this way, the absorption properties of the relevant Materials, but also other properties such. B. extensibility, Tear resistance, wetting behavior and like, exactly control.

The mentioned fibers in contrast to the mentioned hydroactive or superabsorbent polymers only relatively little moisture and therefore retain their structural integrity for longer or strength. So they form, so to speak, the "backbone" of the wound care article according to the invention, thus this, when it has absorbed moisture, turns out to be whole remove the wound.

there may in particular be provided that a tissue is provided, in the z. As the warp threads of superabsorbent yarns are made while the weft threads from others Consist of yarns z. B. supporting fibers according to the above list included. Such a fabric has directional hydroactive properties, d. H. it takes liquid in one direction and forward it.

cellulose is a naturally occurring, unbranched polysaccharide, that from several hundred to ten thousand β-D-glucose molecules with (1-4) β-glycosidic linkage. It is the main ingredient of the pulp.

Viscose fibers are fibers that consist of the base material cellulose and are processed using a chemical finishing process. The cellulose is first with Nat sodium hydroxide solution, swells and forms sodium cellulose. These can be carbon disulphide (CS ₂ ) act. This produces sodium xanthate (xanthate), which is soluble in aqueous, dilute NaOH solution and forms a viscous solution. Both before the reaction with CS ₂ and after dissolving in sodium hydroxide solution, the soda-cellulose or the spun-viscose is given time for the respective chemical reactions.

For this include the shortening of the chain lengths the polymeric cellulosic molecules before the xanthogenation reaction and rearrangement reactions after the dissolution process. After two- or triple filtration and venting then possesses the dope has the appropriate viscosity and maturity - reactivity opposite to the spinning bath - to subsequently spun to be able to.

For the viscose fibers in the classical manufacturing process, a sulfuric acid spinning bath is used, which additionally - almost to the saturation limit - sodium sulfate and a small amount of zinc sulfate to retard the cellulose precipitation reaction contains. The Viskosepinnmasse is by means of gear pumps pressed through the spinnerets. The typical hole diameter a single hole of the spinnerets is about 50 μm.

The fiber thus obtained differs from classical cellulose fibers by a very smooth surface, which prevents any adhesion with the wound, and causes a higher tensile strength. Viscose is available under the trade name Rayon Alginates are obtained from the brown algae and can be processed in fiber form into a nonwoven or fabric. Chemically, it is polysaccharides, namely calcium and / or Natrimsalze the alginic acids. Alginates can absorb up to 20 times their own weight of liquid, while the wound exudate is stored in the cavities. The Ca ²⁺ ions contained in the alginate lattice are exchanged with the Na ⁺ ions from the exudate until the degree of saturation of Na ions in the alginate is reached. This leads to a swelling of the wound dressing and the conversion of the alginate fiber into a gel body by swelling of the fibers. This occurs, however, z. B. in contrast to superabsorbent polymers only at much higher liquid levels, so that alginates come as supporting fibers in the context of the present invention in question.

• a) hydroaktive Polymere, und/oder
• b) partikulare superabsorbierende Polymere

Furthermore, it is preferably provided that the wound care article contains, in addition to said yarns or fibers, at least one further constituent selected from the group comprising

• a) hydroactive polymers, and / or
• b) particulate superabsorbent polymers

• • Agar,
• • Carrageen,
• • Johannisbrotkernmehl,
• • Guarkernmehl,
• • Traganth,
• • Gummi arabicum, d
• • Xanthan,
• • Karaya,
• • Tarakernmehl,
• • Gellan,
• • Pektin,
• • Chitosan,
• • Hyaluronsäure,
• • Modifizierte Stärke, sowie
• • Zellulose und Zelluloseether, wie z. B.
• • Carboxymethylcellulose,
• • Hydroxypropylcellulose,
• • Hydroxypropylmethylcellulose,
• • Methylcellulose und
• • Methylethylcellulose.

The term "hydroactive polymers" is to be understood below as meaning polymers which have moisture-binding properties

• • agar,
• • carrageenan,
• • locust bean gum,
• • guar gum,
• • tragacanth,
• • gum arabic, d
• Xanthan gum,
• • Karaya,
• Tarakernmehl,
• • Gellan,
• • pectin,
• • Chitosan,
• • hyaluronic acid,
• • Modified strength, as well
• • cellulose and cellulose ethers, such. B.
• Carboxymethyl cellulose,
• Hydroxypropyl cellulose,
• Hydroxypropylmethylcellulose,
• • Methylcellulose and
• • methyl ethyl cellulose.

The Hydroactive polymers mentioned take aqueous wound exudates and also form a moist surface out. Possibly. assume a gelatinous form. The moist surface or the gel form contributes to the tendency of the wound care article to become sore reduce it, leaving it atraumatic after use and relieve painlessly. Through the gel form the wound care article has a cooling and thus scherzlindernde Effect on. Moreover, the gel form allows the Training of a wound healing moisturizing climate.

Especially Preferably, the hydroactive polymers are in the form of fibers. These Fibers can be of the type that have their structural integrity retain on absorption of water or exudate, or may of the type that lose their fiber shape upon absorption of exudate and become a structureless gel or solution. The latter is especially true for fibers of methyl cellulose and their derivatives.

Prefers may be provided that the absorption properties the superabsorbent yarns or fibers and the hydroactive used Differentiate polymers. In this way, z. B. a wound care article made of a highly absorbent core and a having low-absorbent shell. This configuration ensures a wound care product that is always dry Surface has.

Mineral ion exchangers, such as zeolites, bentonites or montmarylinites, may also be used Be part of the wound care article, in particular his mat. Zeolites can, inter alia, absorb pollutants, such as heavy metals.

In Another preferred embodiment provides that the wound exudates absorbing body at least one material which is selected from the group comprising a mat, in particular of an airlaid of said yarns or Fibers made of superabsorbent polymers with incorporated superabsorbent Polymers, and / or a loose filling of superabsorbent Polymers. Said airlaid mat preferably prefers a substantially flat material portion of absorbent material, the z. B. from an absorbent fleece of said fibers with distributed therein superabsorbent polymers.

This wound exudate absorbent body, with the exception that fibers or yarns of superabsorbent polymers are used here instead of cellulose fibers, correspond to the absorbent pad contained in a wound dressing of the applicant of the present invention, as described, for example, in US Pat WO03094813 , of the WO2007051599 and the WO0152780 is disclosed and marketed under the trade name "sorbion sachet." The disclosure content of the cited documents is fully attached to the disclosure content of this document.

Of the Wound exudate absorbing body can be in another Design also form a core, the - possibly flake - fibers or yarns of superabsorbent polymers and superabsorbent Having polymers in granular form, wherein the granules of the fibers or yarns glued or welded in several heights are, and the granules over more than 50% of the total Height distributed at least a portion of the core are where there are mixed areas of granules and fibers. The proportion by weight of superabsorbent polymers may be preferred range between 10-25% by weight. Similar Constructions are made of conventional incontinence materials known and sanitary napkins for their cushioning properties known.

Around said core may be arranged around a shell, the is arranged overlapping in areas, and the z. B. an adhesive seam is covered or part of the same.

As well may be within the envelope a portion of a hydrophobic and / or water-repellent or water-impermeable material be provided, the Durchnässungs- or laundry protection acts.

Of the Wound exudate absorbing body can be in another Embodiment also at least one flat layers having fibers or yarns of superabsorbent polymers to which Superabsorbent polymers are glued in granular form. Thereby results in a preferred embodiment, a structure of the body, the has at least three layers, wherein two cover layers a Layer comprising superabsorbent polymers surrounded.

there lie in the plane no mixing of fibers and superabsorbent Polymers in front; but only fixed notices of both Materials. The possibly provided several layers can in a preferred embodiment by rolling, pressing, Calendering or similar processes physically with each other be compacted. Moreover, the body can become have repetitive patterns or grains, such. B. a Check pattern, a punch pattern or the like.

Of the said wound exudates absorbent body can also possibly a shell made of a permeable material exhibit; this can have different connections or Have seams that produced in particular by bonding are. So z. B. be provided that the connection area between your two sides of the case on at least one Side of wound exudate absorbent body - preferred in the longitudinal direction - is designed narrower than on at least one other side, so that in the former case, unlike in the latter case, a foldable supernatant results.

Said sheath may preferably consist of a polypropylene nonwoven having a basis weight of 10-40 g / m ² .

Prefers may also be provided that the so-described Wound exudates absorbing bodies on at least one inside the surrounding shell is fixed, preferably by gluing.

Especially It is preferred that the superabsorbent polymers present in yarn form at least partially in the form of a fabric, a fabric, a Knitwear and / or a knitted fabric. Likewise the individual yarns also welded together in the form of a grid be.

In this form, the superabsorbent yarns z. B. act as a wrapper of a wound dressing. Likewise, from said material a dressing similar to a gauze bandage can be made. However, it can also be a three-dimensional tissue or knit fabric that acts as a central absorbent body of a wound dressing. In this case, the superabsorbent yarns may be the sole constituent of the respective material, but they may also be used in combination with other fibers, such. B. with pulp, viscose, cotton and / or polyolefin fibers.

On this way, the absorption properties of the relevant Materials, but also other properties such. B. extensibility, Tear resistance, wetting behavior and like, exactly control.

Further If a wound care article is provided according to the invention, characterized in that in fiber and / or yarn form present superabsorbent polymers part of a planar Mat and / or a flat wound dressing are.

As well If a wound care article is provided according to the invention, characterized in that in fiber and / or yarn form present superabsorbent polymers component of a three-dimensional Absorbent body are.

As well If a wound care article is provided according to the invention, characterized in that in fiber and / or yarn form present superabsorbent polymers part of a shell a wound dressing.

alternative it is envisaged that the present in fiber and / or yarn form superabsorbent polymers are part of a foam. In this Foam can be z. B. selected from a material the group containing thermoplastic flexible foams, such as Polyurethane, polyamide or polyether foam, silicone foam as well Cellulose foam or natural sponge is.

natural sponges for example, the class of Hornkieselschwämme (Demospongiae) Similar to technical foams have an absorbency for liquids. Moreover, they show Growth-inhibiting properties against microorganisms to protect themselves from settling sessile organisms. These properties may also be related to wound care be useful to bacterial growth in the wound dressing and / or to prevent in the wound. Likewise, these sponges have growth inhibiting Properties against fungi and unicellulars on. in addition comes from having such sponges to absorb liquids and are therefore excellently able to absorb exudates suitable.

said Natural sponge can in thin slices, the z. B. by thermal Cutting have been produced, be placed on the wound.

Of the Flexible foam may optionally be designed multi-layer, the individual layers may preferably have thicknesses between 0.5 mm and 10 mm.

Of the Flexible foam can be open-celled and closed-celled be. In particular, in the latter case can be provided that the material has punches and / or perforations, which the liquid inlet and passage in or through the Accelerate soft foam. Moreover, the flexible foam can be designed as integral foam.

In In this case, the superabsorbent fibers or Yarns already before foaming the foam in the Starting material are introduced. Alternatively you can They are also pressed by means of pressure in the finished foam material become.

On this way, the absorption capacity of the invention Wound care article further increased. Moreover, you can the fibers or yarns have a wicking effect. This is insofar advantageous, since it ensures that the surface of the Wound care article remains dry and ingested exudate quickly is forwarded to the inside.

Farther may be anticipated that the present in fiber and / or yarn form Superabsorbent polymers are applied to a carrier layer.

Here may be provided that the fibers in a jumble arrangement if necessary, sprinkle on both sides on a layer previously with an adhesive material was coated. Here can it is z. B. paraffin or glycerol act. Likewise, a Fabric having superabsorbent yarn applied to said layer be. Several of these layers can z. B. in an inventive Wound care article should be superimposed.

As well can be provided that the present in fiber and / or yarn form superabsorbent component of a bandage or wrap that are possibly having elastic properties. For this purpose, it can be provided that the fibers in the manner described above with elastic fibers have been processed into a yarn.

Further is the use of a wound care article according to the invention for the treatment of chronic wounds, acutely bleeding wounds and traumatic provided wounds.

As well is the use of a wound care article according to the invention for surgical or postoperative care or for military purposes.

Farther is a kit for the acute, emergency or military medical or the chronic care provided, having an inventive Wound care products.

variants

Preferably there is a possibly provided shell of at least partially also from a hydrophobic material, such as polypropylene or made of a hydrophobic natural material, such as cotton. The hydrophobic properties of the shell prevent this Adhere to the wound surface and contribute to that the wound exudate can reach the interior of the shell more quickly.

The Case can also be made of another plastic, in particular a polyurethane or polyethylene film or artificial Be made of spider silk foil.

The material of the sheath may be structured such that the sheath has a rough inner surface and a smooth outer surface. Preferably, the rough inner surface of the shell is formed by funnel-shaped perforations, each tapering towards the inner surface and terminating in a free opening edge ("protrusion"), this rough inner surface counteracting the displacements of the contents of the shell, so as to provide adhesion with adhesive dots Accordingly, the smooth outer surface of the sheath material may be formed by curved sections of material extending between the perforations, such a sheath material may be referred to as "three-dimensional" as opposed to a bilaterally planar one. B. from the DE102006017194 the applicant of the present application, the disclosure content of which is fully referenced here.

Prefers is also provided in this context that the Wound care article also has at least one nutritive, at least one disinfecting or decontaminating and / or at least one protease inhibiting agent and / or Active complex has.

at the disinfecting active ingredient and / or active ingredient complex can it be z. B. to a composition of at least one Vitamin or vitamin derivative, a metal ion and a detergent act. It may also be an BLIS (bacteriocin like inhibitory substance) or coated magnetic particles act.

at the nutritive active ingredient and / or active ingredient complex can it is a composition containing at least the constituents an enteral and / or parenteral dietetics. Likewise, it may be selected at least one active element from the group containing insulin, recombinant insulin, proinsulin, an insulin-like growth factor (insulin-like growth factor, IGF), an insulin mimetic and / or a diabetic, non-glucose or sucrose-based energy sources act.

at the protease inhibiting drug and / or drug complex it can be selected from at least one active element the group containing protease inhibitors, superabsorbent polymers, Chelators for divalent cations, collagen, coated magnetic particles, acids, buffers, non-pathogenic acid-producing microorganisms, Probiotics and / or Symbiotics act.

Further connections and backgrounds to the nutritive, a disinfecting or decontaminating and / or proteases inhibiting acting active substances and / or active substance complexes are in the DE102007030931 the applicant of the present application, the contents of which are incorporated herein by reference. In the DE102007030931 Other nutritive, disinfecting or decontaminating and / or protease-inhibiting active ingredients and / or active substance complexes are also described, which are also to be regarded as disclosed in this application.

the Wound care articles can be added to substances which can increase the osmotic pressure. To the Substances include z. B. Osmodiuretics, such as mannitol.

Mineral Ion exchangers, such as zeolites, bentonites or montmarylinites, can also part of the wound care article, especially his Be a mat. Zeolites can u. a. Pollutants, such as heavy metals, absorb. Moreover, they develop a hemostatic Effect.

Furthermore, the wound care article according to the invention can also be introduced into a wound care system for wound drainage using negative pressure. Such systems are for. B. in the writings DE202004017052 . WO2006048246 and DE202004018245 The applicant of the present invention discloses the disclosure content of the present invention to be considered as belonging.

Out the former is a device for wound treatment under use of negative pressure, comprising a gas-tight wound covering element, the condition created on the patient's body remaining between the respective wound and the wound covering element Room forms, and at least one connection point with the room is in contact and about which in-room Air can be evacuated, wherein the wound covering element of at least one planar, the wound secretions receiving wound care articles is highlighted, its volume in the course of the absorption process increases so that the absorbed wound secretions within the wound care article and thus below the wound covering element until removal of the wound care article remain from the body of the patient, the Wound care article at least one layer of superabsorbent enriched textile section is that with a liquid-permeable shell surrounded, and the situation in plan view on its flat side one Area that is 3% to 90% smaller than that of the shell so that the wound care article is close to his total filling capacity in cross section of a Can approximate circular shape.

Out the second is a multi-component dressing for wound treatment of the human or animal body of negative pressure, comprising: a wound covering element for Attachment to skin and mucosal surface, at least a junction that is in contact with the wound space and over which the substances located in the wound space can be evacuated, this having superabsorbent polymers, wherein the absorbed Wound secretions bound to polymers in wound space until removal remain in the wound space, the polymers by their binding capacity mutual synergies with subatmospheric pressures support.

Out the latter is a drainage device for wound treatment under Use of negative pressure known, comprising a gas-tight, from foil-like Material existing wound covering element that in the body the patient's condition on the Hautoberflä surface is adhesively secured around the wound area and a remaining between the respective wound and the wound covering element, sealed space, at least one drainage tube, the can be used in the room over which the substances in the room can be evacuated, and at least one within arranged in the room, the wound secretions absorbing wound care articles, the at least one layer of superabsorbent enriched Textile section having, with a liquid-permeable Envelope is surrounded, with the absorbed wound secretions within the wound care article and thus below the wound cover element until removal of the wound care article from the body the patient remain, and wherein the wound cover element a gas-tight sealable treatment opening, through the wound care article can be inserted into the room and out of the room is removable.

Of the Moreover, wound care articles according to the invention can have a shape adapted to anatomical conditions. For this can he z. B. be formed in the form of a cuff; the over the an arm or a leg or a joint be put over can, or in the form of an on the heel, the elbow joint or the same adapted bandage.

The wound care article according to the invention may also be designed so that it is suitable for transfer around a surgically applied line. For this purpose, the wound care article z. B. have at least one slot, which makes it possible to transfer the dressing on the body of a patient around a conduit (eg., A drainage line or a catheter), wherein the wound care article is associated with a second, also planar wound care article that of the first wound care article is at a distance, wherein the distance is bridged by a connecting strip or web. Such a wound care article is z. B. from the DE202006005966 by the assignee of the present invention, the content of which is to be fully incorporated in the disclosure of the present specification.

As well is in this context preferably provided that the wound care article has at least one agent that the bleeding or bleeding tendency can restrict.

Said agent may be at least one chemically and / or physiologically acting active substance or active substance complex or at least one physically acting active element. Such a wound care article is z. B. from the DE 10 2007 030 931 the applicant of the present application.

• • als im wesentlichen flacher Materialabschnitt aufweisend Absorptionsmaterial, der aus einem aufsaugenden Vlies mit darin verteilten superabsorbierenden Polymeren sowie mindestens einem chemisch und/oder physiologisch wirkende Wirkstoff bzw. Wirkstoffkomplex ausgebildet sein,
• • als oder in Kombination mit einem Druck- oder Kompressionsverband,
• • als eine Kombination aus einer primären, nicht oder nur unwesentlich absorbierenden Wundauflage, die mindestens einen chemisch und/oder physiologisch wirkenden Wirkstoff bzw. Wirkstoffkomplex aufweist, und einer peripher von dieser primären Wundauflage angeordneten sekundären Wundauflage, die superabsorbierende Polymere enthält, wobei ggf. zwischen beiden eine Diffusionsbarriere angeordnet ist,
• • in Form eines Verbandpäckchens, aufweisend eine primäre Wundauflage mit mindestens einem chemisch und/oder physiologisch wirkenden Wirkstoff bzw. Wirkstoffkomplex sowie einem an der Wundauflage angeordneten Wickelabschnitt, der zumindest abschnittsweise superabsorbierende Polymere aufweist, und/oder
• • als Materialabschnitt mit einer Längserstreckung aufweisend Absorptionsmaterial, wobei der Materialabschnitt elastisch verformbare Eigenschaften aufweist, und wobei der Materialabschnitt superabsorbierende Polymere sowie ggf. mindestens einen chemisch und/oder physiologisch wirkende Wirkstoff bzw. Wirkstoffkomplex aufweist

For this purpose, the wound care article, for example

• As substantially flat material section comprising absorption material which is formed from an absorbent fleece with superabsorbent polymers distributed therein and at least one chemically and / or physiologically active agent or complex of active substances,
• • as or in combination with a compression or compression bandage,
• As a combination of a primary, insignificant or insubstantially absorbent wound position, which has at least one chemically and / or physiologically acting active substance or active substance complex, and a secondary wound dressing arranged peripherally of this primary wound dressing, which contains superabsorbent polymers, a diffusion barrier optionally being arranged between the two,
• In the form of a bandage packet, comprising a primary wound dressing with at least one chemically and / or physiologically acting active substance or complex of active substances and a winding section arranged on the wound dressing, which has superabsorbent polymers at least in sections, and / or
• As a material section having a longitudinal extent comprising absorbent material, the material section having elastically deformable properties, and wherein the material section has superabsorbent polymers and optionally at least one chemically and / or physiologically acting active substance or active substance complex

Prefers it is the chemically and / or physiologically acting Active substance or active substance complex around at least one substance or one Composition that has hemostatic properties. These Substances are under the generic term "hemostatics" known.

Prefers it is the chemically and / or physiologically acting Active substance or active substance complex around at least one substance or one Composition that has hemostatic properties. These Substances are under the generic term "hemostatics" known.

at the physically acting active element is z. B. order a binding, a pressure pad, a pressure bandage or a Compression bandage.

definitions

Of the The term "wound care article" is intended below in particular a Wound dressing, preferably a flat wound dressing or a Designate wound care cloth. Said wound dressing can both absorbing as well as not or only insignificantly absorbent designed be. In particular, the term "wound care article" may also be referred to as an ensemble of different products to be understood in one given arrangement can be arranged on the wound to be treated. This ensemble can form a physical unit by the different products in a common shell or - if necessary without sheath - adhesive connected to each other. However, the ensemble can also be in shape of a kit that uses the different products a wrap in the given arrangement on the treated Wound are arranged.

Prefers may be provided that the wound care article as a rinsing body acts. For this purpose, it is provided that the wound care article before application on the wound with a physiological solution (eg 0.9% Common salt, Ringer's solution or the like) is present or impregnated prefabricated accordingly. Such a wound care article gives during use continuously fluid to the wound, rinses this and takes exudate, cell debris, necrotic components, Bacteria, debris and the like on. Spülkörper this type are known under the brand name TenderWet.

Of the The term "fleece" refers to a textile fabric made of individual fibers, which in contrast to fabrics, crocheted and Knitted fabrics are not made from yarns. Nonwovens retain their structural properties Integrity i. d. R. by adhesion of the individual fibers together. They are also called "nonwovens", and Z. B. made by forging the fibers.

Of the The term "airlaid" refers to a special pulp nonwoven fabric and polyolefin fibers in which optionally superabsorbent polymers are embedded.

The term "exudate" refers to a wound fluid derived from the blood plasma via the inflammatory processes of wound edema. Just as the blood is responsible for the transport of nutrients and other messengers, and thus for the supply of various parts of the body, the exudate serves in a similar way the supply of the wound bed and the healing processes occurring therein. To cope with this multitude of functions, it contains a wide range of components, resulting in a specific weight that is slightly above that of water. This is also different from the transudate, which is derived from non-inflammatory processes and has a significantly lower specific gravity with a low cell and protein content. In addition to providing nutrients to the fibroblasts and epithelial cells, exudate coordinates the various processes of wound healing both temporally and spatially through its high content of growth factors and cytokines. These are mainly formed by platelets, keratinocytes, macrophages and fibroblasts. They influence the motility, migration and proliferation of the various cells involved in wound healing. Thus, the infiltration of cells into the wound base is promoted as well as the supply of the newly formed granulation tissue by angiogenesis. The wound cleansing is also supported by the exudate. It contains various serine, cysteine and aspar Tat proteases and matrix metalloproteases, which in their activity strictly regulated irreversibly degrade damaged tissue and thus prepare the wound bed for the subsequent stages of healing.

ingredients of the physiological exudate are in particular salts, glucose, cytokines and growth factors, plasma proteins, proteases (especially matrix metalloproteases), Granulocytes and macrophages.

Under the term "chemically and / or physiologically acting Active substance or active substance complex "are to be understood in the following as meaning such active substances or drug complexes are understood that the bleeding or the Bleeding tendency are able to limit without that while physical forces must be applied. The pathway here is a chemical and / or physiological Interaction with the wound environment.

Under The term "active ingredient complex" is not meant to be a complex below be understood in the chemical sense, but in particular a composition synergistically an effect-inducing agents.

Under the term "physically acting active element" is intended below an active element is understood that by physical means, d. H. by the exercise of pressure, train, cold and the like to limit the bleeding or bleeding tendency is able.

Under The term "ligation" is in the following an emergency medical Measure to be understood, which is capable of the arterial Blood flow z. B. in a limb, so as to prevent an unacceptable loss of blood in a wound. Indication for such a ligation are usually traumatic events leading to injury at least an artery lead.

Under The term "chronic wounds" should be understood as wounds, which are not primarily due to traumatic effects. True, traumatic effects can be the original trigger have been such a wound, but the chronic wound draws especially due to delayed wound healing. chronic Wounds often indicate - if anything - only easy bleeding on, but often a strong exudation.

Under The term "slight bleeding" should be understood as a bleeding, which is not of arterial origin, but possibly venous Origin or interstitial or capillary origin, and the in any case so easy that they are not medi- or is directly life-threatening.

Under The term "acute bleeding wounds" should be understood to mean such wounds which lead to large blood loss. In usually arterial bleeding is responsible for this, the z. B. caused by traumatic effects. Acute bleeding Wounds can u. U. medium or directly life threatening be. For this reason bleeding stops in acute bleeding wounds a very high priority.

Under The term "pressure bandage" is intended below from the emergency medicine known pressure bandage understood, this consists of a not too hard, non-absorbent object (pressure pad) with no sharp or hard edges on an already covered Wound is applied and using a wrap with moderate Train is attached. Due to the applied pressure, the blood circulation of the affected body part diminished and the traumatic opened blood vessels are closed again.

Under the term "non or only insignificant absorbent wound dressing" should designate a wound dressing that has a low absorption capacity for liquids. Overall, the absorption capacity while less than 60 wt .-%, preferably less than 20 wt .-% the dry weight of the wound dressing. Primary task Such a wound dressing is therefore not the uptake of Blood or exudates, but the delivery of hemostatic agents in the sense of the present invention.

Under The term "compression bandage", however, is usually a Understood association, which acts much like a pressure bandage, but waived the said pressure pad. The pressure or the compression on the wound becomes exclusive exercised through the winding. Here, the wrapping material be elastic.

Alginates are extracted from brown algae and woven into a fibrous web. Chemically, they are polysaccharides, calcium and / or sodium salts of alginic acids. Alginates can absorb up to 20 times their own weight of liquid, while the wound exudate is stored in the cavities. The Ca ²⁺ ions contained in the alginate lattice are exchanged with the Na ⁺ ions from the exudate until the degree of saturation of Na ions in the alginate is reached. This leads to a swelling of the wound dressing and the conversion of the alginate fiber into a gel body by swelling of the fibers.

Carboxymethylcellulose in particular is in the form of sodium carboxymethylcellulose and is commercially available under the name "hydrofibre". In hygiene and wound products, the fibers in transferred a planar matrix. By absorbing fluid from the wound exudate, the fibers are gradually transformed into a gel pad that holds the fluid and does not release it again. The fibers are constructed so that the wound exudate is absorbed only in the vertical direction. This means that, as long as the capacity is sufficient, the exudate does not flow over the edge of the wound. In this way, wound edge maceration can be effectively prevented.

Drawings and examples

The The present invention is characterized by the following discussed figures and examples explained in more detail. there It should be noted that the figures and examples are only descriptive in nature and are not meant to be the invention in any way Restrict shape.

The Figures show:

1 a first embodiment of the wound care article, with a nonwoven absorbent body, in a schematic sectional view;

2a and 2 B a second embodiment of the wound care article, with a covered, tissue-like absorbent body, in a schematic sectional view;

3 a tissue section, in a perspective view;

4 a tubular wound care article made from the fabric according to 3 in a perspective view;

5 another embodiment of the wound care article, with a nonwoven absorbent body and a foam-like sheath, also in a schematic sectional view;

6 a further embodiment of the wound care article according to 1 but with a sandwich-type absorbent core and

7 a wound care article according to 2a but with additional liquid impermeable insert.

In 1 is a wound care article 100 represented, comprising a liquid-permeable shell 2 of polypropylene film of a basis weight of 25 g / m ² . The case 2 is rectangular in plan view on its flat side (see. 2 B ) and includes an absorbent body 1 which completely surrounds. In a further, not shown embodiment, the shell 2 circular. The case 2 consists of two congruent shell walls 2.1 . 2.2 together, at their periphery with an ultrasonic seam 16 are welded together.

The absorbent body 1 lies in the form of a loose, airy fleece layer 11 which consists of superabsorbent short cut fibers (staple fibers). The properties of the high-absorbency short fibers are evident, for example, from the datasheet published by the manufacturer, Technical Absorbents, Grimsby, Great Britain.

The short cut fibers of an average length of about 8 to 10 mm interlock with each other, thereby enabling the formation of the cotton-like nonwoven layer 11 , The liquid-permeable casing 2 is fine-pored and allows penetration of the wound exudate into the absorbent body 1 into it. This fine-pored structure also provides a barrier to the individual short fibers. The product can be placed on the wound with both its "left" and "right" flat sides.

A similar wound care article (reference number 200. ) shows 5 , The absorbent, cotton-like absorbent body 1 surrounds a foam-like shell 12 , their shell walls 12.1 . 12.2 also congruent and by means of the peripheral ultrasonic seam 16 connected to each other. In the cotton-like fleece layer 11 are superabsorbent powdery particles 15 interspersed. The two forms of superabsorbent material (powder or granules and short fibers) contribute to a significantly increased absorption capacity of the body 3 at. As material for the shell 12 is provided with fine-pored, therapeutically effective polyurethane foam.

In 6 is another embodiment (reference number 300 ) of the wound care article, wherein an absorbent body 3 is present in a form similar to the known Airlaid mat. The sandwich-like body 3 consists of a fleece core 13 made of superabsorbent short fibers and two cellulosic cover layers 14.1 . 14.2 , The body 3 surrounds the shell already described 2 , The fleece core 13 may also include other textile fibers, such as CMC fibers (not shown).

As already listed above, the superabsorbent Short fibers are spun into a yarn, for example by said company Technical Absorbents, Grimsby. It is preferred that the superabsorbent yarn be of a diameter 0.3 mm to 1.0 mm for the production of wound dressings use. It should be noted that the increasing yarn diameter corresponding to the increasing absorption capacity.

A use of yarns 10 is the following 2a . 2 B . 3 . 4 and 7 described. So is according to 3 from yarns 10 0.5 mm diameter superabsorbent tissue 17 (see. 3 ), whose meshes are about 2 to 3 mm in size. The superabsorbent tissue 17 is adhesive over the entire surface with a cover foil 18 connected. A pointwise bonding is also possible. The tissue 17 with the cover foil placed on top 18 forms a wound care article 400 which, if applied to a wound, not shown, is preferably backed by a wound spacer grid.

In 4 is a fabric hose 19 shown, from the yarn 10 made of an exemplary diameter 0.3 mm. The fabric hose 19 has 2 to 3 mm mesh size 21 on, which can increase accordingly when used on the wound, if the fabric tube 19 over a limb, z. B. lower leg of the patient is everted and expands. The superabsorbent fabric hose 19 can also fulfill a fixing function. The superabsorbent fabric hose 19 provides a wound care article 500 for extremities

According to the 2a and 2 B is inside the shell 2 an absorbent body 4 housed, consisting of the in 3 described, superabsorbent tissue 17 , The two components form a wound care article 600 , The superabsorbent tissue 17 is in plan view of its flat side (see. 2 B ) also rectangular and has about 25% smaller dimensions than the shell 2 so that the tissue can unfold unhindered during the absorption process.

Finally, that is 7 another superabsorbent wound care article 700 to remove, consisting of the shell 2 according to 1 , an absorbent body 4 (Tissue 17 ) according to 2a and 2 B as well as one between the tissue 17 and the sore wall facing away from the wound 2.1 flat-laid liquid-impermeable film section 22 , The foil section 22 fulfills the laundry protection function here.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• WO 03094813 [0016, 0041]
• WO 2007051599 [0016, 0041]
• WO 0152780 [0016, 0041]
• - DE 69807337 [0020]
• WO 0106047 [0022, 0023]
• - EP 1072698 [0023]
• - DE 102006017194 [0071]
• - DE 102007030931 [0076, 0076, 0086]
• DE 202004017052 [0079]
• - WO 2006048246 [0079]
• - DE 202004018245 [0079]
• DE 202006005966 [0084]

Claims (15)

Wound care article comprising a proportion of superabsorbent Polymers, wherein said superabsorbent polymers in fiber and / or yarn form available. Wound care article according to claim 1, characterized in that the present in fiber form superabsorbent Polymers at least partially in the form of a batt, a fleece, an airlaid and / or a nonwoven. Wound care article according to claim 1, characterized in that the present in yarn form superabsorbent Polymers at least partially in the form of a fabric, a gel, a knitted fabric and / or a knit fabric. Wound care article according to one of preceding claims, characterized in that the Wound care article also has a proportion of supporting Fibers, which also in a wet state integrity ensure the wound dressing with said fibers selected are from the group containing a) cellulose fibers, b) viscose, c) alginate fibers, and / or d) polyester, Polyolefins, polyurethanes, polyvinyl alcohol or polymaid fibers, or mixtures or copolymers thereof. Wound care article according to one of preceding claims, characterized in that the Wound care article besides said yarns or fibers at least a further component selected from the Containing group a) hydroactive polymers, and / or b) particulate superabsorbent polymers. Wound care article according to one of previous claims, characterized in that the fiber and / or yarn superabsorbent polymers Part of a flat mat and / or a flat Wound pad are. Wound care article according to one of previous claims, characterized in that the fiber and / or yarn superabsorbent polymers Part of a three-dimensional absorption body are. Wound care article according to one of previous claims, characterized in that the fiber and / or yarn superabsorbent polymers Part of a wrap of a wound dressing are. Wound care article according to one of previous claims, characterized in that the fiber and / or yarn superabsorbent polymers Part of a foam are. Wound care article according to one the previous claims, characterized in that the superabsorbent fibers and / or yarns Polymers are applied to a carrier layer. Wound care article according to one the previous claims, characterized in that the superabsorbent fibers and / or yarns Polymer component of a swab, a wound wipe, a wound dressing, a wound compress, a wound pad, a bandage or a Stocking are. Wound care article according to one the previous claims, characterized in that the superabsorbent fibers and / or yarns Part of a bandage or wraps are that may have elastic properties having. Use of a wound care article according to a the previous claims for the treatment of chronic Wounds, acute bleeding wounds, traumatic wounds. Use of a wound care article according to a the previous claims for operative or postoperative Supply or for military purposes. Kit for the acute, emergency or military medical or the chronic care, having a wound care article according to one of the preceding claims.