CN107684433A - Device and method that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound - Google Patents
Device and method that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound Download PDFInfo
- Publication number
- CN107684433A CN107684433A CN201710607266.6A CN201710607266A CN107684433A CN 107684433 A CN107684433 A CN 107684433A CN 201710607266 A CN201710607266 A CN 201710607266A CN 107684433 A CN107684433 A CN 107684433A
- Authority
- CN
- China
- Prior art keywords
- wound
- variety
- physiological parameter
- thin film
- sensitive thin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
Abstract
The invention discloses a kind of device for detecting a variety of physiological parameter indexs of the surface of a wound, including：Reflection type photoelectricity detection module, the sensitive thin film to surface of a wound physiological parameter sensitivity and the transparent isolation layer film between sensitive thin film and photoelectric device；Described reflection type photoelectricity detection module includes a photoelectric receiving tube, n LED and drive circuit and formed.By with the one-to-one n kinds sensitive thin films of the LED of different wave length according to the one-to-one location layout of reflected light path, it has been multiplexed the Photoelectric Detection of multiple physiological parameters, a variety of physiological parameters of the light timesharing detection surface of a wound of different wave length can be utilized, and realize online a variety of physio-parameter detections in situ.
Description
Technical field
The invention belongs to biomedical engineering field, and in particular to a kind of light using different wave length realizes that timesharing original position exists
The device and method of a variety of physiological parameters of the line detection surface of a wound.
Background technology
The annual operation patients in China are very universal in 65,000,000 people or so, the bandage technology application for the treatment of of wounds.For hand
Art patient, the major issue faced are postoperative Wound healing problems.Conventional is the bandage using compressive stress state
With the mode of gauze winding parcel, this method is simple and easy, but after wound is wrapped up, and doctor just can not real-time in-situ
The growth conditions of wound are monitored, inflammation etc. can not be treated in real time, and wound healing is a longer time, at this
Wound all accurately cannot be observed and diagnosed in the individual long period, even the operation of skin surface, skin healing is also in 10-
20 days or so, if there is wound Earlier period of inflammation or other problemses during this, it cannot treat in time.For example, surface of a wound sense
Dye not only results in wound healing delay, and the life of entail dangers to patient is gone back when serious.In clinical diagnosis, in early days using invasive
Gold standard method, although measurement is more accurate, need constantly to open gauze to detect surface of a wound state, this wound resulted in
The secondary injury of mouth simultaneously increases the risk of superinfection, and has the shortcomings that expensive, time-consuming and can not continuously measure.Cause
This, detects surface of a wound situation using the biology sensor to trauma surface infestation mark (such as PH) sensitivity, there is important clinic to refer to
Lead meaning.
Based on this, there has been proposed electronics bandage technology.The present invention has been multiplexed the Photoelectric Detection of multiple physiological parameters, can be with
A variety of physiological parameters, including arterial oxygen saturation, pH value, lactic acid content etc. are detected using the light timesharing of different wave length, is realized
The function of one a variety of physiological parameter of the tiny devices original position on-line checking surface of a wound.
The content of the invention
In view of above-mentioned, the present invention proposes device that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound, passes through the dress
A variety of physiological parameters of the on-line checking surface of a wound in situ can be realized by putting, including arterial oxygen saturation, PH, lactic acid content etc..
The technical scheme is that：
Device that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound, it is characterised in that including：
Including at least a photoelectric receiving tube, the LED of n different wave length and the control light-emitting diodes
The reflection type photoelectricity detection module of pipe LED drive circuit；
The sensitive thin film sensitive to surface of a wound physiological parameter；And
Transparent isolation layer film between the sensitive thin film and the reflection type photoelectricity detection module.
Operation principle is：The laser signal of n LED time division emission different wave length, optical signal passes through transparent
Isolated layer film is irradiated in sensitive thin film surface, and sensitive thin film causes to change colour, under fixed wave length light because physiological parameter changes
There is different absorbances for the various concentrations of certain surface of a wound physiological parameter, and reflect the laser of different wave length, reflected light is led to
Transparent isolation layer film is crossed, into photoelectric receiving tube, photoelectric receiving tube produces photoelectric current or voltage after receiving optical signal, passes through
Calculate photoelectric current or voltage swing obtains the light signal strength of different wave length, so as to obtain the size variation of the physiological parameter.
It is more than 70% preferably, described transparent isolation layer film is light transmittance and there is the transparent of bio-compatibility
Film.Further preferably, described transparent isolation layer film is polydimethylsiloxane or polylactic acid PLA.The septum pellucidum
Absciss layer film prevents surface of a wound corrosion reflection type photoelectricity detection module, while has air permeable effect.
Preferably, the thickness of described isolated layer film is 90~110 μm.
Preferably, described sensitive thin film is spun on transparent isolation layer film, sensitive thin film contact surface of a wound during work,
Realize the sensing to surface of a wound physiological parameter.
Preferably, the thickness of described sensitive thin film is 1 μm~30 μm.
Preferably, described sensitive thin film be PH sensitive thin films, glucose sensitive film, lactic acid sensitive thin film, chlorine from
Sub- sensitive thin film or metal ion-sensitive film.
Preferably, described device includes the one-to-one n kinds sensitive thin film of LED with different wave length,
The light that corresponding LED is launched is reflexed to photoelectric receiving tube by every kind of sensitive thin film.It is corresponding with sensitive thin film
LED be by ultraviolet-visible spectrophotometer to sensitive thin film carry out absorbance test determine, the hair
Under optical diode LED illumination, the absorbance resolution ratio highest of sensitive thin film.It is more so rapidly and accurately can to detect the surface of a wound simultaneously
Kind physiological parameter.
One kind detection a variety of physiological parameters of the surface of a wound refer to calibration method, using said apparatus, are multiplexed the light of multiple physiological parameters
Electro-detection, a variety of physiological parameters of the surface of a wound are detected using the light timesharing of different wave length, and realize online a variety of physiology ginseng in situ
Number detection.
Compared to prior art, the device have the advantages that being：By by the one-to-one n of the LED of different wave length
Kind sensitive thin film utilizes the light timesharing of different wave length to detect a variety of lifes of the surface of a wound according to the one-to-one location layout of reflected light path
Parameter is managed, can realize while detect a variety of surface of a wound physiological parameter indexs.Meet the developing direction of future biological sensor-small-sized
Change multi-functional and will not give people to bring sense of discomfort.
Brief description of the drawings
Fig. 1 is that the device that the surface of a wound a variety of physiological parameter indexs are detected while embodiment 1 provides is covered on surface of a wound surface
Structural representation；
Fig. 2 is that the device that the surface of a wound a variety of physiological parameter indexs are detected while embodiment 2 provides is covered on surface of a wound surface
Structural representation.
Fig. 3 is the oximetry value distribution map of the measurement device provided using embodiment 2；
Fig. 4 is the pH value distribution map of the measurement device provided using embodiment 2；
The blood oxygen that Fig. 5 is measured when being spin coating sensitive thin film non-using the reflective blood oxygen transducer provided in embodiment 2 is satisfied
With angle value distribution map.
Embodiment
In order to more specifically describe the present invention, below in conjunction with the accompanying drawings and embodiment is to technical scheme
It is described in detail.
Embodiment 1
Fig. 1 is that device that is provided in an embodiment of the present invention while detecting a variety of physiological parameter indexs of the surface of a wound is covered on surface of a wound table
The structural representation in face.This includes：Reflection type photoelectricity detection module 1, it is coated on the transparent of the surface of reflection type photoelectricity detection module 1
Isolated layer film 2, the PH sensitive thin films 31 being spin-coated on transparent isolation layer film 2, lactic acid sensitive thin film 32, glucose-sensitive are thin
Film 33 and the surface of a wound 8.Wherein, the LED4 containing the one-to-one most optimum wavelengths of sensitive thin film in reflection type photoelectricity detection module 1,
LED5, LED6 and photodiode 7.
Embodiment 2
In the present embodiment, a kind of PH sensitive thin films of a spin coating all apply in transparent isolation layer film, and by PH sensitive thin films
Completely on transparent isolation layer film.As shown in Fig. 2 the device that the present embodiment provides includes：Model SFH7050 reflective blood
Lambda sensor 1, the PDMS 2 for being coated on the reflective surface of blood oxygen transducer 1, the PH sensitive thin films 3 being spin-coated on PDMS 2 and
The surface of a wound 8.Wherein, red-light LED 4, green light LED 5, infrared LED 6 and photodiode 7 are contained in reflective blood oxygen transducer 1.
PH sensitive thin films 3 coat acid-base indicator dye molecule to sol-gel precursors using sol-gel technique and prepared
Obtain.Wherein, acid-base indicator dye molecule includes bromocresol green, bromocresol green sodium salt, methyl red and dimethyl diaminophenazine chloride.
Sol-gel precursors are divided into inorganic precursor, organic precursor and the class of hybrid inorganic-organic precursor three, wherein, it is inorganic
Precursor includes tetraethyl orthosilicate (TEOS), tetramethoxy-silicane (TMOS)；Organic precursor includes γ-glycidyl ether oxygen propyl
Trimethoxy silane (GLYMO), MTES (MTES), ethyl triethoxysilane are modified (ETES) or phenyl three
Methoxy silane (FTMS)；Hybrid inorganic-organic precursor is that organic precursor is mixed to get in varing proportions with inorganic precursor.
The thickness of PH sensitive thin films 3 is 10 μm, in order to which PH sensitive thin films are in mechanical performance, optical clear and response time
Between obtain optimal result, organic precursor is 3 with inorganic precursor volume ratio:7 (total 1mL).It is prepared by the following method to obtain：
First, by 1.2mL ethanol, 16.3mg bromocresol green sodium salts, 0.3mL γ-glycidyl ether oxygen propyl trimethoxy
Silane (GLYMO), 0.7mL tetraethyl orthosilicates (TEOS) and 0.4mL catalyst (0.1M HCL) are mixed with colloidal sol, then
Ultra sonic bath homogenizes 10min, and aging 3 days, are spun on PDMS by spin coating technique afterwards at room temperature, is placed under the conditions of room temperature lucifuge
3 days.
The light that LED is sent in reflective blood oxygen transducer SFH7050 is irradiated to wound through isolated layer film and sensitive thin film
On face, remove scattering and absorb part, reflected light by photodiode be received and converted into the directly proportional electric signal of light intensity,
Blood oxygen saturation is drawn using arterial oxygen saturation calculation formula, and in electric signal, light passes through absorption feelings when tissue and blood vessel
Condition, ripple component (such as arterial blood) and non-pulsating composition (such as skin, tissue, venous blood) can be divided into, you can be referred to as of ac
(AC) and DC quantity (DC), because cataclysm will not occur for wound pH value, therefore absorption of the PH sensitive membranes to light is as DC parts.
Surface of a wound surface is placed in using device manufactured in the present embodiment, based on Lambert-Beer's law, utilizes feux rouges and infrared by two
Paths of LEDs photo measure obtains electric signal, i.e. photoplethysmogra (PPG), and bleeding is obtained by arterial oxygen saturation calculation formula
Oxygen saturation, as a result as shown in Figure 3.
It is placed in using device manufactured in the present embodiment in different PH buffer solutions, pH value 5-9, at intervals of 1, uses green light LED
The electric signal that the photo measure of transmitting obtains characterizes PH sizes, as a result as shown in Figure 4.
Surface of a wound surface is placed in during spin coating PH sensitive thin films non-using the reflective blood oxygen transducer of the present embodiment offer, is passed through
The PPG signals that feux rouges and infrared two-way wavelength photo measure obtain, blood oxygen saturation is calculated with reference to Lambert-Beer's law.Calculate public
Formula is as follows：
[HbO2] and [Hb] represent the concentration of oxygen-containing hemoglobin and deoxyhemoglobin respectively.
α(HbO2,λRed),α(HbO2,λIR),α(Hb,λRed),α(Hb,λIR) it is HbO respectively2With Hb pairs
Feux rouges and infrared absorption coefficient.R is calculated as follows：
According to HbO2/ Hb spectral absorption characteristics, absorption coefficient meet following relation：
α(Hb,λRed) ＞ ＞ α (HbO2,λRed) (4)
α(Hb,λIR)≈α(HbO2,λIR) (5)
Therefore, formula (1) can be reduced to：
A and B is calibrated using commercial anoxia-photometer.
Blood oxygen saturation is calculated through above formula, as a result as shown in Figure 5.Corresponding each measurement result, the embodiment of the present invention
The device of a variety of physiological parameter indexs of the detection surface of a wound of offer tests obtained blood oxygen saturation only with non-spin coating PH sensitive thin films
There is 0.1%-0.2% difference.The result shows that the presence of PH sensitive thin films does not influence the measurement of blood oxygen saturation.
Therefore, the present embodiment can realize on-line checking surface of a wound arterial oxygen saturation and pH value in situ.
Technical scheme and beneficial effect are described in detail above-described embodiment, Ying Li
Solution is to the foregoing is only presently most preferred embodiment of the invention, is not intended to limit the invention, all principle models in the present invention
Interior done any modification, supplement and equivalent substitution etc. are enclosed, should be included in the scope of the protection.
Claims (8)
1. device that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound, it is characterised in that including：
Including at least a photoelectric receiving tube, the LED of n different wave length and the control light emitting diode
The reflection type photoelectricity detection module of LED drive circuit；
The sensitive thin film sensitive to surface of a wound physiological parameter；And
Transparent isolation layer film between the sensitive thin film and the reflection type photoelectricity detection module.
2. the device as claimed in claim 1 for detecting a variety of physiological parameter indexs of the surface of a wound simultaneously, it is characterised in that described is saturating
Bright isolated layer film is that light transmittance is more than 70% and the transparent membrane with bio-compatibility.
3. the device as claimed in claim 2 for detecting a variety of physiological parameter indexs of the surface of a wound simultaneously, it is characterised in that described is saturating
Bright isolated layer film is polydimethylsiloxane or polylactic acid PLA.
4. the device as claimed in claim 1 for detecting a variety of physiological parameter indexs of the surface of a wound simultaneously, it is characterised in that described is quick
Sense film is spun on transparent isolation layer film, and the sensitive thin film contact surface of a wound, realizes the sensing to the surface of a wound physiological parameter during work.
5. the device as claimed in claim 1 for detecting a variety of physiological parameter indexs of the surface of a wound simultaneously, it is characterised in that described is quick
The thickness for feeling film is 1 μm~30 μm.
6. the device as claimed in claim 1 for detecting a variety of physiological parameter indexs of the surface of a wound simultaneously, it is characterised in that described is quick
Sense film is that PH sensitive thin films, glucose sensitive film, lactic acid sensitive thin film, chlorion sensitive thin film or metal ion-sensitive are thin
Film.
7. detect the device of a variety of physiological parameter indexs of the surface of a wound simultaneously as claimed in claim 6, it is characterised in that described device bag
Include and corresponding lights with the one-to-one n kinds sensitive thin film of the LED of different wave length, every kind of sensitive thin film
The light of diode (LED) transmitting reflexes to photoelectric receiving tube.
8. a kind of, detecting a variety of physiological parameters of the surface of a wound refers to calibration method simultaneously, it is characterised in that any using claim 1~7
Described device, the Photoelectric Detection of multiple physiological parameters is multiplexed, a variety of physiology of the surface of a wound are detected using the light timesharing of different wave length
Parameter, and realize online a variety of physio-parameter detections in situ.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710607266.6A CN107684433B (en) | 2017-07-24 | 2017-07-24 | device and method for simultaneously detecting multiple physiological parameter indexes of wound surface |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710607266.6A CN107684433B (en) | 2017-07-24 | 2017-07-24 | device and method for simultaneously detecting multiple physiological parameter indexes of wound surface |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107684433A true CN107684433A (en) | 2018-02-13 |
| CN107684433B CN107684433B (en) | 2019-12-10 |
Family
ID=61152916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710607266.6A Active CN107684433B (en) | 2017-07-24 | 2017-07-24 | device and method for simultaneously detecting multiple physiological parameter indexes of wound surface |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107684433B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009050A (en) * | 2018-06-21 | 2018-12-18 | 浙江大学 | A kind of reflective pulse rate signal detection device of anti motion interference based on optical means |
| CN111449641A (en) * | 2020-04-20 | 2020-07-28 | 浙江大学 | Evaluation device and evaluation method for muscle function state based on photoelectric signal detection |
| CN114098668A (en) * | 2020-08-31 | 2022-03-01 | 荣耀终端有限公司 | Living body detection method and electronic equipment |
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009103034A2 (en) * | 2008-02-13 | 2009-08-20 | Board Of Regents, The University Of Texas System | System, method and apparatus for an amorphous iridium oxide film ph sensor |
| CN104257359A (en) * | 2014-09-16 | 2015-01-07 | 苏州能斯达电子科技有限公司 | Wearable flexible sensor for monitoring wrist pulse and preparation method thereof |
| CN104248421B (en) * | 2014-09-24 | 2016-06-01 | 中国科学院电子学研究所 | A kind of reflective photoelectric sensor for gingival blood flow monitoring and its preparation method |
| CN105636511A (en) * | 2013-10-17 | 2016-06-01 | 拉夫伯勒大学 | Opto-physiological sensor and method of assembly |
| CN105852806A (en) * | 2016-03-24 | 2016-08-17 | 浙江大学 | Electronic skin for wound real-time monitoring |
| CN205814538U (en) * | 2016-03-04 | 2016-12-21 | 北京市中医研究所 | Intelligence binder and intelligence bandage systems |
-
2017
- 2017-07-24 CN CN201710607266.6A patent/CN107684433B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009103034A2 (en) * | 2008-02-13 | 2009-08-20 | Board Of Regents, The University Of Texas System | System, method and apparatus for an amorphous iridium oxide film ph sensor |
| CN105636511A (en) * | 2013-10-17 | 2016-06-01 | 拉夫伯勒大学 | Opto-physiological sensor and method of assembly |
| CN104257359A (en) * | 2014-09-16 | 2015-01-07 | 苏州能斯达电子科技有限公司 | Wearable flexible sensor for monitoring wrist pulse and preparation method thereof |
| CN104248421B (en) * | 2014-09-24 | 2016-06-01 | 中国科学院电子学研究所 | A kind of reflective photoelectric sensor for gingival blood flow monitoring and its preparation method |
| CN205814538U (en) * | 2016-03-04 | 2016-12-21 | 北京市中医研究所 | Intelligence binder and intelligence bandage systems |
| CN105852806A (en) * | 2016-03-24 | 2016-08-17 | 浙江大学 | Electronic skin for wound real-time monitoring |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009050A (en) * | 2018-06-21 | 2018-12-18 | 浙江大学 | A kind of reflective pulse rate signal detection device of anti motion interference based on optical means |
| CN109009050B (en) * | 2018-06-21 | 2023-06-06 | 浙江大学 | Anti-motion interference reflective pulse rate signal detection device based on optical method |
| CN111449641A (en) * | 2020-04-20 | 2020-07-28 | 浙江大学 | Evaluation device and evaluation method for muscle function state based on photoelectric signal detection |
| CN111449641B (en) * | 2020-04-20 | 2021-07-20 | 浙江大学 | Evaluation device and evaluation method for muscle function state based on photoelectric signal detection |
| CN114098668A (en) * | 2020-08-31 | 2022-03-01 | 荣耀终端有限公司 | Living body detection method and electronic equipment |
| CN114098668B (en) * | 2020-08-31 | 2022-11-11 | 荣耀终端有限公司 | Living body detection method and electronic equipment |
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
| CN115645149B (en) * | 2022-12-14 | 2024-01-23 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107684433B (en) | 2019-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107684433A (en) | Device and method that is a kind of while detecting a variety of physiological parameter indexs of the surface of a wound | |
| US20200275871A1 (en) | Physiological measurement devices, systems, and methods | |
| Kleiser et al. | Comparison of tissue oximeters on a liquid phantom with adjustable optical properties | |
| JP2007509718A5 (en) | ||
| NL2002852C2 (en) | EAR SENSOR SYSTEM FOR NON INVASIVE MEASUREMENT OF METHODS. | |
| JP2014501910A (en) | Presence detection system and certification system | |
| US10251587B2 (en) | Conditioning of chemo-optical sensors for transcutaneous application | |
| EP3145398B1 (en) | Device and method for noninvasively determining the hematocrit value of a subject | |
| JP2015506197A (en) | Method, assembly device, sensor, and computer program product for non-invasive measurement of hemoglobin concentration in blood | |
| JP6074070B2 (en) | Correction of osmotic pressure fluctuations in chemical-optical sensor spots | |
| CN105942984B (en) | Jaundice detection method and its device | |
| Mizukoshi et al. | Investigation of oxygen saturation in regions of skin by near infrared spectroscopy | |
| RU2633494C2 (en) | Biosensor for non-invasive optical monitoring of biological tissues pathology | |
| CN111803085A (en) | Noninvasive hemoglobin concentration level measuring device based on color characteristics | |
| CN109916894A (en) | A kind of dry chemistry reagent piece and preparation method thereof quantitative determining concentration of glucose | |
| US20230263392A1 (en) | Systems and methods for monitoring an analyte or parameter for a patient | |
| CN106999112A (en) | System and method for non-invasive medical sensor | |
| JP3016160U (en) | Near infrared non-invasive biometric device | |
| Patil et al. | Measurement of pulse oximetry, capnography and pH | |
| Deepthi et al. | A Device to Detect Hyperbilirubin through Non-Invasive Technique | |
| Abidin et al. | Measurement of Glucose in Blood Using a Simple Non Invasive Method | |
| KR102572774B1 (en) | Patch-type apparatus for sinusitis diagnosis | |
| TWI615131B (en) | Image based oxygen saturation measuring device and method thereof | |
| WO2021245406A1 (en) | Sensor and methods for sensing the oxygenation of tissue | |
| Li et al. | Venous oxygenation mapping with a CCD camera |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |