CN105031714A - Adhesive bandage and method for manufacturing same - Google Patents
Adhesive bandage and method for manufacturing same Download PDFInfo
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- CN105031714A CN105031714A CN201510352671.9A CN201510352671A CN105031714A CN 105031714 A CN105031714 A CN 105031714A CN 201510352671 A CN201510352671 A CN 201510352671A CN 105031714 A CN105031714 A CN 105031714A
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- adhesive bandage
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Abstract
The invention discloses adhesive bandage and a method for manufacturing the same, and belongs to the field of medical treatment and public health materials. The adhesive bandage comprises non-woven base cloth and a wound contact layer which are adhered with each other. The wound contact layer is a micro-nano silk fibroin film. The adhesive bandage and the method have the advantages that biological adhesive is added in spaces between two layers of materials, and the two layers of materials are adhered with each other in a midpoint adhesion mode by the aid of a heat adhesion process; the antibacterial and sterilization properties and the wound healing promoting capacity of the adhesive bandage can be improved by the aid of the method for adding nano-silver, aloe stock solution and hemostasia drugs to the adhesive bandage; the adhesive bandage is excellent in biocompatibility and breathability; the base cloth layer can be in an appropriate shape according to difference of use positions, and accordingly the adhesive bandage is favorable for firm adhesion and convenient to use.
Description
Technical field
The present invention relates to a kind of bio-medical material that can be used for wound repair, particularly a kind of have adhesive bandage of good wound healing, repairing performance and permeability and preparation method thereof.
Background technology
Adhesive bandage is a kind of conventional outer medical and health, for the hemostasis of acute minor cut or wound, antiinflammatory and wound healing.Mainly be applicable to otch neat, clean, show shallow, wound is less and the incised wound not needing to sew up, scratch or stab.Therefore the adhesive bandage that serviceability is good should have anti-inflammation, promote an effect for wound healing, and because adhesive bandage is direct and contact human skin, therefore also should possess biocompatibility.
Before making the present invention, publication number is the manufacture method disclosing a kind of chitosan sponge pad adhesive bandage in the Chinese utility model patent of CN203777148U, this invention is that raw material is prepared foam-rubber cushion and adds Aloe extract with chitosan, prepares a kind of adhesive bandage that can make burn quickly-healing using adhesive fabric as cladding material.But this adhesive bandage biocompatibility is poor, and antibacterial action is not obvious, easily makes wound infect.Publication number is the adhesive bandage disclosing a kind of good biocompatibility in the Chinese utility model patent of CN203468856U, this adhesive bandage has peel ply, dressing layer, medicine layer and adhered layer four-layer structure, dressing layer is made up of biology cellulose, and adhered layer is medical proof fabric with holes.Though this adhesive bandage has good biocompatibility, because medicine layer and dressing layer separate, slow releasing function and the drug effect of medicine are not satisfactory.The adhesive bandage number of plies is too much, have impact on water-permeable and air permeable, is unfavorable for for wound provides good healing environment.Publication number is the adhesive bandage that the Chinese utility model patent of CN203815714U discloses the making of a kind of bactericidal poromeric material, and this adhesive bandage comprises breathability adhesive plaster, medicinal sponge and mould release membrance.There are the zinc layers film, silver layer film, the zinc oxide tunic that are formed through magnetron sputtering its medicinal sponge last time, and containing hemostasis bactericidal agent.This adhesive bandage can reach good antibiotic and sterilizing effect, but is formed by surface sputtering due to its antimicrobial component, and therefore persistency is good not, and strengthens the complexity of preparation.Further, the adhesive bandage described in above three kinds of patents all uses the leachy adhesive plaster of band as adhered layer, and first antianaphylaxis is good not, secondly on adhesive plaster, adds the preparation section that hole adds adhesive bandage equally, increases complex process degree.Publication number is that the Chinese invention patent of CN104288829A discloses a kind of adhesive bandage and preparation method thereof, this adhesive bandage comprises adhesive tape and ointment, described ointment is impregnated non-woven fabrics in medicinal liquid, and publication number is the preparation method that the Chinese invention patent of CN104208744A discloses a kind of antibacterial adhesive bandage containing povidone iodine.Above two kinds of the former antibiotic properties of invention are slightly poor, and the latter promotes that wound healing effect is slightly poor, and the two medicine used is all be attached on non-woven fabrics by dipping method, and therefore sustained drug release effect has much room for improvement.
Fibroin albumen is the natural polymer fibrin extracted from silkworm silk, there is good biocompatibility and biological degradability, after making fibroin protein film, there is good breathability and not easily by bacterial penetration, and meet wet after more soft, good with the attaching of wound surface, adding fibroin protein film smooth pliable, nonirritant, is therefore highly desirable wound surface cladding material.In addition, because fibroin membrane itself has special porous reticular membrane structure, make it have excellent absorption and slow-release function, therefore fibroin can become good medicinal slow release agent, after making adhesive bandage, at wound sustained release drugs, drug effect can be improved, reach quick-acting haemostatic powder, promote effect of wound healing.
Summary of the invention
The present invention is directed to the deficiency that existing adhesive bandage product exists, to provide a kind of be base stock with fibroin albumen, there is good adhesive bandage of good promotion wound-healing abilities, sterilization anti-infection ability and biocompatibility and preparation method thereof.
To achieve the above object of the invention, the technical solution used in the present invention is: provide a kind of adhesive bandage, and described adhesive bandage is double-decker, and base cloth layer is the non-woven fabrics of band glue, and wound contact layer is the Static Spinning fibroin protein film being loaded with antibacterial anti hemorrhagic medicine.
Technical solution of the present invention also comprises a kind of preparation method of adhesive bandage as above, after silkworm silk being prepared into fibroin membrane by prior art, then carries out the processing of following steps:
A. fibroin membrane is dissolved in formic acid solvent, makes the formic acid silk fibroin protein solution that mass concentration is 10% ~ 20%;
B. join in formic acid silk fibroin protein solution by antibacterial anti hemorrhagic medicine, the mass concentration of medicine is 0.5% ~ 1.2%, adopts electrostatic spinning process, electrostatic spinning collecting board is collected micro/nano level fibroin fiber film, obtains adhesive bandage wound contact layer;
C. binding agent is coated on non-woven fabrics to show, obtains the nonwoven fabric base layer of cloth being with glue, adopt heat fusion joint adhesion technique, wound contact layer and base cloth layer are bonded, obtains a kind of adhesive bandage.
In technical solution of the present invention:
Described antibacterial anti hemorrhagic medicine comprises the one in Aloe original juice, nano-Ag particles, aspirin, heparin, YUNNAN BAIYAO, or their combination in any.
Described base cloth layer is the one in H-shaped, circular arc or butterfly shape.
Described binding agent is chitosan, osseocolla or Aloe glue.
Described electrostatic spinning process parameter is: voltage 8 ~ 25kv, receiving range 10 ~ 20cm, and solution injects speed 0.1 ~ 1.5mL/h.
A kind of fibroin albumen adhesive bandage provided by the invention, primary raw material is fibroin material, and add the material such as Aloe original juice, nanometer silver, be fibroin albumen Static Spinning material with Wound contact position, and add Aloe original juice, the nano-Ag particles with good promotion wound healing and antibiotic and sterilizing effect, its outer base cloth is non-woven fabrics (as the non-woven fabrics that the spun-bond processes such as PU, PP, PET or other method are made), and two-layer use biogum (as chitosan) is bonded by the bonding mode of some bonding.According to the different parts used, different shapes is provided to base cloth layer, be conducive to that bonding is carried out to the wound of different parts and fix, easy to use.
Adopt technical scheme provided by the present invention, there is following obvious advantage:
The core position of the adhesive bandage 1, prepared by the present invention---wound contact layer is the thin film that raw material is made by electrostatic spinning technique by fibroin albumen, and this film has nanoscale fibre net structure, has excellent breathability and biocompatibility.Also there is good water absorption, the body fluid that Absorbable rod wound goes out to ooze out, blood simultaneously, keep wound surface clean dried, be beneficial to wound and recover.
2, the nonwoven fabric base cloth of adhesive bandage and wound contact layer are bonded together by the some bonding mode in thermal bond pattern, and the binding agent of use is biological level binding agent.Biological level binding agent this as natural glue, biological degradability is good and have sterilization antibacterial action, and reduction skin allergy rate.The bonding mode of some bonding can reduce bond area, thus does not affect the breathability of adhesive bandage.The wound contact layer of the adhesive bandage prepared by the present invention, its antibacterial Promotive union principle for directly to add nanometer silver, Aloe original juice and haemostatic medicament in spinning liquid, compared at surface sprinkling medicine, directly additive is joined the fibroin protein film containing antibacterial anti hemorrhagic medicine made in spinning liquid, there is better controlled drug release and lasting medicine.
3, the fibroin protein film of wound contact layer made by electrostatic spinning process of this adhesive bandage, there is ultra-fine fibre net structure, therefore thickness ultrathin, after being combined with nonwoven fabric base cloth, do not have that obvious projection of similar traditional sponge pad adhesive bandage, adhesive bandage can be fitted tightly with skin, better improve antibiotic property.Due to the characteristic of non-woven fabrics porous, compared to traditional adhesive fabric, non-woven fabrics is used to improve adhesive bandage breathability greatly as adhesive bandage base cloth.
4, different according to injury, the outer of adhesive bandage is designed to difformity, easy to use.As for finger tip, the butterfly shape referring to the Minor articulus places such as root, for the circular arc at knee, elbow place.
5, the invention solves traditional adhesive bandage and easily make skin generation allergic phenomena, waterproof and breathable performance is poor, antibacterial ability is weak and to wound healing without problems such as obvious facilitations.Important scientific meaning and practical value is had to the research of medical and health.
Accompanying drawing explanation
Fig. 1 is the schematic side view of the fibroin albumen adhesive bandage structure that the embodiment of the present invention provides;
Fig. 2 is the schematic shapes of the adhesive bandage for different parts wound that the embodiment of the present invention provides;
In figure, 1, nonwoven fabric base layer of cloth; 2, wound contact layer; 3, cementing layer.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, set forth the present invention further.
Embodiment 1
The present embodiment provides fibroin albumen adhesive bandage preparation process as follows:
1, measure 12L deionized water to be placed on heating aluminium-foil paper on electromagnetic oven and to claim 30g silkworm silk, take 25.44g sodium carbonate, water pours sodium carbonate into after opening, stir with Glass rod, add silkworm silk, stir 30 ~ 40min, a part of deionized water again, burns the degree of the pure man contact skin slight fever, with cold water, fibroin is cleaned five times.Washed fibroin is spread out to be placed on aluminium-foil paper, puts into 60 DEG C of oven for drying 24 hours.
2, take out the fibroin of drying, title quality is 20.46g, and the lithium bromide adding 76ml9.3mol/L dissolves fibroin.Some lithium-bromide solutions first fall during dissolving in beaker, puts fibroin albumen, then fall lithium-bromide solution, then put fibroin albumen, be circulated to fibroin albumen and discharge, then use plastic film seal, put into 60 DEG C of oven for drying 4 ~ 5 hours, rock once every 30min.
3, be dialysis material with cellulose membrane, the fibroin albumen mixed solution deionized water of gained dialysed, removes the impurity such as lithium bromide, obtain pure silk fibroin protein solution, regulate silk fibroin protein solution mass concentration to be 3%.
5, suck silk fibroin solution with syringe, it is slowly injected on culture dish.After injection, in fume hood, dry 24h, dry film forming
6, silk fibroin powder is obtained after being pulverized by obtained fibroin protein film.Take the broken last 1.2g of fibroin with electronic balance, be dissolved in 8.8g formic acid, then stirring and dissolving 3 ~ 4 hours, make the formic acid fibroin albumen spinning liquid that concentration is 12%.
7, nanometer silver powder, aloe stoste and each 0.02g of aspirin powder are joined in the spinning liquid prepared, magnetic agitation 10h.
8, loaded by the electrostatic spinning solution of medicine mixed in step 7 in the injection device of electrostatic apparatus, select Static Spinning voltage 15 kilovolts, injection device injects speed 0.5 ml/hour, pole span 12 centimetres.Electrostatic spinning collecting board collects fibroin protein film.
9, fibroin protein film is cut into a certain size rectangle, take chitosan as binding agent, nonwoven fabric base layer of cloth applies cementing layer, and adopt the bonding mode of some bonding fibroin protein film and nonwoven fabric base cloth to be combined.
See accompanying drawing 1, it is the schematic side view of the fibroin albumen adhesive bandage structure that the present embodiment provides; The structure of adhesive bandage is: on nonwoven fabric base layer of cloth 1, apply cementing layer 3, and wound contact layer 3 is for being loaded with the Static Spinning fibroin protein film of antibacterial anti hemorrhagic medicine, glued together by cementing layer 3 and base cloth layer 1.The profile of nonwoven fabric base layer of cloth is common rectangle.
Embodiment 2:
1,1 kilogram of cocoon shell is put into the neutral soap solution that 50 mass per liter concentration are 0.5%, in 98 ~ 100 DEG C of process 2 hours, make cocoon case degumming, fully obtain pure silk element (i.e. fibroin albumen) after washing.By plain for the pure silk after drying, with the lithium bromide water solution of 5 liter of 9.3 mol/L, 65
+2 DEG C of stirring and dissolving become fibroin albumen mixed solution.
2, be dialysis material with cellulose membrane, the fibroin albumen mixed solution deionized water of gained dialysed, removes the impurity such as lithium bromide, obtain pure silk fibroin protein solution, regulate silk fibroin protein solution mass concentration to be 3%.
3, poured in polyethylene vessel by silk fibroin protein solution, room temperature dries, and obtains fibroin protein film, obtains silk fibroin powder after being pulverized.
4, take the broken last 1.5g of fibroin with electronic balance, be dissolved in 8.5g formic acid, then stirring and dissolving 3 ~ 4 hours, make the formic acid fibroin albumen spinning liquid that concentration is 15%.
5, nanometer silver powder, aloe stoste and each 0.04g of YUNNAN BAIYAO powder are joined in the spinning liquid prepared, magnetic agitation 10h
6, loaded by the electrostatic spinning solution of 15% of medicine mixed in step 5 in the injection device of electrostatic apparatus, select Static Spinning voltage 15 kilovolts, injection device injects speed 1 ml/hour, pole span 20 centimetres.Electrostatic spinning collecting board collects fibroin protein film.
7, fibroin protein film being cut into a certain size circle, take Aloe glue as binding agent, uses the bonding mode of some bonding fibroin protein film and nonwoven fabric base cloth to be combined.The structure of adhesive bandage as shown in Figure 1.
See accompanying drawing 2, it is the schematic shapes of the adhesive bandage for different parts wound that the present embodiment provides; Wherein, (a) is H-shaped; B () is circular arc, be applicable to knee, elbow place; C () is butterfly shape, be applicable to finger tip, refer to the Minor articulus places such as root.
Embodiment 3:
1,200 grams of silkworm silks being put into 10 mass per liter concentration is the aqueous sodium carbonate of 0.3%, in 98 ~ 100 DEG C of process 2 hours, makes cocoon case degumming, fully obtains pure silk element (i.e. fibroin albumen) after washing.By plain for the pure silk after drying, with the lithium bromide water solution of 100 milliliter of 9.3 mol/L, 65
+at 2 DEG C, stirring and dissolving becomes fibroin albumen mixed solution.
2, be dialysis material with cellulose membrane, the fibroin albumen mixed solution deionized water of gained dialysed, removes the impurity such as lithium bromide, obtain pure silk fibroin protein solution, regulate silk fibroin protein solution mass concentration to be 6%.
3, poured in polyethylene vessel by silk fibroin protein solution, room temperature dries, and obtains fibroin protein film, obtains silk fibroin powder after being pulverized.
4, silk fibroin powder is obtained after being pulverized by obtained fibroin protein film.Take the broken last 1.8g of fibroin with electronic balance, be dissolved in 7.2g formic acid, then stirring and dissolving 3 ~ 4 hours, make the formic acid fibroin albumen spinning liquid that concentration is 20%.
5, nanometer silver powder, aloe stoste and each 0.035g of heparin powder are joined in the spinning liquid prepared, magnetic agitation 10h
6, loaded by the electrostatic spinning solution of 18% of medicine mixed in step 5 in the injection device of electrostatic apparatus, select Static Spinning voltage 20 kilovolts, injection device injects speed 0.5 ml/hour, pole span 20 centimetres.Electrostatic spinning collecting board collects fibroin protein film.
7, fibroin protein film being cut into a certain size rectangle, take osseocolla as binding agent, uses the bonding mode of some bonding fibroin protein film and nonwoven fabric base cloth to be combined.
Claims (7)
1. an adhesive bandage, is characterized in that: described adhesive bandage is double-decker, and base cloth layer is the non-woven fabrics of band glue, and wound contact layer is the Static Spinning fibroin protein film being loaded with antibacterial anti hemorrhagic medicine.
2. a kind of adhesive bandage according to claim 1, is characterized in that: described antibacterial anti hemorrhagic medicine is selected from the one in Aloe original juice, nano-Ag particles, aspirin, heparin, YUNNAN BAIYAO, or their combination in any.
3. a kind of adhesive bandage according to claim 1, is characterized in that: described base cloth layer is the one in H-shaped, circular arc or butterfly shape.
4. a preparation method for adhesive bandage as claimed in claim 1, is prepared into fibroin membrane by silkworm silk, it is characterized in that the processing carrying out following steps again:
A. fibroin membrane is dissolved in formic acid solvent, makes the formic acid silk fibroin protein solution that mass concentration is 10% ~ 20%;
B. join in formic acid silk fibroin protein solution by antibacterial anti hemorrhagic medicine, the mass concentration of medicine is 0.5% ~ 1.2%, adopts electrostatic spinning process, electrostatic spinning collecting board is collected micro/nano level fibroin fiber film, obtains adhesive bandage wound contact layer;
C. binding agent is coated on non-woven fabrics to show, obtains the nonwoven fabric base layer of cloth being with glue, adopt heat fusion joint adhesion technique, wound contact layer and base cloth layer are bonded, obtains a kind of adhesive bandage.
5. the preparation method of a kind of adhesive bandage according to claim 4, is characterized in that: described antibacterial anti hemorrhagic medicine comprises the one in Aloe original juice, nano-Ag particles, aspirin, heparin, YUNNAN BAIYAO, or their combination in any.
6. the preparation method of a kind of adhesive bandage according to claim 4, is characterized in that: described binding agent is chitosan, osseocolla or Aloe glue.
7. the preparation method of a kind of adhesive bandage according to claim 4, is characterized in that: described electrostatic spinning process parameter is: voltage 8 ~ 25kv, receiving range 10 ~ 20cm, and solution injects speed 0.1 ~ 1.5mL/h.
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Cited By (10)
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| CN106048766A (en) * | 2016-05-27 | 2016-10-26 | 东莞市联洲知识产权运营管理有限公司 | Anti-corrosive granulation-promoting fabric containing silk protein and preparation method thereof |
| CN106109091A (en) * | 2016-08-24 | 2016-11-16 | 广东中科国丝生物科技有限公司 | A kind of silkworm silk bandage |
| CN106361499A (en) * | 2016-10-24 | 2017-02-01 | 苏州维度丝绸有限公司 | Novel silk band-aid |
| CN106361498A (en) * | 2016-10-24 | 2017-02-01 | 苏州维度丝绸有限公司 | Adjustable silk band-aid |
| CN108714237A (en) * | 2018-06-01 | 2018-10-30 | 苏州先蚕丝绸有限公司 | A kind of natural silk adhesive bandage |
| CN109112827A (en) * | 2018-07-27 | 2019-01-01 | 望江汇通纺织有限公司 | A kind of medical non-woven fabrics of promoting healing |
| CN111529751A (en) * | 2020-05-07 | 2020-08-14 | 金珊珊 | Preparation method of medical sanitary non-woven fabric |
| CN113797019A (en) * | 2021-09-16 | 2021-12-17 | 杭州昀鼎医疗科技有限公司 | Ionic pulse-activating plaster adopting micro-ionic conduction technology and production equipment |
| CN114631934A (en) * | 2022-03-14 | 2022-06-17 | 中国人民解放军联勤保障部队第九二〇医院 | Dressing capable of creating hypoxia microenvironment to promote early healing of acute wound |
| RU2806598C1 (en) * | 2022-12-29 | 2023-11-01 | Автономная некоммерческая образовательная организация высшего образования "Научно-технологический университет "Сириус" | Method for producing nonwoven material using electrospinning |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106048766A (en) * | 2016-05-27 | 2016-10-26 | 东莞市联洲知识产权运营管理有限公司 | Anti-corrosive granulation-promoting fabric containing silk protein and preparation method thereof |
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| CN106109091A (en) * | 2016-08-24 | 2016-11-16 | 广东中科国丝生物科技有限公司 | A kind of silkworm silk bandage |
| CN106361499A (en) * | 2016-10-24 | 2017-02-01 | 苏州维度丝绸有限公司 | Novel silk band-aid |
| CN106361498A (en) * | 2016-10-24 | 2017-02-01 | 苏州维度丝绸有限公司 | Adjustable silk band-aid |
| CN108714237A (en) * | 2018-06-01 | 2018-10-30 | 苏州先蚕丝绸有限公司 | A kind of natural silk adhesive bandage |
| CN109112827A (en) * | 2018-07-27 | 2019-01-01 | 望江汇通纺织有限公司 | A kind of medical non-woven fabrics of promoting healing |
| CN111529751A (en) * | 2020-05-07 | 2020-08-14 | 金珊珊 | Preparation method of medical sanitary non-woven fabric |
| CN111529751B (en) * | 2020-05-07 | 2021-02-23 | 苏州杜康宁医疗用品有限公司 | Preparation method of medical sanitary non-woven fabric |
| CN113797019A (en) * | 2021-09-16 | 2021-12-17 | 杭州昀鼎医疗科技有限公司 | Ionic pulse-activating plaster adopting micro-ionic conduction technology and production equipment |
| CN114631934A (en) * | 2022-03-14 | 2022-06-17 | 中国人民解放军联勤保障部队第九二〇医院 | Dressing capable of creating hypoxia microenvironment to promote early healing of acute wound |
| RU2818816C1 (en) * | 2022-12-13 | 2024-05-06 | Кирилл Андреевич Абрамов | Drug for treating endometriosis |
| RU2806598C1 (en) * | 2022-12-29 | 2023-11-01 | Автономная некоммерческая образовательная организация высшего образования "Научно-технологический университет "Сириус" | Method for producing nonwoven material using electrospinning |
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Application publication date: 20151111 |
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| RJ01 | Rejection of invention patent application after publication |