WO2012035303A3 - A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon - Google Patents

A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon Download PDF

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Publication number
WO2012035303A3
WO2012035303A3 PCT/GB2011/001355 GB2011001355W WO2012035303A3 WO 2012035303 A3 WO2012035303 A3 WO 2012035303A3 GB 2011001355 W GB2011001355 W GB 2011001355W WO 2012035303 A3 WO2012035303 A3 WO 2012035303A3
Authority
WO
WIPO (PCT)
Prior art keywords
ramelteon
synthesis
novel process
key intermediates
intermediates
Prior art date
Application number
PCT/GB2011/001355
Other languages
French (fr)
Other versions
WO2012035303A8 (en
WO2012035303A2 (en
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Maruti Ganpati Ghagare
Sandip Vasant Chikhalikar
Original Assignee
Cipla Limited
Cottrill, Emily Elizabeth Helen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Limited, Cottrill, Emily Elizabeth Helen filed Critical Cipla Limited
Publication of WO2012035303A2 publication Critical patent/WO2012035303A2/en
Publication of WO2012035303A8 publication Critical patent/WO2012035303A8/en
Publication of WO2012035303A3 publication Critical patent/WO2012035303A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems

Abstract

The present invention relates to a novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon.
PCT/GB2011/001355 2010-09-17 2011-09-16 A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon WO2012035303A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2605MU2010 2010-09-17
IN2605/MUM/2010 2010-09-17

Publications (3)

Publication Number Publication Date
WO2012035303A2 WO2012035303A2 (en) 2012-03-22
WO2012035303A8 WO2012035303A8 (en) 2012-06-14
WO2012035303A3 true WO2012035303A3 (en) 2012-08-23

Family

ID=44677962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/001355 WO2012035303A2 (en) 2010-09-17 2011-09-16 A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon

Country Status (1)

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WO (1) WO2012035303A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664849B (en) * 2012-08-31 2017-03-29 上海阳帆医药科技有限公司 Prepare the 2 (methods of 1,6,7,8 tetrahydrochysene 2H indenos [5,4 b] furan, 8 subunit ethamine
CN104119306A (en) * 2013-04-24 2014-10-29 辰欣药业股份有限公司 Preparation method for 2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine
CN104529958B (en) * 2015-01-08 2016-08-31 济川药业集团有限公司 A kind of preparation method of ramelteon
CN107325066A (en) * 2017-05-23 2017-11-07 万特制药(海南)有限公司 The method for splitting of ramelteon intermediate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034239A (en) * 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
WO2010092107A1 (en) * 2009-02-12 2010-08-19 Lek Pharmaceuticals D.D. Synthesis of (s)-n-[2-(1,6,7,8-tetrahydro-2h-indeno-[5,4-b]furan-8-yl)ethyl]propionamide
WO2010103553A1 (en) * 2009-03-10 2010-09-16 Industriale Chimica S.R.L. Process for the preparation of ramelteon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ330656A (en) 1996-03-08 1999-06-29 Takeda Chemical Industries Ltd Tricyclic compounds, their production and use
TWI400220B (en) 2004-09-13 2013-07-01 Takeda Pharmaceutical Process for producing optically active amine derivatives
WO2008062468A2 (en) 2006-10-26 2008-05-29 Cadila Healthcare Limited Process for the preparation of optically pure indeno [5,4-b] furan derivatives
EP2139845A1 (en) 2007-02-26 2010-01-06 Teva Pharmaceutical Industries Ltd. Intermediates and processes for the synthesis of ramelteon
WO2009106966A1 (en) 2008-02-28 2009-09-03 Medichem, S.A. Process for preparing ramelteon.
WO2010045565A1 (en) 2008-10-16 2010-04-22 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
WO2010055481A1 (en) 2008-11-14 2010-05-20 Watson Pharma Private Limited Process for the preparation of ramelteon

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034239A (en) * 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
WO2010092107A1 (en) * 2009-02-12 2010-08-19 Lek Pharmaceuticals D.D. Synthesis of (s)-n-[2-(1,6,7,8-tetrahydro-2h-indeno-[5,4-b]furan-8-yl)ethyl]propionamide
WO2010103553A1 (en) * 2009-03-10 2010-09-16 Industriale Chimica S.R.L. Process for the preparation of ramelteon

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CADDICK S DE K ET AL: "Convenient synthesis of protected primary amines from nitriles", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 41, no. 18, 1 April 2000 (2000-04-01), pages 3513 - 3516, XP004198073, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)00410-X *
CADDICK S ET AL: "A generic approach for the catalytic reduction of nitriles", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 59, no. 29, 14 July 2003 (2003-07-14), pages 5417 - 5423, XP004437405, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(03)00858-5 *
NATALIA LOZINSKAYA ET AL: "Simple Synthesis of Some 2-Substituted Melatonin Derivatives", SYNTHESIS, vol. 2011, no. 02, 1 January 2011 (2011-01-01), pages 273 - 276, XP055011048, ISSN: 0039-7881, DOI: 10.1055/s-0030-1258361 *

Also Published As

Publication number Publication date
WO2012035303A8 (en) 2012-06-14
WO2012035303A2 (en) 2012-03-22

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