WO2010097799A1 - Electrospun wound dressing - Google Patents
Electrospun wound dressing Download PDFInfo
- Publication number
- WO2010097799A1 WO2010097799A1 PCT/IL2010/000165 IL2010000165W WO2010097799A1 WO 2010097799 A1 WO2010097799 A1 WO 2010097799A1 IL 2010000165 W IL2010000165 W IL 2010000165W WO 2010097799 A1 WO2010097799 A1 WO 2010097799A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dressing
- wound
- capillary
- exudate
- fibers
- Prior art date
Links
- 210000000416 exudates and transudate Anatomy 0.000 claims abstract description 28
- 239000011148 porous material Substances 0.000 claims abstract description 13
- 238000001523 electrospinning Methods 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000835 fiber Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 7
- 229920000515 polycarbonate Polymers 0.000 claims description 7
- 239000004417 polycarbonate Substances 0.000 claims description 7
- 229910052710 silicon Inorganic materials 0.000 claims description 7
- 239000010703 silicon Substances 0.000 claims description 7
- 229920005594 polymer fiber Polymers 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 230000035876 healing Effects 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 206010052428 Wound Diseases 0.000 description 47
- 208000027418 Wounds and injury Diseases 0.000 description 47
- 238000011109 contamination Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
Classifications
-
- A61F13/01042—
-
- A61F13/05—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/91—Suction aspects of the dressing
- A61M1/915—Constructional details of the pressure distribution manifold
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/91—Suction aspects of the dressing
- A61M1/918—Suction aspects of the dressing for multiple suction locations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00536—Plasters use for draining or irrigating wounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00855—Plasters pervious to air or vapours
- A61F2013/00863—Plasters pervious to air or vapours with pores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/98—Containers specifically adapted for negative pressure wound therapy
- A61M1/984—Containers specifically adapted for negative pressure wound therapy portable on the body
- A61M1/985—Containers specifically adapted for negative pressure wound therapy portable on the body the dressing itself forming the collection container
Definitions
- US patent 7070584 provides a ceramic foam dressing.
- the capillaries draw liquid through the dressing from the wound.
- the length of the capillaric pathway is long, and vulnerable to clogging, thereby limiting removal of suppurating liquid from the wound.
- ceramic dressings are frangible, making the total fluid removal effect unpredictable and in many cases inadequate and again, vulnerable to clogging.
- the clogged exudate will eventually become a source of serious bacterial contamination.
- the aforesaid dressing comprises a plurality of capillary-like pores.
- the dressing is adapted to be removably adhered to the wound in an air-tight way and remove exudate therefrom.
- the invention is a core purpose of the invention to provide the capillary dressing provided by means of electrospinning.
- the dressing is characterized by porosity ranged between about 3 and about 50 microns.
- Another object of the invention is to disclose the capillary dressing made of polymer fibers.
- the polymer is selected from the group consisting of polyurethane-silicon copolymer, Polyurethanecarbonate, Polycarbonate and any combination thereof.
- a further object of the invention is to disclose the capillaries characterized by water suction height ranged between about 50 and about 150 mm.
- a further object of the invention is to disclose the capillaries characterized by protein suction productivity ranged between about 0.05 g-cm ⁇ -min "1 and 0.3 g-cm ⁇ -min "1 .
- a further object of the invention is to disclose the capillary which is in a fluid communication with a pump providing air rarefaction in a wound area.
- a further object of the invention is to disclose the step of removing the exudate from the wound further comprising a step of vacuuming a wound area by means of a pump fluidly connected to the dressing.
- FIG. 1 is a schematic presentation of the experimental measurement of maximum height provided due to capillary water suction.
- the term 'wound' hereinafter refers to a type of injury in which the skin is torn, cut or punctured (an open wound), or where blunt force trauma causes a contusion
- dressing refers to an adjunct used by a person for application to a wound in order to promote healing and/or prevent further harm.
- a dressing is designed to be in direct contact with the wound.
- exudate' hereinafter refers to any fluid that filters from the circulatory system into lesions or areas of inflammation. Its composition varies but generally includes water and the dissolved solutes of the blood, some or all plasma proteins, white blood cells, platelets and (in the case of local vascular damage) red blood cells.
- a biocompatible wound dressing is shaped to conform to a wound site.
- the aforesaid dressing comprises a plurality of capillary-like pores.
- the dressing is adapted to be removably adhered to the wound in an air-tight manner and remove fresh exudate continuously with little or no blocking.
- the dressing or at least the part of the dressing which comes into contact with the wound surface is constructed of special electrospun material characterised by a plurality of capillary pores, which are effectively hollow capillary tubes, extending continuously from the surface of the wound (the lower surface of the dressing) to the upper surface of the dressing.
- the dressing facilitates the removal of fresh exudate, and the aforesaid dressing is characterized by porosity ranged between about 3 and about 50 microns.
- the capillaries are characterized by water suction height ranged between about 50 and about 150 mm.
- the capillaries are characterized by protein suction productivity ranged between about 0.05 g-cm ⁇ -min "1 and
- the capillary dressing is in a fluid communication with a pump providing air rarefaction (suction) over the wound area.
- the step of providing the dressing further comprises a step of electrospinning polymer fibers.
- the fibers are selected from the group consisting of polyurethane-silicon copolymer fibers,
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
Abstract
A biocompatible wound dressing shaped to conform to a wound site is disclosed. The aforesaid dressing comprises capillary-like pores. The dressing is adapted to be removably adhered to the wound in an air-tight manner and remove exudate therefrom. The capillary dressing is provided by means of electrospinning and characterized by porosity ranged between about 3 and about 50 microns.
Description
ELECTROSPUN WOUND DRESSING
FIELD OF THE INVENTION
The present invention relates to a wound dressing, and, more specifically, to a wound dressing which provides wound exudate removal due to capillary forces.
BACKGROUND OF THE INVENTION
A dressing is an adjunct used by a person for application to a wound in order to promote healing and/or prevent further harm. Traditional wound dressings usually comprise a fabric or felt of absorptive material such as a gauze in direct contact with the wound. Such dressings are normally covered in order to avoid or reduce bacterial contamination but are not efficient in this respect. They have the general advantage of absorbing exudate from the wound but on the other hand, tend to stick to the wound surface, thus inhibiting healing. Often, exudate that has been removed from a wound recontaminates the wound. Furthermore, removal of the dressing is commonly painful where such sticking has taken place.
US patent 7070584 provides a ceramic foam dressing. The capillaries draw liquid through the dressing from the wound. However, the length of the capillaric pathway is long, and vulnerable to clogging, thereby limiting removal of suppurating liquid from the wound. Furthermore, ceramic dressings are frangible, making the total fluid removal effect unpredictable and in many cases inadequate and again, vulnerable to clogging. The clogged exudate will eventually become a source of serious bacterial contamination. In view of the above, there is a long term and unmet need to provide means and methods of continuously removing fresh wound exudate from a wound site, without danger of reinfecting the wound by contamination with old exudate and exudative debris.
SUMMARY
It is hence one object of the invention to disclose a biocompatible wound dressing shaped to conform to a wound site. The aforesaid dressing comprises a plurality of capillary-like
pores. The dressing is adapted to be removably adhered to the wound in an air-tight way and remove exudate therefrom.
It is a core purpose of the invention to provide the capillary dressing provided by means of electrospinning. The dressing is characterized by porosity ranged between about 3 and about 50 microns.
Another object of the invention is to disclose the capillary dressing made of polymer fibers. The polymer is selected from the group consisting of polyurethane-silicon copolymer, Polyurethanecarbonate, Polycarbonate and any combination thereof.
A further object of the invention is to disclose the capillaries characterized by water suction height ranged between about 50 and about 150 mm.
A further object of the invention is to disclose the capillaries characterized by water suction productivity ranged between about 0.02 g-cm^-min"1 and 0.2 g-cm^-min"1.
A further object of the invention is to disclose the capillaries characterized by protein suction productivity ranged between about 0.05 g-cm^-min"1 and 0.3 g-cm^-min"1.
A further object of the invention is to disclose the capillary which is in a fluid communication with a pump providing air rarefaction in a wound area.
A further object of the invention is to disclose a method of removing an exudate from a patient's wound. The method comprises the steps of (a) providing a capillary wound dressing further comprising a plurality of capillary-like pores; the dressing adapted to be removably adhered to the wound in an air-tight way and remove exudate therefrom; (b) adhering the capillary dressing to the wound in an air-tight way; (c) removing said exudate from the wound.
The step of removing said exudate is performed by means capillary forces originated from capillary-like pores characterized by sizes ranged between about 50 and about 150 micron.
A further object of the invention is to disclose the step of providing the dressing further comprising a step of electrospinning polymer fibers. The fibers are selected from the group consisting of polyurethane-silicon copolymer fibers, Polyurethanecarbonate fibers,
Polycarbonate fibers and any combination thereof.
A further object of the invention is to disclose the step of removing the exudate from the wound further comprising a step of vacuuming a wound area by means of a pump fluidly connected to the dressing.
BRIEF DESCRIPTION OF THE DRAWINGS
In order to understand the invention and to see how it may be implemented in practice, a plurality of embodiments is adapted to now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which FIG. 1 is a schematic presentation of the experimental measurement of maximum height provided due to capillary water suction.
DETAILED DESCRIPTION OF THE INVENTION
The following description is provided, alongside all chapters of the present invention, so as to enable any person skilled in the art to make use of said invention and sets forth the best modes contemplated by the inventor of carrying out this invention. Various modifications, however, are adapted to remain apparent to those skilled in the art, since the generic principles of the present invention have been defined specifically to provide a biocompatible wound dressing and a method of removing an exudate from a patient's wound.
In medicine, the term 'wound' hereinafter refers to a type of injury in which the skin is torn, cut or punctured (an open wound), or where blunt force trauma causes a contusion
(a closed wound).
The term 'dressing' hereinafter refers to an adjunct used by a person for application to a wound in order to promote healing and/or prevent further harm. A dressing is designed to be in direct contact with the wound.
The term 'exudate' hereinafter refers to any fluid that filters from the circulatory system into lesions or areas of inflammation. Its composition varies but generally includes water and the dissolved solutes of the blood, some or all plasma proteins, white blood cells, platelets and (in the case of local vascular damage) red blood cells.
In accordance with a preferred embodiment of the current invention, a biocompatible wound dressing is shaped to conform to a wound site. The aforesaid dressing comprises a
plurality of capillary-like pores. The dressing is adapted to be removably adhered to the wound in an air-tight manner and remove fresh exudate continuously with little or no blocking. In order to achieve this, the dressing or at least the part of the dressing which comes into contact with the wound surface, is constructed of special electrospun material characterised by a plurality of capillary pores, which are effectively hollow capillary tubes, extending continuously from the surface of the wound (the lower surface of the dressing) to the upper surface of the dressing. The dressing facilitates the removal of fresh exudate, and the aforesaid dressing is characterized by porosity ranged between about 3 and about 50 microns.
In accordance with the current invention, the capillary dressing is made of polymer fibers. The polymer is selected from the group consisting of polyurethane-silicon copolymer, Polyurethanecarbonate, Polycarbonate and any combination thereof.
In accordance with a further embodiment of the current invention, the capillaries are characterized by water suction height ranged between about 50 and about 150 mm.
In accordance with a further embodiment of the current invention, the capillaries are characterized by water suction productivity ranged between about 0.02 g-cm^-min"1 and about 0.2 g-cm"2-min"'.
In accordance with a further embodiment of the current invention, the capillaries are characterized by protein suction productivity ranged between about 0.05 g-cm^-min"1 and
0.3 g-cm^-min'1.
In accordance with a further embodiment of the current invention, the capillary dressing is in a fluid communication with a pump providing air rarefaction (suction) over the wound area.
In accordance with a further embodiment of the current invention, a method of removing an exudate from a patient's wound comprising the steps of (a) providing a capillary wound dressing further comprising a plurality of capillary-like pores; the dressing adapted to be removably adhered to the wound in an air-tight way and remove exudate therefrom; (b) adhering said capillary dressing to the wound in an air-tight way; (c) removing the exudate from the wound.
The step of removing the exudate is performed by means capillary forces originated from capillary-like pores characterized by sizes ranged between about 50 and about 150 micron.
In accordance with a further embodiment of the current invention, the step of providing the dressing further comprises a step of electrospinning polymer fibers. The fibers are selected from the group consisting of polyurethane-silicon copolymer fibers,
Polyurethanecarbonate fibers, Polycarbonate fibers and any combination thereof.
In accordance with a further embodiment of the current invention, the step of removing the exudate from the wound further comprises a step of vacuuming a wound area by means of a pump fluidly connected to the dressing.
The proposed technical solution is experimentally tested. Standard samples of electrospun dressings with dimensions of 2*40 mm2 were produced. The samples were made of following polymers: Polyurethane-Silicon Copolymer, Polyurethanecarbonate, and Polycarbonate. The following parameters were measured: Average Pore Size, Water
Suction Max Height, Water Suction Productivity, and Protein Suction Productivity. The obtained experimental data are presented in Table I. The size of sample pores was determined according to a method of capillary flow.
Reference is now made to Figure 1, presenting an experimental setup for measuring water suction maximum height. Specifically, one terminal of an electrospun dressing 20 is immersed into water accommodated in a bath 10. A holder 30 hangs another terminal of the dressing 20 over the bath 10. The water accommodated in a bath 10 flows up due to capillary forces up to a height H.
TABLE 1
Claims
1. A biocompatible wound dressing useful for healing a wound, said dressing shaped to conform to a wound site; said dressing comprising a plurality of capillary-like pores, said dressing adapted to be removably adhered to said wound in an air-tight manner and remove exudate therefrom; wherein said capillary dressing comprises electrospun material; said dressing is characterized by porosity ranged between about 3 and about 50 microns.
2. The capillary dressing according claim 1, made of polymer fibers; said polymer is selected from the group consisting of polyurethane-silicon copolymer, Polyurethanecarbonate, Polycarbonate and any combination thereof.
3. The capillary dressing according claim 1, wherein said capillaries are characterized by water suction height ranged between about 50 and about 150 mm.
4. The capillary dressing according claim 1, wherein said capillaries are characterized by water suction productivity ranged between about 0.02 g-cm"2- min'1 and about 0.2 g-cm"2-min"'.
5. The capillary dressing according claim 1, wherein said capillaries are characterized by protein suction productivity ranged between about 0.05 g-cm 2- min"1 and about 0.3 g-cm^-min"1.
6. The capillary dressing according claim 1, being in a fluid communication with a pump providing air rarefaction in a wound area.
7. A method of removing an exudate from a patient's wound comprising the steps of
(a) providing a capillary wound dressing further comprising a plurality of capillary-like pores, said dressing adapted to be removably adhered to said wound in an air-tight way and remove exudate therefrom;
(b) adhering said capillary dressing to said wound in an air-tight way;
(c) removing said exudate from said wound; wherein said step of removing said exudate is performed by means capillary forces originated from capillary-like pores characterized by sizes ranged between about 50 and about 150 micron.
8. The method according claim 7, wherein said step of providing said dressing further comprises a step of electrospinning polymer fibers; said fibers are selected from the group consisting of polyurethane-silicon copolymer fibers, Polyurethanecarbonate fibers, Polycarbonate fibers and any combination thereof.
9. The method according claim 7, wherein said step of removing said exudate from said wound further comprises a step of vacuuming a wound area by means of a pump fluidly connected to said dressing.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15518309P | 2009-02-25 | 2009-02-25 | |
US61/155,183 | 2009-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010097799A1 true WO2010097799A1 (en) | 2010-09-02 |
Family
ID=42132266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2010/000165 WO2010097799A1 (en) | 2009-02-25 | 2010-02-25 | Electrospun wound dressing |
Country Status (1)
Country | Link |
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WO (1) | WO2010097799A1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060084340A1 (en) * | 2004-04-19 | 2006-04-20 | The Procter & Gamble Company | Fibers, nonwovens and articles containing nanofibers produced from high glass transition temperature polymers |
US20060094320A1 (en) * | 2004-11-02 | 2006-05-04 | Kimberly-Clark Worldwide, Inc. | Gradient nanofiber materials and methods for making same |
US7070584B2 (en) | 2001-02-20 | 2006-07-04 | Kci Licensing, Inc. | Biocompatible wound dressing |
WO2007060433A1 (en) * | 2005-11-25 | 2007-05-31 | Smith & Nephew, Plc | Fibrous dressing |
US20070225631A1 (en) * | 2002-10-04 | 2007-09-27 | Bowlin Gary L | Sealants for Skin and Other Tissues |
US20080275409A1 (en) * | 2007-05-01 | 2008-11-06 | The Brigham And Women's Hospital, Inc. | Wound healing device |
-
2010
- 2010-02-25 WO PCT/IL2010/000165 patent/WO2010097799A1/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070584B2 (en) | 2001-02-20 | 2006-07-04 | Kci Licensing, Inc. | Biocompatible wound dressing |
US20070225631A1 (en) * | 2002-10-04 | 2007-09-27 | Bowlin Gary L | Sealants for Skin and Other Tissues |
US20060084340A1 (en) * | 2004-04-19 | 2006-04-20 | The Procter & Gamble Company | Fibers, nonwovens and articles containing nanofibers produced from high glass transition temperature polymers |
US20060094320A1 (en) * | 2004-11-02 | 2006-05-04 | Kimberly-Clark Worldwide, Inc. | Gradient nanofiber materials and methods for making same |
WO2007060433A1 (en) * | 2005-11-25 | 2007-05-31 | Smith & Nephew, Plc | Fibrous dressing |
US20080275409A1 (en) * | 2007-05-01 | 2008-11-06 | The Brigham And Women's Hospital, Inc. | Wound healing device |
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