經濟部智慧財產局貝工消费合作社印數 401309 A7 ____B7___ 五、發明說明（1 ) 發明領域 本發明有關於一種電極，更特定的說，本發明的電極 被用在離子電滲設備及方法中，以傳送化學品（例如各種 藥、營養劑、化妝品）到皮虜裡。 先前技術 化學品的滲皮膚的（transcutaneous)傳送（亦即把化 學品傳到病患的皮膚裡）是在藥品傳送應用中常用的。已 知許多滲皮虜系統。最簡單的可能是使要傳送的化學品接 病患的皮膚並允許該化學品透過毛細孔而參透皮膚並即時 發生大量傳送現象。此技術就提供各種化妝保養品（例如 皮膚軟化劑及類似者）給皮虜的方法而言是最普通。保養 品簡單的被散在皮虜上且被允許留在那，使保養品的某些 成分可滲透皮膚。 一種更複雜的滲皮膚化學傳送技術（被稱爲離子電滲 )用電能引導化學品滲透皮膚。離子電滲允許對化學品的 傳送的速率及對化學品滲透到皮膚的深度的較佳控制。此 外，離子電滲使較大分子滲透皮膚。 剖析到最裸露的重點，離子電滲涉及電動力驅使離子 化學品到皮虜裡。離子電滲設備包括二電極。在任一時刻 ，該等電極之一在它附近有離子可被驅動到皮膚裡β在使 用中，二電極皆接觸皮庙。電動力被提供到該等電極，在 該等電極之間產生電流，該電流通過皮膚且驅使離子化學 品離開第一電極並進入第二電極。 — — —— — — — — — — — — i — — — — — — — — <請先Μ讀背面之注f項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -4- 經濟部智慧財產局貝工消費合作社印製 A7 __B7 _____ 五、發明說明（2 ) 已知若干生化電極可感應生化訊號，例如心電圖訊號 或腦電圖訊號。此外，已知若干電極可被動感應滲皮膚的 電流或滲皮膚的引導電能。 然而，無一能在整個電極提供均勻電流。在特定應用 中，吾人希望在整個電極有均勻電流分布或電位。提供展 現高導電性及低電阻的電極，即能達成此目標。目前，無 電極呈現這些特質。 此外，既存的電極無一可良好的被用在皮虜深度變化 且對電流的感應性變化的身體部分。此類電極或設備應有 均勻電流分布及低電阻以避免因燃燒或電解而傷害皮麻面 的更敏感部分。此外，既存的電極無一可良好的被用在身 體中有神經末端高密度的部分，例如臉、手、腳或頭。在 有神經末端高密度的例子之中，從既存的能感應離子電滲 的設備有減增的可能性。 有些特定藥品的最佳傳送方向可能是滲皮虜的。舉例 而言，一些藥品在它們直被被傳送到發生青春痘的部分的 表面時是最、有效的。這些情況是此一藥品的離子電滲的良 好成果。目前，無電極、離子電滲設備或方法能有效傳送 此類藥品而不傷害皮膚。無既存電極或離子電滲設備或方 法考慮皮膚的一部分到另一部分對電流的引導的皮虜敏感 性的變化。 在一些情況中，特定藥品的滲皮的應用可能是零亂的 ，或在某部分的處理中該部分應被隔離。舉例而言，指甲 黴菌處理須直接被提供到腳趾甲或手指甲。在這些處理中 本紙張尺度適用中國國家標準（CNS>A4規格（2】0 X 297公釐） ~! — — — — — — — — — — — —^!|^_!·^ (請先《讀背面之注意事項再填寫本頁) A7 匕之3挪 '__B7_ 五、發明說明（3 ) ，在醫療進行中’病患可能要隔離這些藥品。在這些情形 中，吾人希望這些電極或離子電滲設備可完全被丟棄且能 配合身體的可應用的輪廓。此外’在醫療中’電極及設備 •應能隔離此一部分以減少任何藥品或狀況擴散到其他部分 、衣服或類似者。要完全可丟棄及配合’此一設備須是可 撓的、薄的且由便宜的材料做成。目前’有數件專利有關 於可丢棄的電極。然而’先前技術無一揭不任何被用在離 子電滲中的可丟棄的電極有變化的電阻以提供預定的程度 的電流分布並補償一些皮膚部分的敏感性的變化並因此避 免有害的燃燒。 因此，一種普遍被承認的需求是：一種在成分及結構 上都被最佳化而最小化或消除對使用者的皮虜的輻射的電 極。 另一需求是：離子電滲設備及方法所用的電極在成分 上及在結構上都被最佳化以最小化或消除對使用者的皮膚 的輻射。 另一需、求是：電極的電阻從一部分到另一部分有變化 以補償皮廣敏感性的變化。 另一需求是：一種離子電滲設備及方法所用的電極中 至少一個電極的電阻從一部分到另一部分有變化以補償皮 虜敏感性的變化。 另一需求是：一種把藥品導入皮膚的方法，其中’接 收電流的電極有變化的電阻，以致藥品可有效進入皮膚， 卻避免燒傷或以其他方式傷害皮虜。 II---— — — — —— — - - - - ----I II---- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局貝工消费合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐〉 -6- 經濟部智慧財產局貝工消费合作社印« 401309 A7 _B7_____ 五、發明說明（4 ) 另一需求是：一種藉由用有變化的厚度的電極導電到 皮膚而有效消除在皮膚表面下的蜂窩織炎的設備及方法。 '發明槪述 如上述，本發明克服與先前技術電極及離子電滲設備 及方法有關的上述缺點或其他缺點。 依據本發明，一種電極有可撓性非導電基板及一層導 電材料，後者被提供到前者的表面的一部分。導電材料有 變化的電阻。 本發明還提供一種以離子電滲法把藥品傳送至皮膚表 面的設備，其包括一可撓的基板及一對分開的電極。這些 電極是由被提供到基板的表面的一部分的導電材料做成。 這些電極中至少一個有變化的電阻。本設備還包括一電源 與每一電極通電。當電源與這些電極通電，電流到皮虜， 造成藥品被提供到皮膚的表面而被傳送到皮麻表面以下。 本發明還提供一種傳送藥品到皮膚的方法。此方法包 括把一對電極固定至一可撓的基板的表面的一部分。這些 電極分開且它們之中至少一個有變化的電阻。此方法還包 括若干步驟：提供藥品到皮虜表面，使這些電極接觸皮膚 表面，從一電源導電到這些電極。 本發明的電極、離子電滲設備及方法優於先前技術， 因爲它們改變至少一電極的電阻而在正常使用中避免皮膚 輻射。電阻是用下列方式之一或組合予以改變：1、改變 導電材料的厚度；2、改變導電材料的導電性：3、改變 本紙張尺度適用中國國家標準<CNS>A4規格（210 X 297公釐〉 — — — — — — — — — III I i! t籲 —1_! !& <請先閱讀背面之注$項再填寫本頁) A7 4013^9 __；_B7_ 五、發明說明（5 ) 導電材料的形狀。電阻的變化的結果是電極展現電阻的垂 直及/或水平變化。垂直電阻是貫穿電極的特定點的厚度 所測量的電阻，水平電阻是沿電極的特定長度所測量的電 阻。電阻的垂直變化對防止熱點（電流聚焦在使用者的皮 膚的不正常導部分，例如小傷口）而言特別重要。使導電 墨層對直接觸及使用者的皮虜的電流比其他部分更敏感， 即可防止這些熱點。遍及電極的變化的電阻維持在電極的 整個表面上的電流密度受控。 本發明的範圍還包括把本發明的設備用於離子電滲以 施加化妝品、應用離子電滲以減少皮下蜂窩織炎的沈積。 各種局部面霜及保養品可被用以減少蜂窩織炎，但以前未 揭示這些面霜及保養品的離子電滲應用的安全及有效的方 法。 因此，本發明的一目的是提供一種有變化的電阻的電 極、離子電滲設備及方法以達成電流的均勻分布。 本發明的另一目的是提供一種有變化的電阻的電極、 離子電滲設備及方法以減少對皮膚的傷害。 本發明的另一目的是提供一種沿表面改變電阻的電極 以補償皮庙敏感度的變化。 本發明的另一目的是提供一種可撓的且可丟棄的並展 現變化的電阻以避免對皮虜的傷害。 本發明的另一目的是提供一種把藥品導入皮膚的方法 ，其中，接收電流的電極有變化的電阻，以致該藥品可有 效進入皮膚，卻避免燒傷或以其他方式傷害皮虜。 本紙張尺度適用中國國家標準（CNS>A4規格（210 X 297公釐） — — — — — — — — — — — — * — — — — — — — — — — — — — — (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消费合作社印製 -8 - A7 B7 五、發明說明（6 ) (請先闓讀背面之注意事項再填寫本頁) 本發明的另一目的是提供一種藉由將電流導至沿著表 面具有變化厚度的電極而有效消除在皮虜表面下的蜂窩織 炎。 本發明的目的，特徵及優點將由以下的詳細說明結合 圖示及所附的申請專利範圍而更爲明確。 圖式簡述 第1圖是本發明的較佳實施例的前面圖。 第2圖是第1圖的較佳實施例的橫剖面圖" 第3 A圖是本發明的第二實施例的前面圖。 第3 B圖是第3 A圖的實施例，最上方的墨層被移走 〇 第4圖是第3 A圖的實施例的橫剖面圖。 第5 A圖是本發明的第三實施例的前面圖，其形式是 —張適合減少皮下蜂窩織炎的貼片。 第5 B圖是第5 A圖的實施例，最上方的墨層被移走 〇 經濟部智慧財產局貝工洧费合作社印製 第6圖呈現要提供電流到本發明的皮虜貼片的電極所 用的較佳電流波前。 主要元件對照表 1 第一面具 2 鼻孔 3 左眼孔 4 右眼孔 10 絕緣基部 11 衛生紙 本紙張尺度適用中國國家標準（CNS>A4規格<210 X 297公釐） -9 - 401309 A7 __;_B7 五、發明說明（7 ) 經濟邾智慧財產局貝工消费合作社印製 1 2 漆層 1 5 絕緣溝 1 6 線 1 8 線 2 0 左電極 2 1 下層 2 2 臉頰部 2 3 下巴部 2 3 導電貼片 3 0 右電極 3 1 下層 3 2 臉頰部 3 3 下巴部 3 4 導電貼片 5 0 面具 6 0 絕緣基部 6 1 衛生紙層 6 2 漆層 6 5 絕緣溝 7 0 左電極 7 1 下層 7 2 臉頰部 7 3 太陽穴部 7 4 導電貼片 7 5 上層 8 0 右電極 8 1 下層 8 2 臉頰部 8 3 太陽穴部 8 4 導電貼片 8 5 上層 1 0 0 貼片 1 1 0 ，絕緣基部 1 2 0 電極 1 2 1 層1 2 6的段 1 2 3 電極1 2 0之較小電阻部分 1 2 5 上層 1 2 6 下層 1 3 0 電極 1 3 2 層1 3 6的段 1 3 3 電極1 3 0之較小電阻部分 1 3 5 上層 1 3 6 下層 — — — — — — — — — — — — — — — — — — I— — — — — — — I (請先閱讀背面之注$項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -10- 401309 A7 經濟部智慧財產局員工消费合作社印製 _：___B7__五、發明說明（8 ) 實施例詳述 參考圖式’第1圖揭示本發明的第一實施例的前面圖 ’其形式是第一面具1。第一面具1是由一絕緣基部1 〇 •所構成’一左電極2 0及一右電極3 0被印在絕緣基部 1 0上’二者之間有一絕緣溝1 5。絕緣基部1 0有一鼻 孔2 0、一左眼孔3、一右眼孔4，以致使用者的鼻及眼 不被離子電滲。絕緣基部1 〇宜由衛生紙1 1做成。衛生 紙應由衛生的、不織的、防水的纖維做成。這種紙的一例 是由Walkisoft所做的第6 0級衛生紙。 左電極2 0由下層2 1及上層組成，上層被印在下層 2 1的頂面上且整個在下層2 1的面積內。上層是由兩個 不連的部分組成’臉頰部2 2及下巴部2 3。相似的，右 電極3 0由下層3 1及上層組成，上層包括臉頰部3 2及 下巴部3 3。兩片導電貼片2 4及3 4被放在下巴部2 3 及3 3的下半部上。貼片2 4及3 4做爲提供電流的電線 的附著點。 第一面具1還包括許多有孔的線16或被壓的線18 *» 以實施面具的折部而實現在使用者的臉上的較佳附著。第 1圖所示的第一面具1的實施例在臉頰部分的每一側上有 有孔的線1 6且在太陽穴部分裡有被壓的線1 8。 第2圖提供第一面具1的剖面圖。一層漆4 0被塗在 基部1 0的頂面上。漆宜爲食物級漆。下層2 1及3 1被 印在漆4 0上且宜由導電墨做成。這些下層宜有均勻厚度 以均勻的把電流分配在電極。上層被印到下層2 1及3 1 ---------I--. I---I — — — — —— — — — (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -11 - 經濟部智慧財產局貝工消费合作社印紫 A7 '_B7_ 五、發明說明（9 ) 上。上層宜由導電墨做成且比外層有較高的電阻。其他能 把下層或上層或漆4 0固定到基部1 0的手段包括鐳射印 刷、轉輪印刷、鋼印及其他已知的方法。 下層2 1及3 1及上層的:¾直及/或水'%電阻可藉由 ..-— 改變數個因素而予以改變。這些因素包括下或上層的厚度 、被用來做上及下層的材料的導電性。可藉由改變所使用 的材料或增加或調整碳粉濃度來改變導電性。較佳的組合 是藥級碳粉在墨裡所佔的重量百分比是6·5至12·5 。適當碳粉包括 M.M.M. Carbon of Willebrock，Belgium 所 製造的「Super P」。較佳的墨是Sicpa Swiss所製造的 G 0 3 — 9 5。 如上述，各種垂直及/或水平電阻的變化可藉數種方 式予以達成，包括改變這些層的厚度及/或改變這些層的 組合以影響導電性。此外，在本發明中，還可能把有均勻 厚度及均勻組成但有不同面積的數層疊在起而達成電阻的 各種變化。以此方式，電極的全厚變化並造成電極的不同 部分有不同p直及水平電阻。 宜調整下層21及31的碳粉以使在下層21或31 上的相距1公分的二探針之間所量到的電阻是在,1 〇 0歐 姆及1 0 0 0歐姆之間。此測量被稱爲水平電阻。頰部 2 2及3 2及下巴部2 3及3 3的水平電阻宜有相似範圍 〇 第2圖呈現絕緣基部1 0是由兩層組成，衛生紙層 1 1及漆層40 »在印刷電極20及30以前，先提供漆 本纸張尺度適用中國园家標準（CNS>A4規格（210 X 297公釐） -12- I — — — — — —^ii^i!·^ (請先閱讀背面之注意Ϋ項再填寫本頁) 經濟部智慧財產局貝工消费合作社印製 401309 A7 __；_ B7_ 五、發明說明（10 ) 層1 2到衛生紙層1 1以防止導電墨滲透衛生紙層1 1。 第2圖還呈現電極2 0及3 0是雙層結構：左電極2 0的 部分包括下層2 1及上層的頰部2 2，且右電極3 0的部 ’分包括下層3 1及上層的頼部3 2。 電極2 0及3 0是由不同的厚度所製成，以便提供橫 向變化的電阻，藉此控制其中的電流密廑。在必須降低電 流的部分，電極2 0及3 0較厚：在電極貼附點附近及導 電貼片2 4及3 4處電流線收斂的部分；以及使用者的臉 頰附近，該處的皮虜較薄，因此需要較小的電流以避免傷 及皮虜。 第3A圖、第3B圖、第4圖呈現本發明的第二實施 例，它的形式是第二面具5 0 »像第一面具1，第二面具 5 0是由絕緣基部6 0及被印在絕緣基部上的左電極7 0 及右電極80，二者被絕緣溝.6 5分開。面具50有一個 嘴開口 5 0及兩個眼開口 5 3及5 4，且因此不需有孔的 線。 第二面具5 0的電極7 0及8 0是多層結構。圖3A 僅呈現電極7 0的一上層7 5及電極8 0的一上層8 5。 第3 B圖呈現第二面具5 0而上層7 5及8 5被移走，呈 現電極70及80的其他層：下層71及81，並拆開中 間層，中間層包括頰部7 2及8 2及太陽穴部7 3及8 3 。下層71及81及中間層的太陽穴部72、 73、 82 及8 3的特性被調整以使在這層之任一者上的相距1公分 的兩支探針所量得的電阻是在1 〇 0歐姆及1 0 0 0歐姆 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐〉 — — — — — — — — — — — — 裝 — II 訂·！1線 (請先閱讀背面之注意事項再填寫本頁) 401309 A7 __ B7 五、發明說明（11) 之間。 上層7 5及8 5的特性被調整以使垂直於上層7 5或 8 5所測的每單位面積的電阻是在5 〇 〇歐姆/平方公分 及5 0 〇 〇歐姆/平方公分之間。如上述，調整這些層之 任一者的厚度或組成，即可調整垂直及/或水平電阻。改 變在導電墨裡的碳的量，即可改變上述組成。此外，可用 這些選擇的組合或排列。 兩層導電貼片7 4及8 4被放在電極7 0及8 0的太 陽穴端之上。像貼片24及34，貼片74及84做爲提 供電流的電線的附著點並保持第二面具5 0所用的包裝材 料的位置。當第二面具5 0就位，貼片7 4及8 4貼近使 用者的耳朵，以致上述電線可被掛在使用者的耳朵的上方 及後方。 圖4爲第二面具50中跨過B—B/的剖面圖。類似 於絕緣基部1 0，絕緣基部6 0是由衛生紙層6 1及漆層 6 2所構成。上層7 5及8 5完全的覆蓋中間層部7 2、 73、 82及83以及下層71及81。 在第一面具1中，把電極20及30印在若干層中， 即可獲得水平變化的電阻。類似的，在第二面具5 0中， 把電極7 0及8 0印在若干層中而使它們的厚度不均勻， 即可獲得水平變化的電阻。換種方式，改變導電性，即可 獲得變化的電阻，例如材料的導電性及/或在導電墨裡的 碳粉的重量百分比。 第5 A圖及第5 B圖呈現被做來減少皮下蜂窩織炎沈 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公« ) (請先閱讀背面之注意事項再填寫本頁) 裝·！ —訂-------線 經濟部智慧財產局貝工消费合作社印製 401309 A7 ___B7 __ 五、發明說明（12 ) (請先Μ讀背面之注項再填寫本頁) 積的本發明的皮膚貼片1 0 0。像第一面具i及第二面具 5 0 ’貼片1 〇 〇由一絕緣基部1 1 〇及被印在絕緣基部 上的電極120及130組成。然而，以此方式，電極 ' 1 2 0及1 3 0是均勻厚度的雙層結構。在第5A圖中， 僅上層1 2 5及1 3 5是可見的。像面具50的上層75 及85 ’貼片100的上層125及135的特徵是垂直 於在絕緣中的任一層所測的每單位面積的電阻是在5 〇 〇 歐姆/平方公分及5 0 0 0歐姆/平方分分之間。在第5 B圖中，上層1 2 5及1 3 5被移.走，暴露下層1 2 6及 1 3 6，它們被印在三段（sections )，每一段有不同電阻 (在相距約1公厘的兩支探針之間所測）。雖然每一段的 電阻的特徵是在1 0 0歐姆及1 〇 〇 〇歐姆之間，層 1 2 6的段1 2 2及層1 3 6的段1 3 2的特徵電阻宜爲 層126的段121及層136的段131的特徵電阻的 一半。在此例中，電極1 2 0及1 30的變化的電阻是藉 由用碳粉的不同重量百分比印層1 2 6及1 3 6的這些段 而得。 經濟部智慧財產局員工消费合作社印製 在使用中，電線（未被呈現）被夾到電極1 2 0及 1 30的有較小電阻的部分1 23及1 33。換種方式， 與貼片2 4及3 4相似的貼片可被提供在上層1 2 5及 1 3 5上。如在絕緣基部1 0的情形中，絕緣基部1 1 0 宜由衛生紙層111及漆層112組成，電極120及 130被印在漆層上。 如在上述實施例之任一裡的另類設計中，可依格形（ 本紙張尺度適用中國國家標準（CNS)A4規格（210 * 297公爱〉 -15- A7 401309 _；___B7__ 五、發明說明（13 ) 有若干孔在其中）把下、小電阻層印在或以其他方式被提 供在上述設備的基部以減少所用的材料量並降低成本。該 格可能是許多方形、長方形、蜂巢設計或其他形狀。 對璟供化妝品、營養或醫藥到臉上而言，把適當的劑 放在使用者的皮膚表面上並用本發明的第一面具1或第二 面具5 0提供電流到藥劑而驅使劑進入皮膚。因爲藥劑的 物理形式通常是洗劑、面霜或膠，在此被通稱爲藥劑，但 本發明的範圍包括所有此類混合。爲化妝使用者的臉的洗 劑宜包括維生素A及/或維生素E、複羥酸，醫藥劑可能 包括四環素、其他抗生素、抗青春痕藥或抗毒素。 爲減少蜂窩織炎沈積，使用者可能提供被用以減少蜂 窩織炎沈積的洗劑並隨後把本發明的第一面具1或第二面 具5 0或皮貼片1 0 0放在臉上以驅使劑進入皮膚。此劑 包括咖啡因粹取物、茶葉鹼萃取物、銀杏萃取物、矽化劑 、鎂及/或高萊（gola )。 申請人還預期本發明的形狀可被改變以配合其他特定 身體部分。舉例而言，本發明包括至少一個有手或指狀而 被用醫療手、指或指甲的皮膚病變的電極。此電極還有上 述的電極的特徵。被提供到皮膚以醫療此類病變的劑包括 維生素A、維生素E、抗黴菌劑及皮膚濕潤劑。進一步的 ，本發明並包括用以治療雙腳、趾或趾甲病變的裝置或方 法。這些包括但並不限於香港腳藥劑、抗霉菌劑、及皮虜 濕潤劑。此種裝置可包括至少一個呈人體腳部或腳趾狀的 電極。此電極可具有此處所述的特性。使用者可施加特別 — — — — — — —— — — — — ^ i — — — — — — — — — — <請先W讀背面之注意事項再填寫本頁) 經濟部智慧財產局興工消费合作社印製 本紙張尺度適用中國國家標準（CNS>A4規格（210 X 297公茇） -16 - A7 4v)i309 ____B7_ 五、發明說明（14) 的藥劑，適用於治療腳部、腳趾或趾甲的病變，並將裝置 施加至有效區以便藉由施加功率來將藥劑驅進皮虜內。 申請人進一步預期本發明可應用到於如牛皮癬及禿頭 •的頭皮病變。用以治療頭部及頭皮病變的藥劑包括：長壓 定、抗頭皮屑劑、及抗牛皮癬藥劑。亦可預期本發明可施 加到陰莖的皮虜表面來治療男性陽痿的症狀。用以治療陽 痿的藥劑包括如前列腺素的陰莖刺激物。使用本發明來治 療特定病變的例子並不限制本發明的範圍。可預期本發明 可應用至人體的不同部位以治療各種疾病。 本發明所用的g宜爲在變化的極性的期間的直流電 以此方式，在一整彼期間中電流依一方向驅動洗劑的一些 化學品，在下一整段期間中電流依相反方向驅動洗劑的化 學品。此外，改變電流的極性防止在皮庸組織中不要的電 解。第6圖顯示一較佳的電流波形。注意，電流是緩增（ 亦即從零緩增到一最大値）且緩減（亦即從最大値緩減至 零），以防止因電流突然通過所引起的輻射。適宜的電流 密度是在5 0微安培/平方公分及5 0 0微安培/平方公 分之間，以有效減少蜂窩織炎而不輻射或燒傷皮膚。適宜 的脈波期間是在3 0秒及1 2 0秒之間，在每一緩變期間 中，電流從零增到全電流或從全値減到零。 雖透過有限量實施例描述本發明，應瞭解本發明還有 許多變化及其他應用。舉例而言，可用薄的不貴的材料取 代衛生紙來做基板，例如布或聚乙烯片。吾人還預期至少 一有可變電阻的電極可由被模製的人造橡膠做成。電極可 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注項再填寫本頁> 裝 II — 訂· — II ! !線 經濟部智慧財產局Λ工消费合作社印製 -17- A7 ._B7____ 五、發明說明（15) 被模製成人身的末梢，例如指、趾而被用到指或趾或類似 部位以治療皮膚或指甲病變。此外，下層可由其他材料做 成，金屬片或膜。此外，吾人預期漆及導電材料可被提供 '到基部而用網版印刷以外的技術，例如轉輪印刷、鐳射印 刷、油印、層壓、擠壓及在先前技術中已知之技術。 申請人還預期上述較佳實施例可能包括單電極而另一 電極附著使用者的身體。舉例而言，吾人預測上述面具可 能包括單電極而另一電極附著使用者的手或其他遠離使用 者的臉的部位。 申請人的發明主要在一對用在離子電滲中的電極。然 而，申請人認爲本發明包括完整的離子電滲設備。此一設 備包括一對上述的電極及一個連到此對電極的電源。此電 源可是有足夠電力以提供要有效傳送劑通過使用者的皮虜 所需的電流及安培數的電池。 I I — — — — — —^· ! — ί —11· I II — I „^ (請先《讀背面之注意事項再填寫本頁) 經濟部智慧財產局貝工消费合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -18-Imprint 401309 A7 ____B7___ of the Intellectual Property Bureau of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the Invention (1) Field of the Invention The present invention relates to an electrode. More specifically, the electrode of the present invention is used in iontophoresis equipment and methods To deliver chemicals (such as medicines, nutrients, cosmetics) to Pirup. Prior art Transcutaneous delivery of chemicals (i.e., the transfer of chemicals to the patient's skin) is commonly used in drug delivery applications. Many osmotic systems are known. The simplest is probably to contact the patient's skin with the chemical to be delivered and allow the chemical to penetrate the skin through the pores and a large amount of delivery occurs immediately. This technique is the most common in terms of providing skin care products with various cosmetic products such as skin softeners and the like. The care products are simply scattered on the skin and allowed to stay there, so that certain ingredients of the care products can penetrate the skin. A more complex skin-penetrating chemical delivery technique (known as iontophoresis) uses electrical energy to direct chemicals to penetrate the skin. Iontophoresis allows better control of the rate of chemical transport and the depth of chemical penetration into the skin. In addition, iontophoresis allows larger molecules to penetrate the skin. Anatomy of the most naked point, iontophoresis involves electric force to drive ionic chemicals into the skin. The iontophoresis device includes two electrodes. At any one time, one of these electrodes has ions near it that can be driven into the skin. In use, both electrodes are in contact with the skin temple. Electric power is provided to the electrodes, and a current is generated between the electrodes, which current passes through the skin and drives the ionic chemicals away from the first electrode and into the second electrode. — — — — — — — — — — — — I — — — — — — — < Please read the note f on the back before filling out this page) This paper size applies to China National Standard (CNS) A4 specifications ( 210 X 297 mm) -4- Printed by the Shelley Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs A7 __B7 _____ V. Description of the Invention (2) It is known that several biochemical electrodes can sense biochemical signals, such as ECG signals or EEG signals. In addition, several electrodes are known to passively induce skin-permeating currents or skin-permeating guided electrical energy. However, none can provide a uniform current across the electrode. In certain applications, we want a uniform current distribution or potential across the electrode. This can be achieved by providing electrodes that exhibit high conductivity and low resistance. Currently, electrodeless displays these qualities. In addition, none of the existing electrodes can be used well for body parts with varying depths of the skin and inductive changes in current. Such electrodes or equipment should have a uniform current distribution and low resistance to avoid damaging the more sensitive parts of the flax surface due to burning or electrolysis. In addition, none of the existing electrodes can be used well in high density parts of the body such as the face, hands, feet or head. In the case of high-density nerve endings, there may be an increase or decrease from existing devices that can sense iontophoresis. The optimal delivery direction for some specific drugs may be permeating. For example, some medicines are most effective when they are delivered directly to the surface of the area where acne is occurring. These conditions are a good result of the iontophoresis of this drug. Currently, no electrodes, iontophoresis devices or methods can effectively deliver such drugs without harming the skin. There are no existing electrodes or iontophoresis devices or methods that take into account changes in skin-to-skin sensitivity to current-guided skin. In some cases, the application of a skin-penetrating drug may be random, or the part should be isolated during the processing of a part. For example, nail mold treatment must be provided directly to the toenails or fingernails. In these processes, the paper size applies the Chinese national standard (CNS > A4 specification (2) 0 X 297 mm) ~! — — — — — — — — — — — — — — — — — — — "Read the precautions on the back and fill in this page again.) A7 Dagger No. 3 '__ B7_ 5. Description of the Invention (3) In the course of medical treatment, the patient may need to isolate these drugs. In these cases, I hope these electrodes or ions The electroosmotic device can be completely discarded and can fit the applicable contours of the body. In addition, the electrodes and equipment 'in medical care' should be able to isolate this part to reduce the spread of any medicine or condition to other parts, clothing or the like. To be completely Disposable and compatible 'This device must be flexible, thin and made of cheap materials. At present, there are several patents related to disposable electrodes. However,' the prior art has not disclosed anything and is not used in ions Disposable electrodes in electroosmosis have variable resistance to provide a predetermined degree of current distribution and compensate for changes in the sensitivity of some skin parts and thus avoid harmful combustion. Therefore, a generally recognized Seek truth: An electrode that is optimized in composition and structure to minimize or eliminate radiation to the skin of the user. Another requirement is that the electrodes used in iontophoresis equipment and methods are in composition and structure Both are optimized to minimize or eliminate radiation to the user's skin. Another need is to change the resistance of the electrode from one part to another to compensate for changes in skin sensitivity. Another need is: The resistance of at least one of the electrodes used in an iontophoresis device and method changes from one part to another to compensate for changes in skin sensitivity. Another need is: a method for introducing a drug into the skin, wherein The electrode has a variable resistance, so that the drug can effectively enter the skin, but avoid burns or other injuries to the skin. II ------------------- I II ---- ( Please read the notes on the back before filling out this page) The paper size printed by the Shellfish Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs applies to Chinese National Standard (CNS) A4 (210 X 297 mm) -6- Ministry of Economic Affairs Printed by the Shell Property Consumer Cooperative of the Intellectual Property Bureau «401309 A7 _B7_____ V. Description of the Invention (4) Another requirement is: a device that can effectively eliminate cellulitis under the skin surface by using electrodes with varying thicknesses to conduct electricity to the skin And method. As described above, the present invention overcomes the above-mentioned shortcomings or other shortcomings related to prior art electrodes and iontophoresis equipment and methods. According to the present invention, an electrode has a flexible non-conductive substrate and a layer of conductive material, The latter is provided to a part of the surface of the former. The conductive material has a variable resistance. The present invention also provides a device for delivering medicine to the skin surface by iontophoresis, which includes a flexible substrate and a pair of separated electrodes. These electrodes are made of a conductive material provided to a part of the surface of the substrate. At least one of these electrodes has a variable resistance. The device also includes a power source to power each electrode. When the power source is energized with these electrodes, current flows to the skin, causing the medicine to be supplied to the surface of the skin and transmitted below the surface of the skin. The present invention also provides a method for delivering medicine to the skin. This method includes fixing a pair of electrodes to a portion of the surface of a flexible substrate. These electrodes are separated and at least one of them has a variable resistance. This method also includes several steps: supplying the drug to the skin surface, bringing the electrodes into contact with the skin surface, and conducting electricity from a power source to the electrodes. The electrodes, iontophoresis devices and methods of the present invention are superior to the prior art because they change the resistance of at least one electrode and avoid skin radiation during normal use. The resistance is changed in one or a combination of the following ways: 1. Change the thickness of the conductive material; 2. Change the conductivity of the conductive material: 3. Change the paper size to the Chinese National Standard < CNS > A4 (210 X 297) Li> — — — — — — — — — — III I i! T appeal—1_!! &Amp; < Please read the note on the back before filling this page) A7 4013 ^ 9 __; _B7_ V. Description of the invention ( 5) the shape of the conductive material. As a result of the change in resistance, the electrodes exhibit vertical and / or horizontal changes in resistance. Vertical resistance is the resistance measured through the thickness of a specific point across the electrode, and horizontal resistance is the resistance measured along a specific length of the electrode. Vertical changes in resistance are particularly important to prevent hot spots (current focusing on abnormally conducting parts of the user's skin, such as small wounds). These hot spots can be prevented by making the conductive ink layer more sensitive to direct contact and the current of the user's skin than other parts. Varying resistance throughout the electrode maintains a controlled current density across the entire surface of the electrode. The scope of the invention also includes the use of the device of the invention for iontophoresis to apply cosmetics, and iontophoresis to reduce the deposition of subcutaneous cellulitis. Various topical creams and skin care products can be used to reduce cellulitis, but safe and effective methods for iontophoresis applications of these creams and skin care products have not been previously disclosed. Accordingly, it is an object of the present invention to provide an electrode, an iontophoresis device, and a method having a variable resistance to achieve a uniform current distribution. Another object of the present invention is to provide an electrode, an iontophoresis device, and a method with varying resistance to reduce damage to the skin. Another object of the present invention is to provide an electrode that changes resistance along the surface to compensate for changes in the sensitivity of the skin temple. Another object of the present invention is to provide a flexible and disposable electrical resistor that exhibits a change in resistance to avoid damage to the skin. Another object of the present invention is to provide a method for introducing a medicine into the skin, wherein the electrodes receiving the current have a variable resistance, so that the medicine can effectively enter the skin, but avoid burns or otherwise injure the skin. This paper size applies to Chinese National Standards (CNS > A4 specifications (210 X 297 mm) — — — — — — — — — — — — — — — — — — — — — — — — (Please read first Note on the back, please fill in this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -8-A7 B7 V. Invention Description (6) (Please read the notes on the back before filling this page) Another of the invention The purpose is to provide an effective elimination of cellulitis under the surface of the skin by directing current to electrodes having varying thicknesses along the surface. The object, features and advantages of the present invention will be illustrated by the following detailed description in conjunction with the drawings and attached The scope of patent application is more clear. Brief Description of the Drawings Figure 1 is a front view of a preferred embodiment of the present invention. Figure 2 is a cross-sectional view of the preferred embodiment of Figure 1 " Figure 3 A It is a front view of the second embodiment of the present invention. Fig. 3B is the embodiment of Fig. 3A, and the uppermost ink layer is removed. Fig. 4 is a cross-sectional view of the embodiment of Fig. 3A. Figure 5A is a front view of a third embodiment of the present invention In the form of a sheet suitable for reducing subcutaneous cellulitis. Figure 5B is an example of Figure 5A. The uppermost ink layer has been removed. 0 Printed by the Shellfish Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. Figure 6 presents the preferred current wavefront used to provide current to the electrodes of the pelvic patch of the present invention. Main component comparison table 1 First mask 2 Nostril 3 Left eyelet 4 Right eyelet 10 Insulation base 11 Toilet paper Standards apply to Chinese national standards (CNS > A4 specifications < 210 X 297mm) -9-401309 A7 __; _ B7 V. Description of invention (7) Printed by the Shellfish Consumer Cooperative of the Bureau of Economics and Intellectual Property 1 2 Lacquer layer 1 5 Insulation groove 1 6 Line 1 8 Line 2 0 Left electrode 2 1 Lower layer 2 2 Cheek section 2 3 Chin section 2 3 Conductive patch 3 0 Right electrode 3 1 Lower layer 3 2 Cheek section 3 3 Chin section 3 4 Conductive patch 5 0 Mask 6 0 Insulating base 6 1 Toilet paper layer 6 2 Varnish layer 6 5 Insulating groove 7 0 Left electrode 7 1 Lower layer 7 2 Cheek section 7 3 Temple section 7 4 Conductive patch 7 5 Upper layer 8 0 Right electrode 8 1 Lower layer 8 2 Cheek Part 8 3 too Cavity 8 4 Conductive patch 8 5 Upper layer 1 0 0 Patch 1 1 0, Insulating base 1 2 0 Electrode 1 2 1 Layer 1 2 6 Segment 1 2 3 Smaller resistance portion of electrode 1 2 0 1 2 5 Upper layer 1 2 6 Lower layer 1 3 0 Electrode 1 3 2 Segment 1 3 6 Smaller resistance portion of electrode 1 3 0 1 3 5 Upper layer 1 3 6 Lower layer — — — — — — — — — — — — — — — — — — I — — — — — — — — I (Please read the note on the back before filling in this page) This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm) -10- 401309 A7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs _: _B7__ V. Description of the Invention (8) Detailed Description of the Embodiments Refer to the drawing 'Figure 1 shows the front view of the first embodiment of the present invention' in the form A mask 1. The first mask 1 is composed of an insulating base 10. An insulating groove 15 is formed between the left electrode 20 and the right electrode 30 on the insulating base 10. The insulating base 10 has a nostril 20, a left eye 3, and a right eye 4 so that the user's nose and eyes are not ionized. The insulating base 10 is preferably made of toilet paper 11. Toilet paper should be made of hygienic, non-woven, waterproof fibers. An example of this type of paper is Class 60 toilet paper made by Walkisoft. The left electrode 20 is composed of a lower layer 21 and an upper layer, and the upper layer is printed on the top surface of the lower layer 21 and is entirely within the area of the lower layer 21. The upper layer is composed of two non-connected parts, the cheek section 22 and the chin section 23. Similarly, the right electrode 30 is composed of a lower layer 31 and an upper layer, and the upper layer includes a cheek portion 32 and a chin portion 33. Two conductive patches 24 and 34 are placed on the lower half of the chin portions 23 and 33. The patches 2 4 and 34 are used as attachment points for the electric current-supplying wires. The first mask 1 also includes a number of perforated lines 16 or pressed lines 18 * »to implement a folded portion of the mask to achieve better attachment on the user's face. The embodiment of the first mask 1 shown in Fig. 1 has perforated lines 16 on each side of the cheek portion and pressed lines 18 in the temple portion. FIG. 2 provides a cross-sectional view of the first mask 1. A layer of paint 40 is applied to the top surface of the base 10. The paint should be a food grade paint. The lower layers 21 and 31 are printed on the lacquer 40 and should be made of conductive ink. These lower layers should have a uniform thickness to evenly distribute the current across the electrodes. The upper layer is printed on the lower layer 2 1 and 3 1 --------- I--. I --- I — — — — — — — — (Please read the precautions on the back before filling this page) This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) -11-Ink A7 '_B7_, Shellfish Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs on the description of the invention (9). The upper layer should be made of conductive ink and have higher resistance than the outer layer. Other means of fixing the lower or upper layer or lacquer 40 to the base 10 include laser printing, rotary printing, steel stamping, and other known methods. The lower layer 2 1 and 31 and the upper layer: ¾ straight and / or water '% resistance can be changed by ..-— changing several factors. These factors include the thickness of the lower or upper layer, and the conductivity of the materials used to make the upper and lower layers. The conductivity can be changed by changing the materials used or increasing or adjusting the toner concentration. The preferred combination is that the weight percentage of pharmaceutical grade toner in the ink is from 6.5 to 12.5. Suitable toners include "Super P" manufactured by M.M.M. Carbon of Willebrock, Belgium. The preferred ink is G 0 3-9 5 manufactured by Sicpa Swiss. As mentioned above, various changes in vertical and / or horizontal resistance can be achieved in several ways, including changing the thickness of these layers and / or changing the combination of these layers to affect conductivity. In addition, in the present invention, it is possible to achieve a variety of resistance changes by stacking numbers having a uniform thickness and a uniform composition but different areas. In this way, the full thickness of the electrode changes and causes different parts of the electrode to have different p and horizontal resistances. The toner of the lower layer 21 and 31 should be adjusted so that the resistance measured between the two probes 1 cm apart on the lower layer 21 or 31 is between 100 ohms and 100 ohms. This measurement is called horizontal resistance. The horizontal resistance of the cheeks 2 2 and 3 2 and the chins 2 3 and 3 3 should have similar ranges. Figure 2 shows that the insulating base 10 is composed of two layers, a toilet paper layer 11 and a lacquer layer 40. Before 30 years, the paper size of the lacquered paper should be provided first. Applicable to the Chinese gardener's standard (CNS > A4 specification (210 X 297 mm) -12- I — — — — — — ^ ii ^ i! · ^ (Please read the back first) Please pay attention to the item (please fill in this page again)) Printed by 401309 A7 __; _ B7_ of the Intellectual Property Bureau of the Ministry of Economic Affairs. Figure 2 also shows that the electrodes 20 and 30 are a two-layer structure: the part of the left electrode 20 includes the lower layer 21 and the upper cheek 22, and the part of the right electrode 30 includes the lower layer 31 and the upper layer.頼 部 3 2. The electrodes 20 and 30 are made of different thicknesses in order to provide a laterally changing resistance, thereby controlling the current density therein. Where the current must be reduced, the electrodes 20 and 30 Thicker: near the electrode attachment point and where the current lines converge at the conductive patches 24 and 34; and near the user's cheek Here, the skin is thinner, so a smaller current is needed to avoid damaging the skin. Figures 3A, 3B, and 4 show a second embodiment of the present invention in the form of a second mask 5 0 »Like the first mask 1, the second mask 50 is divided by the insulating base 60 and the left electrode 70 and the right electrode 80 printed on the insulating base. The two are separated by the insulating groove .65. The mask 50 has one Mouth opening 50 and two eye openings 5 3 and 54, and therefore no perforated lines are needed. The electrodes 70 and 80 of the second mask 50 are multi-layered structures. Figure 3A shows only one upper layer of electrode 70. 7 5 and an upper layer 8 5 of the electrode 80. Figure 3B shows the second mask 50 and the upper layers 7 5 and 8 5 are removed, showing the other layers of the electrodes 70 and 80: the lower layers 71 and 81, and disassembled. Intermediate layer, which includes cheeks 7 2 and 8 2 and temple portions 7 3 and 8 3. The characteristics of lower layers 71 and 81 and the temple portions 72, 73, 82, and 8 3 of the intermediate layer are adjusted so that in this layer The resistance measured by two probes with a distance of 1 cm on either one is 100 ohms and 100 ohms. This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm). — — — — — — — — — — — — — Equipment — II order · 1 line (Please read the precautions on the back before filling out this page) 401309 A7 __ B7 V. Description of the invention (11). Upper layer 7 5 And 85 characteristics are adjusted so that the resistance per unit area measured perpendicular to the upper layer 75 or 85 is between 5000 ohm / cm2 and 5000 ohm / cm2. As described above, the vertical and / or horizontal resistance can be adjusted by adjusting the thickness or composition of any of these layers. The above composition can be changed by changing the amount of carbon in the conductive ink. In addition, a combination or permutation of these choices is available. Two layers of conductive patches 74 and 84 are placed on the ends of the solar holes of electrodes 70 and 80. Like the patches 24 and 34, the patches 74 and 84 serve as attachment points for the electric current-supplying wires and hold the position of the packaging material used for the second mask 50. When the second mask 50 is in place, the patches 74 and 84 are close to the user's ears so that the wires can be hung above and behind the user's ears. FIG. 4 is a cross-sectional view of the second mask 50 across BB /. Similar to the insulating base 10, the insulating base 60 is composed of a toilet paper layer 61 and a lacquer layer 62. The upper layers 7 5 and 8 5 completely cover the middle layer portions 7 2, 73, 82 and 83 and the lower layers 71 and 81. In the first mask 1, the electrodes 20 and 30 are printed in several layers to obtain a resistance that varies in level. Similarly, in the second mask 50, the electrodes 70 and 80 are printed in several layers so that their thicknesses are not uniform, so as to obtain a horizontally variable resistance. In another way, changing the conductivity can obtain changing resistance, such as the conductivity of the material and / or the weight percentage of the toner in the conductive ink. Figures 5A and 5B are shown to reduce the size of the subcutaneous cellulitis. The paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 male «) (Please read the precautions on the back before filling this page. ) Outfit! —Order ------- Printed by Shelley Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 401309 A7 ___B7 __ V. Description of Invention (12) (Please read the note on the back before filling this page) Skin patch 1 0 0. Like the first mask i and the second mask 50 ', the patch 100 is composed of an insulating base 1 10 and electrodes 120 and 130 printed on the insulating base. However, in this manner, the electrodes' 120 and 130 have a double-layered structure of uniform thickness. In Figure 5A, only the upper layers 125 and 135 are visible. Like the upper layers 75 and 85 of the mask 50, the upper layers 125 and 135 of the patch 100 are characterized by the resistance per unit area measured perpendicular to any of the layers in the insulation at 500 ohms / cm2 and 5 0 0 0 Ohm / square minute. In Figure 5B, the upper layers 1 2 5 and 1 3 5 are removed. The lower layers 1 2 6 and 1 3 6 are exposed. They are printed in three sections, each of which has a different resistance (at a distance of about 1 Measured between two probes in millimeters). Although the characteristic of the resistance of each segment is between 100 ohms and 1000 ohms, the characteristic resistance of the segment 12 of the layer 12 2 and the segment 13 of the layer 1 36 should be the segment 126 The characteristic resistance of segment 131 of layer 121 and layer 136 is half. In this example, the varying resistances of the electrodes 120 and 130 are obtained by printing the segments 1 2 6 and 1 3 6 with different weight percentages of carbon powder. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. In use, the wires (not shown) are clamped to the electrodes 1 2 0 and 1 30 with the smaller resistance parts 1 23 and 1 33. Alternatively, patches similar to the patches 24 and 34 can be provided on the upper layers 125 and 135. As in the case of the insulating base 10, the insulating base 110 should preferably be composed of a toilet paper layer 111 and a paint layer 112, and the electrodes 120 and 130 should be printed on the paint layer. As in the alternative design in any of the above embodiments, it can be in accordance with the grid shape (this paper size applies the Chinese National Standard (CNS) A4 specification (210 * 297 public love) -15- A7 401309 _; ___B7__ V. Description of the invention (13) There are several holes in it. The lower and small resistance layer is printed on or otherwise provided at the base of the above equipment to reduce the amount of materials used and reduce costs. The grid may be many square, rectangular, honeycomb designs or For other shapes: For cosmetics, nutrition or medicine to be applied to the face, put a suitable agent on the skin surface of the user and use the first mask 1 or the second mask 50 of the present invention to supply current to the agent to drive the agent Enters the skin. Because the physical form of a medicament is usually a lotion, cream or gel, commonly referred to herein as a medicament, but the scope of the invention includes all such blends. A lotion for the face of a makeup user should preferably include vitamin A and / Or vitamin E, bihydroxy acids, pharmaceuticals may include tetracycline, other antibiotics, anti-age scars, or antitoxins. To reduce cellulitis deposition, users may be provided to reduce cellulite Weave deposited lotion and then put the first mask 1 or the second mask 50 or the skin patch 100 of the present invention on the face to drive the agent into the skin. This agent includes caffeine extract, theophylline Extract, ginkgo extract, silicide, magnesium and / or gola. The applicant also anticipates that the shape of the invention may be altered to fit other specific body parts. For example, the invention includes at least one hand or Finger-like electrode for medical treatment of skin lesions of hands, fingers or nails. This electrode also has the characteristics of the electrode described above. Agents provided to the skin to treat such lesions include vitamin A, vitamin E, antimycotics, and skin Wetting agents. Further, the present invention does not include devices or methods for treating lesions in the feet, toes, or toenails. These include, but are not limited to, Hong Kong foot agents, antifungal agents, and skin wetting agents. Such devices may include At least one electrode that is shaped like a human foot or toe. This electrode can have the characteristics described here. The user can apply special — — — — — — — — — — — ^ i — — — — — — — — — — ≪ Please read the precautions on the back before filling out this page) Printed on the paper standard printed by the Industrial and Commercial Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (CNS > A4 size (210 X 297 cm) -16- A7 4v) i309 ____B7_ 5. The medicament of the invention (14) is suitable for treating the lesions of the feet, toes or toenails, and the device is applied to the effective area to drive the medicament into the skin by applying power. The applicant further anticipates that the invention can be applied to scalp lesions such as psoriasis and baldness. Agents used to treat head and scalp lesions include: Changding, anti-dandruff agents, and anti-psoriasis agents. It is also expected that the present invention can be applied to the skin of the penis to treat the symptoms of impotence in men. Agents used to treat impotence include penile stimuli such as prostaglandins. Examples of using the invention to treat a specific lesion do not limit the scope of the invention. It is expected that the present invention may be applied to different parts of the human body to treat various diseases. The g used in the present invention is preferably a direct current during a period of changing polarity. In this way, the current drives some chemicals in one direction during one complete period, and the current drives the lotion in the opposite direction during the next entire period. Chemicals. In addition, changing the polarity of the current prevents unwanted electrolysis in Piyon tissue. Figure 6 shows a preferred current waveform. Note that the current is ramped up (that is, ramped up from zero to a maximum chirp) and ramped down (that is, ramped down from maximum chirp to zero) to prevent radiation caused by the sudden passage of current. A suitable current density is between 50 microamps / cm2 and 500 microamps / cm2 to effectively reduce cellulitis without radiating or burning the skin. A suitable pulse period is between 30 seconds and 120 seconds. In each ramp period, the current increases from zero to full current or decreases from full chirp to zero. Although the invention has been described through a limited number of embodiments, it should be understood that the invention has many variations and other applications. For example, thin, inexpensive materials can be used instead of toilet paper as the substrate, such as cloth or polyethylene sheets. We also expect that at least one of the electrodes with variable resistance can be made of molded elastomer. The electrode can be used in accordance with the Chinese National Standard (CNS) A4 specification (210 X 297 mm) for this paper size (please read the note on the back before filling out this page)> Installation II — Order · — II!! Intellectual Property Bureau of the Ministry of Economic Affairs Printed by Λ 工 consuming cooperatives -17- A7 ._B7 ____ 5. Description of the invention (15) Moulded to the end of the human body, such as fingers, toes, and used on fingers or toes or similar parts to treat skin or nail lesions. In addition, The lower layer can be made of other materials, metal sheets or films. In addition, we expect that lacquers and conductive materials can be provided to the base and used technologies other than screen printing, such as rotary printing, laser printing, mimeographing, lamination, extrusion And the technology known in the prior art. The applicant also anticipates that the above-mentioned preferred embodiment may include a single electrode and another electrode attached to the user's body. For example, we predict that the above mask may include a single electrode while the other electrode is attached and used The user's hand or other part away from the user's face. The applicant's invention is mainly a pair of electrodes used in iontophoresis. However, the applicant believes that the invention includes a complete ion Osmotic equipment. This equipment includes a pair of electrodes as described above and a power source connected to the pair of electrodes. The power source is a battery with sufficient power to provide the current and amperage required to effectively transfer the agent through the skin of the user. II — — — — — — ^ ·! — Ί —11 · I II — I „^ (Please read the“ Notes on the back side before filling out this page ”) The paper size printed by Shelley Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs applies China National Standard (CNS) A4 (210 X 297 mm) -18-