TW201808348A - Method for inhibiting wound bacteria using carbonized fabric characterized in that bacterial growth is inhibited by covering wounds with carbonized fabric comprising a conductive carbon-containing host - Google Patents

Abstract

A method for inhibiting bacteria using a carbonized material comprises: (A) providing a carbonized material, wherein the carbonized material comprises a conductive carbon-containing host, and the carbon-containing host is at least one selected from a group consisting of carbon fiber cloth, graphene, and graphene oxide; (B) contacting the carbonized material with a liquid environment; and (C) providing a direct current to the carbon-containing host. In this way, oxygen in the liquid environment is synthesized into hydrogen peroxide after the carbon-containing body is electrically energized, thereby inhibiting bacterial growth.

Description

Method for inhibiting bacteria by using carbonized material

The invention relates to a method for inhibiting bacteria by using the carbonized material; in particular, it relates to a method for inhibiting the growth of wound bacteria by combining a conductive carbon-containing body.

In daily life, wounds such as cuts, abrasions, and burns are often caused by carelessness. If the wounds are not properly handled or taken care of, they will not only affect the recovery of the wounds, but may also be affected by pathogens. Among them, the care and management of large-scale burns are not only the most difficult to control, but also because the skin is the first line of defense for the human body. Once a large area of burns occurs, the front-line mechanism of the human body will collapse, followed by difficult problems such as dehydration and temperature loss. Later, if poor care is taken, large-scale infections, respiratory failure, or multiple organ failures caused by a few days after injury will easily lead to injury and death. Therefore, in the course of treatment, in addition to trying to maintain the patient's life, the human body's protective cover must be reconstructed, which is undoubtedly a major challenge for the medical care unit.

As for patients with burns, especially in the case of the depth of the burns and the reticular layer of the dermis, autografts need to be performed during the wound repair process to avoid the rejection of other people's skin. However, the most commonly encountered medical problem is that the patient's healthy skin is not enough, and the amount is not enough to repair the affected area, or the wound just after skin grafting needs an extra layer of protection. At this time, artificial skin or a wound dressing is required as a skin substitute. Thing. Alginate artificial skins that maintain wound humidity, or non-stick silicone gauze and other protective materials are currently known, which have the advantages of protection, easy replacement, and maintaining a suitable wound healing environment.

However, no matter what kind of conventional artificial skin or wound dressing can not effectively inhibit the growth of bacteria, it needs to be replaced after a period of time. As a result, the consumption of medical materials is very large; and for patients, Frequent dressing changes also cause great physical and mental pain. Therefore, for patients with burns, how to achieve better healing results in a less painful manner is an urgent problem to be solved.

In view of this, an object of the present invention is to provide a method for inhibiting bacteria using a carbonized material covering a wound, which can have a continuous and effective antibacterial effect.

In order to achieve the above object, the present invention provides a method for suppressing bacteria by using a carbonized material, including the following steps: A. Providing a carbonized material, wherein the carbonized material includes a conductive carbon-containing body; the carbon-containing main system is selected from At least one of a group consisting of carbon fiber cloth, graphene, and graphene oxide; B, contacting the carbonized material with a liquid environment; and C, providing direct current to the carbon-containing body. Therefore, after the oxygen in the liquid environment is energized to the carbon-containing body, hydrogen peroxide can be synthesized to inhibit the growth of bacteria.

The effect of the present invention is that bacterial growth can be effectively inhibited by the trace amount of hydrogen peroxide generated after the carbon-containing body is energized.

In order to explain the present invention more clearly, a preferred embodiment is described in detail below with reference to the drawings. Please refer to FIG. 1, a wound carbonized material 100 according to a preferred embodiment of the present invention includes a carbon-containing body 10 and a plurality of silver particles 20 attached to the carbon-containing body 10. The carbon-containing body 10 has electrical conductivity and is selected from at least one of carbon fiber cloths (CF), graphene, and graphene oxide (GO). The carbon fiber cloth has excellent properties. Adsorption characteristics and moisture retention, and as shown in FIG. 2, the carbon fiber cloth includes a plurality of carbon fibers 12, wherein a distance D between each of the carbon fibers 12 and another adjacent carbon fiber 12 is 0.2 nm to 0.25 nm. Example is 0.23 nm. In addition, in practice, the carbon-containing body 10 may also be a porous fiber cloth (activated carbon fiber cloth) disclosed by the applicant of the present application in the Republic of China Patent Publication No. I334891. In addition, in this embodiment, the graphene and graphene oxide of the carbon-containing body 10 are stacked into a multilayer structure of two or more layers.

The weight ratio of the silver particles 20 to the carbon-containing body 10 is 0.5 to 5. In the carbonized material 100 produced by mixing in this ratio range, the (111) crystal plane distance of the silver particles is 0.23 nm. Therefore, the carbon-containing body 10 can be easily attached. In addition, the ratio of the weight of the silver particles 20 to the carbon-containing body 10 is preferably 5, preferably 1, and 0.5; wherein the silver particles 20 and the carbon-containing body 10 are mixed in a liquid. . In this embodiment, the ratio of the silver particles 20 to the carbon-containing body 10 is 5, and when the carbonized material 100 covers the wound, it can effectively absorb blood-water exudate and bacteria, and also provide a moist environment for the wound.

FIG. 3 and FIG. 4 disclose a method of using the carbonized material 100 to suppress bacteria. First, the carbonized material 100 is brought into contact with a liquid environment 1, wherein the liquid environment 1 contains oxygen. In fact, the liquid environment 1 can be a wound of a living body, that is, the carbonized material 100 directly covers the wound of a living body. . Next, a direct current is provided to the carbonaceous body 10, wherein the direct current is output by a power source 30, and the power source 30 provides a voltage of 1.75N (a multiple of 1.75) volts, and N is a positive integer and meets the following conditions: 1 ≦ N ≦ 8; In this embodiment, N = 2, that is, the power source 30 is a battery capable of providing a voltage of 3.5 volts.

After the conductive carbonaceous body 10 is energized, it can transform the oxygen in the liquid environment 1 into hydrogen peroxide 2 with a low concentration through the electrochemical reaction, and release it to the wound surface to inhibit the growth of bacteria at the wound site. If the voltage provided by the power source 30 is too large, the concentration of hydrogen peroxide 2 will be too high and the normal tissues of the living body will be damaged; otherwise, when the voltage provided by the power source 30 is too small, the concentration of hydrogen peroxide 2 will be too low. The effect of inhibiting the growth of bacteria cannot be achieved.

The effect of the above application method for the carbonized material 100 is that after the carbonaceous body 10 is powered on, the release of low-concentration hydrogen peroxide 2 can inhibit the proliferation of bacteria on the surface of the wound, and achieve a preliminary bacteriostatic effect. A few bacteria that proliferate in the presence of hydrogen peroxide 2 will be attracted by the carbonized material 100, and then be punctured by the silver particles 20 therein to die. Therefore, in the end, the carbonized material 100 can reduce the number of bacteria in the wound to the lowest through the multiple bacteriostatic effects, and achieve the purpose of effectively reducing wound infection. In addition, in the carbon-containing body 10, a multilayer structure composed of graphene or graphene oxide can be used to block bacteria layer by layer, avoid the proliferation of bacteria at the wound and form clusters of colonies, and further inhibit the proliferation of bacteria in large wounds.

In addition, the degree of wound moisturization is also a key factor in the process of wound repair. If the humidity is insufficient, the state of cell repair and re-growth is not ideal. As described above, in the preferred embodiment, the carbonaceous body 10 in the carbonized material 100 is a carbon fiber cloth having excellent moisture retention, so it can effectively maintain the humidity of the wound.

Since the carbonized material 100 has the above-mentioned characteristics, it is very suitable for the care management of a large area wound, such as a large burn. In addition, the power source 30 can continuously supply power to the carbon-containing body 10, so that the carbonized material 100 continuously releases hydrogen peroxide 2 to the covered large wound surface, so as to enhance the bacteriostatic effect and accelerate the time for wound healing. For patients with burns and burns, the carbonized material 100 of the present invention is indeed a boon.

The above descriptions are only the preferred and feasible embodiments of the present invention, and any equivalent changes made by applying the description of the present invention and the scope of patent application should be included in the patent scope of the present invention.

[this invention]
1‧‧‧ liquid environment
2‧‧‧ hydrogen peroxide
100‧‧‧Carbonized material covering the wound
10‧‧‧ Carbon-containing body
12‧‧‧ carbon fiber
14‧‧‧ Hole
D‧‧‧Pitch
20‧‧‧ silver particles
30‧‧‧ Power

FIG. 1 is a schematic diagram of a carbonized material according to a preferred embodiment of the present invention. FIG. 2 is a partial schematic view of a carbonized material according to the above-mentioned preferred embodiment of the present invention, revealing that the carbon fiber cloth includes a plurality of carbon fibers that are crisscrossed. FIG. 3 is a flowchart of a method of using the carbonized material of FIG. 1. FIG. 4 is a schematic view of the carbonized material of FIG. 1 in use.

100‧‧‧Carbonized material covering the wound

10‧‧‧ Carbon-containing body

14‧‧‧ Hole

20‧‧‧ silver particles

Claims (7)

A method for inhibiting bacteria using a carbonized material includes the following steps: A. Providing a carbonized material, wherein the carbonized material includes a conductive carbon-containing body; the carbon-containing main system is selected from the group consisting of carbon fiber cloth, graphene, and graphene At least one of the group consisting of oxides; B. contacting the carbonized material with a liquid environment; C. providing direct current to the carbon-containing body; thereby, after the oxygen in the liquid environment is energized by the carbon-containing body, It can synthesize hydrogen peroxide to inhibit bacterial growth. The method for suppressing bacteria using a carbonized material as described in claim 1, wherein the carbon-containing body comprises a multilayer structure, wherein each layer is selected from graphene or graphene oxide. The method for suppressing bacteria by using a carbonized material according to claim 1, wherein the carbon fiber cloth includes a plurality of carbon fibers, and a distance between each of the carbon fibers and another adjacent carbon fiber is between 0.2 nm and 0.25 nm . The method for suppressing bacteria by using a carbonized material as described in claim 1, wherein the carbonized material further comprises a plurality of silver particles, and the silver particles are attached to the carbon-containing body; The ratio by weight is 0.5 to 5. The method for suppressing bacteria using a carbonized material as described in claim 1, wherein the direct current in step C is output by a power source, and the power source provides a voltage of 1.75N volts. The method for suppressing bacteria using a carbonized material as described in claim 5, wherein N is a positive integer and meets the following conditions: 1 ≦ N ≦ 8. The method for suppressing bacteria by using a carbonized material as described in claim 1, wherein the liquid environment of step B includes a wound of an organism; thereby, the carbonized material synthesizes a small amount of hydrogen peroxide to suppress the organism through electrochemical action. Bacterial growth in body wounds.