SG11201908066XA - Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same - Google Patents

Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same

Info

Publication number
SG11201908066XA
SG11201908066XA SG11201908066XA SG11201908066XA SG11201908066XA SG 11201908066X A SG11201908066X A SG 11201908066XA SG 11201908066X A SG11201908066X A SG 11201908066XA SG 11201908066X A SG11201908066X A SG 11201908066XA SG 11201908066X A SG11201908066X A SG 11201908066XA
Authority
SG
Singapore
Prior art keywords
labeled
radioactive fluorine
compound
carbon atoms
same
Prior art date
Application number
SG11201908066XA
Inventor
Masato KIRIU
Hiroaki Ichikawa
Yuki Okumura
Hiroshi Tanaka
Original Assignee
Nihon Mediphysics Co Ltd
Tokyo Inst Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd, Tokyo Inst Tech filed Critical Nihon Mediphysics Co Ltd
Publication of SG11201908066XA publication Critical patent/SG11201908066XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/76—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/77—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

There is provided a labeling precursor compound represented by the general formula (2): wherein S represents a substrate, L represents a straight 5 alkyl group having 1 to 6 carbon atoms which may contain an ether group, R1 and R2 each independently represent a straight or branched alkyl group having 1 to 30 carbon atoms, or a substituted or unsubstituted monocyclic or condensed polycyclic aryl group, R3 each independently 10 represent an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, and p represents an integer of 0 to 4.
SG11201908066XA 2017-03-07 2018-03-05 Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same SG11201908066XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017042783 2017-03-07
PCT/JP2018/008287 WO2018164043A1 (en) 2017-03-07 2018-03-05 Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same

Publications (1)

Publication Number Publication Date
SG11201908066XA true SG11201908066XA (en) 2019-09-27

Family

ID=63448846

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908066XA SG11201908066XA (en) 2017-03-07 2018-03-05 Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same

Country Status (10)

Country Link
US (1) US20200009273A1 (en)
EP (1) EP3594200B1 (en)
JP (1) JP7165853B2 (en)
KR (1) KR20190126357A (en)
CN (1) CN110312704A (en)
AU (1) AU2018232211A1 (en)
CA (1) CA3055417A1 (en)
ES (1) ES2909126T3 (en)
SG (1) SG11201908066XA (en)
WO (1) WO2018164043A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022110777A (en) 2021-01-19 2022-07-29 国立大学法人東京工業大学 Radioactive halogen-labeled precursor compound

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19727812A1 (en) 1997-06-30 1999-01-07 Technoworld Gmbh Training device
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
ES2663496T3 (en) * 2005-11-29 2018-04-13 Nihon Medi-Physics Co., Ltd. Precursor compound of radioactive halogen-labeled organic compound
CN101466711A (en) * 2006-05-19 2009-06-24 日本医事物理股份有限公司 Novel compound having affinity for amyloid
ATE535527T1 (en) 2006-05-19 2011-12-15 Nihon Mediphysics Co Ltd CONNECTION WITH AFFINITY TO AMYLOID
AU2007337481B2 (en) * 2006-12-27 2012-02-09 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
EP2110367A1 (en) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures
GB0821432D0 (en) * 2008-11-24 2008-12-31 Gen Electric Imaging ligands
CA2767470A1 (en) 2009-07-11 2011-01-20 Bayer Pharma Aktiengesellschaft Non-polar and polar leaving groups
EP3162802B1 (en) 2014-06-26 2020-08-19 Nihon Medi-Physics Co., Ltd. 2-(3-pyridinyl)-1h-benzimidazole derivative compound and medicine containing same
JP2017042783A (en) 2015-08-26 2017-03-02 昭和電工株式会社 Method for manufacturing heat radiation substrate
JP6523107B2 (en) 2015-09-08 2019-05-29 日本メジフィジックス株式会社 Radioactive fluorine labeled precursor compound and method for producing radioactive fluorine labeled compound using the same

Also Published As

Publication number Publication date
AU2018232211A1 (en) 2019-09-26
US20200009273A1 (en) 2020-01-09
EP3594200A1 (en) 2020-01-15
JP7165853B2 (en) 2022-11-07
JPWO2018164043A1 (en) 2020-01-09
ES2909126T3 (en) 2022-05-05
EP3594200A4 (en) 2020-03-11
CN110312704A (en) 2019-10-08
EP3594200B1 (en) 2022-03-02
KR20190126357A (en) 2019-11-11
CA3055417A1 (en) 2018-09-13
WO2018164043A1 (en) 2018-09-13

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