RU2571062C1 - Method for combined surgical application of fly larvae - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: fly larvae are grown in the sterile environment and placed onto a wound surface in a pyoinflammatory disease of any aetiology. That is combined with exposing the wound surface to low-energy laser light at a wave length of 0.9 mcm, a laser pulse average power of not less than 4 W, a laser frequency of 80 Hz, and an exposure length of 5 minutes. Besides, vitamins B6 in a dose of 100 mg a day and B12 in a dose of 300 mcg every second day are administered intramuscularly for 2 weeks.

EFFECT: effective management of the wound process in individuals with the depressed immune system function and disturbed trophism and innervation in the involved organ.

Description

FIELD OF THE INVENTION

The invention relates to medicine and can be used in surgery for the treatment of purulent wounds of any etiology, pressure sores, trophic ulcers and diabetic foot syndrome.

State of the art

Numerous publications of recent years, clinical practice data indicate that surgical infection remains one of the most important and pressing problems of surgery. Patients with purulent-inflammatory diseases make up more than a third of patients with a surgical profile. Over the years, the number of patients with purulent-inflammatory diseases of the soft tissues and their mortality do not decrease.

At the present stage of the development of surgery, the treatment and prevention of purulent-inflammatory complications remains one of the most important and intractable problems. This is due not only to the widespread spread of purulent infection, but, often, also to the severity of its diagnosis, the features of the clinical course, the complexity of treatment and the unpredictability of the outcome.

Acute purulent-inflammatory diseases account for up to 40% of the total number of surgical diseases for which inpatient and outpatient care is provided [Purulent surgery: Atlas / S.V. Goryunov, D.V. Romashov, I.A. Butivshchenko; Ed. Ph.D. I.S. Abramova. - M .: BINOM. Laboratory of Knowledge, 2004, pp. 9-30].

The well-known "Method of obtaining funds from larvae of flies for the treatment of wounds and the means obtained by this method" [Fleischmann Wilhelm, RF Patent for invention No. 2351347].

The essence of the method of obtaining funds from larvae of flies for the treatment of wounds and the means obtained by this method is that larvae are grown from eggs of flies, contaminated with bacteriophages and introduced into the wound being treated.

The disadvantage of this method is that:

- Patients see larvae, and this can cause a negative attitude to treatment.

- Due to the activity of the larvae, it is difficult to place and hold them in the wound.

- There are difficulties in removing all the larvae from the wound in the presence of streaks in it.

- The method cannot be used when communicating wounds with the joint cavity, abdominal and chest cavities.

- When using a tampon with the secret of larvae, it has significantly lower biological activity compared to larvae.

As a prototype, US 6359189 B1 is selected. The essence of the method is to place the larvae of flies in bags consisting of various materials, before applying them to the wound surface.

The disadvantage of this method is that:

- The substances secreted by the larvae act only locally on the area of the purulent process, without affecting the main links of pathogenesis.

- The effect of action stops immediately after or in a very short time after the end of treatment.

- The substances secreted by the larvae do not act on all microorganisms, for example, Proteus.

- A preventive effect is not created to prevent relapse of the disease.

- When using larvae, many patients experience pain.

Disclosure of invention

The objective of the invention is to increase the efficiency and expand the ability to use larvae of flies in surgery.

The invention as a technical solution is expressed:

- Breeding of larvae from eggs.

- Intramuscular administration of Vitamin B6 (Pyridoxine).

- Intramuscular administration of Vitamin B12 (Cobalamin).

- Irradiation with a low-energy therapeutic laser.

The technical result of the method is the application to the purulent surface of larvae of flies with the simultaneous use of a low-energy therapeutic laser and Vitamins B6 and B12 during treatment, which can be used in the treatment of purulent wounds of any etiology, pressure sores, trophic ulcers and diabetic foot syndrome, and this can be used to treat purulently -inflammatory processes in people with reduced immunity, with impaired trophism and innervation in the affected organ.

The implementation of the invention

The task and its result are achieved by the fact that in the method of the complex use of larvae of flies in surgery, flies are grown in sterile conditions, after which they are placed on the wound surface with a purulent-inflammatory disease of any etiology, while immunocorrective, anti-inflammatory, decongestant, angioproliferative therapy and improved innervation with Vitamins B6 and B12 at therapeutic doses and a low-energy therapeutic laser.

Despite the fact that low-energy laser radiation has certain specific properties, it is primarily an external physical factor familiar to the human body, in particular electromagnetic radiation of the optical spectrum, under the influence of which all living organisms on Earth appeared and evolved. The functioning of a biological object or organ during low-energy laser exposure does not fundamentally change; this effect does not introduce new photochemical reactions into the body that would not have been initially incorporated there. In laser therapy, only a corresponding intensification of metabolic processes is observed, their speed changes (V.M. Chudnovsky et al., 2002).

The final result of exposure to low-energy laser radiation is manifested by the integral response of the body. This is reflected in the clinical effects of laser therapy. As a result of lowering receptor sensitivity, reducing or eliminating interstitial edema and tissue tension, an analgesic effect is manifested. With a decrease in the duration of the phases of inflammation and swelling of the tissues, we get anti-inflammatory and decongestant effects. An increase in blood flow velocity, an increase in the number of functioning capillaries and the emergence of new vascular collaterals improves regional blood circulation. The combination of these manifestations together with the acceleration of metabolic reactions and an increase in cell proliferation contribute to the process of physiological and reparative regeneration. With laser therapy, many authors noted desensitizing, hypocholesterolemic effects, increased activity of local and general factors of immune defense. Bacteriostatic and bactericidal effects are manifested depending on the wavelength of low-energy laser irradiation (I.M.Baibekov et al., 1991; V.E. Illarionov, 1992; V.I. Kozlov et al., 1993; V.N. Koshelev, 1980; A.S. Kryuk et al., 1986; V.A. Mostovnikov et al., 1989, 1990; A.K. Polonsky, 1984; A.A. Prokhonchukov, N.A. Zhizhina, 1986; V. V. Skupchenko, E.S. Milyudin, 1994; P.I. Tolstoy et al., 1994).

One of the typical representatives of low-energy lasers is the ALT UZOR A 2K laser therapy apparatus, and the optimal operating mode for our goal is as follows: a radiation wavelength of 0.9 μm, an average radiation pulse power of at least 4 W, a radiation frequency of 80 Hz, an exposure time of 5 min .

B vitamins are traditionally used to treat various neurological diseases. Clinicians know that a deficiency of vitamins B6 (pyridoxine) and B12 (cobalamin) leads to the development of peripheral nerve damage, so the use of neurotropic vitamins in diseases of the peripheral nervous system is physiologically justified.

The ability of B vitamins to reduce pain until recently has been called into question, since their mechanisms of action were not known for various pain syndromes, but after a detailed study of the subtle mechanisms of action, opinions have radically changed. However, the antinociceptive effect of pyridoxine and cobalamin is well known to clinicians, as vitamin B12 has been used in various countries to treat pain since 1950 [Danilov AB Group B vitamins in the treatment of acute back pain: myth or reality? // The attending physician - 2007. - No. 4. - S. 1-8; Danilov A.B., Davydov O.S. Neuropathic pain - “Borges”. - 2007. - S. 191].

In combination, Vitamins B6 and B12 not only have a persistent angioproliferative effect, but also improve the innervation of the damaged organ, which is necessary for the treatment of purulent-inflammatory process, especially in the treatment of trophically caused processes, as well as diabetic foot syndrome, which make up 50% of all purulent -inflammatory processes in a surgical hospital, it should be noted that the effect appears after the first course and is long, up to the possibility of only one course. The optimal therapeutic effect is created by intramuscular injection of Vitamin B6 at a dosage of 100 mg per day and B12 at a dosage of 300 μg per day every other day for 2 weeks.

Vitamins B6 and B12 have a synergistic effect with a low-energy therapeutic laser, which adds anti-inflammatory and anti-edematous effects that reduce tissue stress and accelerate repair processes, in addition, the bacteriostatic and bactericidal effect of the laser enhances the effect of the substances secreted by the larvae, which contributes to the fastest resolution of the infection site . It is important that this treatment also has an analgesic effect, as a result of which the pain syndrome manifested in many patients as a result of treatment with larvae becomes less pronounced or does not appear at all.

Claims (1)

 A method for the complex use of fly larvae in surgery, in which larvae are grown from flies' eggs that are introduced onto the wound surface, characterized in that the wound surface is irradiated with a low-energy therapeutic laser with a radiation wavelength of 0.9 μm, an average radiation pulse power of at least 4 W, with a radiation frequency of 80 Hz, an exposure of 5 minutes, and intramuscular injections of Vitamin B6 at a dosage of 100 mg per day and B12 at a dosage of 300 μg per day every other day for 2 weeks are performed.