KR100673813B1 - Gel composition for tooth whitening - Google Patents

Abstract

The present invention relates to an oral gel formulation composition having an excellent effect on tooth whitening, and more particularly, ethyl cellulose, ethylene / acrylic acid copolymer, ethylene / acrylic acid / vinylacetate copolymer and ethylene as a film forming agent together with the tooth whitening component. It is characterized by containing at least one water-insoluble polymer selected from the group consisting of / propylene copolymer.

The gel for teeth whitening of the present invention forms a water-insoluble film immediately upon application to teeth to increase resistance to saliva in the oral cavity and adhesion to the tooth surface, and to increase the contact time with the whitening component, thereby providing an excellent tooth whitening effect. have.

Teeth, whitening, gels, water-insoluble membranes

Description

Gel composition for tooth whitening {Gel composition for tooth whitening}

The present invention relates to a whitening gel having excellent whitening effect and ease of use. More specifically, the present invention forms a thin non-aqueous film on the surface immediately after applying to the teeth and is strongly adhered to protect the whitening component from saliva in the oral cavity and effectively deliver and penetrate the whitening component deep into the corner of the tooth. It relates to a whitening gel.

Recently, as interest in teeth whitening has increased, various types of self-whitening agents, such as a mouse tray, a strip, a nail polish, and a lip gloss, have been developed. Among them, a patch formulation using a thin strip and a gel formulation product without a mouse tray are convenient for use and have a relatively high concentration of whitening components compared to general whitening toothpastes, so they have been excellently studied in terms of whitening effects.

U.S. Patent Nos. 5,879,691, 5,894,017, and 5,891,453 disclose delivery systems for applying professional whitening products to teeth by applying thin, flexible polyethylene strips. The simplicity of use is improved by not using the mouse tray, but it is difficult to selectively whiten the desired teeth by designing the shape of the strip to the general tooth shape standard, and it is difficult to completely adhere to the teeth and irregular teeth due to the patch property. There is this. There is also a risk of swallowing the strip during use.

In Korean Patent Nos. 2001-10022, 2002-45224, 2002-97297, 2003-528, 2003-528, tooth enamel in wet oral cavity by using a hydrophobic glass polymer as a peroxide and a base as a whitening agent in a matrix type adhesion layer. A new dry type patch that produces strong adhesion when hydrated to layers and releases whitening ingredients has been minimized, which minimizes the disadvantages of increased adhesion and peroxide on the back of hands when used, but remains strong when desorbed after use. There is a disadvantage in that the tooth remains a lot to be removed by brushing teeth, and also the problems of the patch formulation itself described above was not improved.

US Pat. Nos. 6,770,266 and 6,669,630 describe flowable gels containing peroxides in combinations of polyethylene oxide and carbomer as film formers. This overcomes the disadvantages of existing patch-type whitening agents as a whitening agent in gel formulations, but has a disadvantage in that the gel is easily washed off by saliva and the contact time between the whitening component and the tooth surface is short.

       In order to enhance the whitening effect of the gel formulation whitening agent, the gel should be attached and maintained on the teeth for a sufficient time for the whitening component to penetrate the tooth surface.

 Existing gel formulation whitening agents have a relatively low whitening effect due to the low adhesion and the water soluble film to be easily washed away by saliva in the oral cavity.

Therefore, the present inventors have studied to improve the whitening effect of the existing gel formulation whitening agent, by using a water-insoluble polymer as a film forming agent with a whitening component, to form a water-insoluble membrane immediately upon application of the gel to the teeth for saliva in the oral cavity It has been found that an excellent tooth whitening effect can be obtained by increasing the resistance and adhesion to the tooth surface and increasing the contact time with the whitening component. Accordingly, it is an object of the present invention to provide a gel for teeth whitening excellent in the feeling of use and the whitening effect of forming a water-insoluble film for continuously releasing the whitening component on the tooth surface.

In order to achieve the above object, the present invention is 5 to 50 to the total weight of the gel to form a non-aqueous film immediately to apply the gel to the teeth to prevent the loss of whitening components by saliva to protect the whitening components It provides a gel for teeth whitening, characterized in that it contains a water-insoluble film-forming agent in weight%.

Hereinafter, the present invention will be described in more detail.

Gel for whitening teeth according to the present invention comprises a water-insoluble film forming agent, a whitening component, a pressure-sensitive adhesive, a neutralizing agent, an emulsifier, a stabilizer, a solvent to safely and effectively deliver the whitening component applied to the teeth.

Hereinafter, the components constituting the gel for teeth whitening according to the present invention will be described in detail.

The water-insoluble film forming agent as a component of the gel for tooth whitening according to the present invention is to form a water-insoluble film immediately when the gel is applied to the teeth to prevent the loss of the whitening component by saliva to enhance the whitening effect. Such water-insoluble film forming agents include ethyl cellulose (ethylcellulose), ethylene / acrylic acid copolymer, ethylene / acrylic acid / vinylacetate copolymer (ethylene / acrylic acid / VA copolymer), ethylene / propylene copolymer ( One or more selected from ethylene / propylene copolymer) group may be used, but is not limited thereto. Such a water-insoluble film former is preferably used in an amount of 5 to 50% by weight based on the total weight of the gel.

As a constituent of the gel for tooth whitening according to the present invention, the whitening component may be one or more selected from the group consisting of peroxide, metal chlorite, percarbonate, peroxide and mixtures thereof, but is not limited thereto. The whitening component is preferably used in an amount of 0.5 to 20% by weight based on the total weight.

The tackifier as a component of the tooth whitening gel according to the present invention is for enhancing the adhesion of the applied gel to the tooth enamel. The pressure-sensitive adhesive may be at least one selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, galang gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethylcellulose and carboxypolymethylene. Can be used, but is not limited thereto. Such a pressure-sensitive adhesive is preferably used in an amount of 10 to 40% by weight based on the total weight.

The neutralizing agent as a constituent of the gel for tooth whitening according to the present invention is to neutralize the film-forming agent and the pressure-sensitive adhesive to obtain an appropriate viscosity and to improve the safety of the teeth and oral mucosa. Such neutralizing agents are selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium monophosphate, disodium phosphate, sodium triphosphate, sodium pyrophosphate, sodium metaphosphate, and the like. One or more may be used, but is not limited thereto. Such neutralizing agent is preferably used in an amount of 0.1 to 5% by weight based on the total weight of the gel.

Emulsifier as a component of the gel for tooth whitening according to the present invention is for uniformly emulsifying the components of the gel. Such emulsifiers may be, but are not limited to, one or more selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglyceryl fatty acids, and fatty acid sugar esters. Such emulsifier is preferably used in an amount of 0.01 to 3% by weight based on the total weight of the gel.

Stabilizers as constituents of the gel for tooth whitening according to the present invention are for stabilizing effective whitening components. The stabilizer may be one or more selected from the group consisting of sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride, and laponite, but is not limited thereto. Such stabilizers are preferably used in amounts of 0.01 to 3% by weight relative to the total weight of the gel.

Solvent as a component of the gel for tooth whitening according to the present invention is a mixture of one or more selected from the group consisting of ethyl alcohol, benzyl alcohol, isopropyl acetate or water which is nontoxic to the human body and can dissolve non-aqueous polymers. May be used, but is not limited thereto.

Gel for whitening teeth according to the present invention may further contain a fragrance in an amount of 0.001 to 1% by weight in addition to the essential ingredients as described above.

In addition to the above components, the gel for teeth whitening according to the present invention may optionally contain active ingredients effective for oral diseases. These ingredients include gum disease prevention components such as sodium chloride, tocopherol acetate, pyridoxine hydrochloride, allantoin, allantoin chlorohydroxyaluminum, tranexamic acid and aminocaproic acid, and prevention of tartar deposition such as sodium pyrophosphate, triclosan and cetylpyridinium chloride. Antibacterial ingredients such as chlorhexidine gluconate may be used, but are not limited thereto.

Gel for whitening teeth according to the invention is characterized in that it is used directly applied to the tooth surface using a tool selected from a brush, a cotton swab or a lip gloss tip.

First, the whitening gel according to the present invention has a resistance to saliva by forming a water-insoluble film immediately upon application to a tooth, and the second gel is strongly adhered to the tooth surface so that the whitening component can be continuously released, and the third fluid gel Since it is a formulation, it is possible to selectively whiten only the desired tooth and deliver the whitening component to the depth between the interdental regardless of the tooth structure. Fourth, unlike conventional patching agents, it does not use a protective film, so there is little foreign matter and there is no risk of swallowing the patching film during use.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the scope of the present invention is not limited thereto, and modifications commonly known in the art may be performed, and such modifications are also included in the scope of the present invention.

EXAMPLES AND COMPARATIVE EXAMPLE Preparation of Tooth Whitening Gel Solution

Each gel solution having a composition of Table 1 was prepared.

[Examples 1-3]

A tooth whitening gel solution was prepared according to the following procedure. Solutane monooleate, tetrasodium pyrophosphate, sodium stearate, and hydrogen peroxide (35%) were dissolved in a mixture of ethyl alcohol and ion water, and ethyl cellulose and polyvinyl pyrrolidone were added and stirred for 20 minutes. Perfume was added and vacuum degassed for 10 minutes.

Comparative Example 1

After dissolving sorbitan monooleate, tetrasodium pyrophosphate and sodium stearate in deionized water, polyvinyl alcohol was added to the mixture and stirred for 20 minutes while maintaining at 60 to 70 ° C. After cooling the mixture to room temperature, hydrogen peroxide (35%) and polyvinylpyrrolidone were added and restirred for 10 minutes. Perfume was added and vacuum degassed for 10 minutes.

TABLE 1

[Test Example 1] Measurement of resistance to artificial saliva of the present invention whitening gel (In Vitro)

The gels of Examples 1 to 3 and Comparative Example 1 were uniformly applied to the hydroxyapatite disc (HAP disc) and then completely dried. The HAP disc was immersed in artificial saliva for 30 minutes, then removed and completely dried. HAP disc weight before and after immersion was measured to determine the residual ratio of the applied gel. The results are shown in Table 2.

TABLE 2

As can be seen from the table, the gels of Examples 1 to 3 of the present invention were relatively excellent in water resistance compared to Comparative Example 1.

[Test Example 2] Measurement of the whitening effect on the teeth of the gel for teeth whitening of the present invention (In Vivo)

In order to measure the tooth whitening effect of the gel for teeth whitening of the present invention, 60 healthy male and female experimenters were selected as samples and tested.

The original tooth chromaticity of the subject was measured using SHADEEYE-EX (SHOFU Co.LTD., Japan). Place the SHADEEYE-EX tip 2 mm above the maxillary left central incisal buccal cervical region and at a right angle to the tooth surface in the middle of the mesial so that light does not leak to the outside, and the baseline (primary reference value) data is measured and collected. The gels of Examples 1 to 3 and Comparative Example 1 were applied twice a day to the upper and lower mandibular buccal areas, and then rinsed with water after 30 minutes. During the test, he was allowed to eat food according to his or her usual diet, but coffee, cola, and tobacco were prohibited before the color measurement on the day of chromaticity measurement. Chromaticity was measured (secondary measurement) after 14 days of gel use.

The results are shown in Table 3 and Table 4, respectively.

Table 3 Measurement results of tooth chromaticity change after 2 weeks

[Table 4] Result of tooth whitening effect measurement after 2 weeks

From the above results, it can be seen that the gel for teeth whitening of the present invention is excellent in the whitening effect. In particular, the gel of Example 3 had the best whitening effect.

As described above, the gel for teeth whitening according to the present invention uses a water-insoluble polymer as a film-forming agent together with a whitening component, thereby forming a water-insoluble film immediately upon application of the gel to the teeth, thereby resisting saliva and adhesion to the tooth surface. It is a very useful invention that provides an excellent tooth whitening effect by increasing the contact time with the whitening component.

Claims (11)

In the whitening agent of the gel formulation used for teeth whitening, The gel is a water-insoluble film forming agent, ethyl cellulose (ethylcellulose), ethylene / acrylic acid copolymer (ethylene / acrylic acid copolymer), ethylene / acrylic acid / vinyl acetate copolymer (ethylene / acrylic acid / VA copolymer) and ethylene / propylene air A fluid gel for teeth whitening, characterized in that it contains at least one selected from the group consisting of ethylene / propylene copolymers, a whitening component and a stabilizer. The method of claim 1, 5 to 50% by weight of the water-insoluble film forming agent, 0.5 to 20% by weight of the whitening component, 10 to 40% by weight of the adhesive, 0.1 to 5% by weight of the neutralizer, 0.01 to 3% by weight of the emulsifier, 0.01 to 3% by weight of the stabilizer and the rest A fluid gel for teeth whitening, characterized by containing a solvent. The method of claim 2, The whitening component is a fluid gel for teeth whitening, characterized in that at least one selected from the group consisting of peroxide, metal chlorite, percarbonate, peroxide and mixtures thereof. The method of claim 2, The pressure-sensitive adhesive is selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol (PVA), xanthan gum, gellan gum, sodium alginate, polyvinylpyrrolidone (PVP), polyvinylformamide, carboxymethylcellulose and carboxypolymethylene Flowable gel for teeth whitening, characterized in that at least one. The method of claim 2, The neutralizing agent is selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium monophosphate, disodium phosphate, sodium triphosphate, sodium pyrophosphate and sodium metaphosphate Flowable gel for teeth whitening, characterized in that more than one species. The method of claim 2, The emulsifying agent is a fluid gel for teeth whitening, characterized in that at least one selected from the group consisting of polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyglyceryl fatty acid and fatty acid sugar ester. The method of claim 2, The stabilizing agent is a fluid gel for teeth whitening, characterized in that at least one selected from the group consisting of sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite. The method of claim 2, The solvent is a fluid gel for teeth whitening, characterized in that the mixture of water or one or more selected from the group consisting of ethyl alcohol, benzyl alcohol and isopropyl acetate capable of dissolving the water-insoluble polymer. The method according to claim 1 or 2, The gel may include sodium chloride, tocopherol acetate, pyridoxine hydrochloride, allantoin, allantoin chlorohydroxyaluminum, tranexamic acid or aminocapronic acid as gum components; Sodium pyrophosphate as a tartar prevention component; And triclosan, cetylpyridinium chloride or chlorhexidine gluconate as an antimicrobial component. The fluid gel for teeth whitening further comprising at least one component selected from the group consisting of: delete delete