JPH1017445A - Composition for oral cavity and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity, holding shapability similar to that of conventional highly viscous toothpaste when put on a toothbrush, while having favorable meltability and dispersibility when put into the oral cavity once and a toothbrushing begins. SOLUTION: This composition for oral cavity contains 5-60wt.% of a polishing agent and a binder composed of xanthan gum and a polyacrylic acid salt in the weight ratio of (2:1) to (1:10) and has a dispersibility index derived from its texture record curve at 25 deg.C.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for oral cavity which is excellent in dispersibility in the mouth and has an improved ease of being placed on a brush (brush shape retention), and a method for producing the same. The present invention relates to the following oral composition and a method for producing an oral composition effective for obtaining such an oral composition.

[0002]

2. Description of the Related Art In order to remove plaque which is a cause of dental caries or periodontal disease, brushing with a toothpaste or mouthwash with a mouthwash has been conventionally performed.

[0003] In dentifrice compositions, especially liquid dentifrices and transparent dentifrices, carboxymethylcellulose, sodium alginate, xanthan gum, carrageenan, sodium polyacrylate and the like are used as binders. Is also effective in terms of stabilizing the dispersion of the abrasive. Specifically, in the liquid dentifrice composition described in JP-B-45-36599, xanthan gum is used for stabilizing the dispersion of the abrasive.

On the other hand, the viscosity of the dentifrice is adjusted to 20 to 1 to improve the feeling of use such as stickiness, ease of rinsing and dispersibility in the mouth.
A dentifrice prepared at 80 poise / 25 ° C. has been proposed.

[0005] However, these dentifrices have a remarkably improved dispersibility in the mouth and an increased feeling of use. However, the dentifrice is soaked into the brush, the amount of use is unclear, and the dentifrice is dripped from the brush. There were drawbacks in use.

In order to improve the above-mentioned drawbacks, Japanese Patent Application Laid-Open No. Hei 4-210908 proposes using a cross-linked polyacrylate in combination.
Japanese Patent Application Laid-Open Nos. 4-217614 and 4-217615 propose a method for more effectively and surely remedying the above-mentioned drawbacks.

The present invention has been made to solve the above problems, and provides an oral composition having excellent dispersibility in an oral cavity and excellent shape retention on a brush, and a method for producing the same. The purpose is to:

[0008]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive studies to achieve the above object, the present inventor has found that the abrasive is blended in an amount of 5 to 60% by weight of the whole composition, and a binder is prepared. Xanthan gum and polyacrylate as 2: 1
When kneading a mixture which is added together at a ratio of 1:10, when the shear rate is 50 to 700 (1 / second), 2
An oral composition having a dispersibility index obtained from a texture recording curve at 5 ° C. of 0.1 to 0.5 is obtained, and an oral composition having such a dispersibility index is
It has excellent dispersibility in the oral cavity and excellent shape retention on a brush.
00 poise, which is advantageous in obtaining a dentifrice composition having a yield value at 25 ° C. of 20 to 200 Pa. The obtained dentifrice composition is one in which the above-mentioned conventional disadvantages are more effectively eliminated.
This composition is easy to put on the brush, does not penetrate into the flocked part when placed on the brush, the toothpaste is put on the toothbrush by the user, the toothpaste is well held on the flocked part of the brush until used in the mouth It was also found that the dispersibility in the mouth was excellent, and the present invention was accomplished.

Accordingly, the present invention comprises 5 to 60% by weight of an abrasive, and uses xanthan gum and polyacrylate as binders in a weight ratio of 2: 1 to 1:10, A composition for oral cavity, wherein a dispersibility index obtained from a texture recording curve at 25 ° C. is 0.1 to 0.5; and an abrasive in an aqueous medium in an amount of 5 to 60% by weight of the whole composition. Xanthan gum and polyacrylate as a binder in a weight ratio of 2: 1 to 1
In producing an oral composition used in a ratio of 1:10, a mixture obtained by adding the above abrasive and binder to an aqueous medium is kneaded at a shear rate of 50 to 700 (1 / second). And a method for producing an oral composition.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention is used as a dentifrice or the like and contains an abrasive and a binder.

The abrasive used herein is preferably a silica-based abrasive such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, and the like. In addition, dibasic calcium phosphate dihydrate and anhydride , Calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, synthetic resin abrasive And these may be used alone or in combination of two or more. Among these, silica-based abrasives are preferably used from the viewpoint of cleaning power and dispersion stability.

The amount of the above-mentioned abrasive is 5 to 60% (% by weight, hereinafter the same) of the whole composition, particularly 10% as described above.
４０40%. If the amount is less than 5%, the decontamination power will not be sufficiently exhibited, and if it is more than 60%, the fluidity will decrease.

In the present invention, xanthan gum and polyacrylate are combined as a binder. In this case, the blending ratio of the polyacrylate and the xanthan gum is 2: 1 to 1:10, preferably 1: 1 to 1: 8, in terms of weight ratio in order to effectively exert the effects of the present invention. The total amount is preferably 0.5 to
It is in the range of 1.5%, more preferably 0.5-1.2%.

In the present invention, in addition to the xanthan gum and the polyacrylate, other binders can be added, if necessary, as long as the effects of the present invention are not impaired. Examples of such binders include carrageenan, sodium carboxymethylcellulose, methylcellulose,
Cellulose derivatives such as hydroxyethyl cellulose,
Gums such as tragacanth gum, karaya gum, and gum arabic; synthetic binders such as polyvinyl alcohol, carboxyvinyl polymer, and polyvinylpyrrolidone; and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite. Alternatively, two or more kinds may be blended. The amount of these other binders is not particularly limited, but is preferably 2.5% or less, particularly preferably 2% or less.

The oral composition of the present invention may further contain, in addition to the above-mentioned components, appropriate components according to the purpose, the type of the composition, and the like.

For example, sorbitol, glycerin, ethylene glycol, propylene glycol,
One or more of 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like can be blended. The compounding amount can be usually 10 to 80%, particularly 20 to 60% of the whole composition.

Menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol,
Citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla Oil, winter green oil, T-shaped oil, fragrances such as eucalyptus oil can be blended alone or in combination, saccharin sodium, stevioside,
Neohesperidyl dihydrochalcone, glycyrrhizin,
Sweeteners such as perillartin, thaumatin, asparatylphenylalanine methyl ester, p-methoxycinamic aldehyde, and the like can be added.

Further, in the present invention, as active ingredients, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, and alkali such as sodium monofluorophosphate and potassium monofluorophosphate are used. Metal monofluorophosphates, fluorides such as sodium fluoride and stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerofos Fate, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, benzalkoni chloride Beam, may be incorporated one or more kinds of active ingredients, such as benzethonium chloride.

As the surfactant, an anionic surfactant, a nonionic surfactant and an amphoteric surfactant are used.

Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristate; sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate; sodium N-myristoyl sarcosinate; and dodecylbenzene sulfone. Sodium acid, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, N-acylglutamate such as sodium N-palmitoylglutamate, sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, Sodium α-olefin sulfonate and the like are used.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolaurate. Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, lauric acid mono- or diethanolamide, fatty acid diethanolamide such as myristic acid mono- or diethanolamide, Sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxy Etc. Ji Ren polyoxypropylene fatty acid ester is used.

Examples of the amphoteric surfactant include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, 2-alkyl-1-alkyl-1-aminoglycine. Hydroxyethylimidazoline betaine sodium is used.

In this case, anionic surfactants are preferably used as the surfactant, and more preferably, sodium alkyl sulfate such as sodium lauryl sulfate is used.

These surfactants may be used alone or in combination of two or more. The amount of the surfactant is usually from 0.01 to 0.01 of the whole composition.
5%, more preferably 0.05 to 3%.

The oral composition of the present invention can be dyed by blending a pigment and a coloring agent.

In this case, various dyes and coloring agents are used. For example, Red No. 2, Red No. 3, Red No. 2
No. 26, Yellow No. 4, Yellow No. 5, Blue No. 1, Blue No. 2, Green No. 3, Blue No. 201, Blue No. 204, titanium mica, titanium oxide and the like are preferably used.

Thus, the oral composition of the present invention has a dispersibility index obtained from a texture recording curve of 0.1 to 0.5.
5, preferably 0.15 to 0.4. When the dispersibility index is smaller than 0.1, the adhesiveness of the preparation in the mouth is low, and the feeling of use is low. On the other hand, if it is larger than 0.5, it has adhesiveness to the oral mucosa, causing a sticky feeling, dispersibility is reduced, and a feeling of use is deteriorated. The dispersibility index is a value obtained by a method described later.

In the oral composition of the present invention having such a dispersibility index, the above-mentioned necessary components including the abrasive and the xanthan gum and the polyacrylate are added to an aqueous medium such as water, and these are kneaded. When the shear rate is 50 to 700
(1 / sec), more preferably 100 to 500 (1 / sec)
It is kneaded so that Shear speed is 50 (1
/ Sec), the mixing properties of the abrasive, the thickener and the like in the composition are not sufficient and uniformity cannot be ensured. On the other hand, if the shear rate is higher than 700 (1 / sec), the molecular weight of the binder is reduced and the abrasive is finely divided, whereby sufficient viscosity and yield value cannot be secured. The kneading time is usually 5 to 50 minutes.

Here, the shear rate in the oral composition means shear rate = peripheral speed (m / sec) / clearance (m), such as kneading of a stirrer for an oral composition such as toothpaste. A measurement result can be obtained by measuring the outermost peripheral speed of the rotary blade used for stirring the contents and the clearance between the blade and the inner wall of the device.

The oral composition according to the present invention comprises 2
The viscosity at 5 ° C. is 300 poise or less, more preferably 100 poise.
It is preferable that the viscosity exceeds 300 poise, more preferably 130 to 250 poise, and particularly 180 poise from the viewpoint of achieving the object of the present invention. If the viscosity is too low, the ease of putting on the toothbrush is reduced, and if it is higher than 300 poise, the fluidity may be reduced.

Further, the oral composition according to the present invention comprises 2
The yield value at 5 ° C. is 200 Pa or less, more preferably 20 to
It is preferably 200 Pa, more preferably 40 to 150 Pa, particularly preferably more than 60 Pa. If the yield value is too low, the penetration from the brush flocked portion is early and the shape retention is not sufficient, and if it is 200 Pa or more, the extrudability from the tube may be deteriorated.

Therefore, when producing the oral composition of the present invention, it is recommended to select the type and amount of the components, particularly the type and amount of the binder, so as to have the above-mentioned ranges of viscosity and yield value. Is done.

In the production method of the present invention, a conventional method can be employed except that the shear rate during kneading is set within the above-mentioned range.

[0034]

EFFECTS OF THE INVENTION The oral composition of the present invention retains the same shape retention properties as a conventional high-viscosity toothpaste when placed on a flocked portion of a brush, and is placed in the oral cavity once, and a good mouthwash is obtained. It is excellent in usability that it has dispersibility and dispersibility.

[0035]

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the examples.

In the following examples, viscosity, yield value,
The dispersibility index, the shape retention on the brush, the dispersibility in the mouth, the shear rate, and the appearance were determined by the following methods. (1) Viscosity Viscometer: BH type viscometer (Tokyo Keiki Seisakusho) Rotor: No. 4-7 rpm: 20 rpm Measurement temperature: 25 ° C. (2) Yield value measuring device: HAAKE viscometer control unit RV12 sensor system MV1 or SV1 Temperature: 25 ° C. rpm: 0-64 / min (3) Dispersibility index measurement Container: Texture analyzer TA ・ XT2
(Eikou Seiki Co., Ltd.) Plunger: P / 20 (diameter 20 mm) Compression speed: 1 mm / s Entry distance: 30 mm Measurement temperature: 25 ° C. Dispersibility index: The sample is broken by compression of the plunger,
The change in the force applied to the strain gauge due to the fracture is shown as the following texture curve. From the curve shown in FIG. 1, dispersibility index = area A2 / area A1 is determined. (4) Shape retention on brush Plastic bottle filled with sample (2 m inside diameter)
Extrude the sample from m) and put 1g of sample on the brush
And the sensory evaluation of the shape retention on the brush after 5 seconds.
In this case, the following was used as the toothbrush. Flocked part: 8.8 mm x 26.8 mm (width x height) Number of flocked holes: 3 holes x 1 row + 4 holes x 9 rows = 39 holes Number of flocked hairs: 20 / hole Hair length: 10.5 cm (5) Dispersibility in the mouth When brushing 1 g of a sample with a toothbrush,
The in-mouth dispersibility was organoleptically evaluated according to the following criteria. Evaluation criteria 3 points: Dispersed in the mouth immediately after brushing and good 2 points: Slightly sticky, but dispersed after a while 1 point: Sticky and difficult to disperse in the mouth (6) Shear speed Brick manufacturing equipment It was calculated from the peripheral speed of the stirring blade, the stirring blade and the clearance by the following equation. Shear speed = peripheral speed (m / sec) / clearance (m) (7) Appearance The appearance of the prepared sample was organoleptically evaluated according to the following evaluation criteria.

Examples and Comparative Examples The components shown in Table 1 were mixed, and this mixture was kneaded at a shear rate shown in Table 1 for 20 minutes to obtain a dentifrice. The results are also shown in Table 1.

[0038]

[Table 1]

[Brief description of the drawings]

FIG. 1 is a graph showing an example of a texture curve obtained by a texture analyzer.

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[Procedure amendment]

[Submission date] June 23, 1997

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0036

[Correction method] Change

[Correction contents]

In the following examples, viscosity, yield value,
The dispersibility index, the shape retention on the brush, the dispersibility in the mouth, the shear rate, and the appearance were determined by the following methods. (1) Viscosity Viscometer: BH type viscometer (Tokyo Keiki Seisakusho) Rotor: No. 4-7 rpm: 20 rpm Measurement temperature: 25 ° C. (2) Yield value measuring device: HAAKE viscometer control unit RV12 sensor system MV1 or SV1 Temperature: 25 ° C. rpm: 0-64 / min (3) Dispersibility index measurement Container: Texture analyzer TA ・ XT2
(Eikou Seiki Co., Ltd.) Plunger: P / 20 (diameter 20 mm) Compression speed: 1 mm / s Entry distance: 30 mm Measurement temperature: 25 ° C. Dispersibility index: The sample is broken by compression of the plunger,
The change in the force applied to the strain gauge due to the fracture is shown as the following texture curve. From the curve shown in FIG. 1, dispersibility index = area A2 / area A1 is determined. (4) Shape retention on brush Plastic bottle filled with sample (2 m inside diameter)
Extrude the sample from m) and put 1g of sample on the brush
And the sensory evaluation of the shape retention on the brush after 5 seconds.
In this case, the following was used as the toothbrush. Flocked part: 8.8 mm x 26.8 mm (width x length) Number of flocked holes: 3 holes x 1 row + 4 holes x 9 rows = 39 holes Number of flocked hair: 20 / hole Hair length: 10.5 mm (5) Dispersibility in the mouth When brushing 1 g of a sample with a toothbrush,
The in-mouth dispersibility was organoleptically evaluated according to the following criteria. Evaluation criteria 3 points: Dispersed in the mouth immediately after brushing and good 2 points: Slightly sticky, but dispersed after a while 1 point: Sticky and difficult to disperse in the mouth (6) Shear speed Brick manufacturing equipment It was calculated from the peripheral speed of the stirring blade, the stirring blade and the clearance by the following equation. Shear speed = peripheral speed (m / sec) / clearance (m) (7) Appearance The appearance of the prepared sample was organoleptically evaluated according to the following evaluation criteria.

Claims (2)

[Claims] 1. An abrasive containing 5 to 60% by weight, xanthan gum and polyacrylate as a binder in a weight ratio of 2: 1 to 1:10, and 25% by weight.
A composition for oral cavity, wherein a dispersibility index obtained from a texture recording curve at 0 ° C is 0.1 to 0.5. 2. A polishing agent is added to an aqueous medium in an amount of 5 to 5 parts of the total composition.
The above-mentioned abrasive and binder were used in producing an oral composition containing 60% by weight of xanthan gum and polyacrylate as binders in a weight ratio of 2: 1 to 1:10. Is kneaded at a shear rate of 50 to 700 (1 / second) at a shear rate of 50 to 700 (1 / sec).