JP4998999B2 - Cover dressing for treatment - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a cover dressing used for treating rotifer.

  Currently, a very large number of patients worldwide suffer from diabetes. According to a survey by the Ministry of Health, Labor and Welfare, it is estimated that there are 13.7 million people in Japan alone, including those who are strongly suspected of having diabetes and those who cannot deny the possibility of diabetes. Diabetes mellitus is a very dangerous disease, but its symptoms are not easily recognized, and it is recognized only after developing complications such as diabetic neuropathy, diabetic retinopathy and diabetic nephropathy There are many. Among the above complications, diabetic neuropathy appears relatively early. Symptoms of neuropathy include numbness and pain in the limbs, dull sensation, repeated diarrhea and constipation, dizziness on standing, dull taste, sweating abnormalities, lack of vigorous urine, and erectile dysfunction. Appears throughout the body. If a neurological disorder is left unattended, it will worsen over time and the sense of pain and heat will be lost. For this reason, there are many cases in which an injury or burn is not noticed, which is worsened and progressed to ulcer or gangrene. Special attention must be paid to foot lesions.

  Foot ulcers, including minor ones, occur in 15% of diabetics. In fact, in Japan, 16-23% of hospitalized diabetic patients are due to foot lesions. Half of the patients with a history of diabetes over 20 years develop foot neurosis, and most patients are forced to have amputations. And one third of patients who have amputated limbs will have amputation of the opposite limb within three years. Since the treatment of foot lesions is largely related to the quality of life of diabetics, the demand and interest in effective therapies is very high.

It has been recognized for centuries that bedworms are effective in treating wounds. In fact, it is known, for example, that Australian natives have been using wilt to clean wounds for thousands of years. Doctors who served during the war also noticed that wounds of wounded soldiers recovered significantly faster. William S. Baer, an American surgeon stationed in France during the First World War, used edible beetles to treat chronic osteomyelitis based on his experiences during the war. The scientific value and therapeutic value of wilt treatment has been recognized because of its remarkable therapeutic effect, and its research and treatment have been continued in many countries in the United States and Europe. However, after World War II, the treatment for wilt disease has been neglected for various reasons (see, for example, Non-Patent Document 1).
With the emergence of antibiotic-resistant infectious ulcers and other factors, the treatment of gonorrhea came into the limelight again in the 1990s. At the same time, it has been shown that the treatment of wilt is indeed more effective in debriding men (ie, removing necrotic tissue and foreign bodies from the wound) of many refractory wounds, thus promoting wound healing. (For example, see Non-Patent Documents 2 to 6). Since then, the effectiveness, convenience, and low toxicity of bed bug treatment have been rapidly accepted by many wound care professionals around the world. In Japan, the treatment for rotifer has been carried out several years ago, and expectations and interest in this treatment method are very high. The treatment for rotifer is particularly suitable for patients with impaired wound healing due to diabetes, but in addition, sterile rotifer is used in various areas such as wounds, burns, venous ulcers, and cancerous ulcers.

  The actual method for treating wilt disease is very simple. That is, after washing the wound with physiological saline, it is simply placed on the patient's wound. As the beetles grow and become cocoons, they prefer a dry environment, and in order to escape from the affected area, it is necessary to change the beetles twice a week. The exchanged beetle is discarded as medical waste.

  It is necessary to protect the skin around the wound from the digestive enzymes secreted by rotifer, the drainage from infected and necrotic wounds, and the itching that occurs because rotifer crawls over unperceived skin. is there. In addition, it is necessary to prevent the rodents from escaping from the wound for as long as possible. Various dressings have been utilized for these purposes.

  The most widely used classical methods are: That is, the skin around the wound is covered with an adhesive hydrocolloid sheet, or a hydrocolloid sheet in which a hole of the size of the wound is hollowed is placed on the wound (see Non-Patent Document 7). In addition, the skin can be protected by applying zinc white ointment to the rest of the exposed skin. Next, a young 2-4 mm large cabbage is placed on the wound. Nylon net, Dacron chiffon or other similar delicately perforated material can be glued on top, taped on top, or both to complete the lowermost cage dressing. Finally, cover the bottom dressing with a simple thin gauze bandage (second dressing). This gauze bandage serves to absorb exudates and liquefied and necrotic tissue during treatment. This second dressing can be easily replaced when needed without losing the cabbage.

Or the dressing in which the rotifer is already confined in the bag is also used for the treatment for rotifer (for example, refer nonpatent literature 8). An example of such a dressing is a biobag (Polymedics, Belgium). The biobag is heat sealed in a square sachet made of polyvinyl alcohol, that is, a polymer compound that allows free entry and exit of air. Lepidoptera secretions flow freely out of the biobag and reach the wound. The biobag absorbs the drainage of the liquefied and necrotic wound and nourishes the rodents inside. This dressing has the advantage of being easy to put on and take off, reducing discomfort, reducing the chances of the escape of the rotifer, and gives the spiritual satisfaction that the rotifer is not opened over the wound. However, there is a discussion that such a dressing is not effective compared to a treatment using a red beetle that can freely crawl the affected area because the red beetle does not directly contact the wound (see, for example, Non-Patent Document 9).
W. Fleischmann et al., "Wound treatment using Maggot Therapy Uzi", Osaka Public University Joint Publications (2006), p17-25 Mucuoglu KY. Et al., Int J Dermatol, 1999 Aug; 38 (8): 623-627. Mucuoglu KY. , Am J Clin Dermatol, 2001; 2 (4): 219-227. Sherman RA. Et al., Arch Phys Med Rehab, 2001 Sep; 82 (9): 1226-1229. Sherman Ra. , Eur Tiss Repair Soc Bull, 2000; 7: 97-98. Sherman RA. Diabetes Care, 2003 Feb; 26 (2): 446-451. Sherman RA. , Plast Reconstr Surg, 1997; 100 (2): 451-456. Glassberger M.M. Dermatol, 2002; 204 (4), 306, et al. Thomas S. Et al., Br J of Nurs. , 2002; 11: S21-S28.

  In view of the importance of rotifer treatment in wound treatment as described above, an object of the present invention is to provide a cover dressing that draws out the effect of radish treatment as much as possible, is easy to use, and is excellent in cost. .

In order to solve the above-mentioned problems, the present inventor made extensive researches by paying attention to the cover dressing that is used to directly contact the rotifer against the affected area and prevent the rotifer from escaping from the affected area. It came to be completed. That is, the present invention is as follows:
[1] A base material having a mesh portion for surrounding and covering the affected area, or a base material having a mesh portion formed by fixing a mesh sheet covering the through hole to a base material having a through hole surrounding the affected area; A cover dressing for treating rotifer having a pressure-sensitive adhesive layer formed on a portion of the substrate excluding the mesh portion.
[2] A base material having a mesh portion formed by fixing a mesh sheet covering the through hole to a base material having a through hole surrounding the affected part, wherein the mesh sheet is fixed on one side of the base material, The cover dressing according to the above [1], which has an adhesive layer on the opposite surface.
[3] The cover dressing according to any one of [1] or [2] above, wherein the pressure-sensitive adhesive layer is coated with a release layer.
[4] The cover dressing according to any one of [1] to [3], wherein the substrate is a nonwoven fabric.
[5] The cover dressing according to the above [4], wherein the material of the nonwoven fabric is polyester, cellulose, polyolefin, polyamide, or a combination thereof.
[6] The cover dressing according to any one of [4] or [5] above, wherein the material of the nonwoven fabric is polyester.
[7] The cover dressing according to any one of the above [1] to [6], wherein the material of the mesh sheet is polyamide or polyester.
[8] The cover dressing according to any one of [1] to [7], wherein the pressure-sensitive adhesive layer is made of an acrylic pressure-sensitive adhesive.
[9] The cover dressing according to any one of the above [1] to [8], wherein the area of the through hole is 1 cm ² or more and 1000 cm ² or less.
[10] The cover dressing according to any one of the above [1] or [2], wherein the mesh portion is formed so as to surround an affected area of the treatment target of the bedworm, and forms a closed space in which the bedworm is active during use. .
[11] A cover dressing for the treatment of rotifer that has a mesh-like sheet and an adhesive layer laminated on the mesh-like sheet, and is formed with at least an adhesive non-laminate that surrounds the affected area of the rotifer treatment target.
[12] The mesh according to any one of [10] or [11] above, wherein the pressure-sensitive adhesive layer is covered with a release layer.

  The cover dressing for treating rotifer of the present invention is simple to use, has a long duration, and is low in cost as compared with a conventional cover dressing.

  The present invention provides a cover dressing used for the treatment of wilt.

  In the present specification, the “curiotherapy” means a therapy that uses a live beetle for the treatment of wounds and the like. Fleischmann et al., “Wound treatment using Maggot Therapy Uzi”, Osaka Public University Joint Publications (2006), or the following Internet homepage: “Magot Treatment Homepage” (http://www.icn-jp.com/~) (maggot / index.html) and the like. “Udzi therapy” is sometimes referred to as “maggot therapy”, “maggot therapy”, “maggot development therapy (MDT)” or “maggot therapy”.

  In this specification, “dressing” is for covering the affected area in order to treat rotifer, for the purpose of physically blocking the escape of rotifer from the affected area, and exudate or liquefied necrotic tissue, etc. It covers the affected area for the purpose of absorbing the blood. In the present specification, “cover dressing” particularly means dressing that is a patch. Usually, after placing a bed bug on the affected area, a cover dressing is stuck on it to physically block the escape of the bed bug from the affected area.

  The cover dressing of the present invention can be used in any scene where bed bug treatment is performed. For example, the cover dressing of the present invention is also used in these scenes because it is applied to the treatment of wounds, wounds, burns, venous ulcers, cancer ulcers, etc. due to diabetes. It is not done. As for the treatment of rotifer, the treatment of wounds due to diabetes is particularly targeted, and therefore it is particularly envisaged that the cover dressing of the present invention is also used in the treatment of wounds due to diabetes.

  The bed bug treatment using the cover dressing of the present invention is performed by placing the bed bug on the affected area to be treated and then applying the cover dressing to cover the affected area with the mesh portion. That is, the affected area of the treatment target of the bed bug is surrounded by the adhesive layer of the cover dressing, the adhesive layer adheres to the skin of the object, and the covered area is covered with the mesh portion to form a closed space in which the bed bug is active. .

Therefore, the beetle under treatment is present in a form covered with a mesh. Moreover, the mesh part should just be the magnitude | size and shape which cover the whole affected part, and what is necessary is just to select the magnitude | size and shape suitably according to the magnitude | size of an affected part. In one embodiment of the present invention, the area of the mesh portion is 1 cm ² or more and 1000 cm ² or less.

If the aspect of the cover dressing of this invention is divided roughly, the following three aspects will be mentioned.
(Aspect 1)
A cover dressing for treating wilt disease having a base material having a mesh part for surrounding and covering an affected part, and an adhesive layer formed on a part of the base material excluding the mesh part, the mesh part Is a cover dressing that is formed so as to surround an affected area of the treatment target for the bed bug and can form a closed space in which the bed bug is active during use.
(Aspect 2)
A base material having a mesh portion formed by fixing a mesh sheet covering the through hole to a base material having a through hole surrounding the affected part, and an adhesive layer formed at a portion of the base material excluding the mesh part; A cover dressing for the treatment of bed bugs, wherein the mesh part is formed so as to surround the affected part of the bed bug treatment target and can form a closed space where the bed bugs are active during use.
(Aspect 3)
A cover dressing for the treatment of rotifer which has a mesh-like sheet and an adhesive layer laminated on the mesh-like sheet, and is formed with at least an adhesive non-laminate that surrounds the affected area of the rotifer treatment target.

As the base material of the cover dressing of the present invention in aspects 1 and 2, what is generally used as a base material for a medical patch may be used. For example, a nonwoven fabric, a woven fabric, a knitted fabric, a perforated film, or Examples include Japanese paper. These base materials may be used after being subjected to water repellent treatment with a known water repellent as required. Further, the substrate may be stretchable or non-stretchable. A substrate having excellent breathability or moisture permeability and good stretchability can be preferably applied. In general, non-woven fabrics have high breathability and moisture permeability, and at the same time, the pressure-sensitive adhesive penetrates into the non-woven fabric layer, so that the interface with the non-woven fabric layer can be increased, so that moisture easily moves to the non-woven fabric layer and is diffused as water vapor Is expensive. Therefore, even if the nonwoven fabric is directly applied to the skin, moisture such as sweat is rapidly dissipated, so that there is little decrease in adhesion and rash. Nonwoven fabrics are also excellent in flexibility and stretchability. Therefore, it is particularly preferable to use a non-woven fabric as the base material of the cover dressing according to the present invention in Embodiments 1 and 2.
The thickness of the substrate is not particularly limited, but is generally 15 to 2000 μm.
In the aspect 3, the mesh sheet itself constitutes the substrate, and the material described in the section of the mesh sheet described later is used as the material of the substrate.

  The material for the nonwoven fabric, woven fabric, knitted fabric, or perforated film is not particularly limited as long as it is usually used as a base material for medical adhesive tapes. Specific examples include polyethylene terephthalate, polybutylene. Polyester fibers such as terephthalate or polytrimethylene terephthalate, cellulose fibers such as rayon or copper ammonia rayon, polyolefin fibers such as polyethylene or polyolefin, polyamide fibers such as nylon 6, nylon 66, nylon 610, or nylon 612 Or mixtures thereof. Among them, polyester fibers such as polyethylene terephthalate, polybutylene terephthalate, or polytrimethylene terephthalate have high resistance to electronic sterilization used for medical devices and are preferably used. In particular, polyethylene terephthalate is more preferably used in terms of high strength and dimensional stability.

  The shape and size of the base material are not particularly limited as long as the cover dressing is usually incapable of being peeled off in close contact with normal body movements or is extremely small in peeling. It is preferable not to have unnecessary portions and sizes. By using a base material having an appropriate shape, the contact surface between the pressure-sensitive adhesive layer adhered to one side of the base material and the skin becomes a necessary and sufficient area, and the healthy skin of the patient to be treated is rashed, etc. Inconvenience is unlikely to occur. As an example of the shape and size of the substrate, one having a periphery in which the periphery of the mesh portion is expanded in an arbitrary shape within a range of 20 mm to 100 mm can be mentioned.

  The cover dressing of the present invention is used as an adhesive tape by providing an adhesive layer on one side of the substrate. The pressure-sensitive adhesive used for the pressure-sensitive adhesive layer is not particularly limited as long as it is used for a normal medical pressure-sensitive adhesive sheet, and is suitable for acrylic pressure-sensitive adhesive, rubber pressure-sensitive adhesive, silicone pressure-sensitive adhesive, and the like. 1 type (s) or 2 or more types can be used for an adhesive. In particular, it is desirable to use an acrylic pressure-sensitive adhesive in consideration of skin irritation. Further, when the acrylic pressure-sensitive adhesive layer is formed on the base material, the stress relaxation property of the base material is further improved. These pressure-sensitive adhesives are coated on the substrate by a conventionally known method such as coating with a roll to form a pressure-sensitive adhesive layer. At this time, the thickness of the pressure-sensitive adhesive layer is not particularly limited, but is preferably about 10 to 150 μm, preferably 20 to 100 μm.

Next, the mesh will be described.
In Embodiments 1 and 3, a mesh portion is formed on the base material itself.
In aspect 2, the base material and the mesh part are formed separately, the mesh part is formed on the base material surface, and an adhesive layer is further formed on the same side, or the base material mesh is formed. A pressure-sensitive adhesive layer is formed on the surface opposite to the portion formed. The latter will be further described. That is, a mesh part is provided in the aspect which fixes to a base material on the opposite side to which the adhesive layer of the base material was provided, and covers a through-hole. The mesh portion is preferably fixed, preferably bonded to at least the peripheral portion of the through-hole of the base material without any gap in order to prevent the escape of wilt.

  During the treatment of rotifer, the rotifer secretes an alkaline fluid containing proteolytic enzymes, and drains from the infected and necrotic wound. This property is very important in bedworm treatment, because if the liquid is not properly removed outside the dressing, the bedbug being treated will drown and die. In the cover dressing of the present invention, these liquids need to be removed to the outside of the cover dressing through the gaps in the mesh portion. Accordingly, the mesh of the mesh portion should be sufficiently spaced to remove the waste liquid to the outside. Furthermore, the mesh size of the mesh portion needs to be such that the wilt does not escape from the mesh. The bed bug used for treatment is usually about 2 mm to 4 mm when initially placed on the affected area, so the mesh opening is usually about 0.5 to 1.5 mm, preferably about 0.5 mm. ~ 1.2 mm.

  The mesh part is preferably transparent or semi-transparent so that the state of wilt can be observed without removing the cover dressing. In addition, the mesh portion must be sufficiently strong so that the mesh is not torn during the treatment of wilt.

The material of the mesh-like sheet is not particularly limited as long as it is usually used as a medical mesh-like sheet. Specifically, for example, polyamide such as nylon 6, nylon 66, nylon 610, or nylon 612, polyester such as PTFE, Dacron ^™ , or Marlex ^™ , polyolefin 7 such as polypropylene, and the like are particularly preferable. Or it is polyester.

In the aspect 1, the mesh part can be formed by punching a base material, for example.
In Aspect 2, the mesh part can be formed by fixing a mesh sheet to the base material.
The mesh sheet and the base material are usually fixed by adhesion, and the adhesion is performed in this field (that is, the medical adhesive tape production field) in order to bond the material of the mesh sheet to be used and the substrate. This is done by any means normally used. For example, what is necessary is just to adhere | attach using the double-sided tape which consists of an appropriate component. As the adhesive, an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive, and the like are used, and may be appropriately selected depending on the combination of the base material and the mesh sheet. For example, when the base material and the mesh-like sheet are polyester fibers, a double-sided tape composed of three layers of an acrylic pressure-sensitive adhesive / non-woven fabric / acrylic pressure-sensitive adhesive can be suitably used. Bonding can also be performed by heat sealing.

  In aspect 2, the adhesion surface of the mesh sheet and the base material needs to have a shape and a size such that the adhesion is not peeled off and the stink bug does not escape. The shape and size are not particularly limited as long as the purpose is satisfied. For example, a portion surrounded by an outer edge of the through hole and a closed curve in which the outer edge of the through hole is expanded to an arbitrary shape within a range of 5 mm to 30 mm. The case where the whole is an adhesive surface is mentioned.

  In the aspect 3, the mesh part is formed by forming the pressure-sensitive adhesive layer using the mesh sheet itself as a base material and leaving a part corresponding to the mesh part.

  In the cover dressing of the present invention, in order to prevent contamination of the pressure-sensitive adhesive layer surface, it is preferable to cover the pressure-sensitive adhesive layer surface with a release layer until use. The release layer is not particularly limited as long as a substance that is toxic or irritating to the skin is not used for medical purposes, and a layer that is usually used for medical adhesive tapes can be used. Examples of the release layer include commercially available general release paper obtained by imparting releasability to glassine paper, polylamination paper, plastic film, etc. by silicone treatment.

  One embodiment of the cover dressing of the present invention is shown in FIG. In FIG. 1, 1 is a base material, 2 is an adhesive layer, 3 is the mesh part provided in the base material itself, 5 is a peeling layer. The figure relates to aspect 1. As shown in FIG. 1, in the cover dressing, a pressure-sensitive adhesive layer 2 is formed on one side of a base material 1, and the pressure-sensitive adhesive layer 2 is further covered with a release layer 5. The peelable layer 5 is peeled off when the cover dressing is used, and the exposed pressure-sensitive adhesive layer 2 is adhered to the vicinity of the affected area of the treatment target for rotifer. It should be noted that in the cover dressing, the mesh portion 3 is provided on the base material 1 itself.

  FIG. 2 is another embodiment of the cover dressing of the present invention. In FIG. 2, 1 is a base material, 2 is an adhesive layer, 3 is a mesh-like sheet, 4 is an adhesive portion between the base material and the mesh-like sheet, and 5 is a release layer. The figure relates to aspect 2. As shown in FIG. 2, in the cover dressing, the substrate 1 has a through hole, and a mesh sheet covering the through hole is fixed to form a mesh portion 3. The base material 1 and the mesh part 3 are bonded via an adhesive part 4 between the base material and the mesh-like sheet, and the edge part of the mesh part 3 is spaced at least around the through hole on the surface of the base material 1. There is no adhesion. In addition, a pressure-sensitive adhesive layer 2 is formed on one side of the base material 1, and the pressure-sensitive adhesive layer 2 is further covered with a release layer 5. The peelable layer 5 is peeled off when the cover dressing is used, and the exposed pressure-sensitive adhesive layer 2 is adhered to the vicinity of the affected area of the treatment target for rotifer.

  FIG. 3 is another embodiment of the cover dressing of the present invention. In FIG. 3, 3 is a mesh sheet, 2 is an adhesive layer, and 5 is a release layer. The figure relates to embodiment 3. As shown in FIG. 3, in the cover dressing, the pressure-sensitive adhesive layer 2 is laminated on one side of the mesh-like sheet 3, and at least a pressure-sensitive adhesive non-laminate part surrounding the affected area of the bedridden treatment target is formed. The pressure-sensitive adhesive layer 2 is covered with a release layer 5, and the release layer 5 is peeled off when the cover dressing is used, and the exposed pressure-sensitive adhesive layer 2 is adhered to the periphery of the affected area of the treatment target for the bed bug.

In practice, the treatment for rotifer using the cover dressing of the present invention is performed, for example, as follows:
1. The wound is washed with saline.
2. Cover the wound with Duoactive (registered trademark).
3. Place the beetle on the wound with a clean brush. About 7 to 8 animals per 1 cm ^{2 of the} affected area are preferable.
4). The cover dressing of the present invention is affixed to the wound with a gap so that it can move even when the rotifer grows.
5. In order to absorb the drained liquid from the affected area, the cover dressing is covered with a water absorbing pad (for example, a paper diaper).
6). In addition, cover with bandages (not essential).
7. Replace wilt twice a week and continue this treatment for about 2-4 weeks. The grown beetle is discarded as medical waste. Replace paper diapers as appropriate. The duration of treatment can be shortened or lengthened depending on the severity of the wound.
8). It is necessary to confirm the improvement of the wound at the time of replacing the dwarf beetle. For this purpose, timely examination of wound bacteriological examination and systemic infection data (white blood cells, CRP, etc.).

  FIG. 4 is a perspective view of a state where the cover dressing (Aspect 1 or 2) of the present invention is applied to an affected area. After the bedworm is placed on the affected area of the treatment target, if the cover dressing has a release layer, it is peeled off to expose the adhesive layer, and then the cover dressing is applied to the skin around the affected area. Here, the mesh part holds the affected part on the inside, and the mesh part and the base material are linked to form a closed space in which the bed bugs are active, thereby physically blocking the bed bug escape. Similarly, the cover dressing of aspect 3 may be applied to the skin around the affected part so that the mesh part holds the affected part inside.

  Hereinafter, the present invention will be described in more detail through examples, but it will be apparent to those skilled in the art that the following examples are merely illustrative and do not limit the present invention in any way.

Example 1: Preparation of cover dressing for treatment of rotifer One of the embodiments of the cover dressing of the present invention was prepared. A top view and a sectional view thereof are shown in FIG. The cover dressing includes a mesh sheet, a double-sided tape, a nonwoven fabric, an adhesive layer, and a release paper as its constituent elements. Each component is specifically as follows:
Mesh sheet: 100% polyester, the number of driven is 101 vertical, 99 horizontal (± 3%), manufactured by Toray Industries, Inc .;
Double-sided tape: Acrylic adhesive / nonwoven fabric / acrylic adhesive three-layer structure, total thickness 0.11 mm, TL-202 manufactured by Lintec Corporation;
Non-woven fabric: 100% polyester, 40 g / m ^2, manufactured by DuPont, etc .;
Pressure-sensitive adhesive layer: acrylic pressure-sensitive adhesive, 25 g / m ² ;
Release paper: bleached kraft paper, polylaminate, silicone coat, manufactured by Lintec Corporation;

Comparative Example 1: Comparison of Cover Dressing of Example 1 and Conventional Dressing Cover dressing of Non-Patent Document 7 (hereinafter also referred to as “conventional dressing”), which has been widely used for the treatment of rotifer, and Example 1 cover dressing (hereinafter also referred to as “dressing of the present invention”). For comparison, 20 cases were tested for each of the conventional dressing and the dressing of the present invention, and the time and duration required for the dressing processing were measured and averaged. The comparison results are shown in Table 1.

  From the comparison of the time required for the dressing processing and the duration of the dressing, it can be seen that the dressing of the present invention achieves a much simpler treatment for rotifer than the conventional dressing. The short time required for processing leads to the advantage that the dwarf does not escape during the dressing operation. Moreover, it turns out that the low cost property is also achieved from the comparison of the cost per day. These advantages can be very important for the further spread of the treatment of Aspergillus.

  It will be apparent to those skilled in the art that various modifications and variations can be made in the cover dressing of the present invention without departing from the spirit or scope of the invention. Accordingly, it is intended that the present invention cover modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.

It is a figure which shows the structure of the cover dressing of this invention. The figure relates to aspect 1. In order to distinguish the areas, hatching is appropriately performed. It is a figure which shows the structure of the cover dressing of this invention. The figure relates to aspect 2. In order to distinguish the areas, hatching is appropriately performed. It is a figure which shows the structure of the cover dressing of this invention. The figure relates to embodiment 3. In order to distinguish the areas, hatching is appropriately performed. It is a perspective view of the state which applied the cover dressing of this invention to the affected part. In order to distinguish the areas, hatching is appropriately performed. The design of the cover dressing of Example 1 is shown. In order to distinguish the areas, hatching is appropriately performed.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Base material 2 Adhesive layer 3 Mesh part 4 Adhesion part of a base material and a mesh-like sheet 5 Peeling layer 6 Affected part of the treatment target

Claims (12)

A base material having a mesh portion for surrounding and covering the affected area, or a base material having a mesh portion formed by fixing a mesh sheet covering the through hole to a base material having a through hole surrounding the affected area; and
Possess a formed in a portion other than the mesh portion of the base material adhesive layer,
A cover dressing for treating rotifer which has a thickness of the substrate of 15 to 2000 µm and an opening of the mesh part of 0.5 to 1.5 mm. Securing the mesh sheet covering the through hole in the substrate having a through hole surrounding the affected area have formed substrate mesh portion, said mesh sheet is secured to one surface of said substrate, said substrate having the adhesive layer on the opposite surface of the cover dressing according to claim 1.   The cover dressing according to claim 1 or 2, wherein the pressure-sensitive adhesive layer is covered with a release layer.   The cover dressing according to any one of claims 1 to 3, wherein the substrate is a nonwoven fabric.   The cover dressing according to claim 4, wherein the material of the nonwoven fabric is polyester, cellulose, polyolefin, polyamide, or a combination thereof.   The cover dressing according to claim 4 or 5, wherein the material of the nonwoven fabric is polyester.   The cover dressing according to any one of claims 1 to 6, wherein a material of the mesh sheet is polyamide or polyester.   The cover dressing according to any one of claims 1 to 7, wherein the pressure-sensitive adhesive layer is made of an acrylic pressure-sensitive adhesive. The cover dressing according to any one of claims 1 to 8, wherein an area of the through hole is 1 cm ² or more and 1000 cm ² or less. The cover dressing according to any one of claims 1 to 9, wherein the mesh part is formed so as to surround an affected part to be treated with a rotifer and forms a closed space in which the rotifer is active during use. Having a mesh sheet and an adhesive layer laminated on the mesh sheet;
At least a non-adhesive layer that surrounds the affected area of the treatment target is formed .
The mesh sheet has a thickness of 15 to 2000 μm, and the mesh opening is 0.5 to 1.5 mm.
Cover dressing for treatment of wilt. The cover dressing according to claim 11 , wherein the pressure-sensitive adhesive layer is covered with a release layer.

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