DE202020106283U1 - Device for treating tumors of multiple organs based on an electric field - Google Patents

Abstract

Device for treating tumors of several organs based on an electric field, characterized in that it comprises:
an electric field generator for outputting AC signals of adjustable voltage waveform, amplitude and frequency;
a lead, one end of which is connected to the electric field generator and the other end to a field energy electrode patch;
a field energy electrode patch comprising a flexible substrate and a plurality of electrode sheet bodies made of insulating capacitor materials arranged in an array on the substrate, the electrode sheet body being able to effectively excite the electric field and avoid generation of conduction current, and the electrode sheet body being connected to the lead;
a portable device, wherein the plurality of field energy electrode patches are disposed on the inside of the portable device; and wherein the portable device comprises any one or any combination of hats, vests, bras and shorts.

Description

TECHNICAL AREA

The present invention relates to an apparatus for treating the tumors of multiple organs based on an electric field.

STATE OF THE ART

The research and clinical results of the last few years have shown that at a frequency of the electric field in a range from 100 to 500 kHz, the external alternating electric field significantly inhibits the growth rate of various cancer cells in vitro and in vivo. Such research later led to the development of a new therapy based on the electric field in the field of tumor treatment. In some countries, the specific technologies have already been used in medical research and clinical treatment of brain tumors and other cancers. Some research results indicated that the application of alternating electric fields of low intensity and medium frequency can inhibit the division and growth of active tumor cells by destroying mitosis. In addition, the finite element simulation calculations have shown that the application of an electric field can influence the division and growth of tumor cells.

Under conditions of an alternating electric field, different electric dipoles rotate due to the alternating direction of the alternating electric field. Compared to tumor cells, ordinary cells show different dielectric reactions, since their internal, locally different chemical composition corresponds to different electrical dipoles. E.g. the ordinary cells have different details of the chemical bonds of the DNA strands compared to the tumor cells, which means that the DNA strands of the two cell types have different dielectric reactions. At present there is already experimental evidence that the alternating electric field at a certain frequency can cause the DNA bond within the tumor cell to be broken and destroyed and then the tumor cell to die, but the applied electric field has no obvious influence on the DNA -Strand of ordinary cells and also does not affect the growth of ordinary cells.

CONTENT OF THE PRESENT INVENTION

The present invention provides an apparatus for treating the tumors of multiple organs based on an electric field.

The present invention adopts the following technical solution.

An apparatus for treating tumors of multiple organs based on an electric field is provided, the key technology of which is that it comprises: an electric field generator for outputting alternating current signals with adjustable voltage waveform, amplitude and frequency; a lead, one end of which is connected to the electric field generator and the other end to a field energy electrode patch; a field energy electrode patch comprising a flexible substrate and a plurality of electrode sheet bodies made of insulating capacitor materials arranged in an array on the substrate, the electrode sheet body being able to effectively excite the electric field and avoid generation of conduction current, and the electrode sheet body being connected to the lead; a portable device, wherein the plurality of field energy electrode patches are disposed on the inside of the portable device; and wherein the portable device comprises any one or any combination of hats, vests, bras and shorts.

The portable device generally consists of medical nonwovens and other elastic materials, with 1 to 100 individual electrodes embedded, depending on the treatment position, and connected via a flexible printed circuit board to form an electrode array that is glued or wrapped on the human body so that the field energy electrode plaster fits snugly the human body.

The output frequency intensity of the electric field generator is 0-55Vpp, the intensity of the electric field is 0-5V / cm, and the modulation frequency is 50-500KHz.

The maximum output voltage of the electric field generator is adjustable and has a range of 50 to 120Vpp, wherein the output waveform of the power supply device is the sine wave, the triangle wave and the square wave, and the output signal of the power supply device is sequentially outputted through at least four terminals, and where the voltage is provided in at least 2 directions, and wherein the output time of each connection is adjustable in a range from 0.1 second to 10 seconds.

• den Blasenkrebs, wobei die Frequenz des elektrischen Felds 100-180 KHz beträgt;
• den Eierstockkrebs, wobei die Frequenz des elektrischen Felds 170-230 KHz beträgt;
• Das Feldenergieelektrodenpflaster in dem Hut wird zum Behandeln von intrakraniellen Tumoren verwendet, wobei die Frequenz des elektrischen Felds 200KHz beträgt;
• wobei das Feldenergieelektrodenpflaster innerhalb der Weste zum Behandeln der Tumoren verwendet wird, die Folgendes umfassen:
  • den Darmtumor, wobei die Frequenz des elektrischen Feldes 50 KHz beträgt;
  • den kleinzelligen Lungenkrebs, wobei die Frequenz des elektrischen Felds 200 KHz beträgt; den nichtkleinzelligen Lungenkrebs, wobei die Frequenz des elektrischen Felds 150 KHz beträgt; und wobei das Feldenergieelektrodenpflaster in dem Büstenhalter zum Behandeln vom Brustkrebs verwendet wird, wobei die Frequenz des elektrischen Felds 120-150 KHz beträgt; wobei das Feldenergieelektrodenpflaster innerhalb der Shorts zum Behandeln der Tumoren verwendet wird, die Folgendes umfassen: den Blasenkrebs, wobei die Frequenz des elektrischen Felds 130-150 KHz beträgt; den Eierstockkrebs, wobei die Frequenz des elektrischen Felds 200 KHz beträgt.
  • An der Rückseite des Elektrodenblattkörpers ist ein Thermistor angeordnet, wobei, wenn der Elektrodenblattkörper sich erhöht und einen voreingestellten Wert überschreitet, der Generator des elektrischen Feldes die Ausgabe reduziert oder die Ausgabe sofort blockiert, und wobei der Vorgang mit einer Alarmmeldung begleitet ist.

The field energy electrode patch in the hat is used to treat intracranial Tumors used, the frequency of the electric field being 170-230KHz,
wherein the field energy electrode patch within the vest is used to treat tumors comprising: the colon tumor, the frequency of the electric field being 30-70 KHz; small cell lung cancer, where the frequency of the electric field is 170-230 KHz; non-small cell lung cancer, where the frequency of the electric field is 120-170 KHz;
and wherein the field energy electrode patch in the brassiere is used for treating breast cancer, the frequency of the electric field being 100-180 KHz;
wherein the field energy electrode patch within the shorts is used to treat tumors which include:

• bladder cancer, where the frequency of the electric field is 100-180 KHz;
• ovarian cancer, the frequency of the electric field being 170-230 KHz;
• The field energy electrode patch in the hat is used to treat intracranial tumors, the frequency of the electric field being 200KHz;
• wherein the field energy electrode patch within the vest is used to treat the tumors comprising:
  • the colon tumor, the frequency of the electric field being 50 KHz;
  • small cell lung cancer, where the frequency of the electric field is 200 KHz; non-small cell lung cancer, where the frequency of the electric field is 150 KHz; and wherein the field energy electrode patch in the brassiere is used for treating breast cancer, the frequency of the electric field being 120-150 KHz; wherein the field energy electrode patch within the shorts is used to treat the tumors comprising: bladder cancer, wherein the frequency of the electric field is 130-150 KHz; ovarian cancer, where the frequency of the electric field is 200 KHz.
  • A thermistor is arranged at the rear of the electrode sheet body, and when the electrode sheet body increases and exceeds a preset value, the electric field generator reduces the output or immediately blocks the output, and the operation is accompanied by an alarm message.

The electrode sheet body is made of ceramic sheet having a high dielectric constant.

Using the above technical solution, the present invention has the following advantages.

In the present invention, the electric field generator is combined with portable clothing devices such as hats, vests, bras, shorts, etc. to form a portable electric field application device that selectively inhibits the growth of certain cells which the patient wears Clothing connected to the field energy electrode patch at the appropriate position, and in accordance with different tumor cells, the intensity of the electric field and the frequency of the pulse signal are adjusted, thereby the growth of tumor cells of various kinds can be inhibited, and it is convenient, safe and convenient to use reliable, and the device is suitable for treating the tumors of various organs and has convenient long-term use.

Figure list

• 1 Figure 11 shows a schematic representation of an electric field generator.
• 2 shows a schematic representation of a device for treating brain tumors with an electric field, which is formed by a connection between the generator of the electric field and a hat with a field energy electrode patch embedded in the interior.
• 3 shows a schematic representation of the inside of the hat after unfolding.
• 4th shows a schematic representation of a field energy electrode patch.
• 5 shows a schematic representation of an unfolded hat made of handkerchief.
• 6th Figure 12 shows a schematic representation of a head-abutting position of the field energy electrode patch in the hat after it has been worn on the head.
• 7th shows a schematic representation of a device for treating the tumor with an electric field, which is formed by a connection between the generator of the electric field and a vest with a field energy electrode plaster embedded in the interior.
• 8th shows a schematic representation of the inside of the vest after unfolding.
• 9 shows a schematic representation of an unfolded vest made of handkerchief.
• 10 shows a schematic representation of a device for treating breast tumors with an electric field, which is formed by a connection between the generator of the electric field and a brassiere with a field energy electrode patch embedded in the interior.
• 11 shows a schematic representation of a field energy electrode plaster arranged on the inside of the brassiere.
• 12th shows a schematic representation of a device for treating the tumor with an electric field, which is formed by a connection between the generator of the electric field and the shorts with a field energy electrode patch embedded in the interior.
• 13 shows a schematic representation of the inside of the shorts after unfolding.
• 14th Figure 12 shows a schematic representation of the unfolded shorts made of handkerchief.
• 15th Figure 12 shows a more detailed schematic of an electric field generator.
• 16 Figure 3 shows a detailed embodiment of the field energy electrode patch.

DETAILED DESCRIPTION

As in 1 to 14th As shown, an apparatus for treating the tumors of multiple organs based on an electric field comprises an electric field generator 100 , one line 107 , a field energy electrode patch 300 and a portable device ( 200 , 400 , 500 , 600 ). As in 1 shown includes an electric field generator 100 a rechargeable battery 101 , a waveform signal generator 102 , a voltage booster 103 and a voltage output switching terminal 104 that are connected to each other. At the electric field generator 100 are four with the voltage output switching terminal 104 connected output interfaces 105 provided, the four output interfaces 105 sequentially output voltages of the same frequency or different frequencies. Any output interface 105 has two sockets and forms a loop with an external circuit.

The electric field generator 100 is for outputting an AC signal with an adjustable voltage waveform, amplitude and frequency, the output voltage is adjustable and has a range of 0 to 65V, and the output waveform of the power supply device is the sine wave, the triangle wave and the square wave, and the output signal of the power supply device through four output interfaces 105 is output sequentially, and where the voltage can be provided in 4 directions, and where the output time of each connection is adjustable in a range from 0.1 second to 10 seconds.

As in 2 shown is one end of the line 107 through an electrode connector 106 with the output interface 105 of the electric field generator 100 connected, the other end to a field energy electrode patch 300 connected is; as in 4th shown comprises the field energy electrode patch 300 a flexible substrate 302 and several in an array on the substrate 302 arranged electrode sheet bodies 301 made of insulating capacitor materials, the electrode sheet body 301 can effectively excite the electric field and avoid the generation of conduction current, and wherein the electrode sheet body 301 with the line 107 connected is. The number of electrode sheet bodies 301 in the array on the field energy electrode patch 300 is 1-100, the frequently occurring number is 2, 3, 4, 9, 12, 16 or 32, the plurality of electrode sheet bodies 301 are connected in parallel to each other. The electrode sheet body 301 is circular or oval, the distance 303 between the adjacent electrode sheet bodies 301 the diameter of the electrode sheet body 301 corresponds.

When with the same diameter of the electrode sheet body 301 the number of the electrode sheet bodies is increased appropriately, the coverage area of the field energy electrode patch becomes 300 increased to increase the area of distribution of the tumors to be treated by the entire device, or by adjusting the position of the field energy electrode patch 300 the device is adapted to the position of the tumors.

• Schritt S101: Verwenden eines zweistufigen Festphasenverfahrens zur Synthese von Pb(1-1,5x)Bi0,5xCe0,5x(Mg1/3Nb2/3)(1-y)TiyO3. Das zweistufige Festphasenverfahren umfasst:
  • Schritt S101-1: Verwenden von MgO und Nb2O5 als Rohstoffe, Wärmehaltung für 2 Stunden bei einer Temperatur von 1000°C bis 1200°C, um MgNb2O6 zu synthetisieren. Nach der Auswahl der Rohstoffe MgO und Nb2O5 sollen sie gemäß dem stöchiometrischen Verhältnis von MgNb2O6 zugeteilt werden; anschließend werden die obigen Rohstoffe mit einem Nasskugelmahlverfahren gemischt; dann werden die gemischten Rohstoffe getrocknet; schließlich erfolgt eine Wärmehaltung für 2 Stunden bei einer Temperatur von 1000°C bis 1200°C, um MgNb2O6 zu synthetisieren. Bevorzugt erfolgt eine Wärmehaltung bei einer Temperatur von 1150°C, wodurch MgNb2O besserer Qualität erhalten wird.
  • Schritt S101-2: Verwenden von MgNb2O6, Pb3O4, TiO2, Bi203, CeO2 als Rohstoffe, Wärmehaltung für 4 Stunden bei einer Temperatur von 820°C bis 850°C, um die Pulver von Pb(1-1,5x)Bi0,5xCe0,5x(Mg1/3Nb2/3)(1-y)TiyO3 zu synthetisieren, dabei bestehen 0,002≤×≤0,04 und 0,05≤y≤0,1, und x und y sind eine Molzahl.
• Der Schritt S101-2 ist insbesondere wie folgt: Zuerst werden MgNb2O6, Pb304, TiO2, Bi2O3 und CeO2 als Rohstoffe verwendet, dabei werden sie gemäß dem stöchiometrischen Verhältnis von Pb(1-1,5x)Bi0,5xCe0,5x(Mg1/3Nb2/3)(1-y)TiyO3 zugeteilt; anschließend werden die obigen Rohstoffe mit einem Nasskugelmahlverfahren gemischt; dann werden die gemischten Rohstoffe getrocknet; schließlich erfolgt eine Wärmehaltung für 4 Stunden bei einer Temperatur von 820°C-850°C, um die Pulver von Pb(1-1,5x) Bi0,5xCe0,5x(Mg1/3Nb2/3)(1-y)TiyO3 zu erhalten; dabei bestehen 0,002<×<0,04 und 0,05≤y≤0,1, und x und y sind eine Molzahl. x beträgt bevorzugt 0,03 und y bevorzugt 0,08. Dadurch werden Pulver besserer Qualität erhalten.

The electrode sheet body is made of a ferroelectric ceramic material having a high dielectric constant (the relative dielectric constant is larger than 8000); wherein the manufacturing method for the ferroelectric ceramic material comprises the following steps:

• Step S101: Use a two-step solid phase method to synthesize Pb (1-1.5x) Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3. The two-step solid phase process includes:
  • Step S101-1: Using MgO and Nb2O5 as raw materials, heat holding for 2 hours at a temperature of 1000 ° C to 1200 ° C to synthesize MgNb2O6. After selecting the raw materials MgO and Nb2O5, they should be allocated according to the stoichiometric ratio of MgNb2O6; then the above raw materials are mixed with a wet ball milling process; then the mixed raw materials are dried; Finally, heat is kept for 2 hours at a temperature of 1000 ° C to 1200 ° C to synthesize MgNb2O6. It is preferred to maintain heat at a temperature of 1150 ° C., as a result of which MgNb2O of better quality is obtained.
  • Step S101-2: Using MgNb2O6, Pb3O4, TiO2, Bi203, CeO2 as raw materials, heat holding for 4 hours at a temperature of 820 ° C to 850 ° C, to make the powders of Pb (1-1.5x) Bi0.5xCe0 To synthesize 5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3, where 0.002 × 0.04 and 0.05 y 0.1, and x and y are moles.
• Specifically, the step S101-2 is as follows: First, MgNb2O6, Pb304, TiO2, Bi2O3 and CeO2 are used as raw materials, thereby becoming Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3 allocated; then the above raw materials are mixed with a wet ball milling process; then the mixed raw materials are dried; Finally, heat retention is carried out for 4 hours at a temperature of 820 ° C-850 ° C to add the powders of Pb (1-1.5x) Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiYO3 receive; where 0.002 <× <0.04 and 0.05 y 0.1, and x and y are a number of moles. x is preferably 0.03 and y is preferably 0.08. This results in powders of better quality.

After the powders of Pb (1-1.5x) Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3 have been synthesized, step S102 is further carried out, and the powders synthesized in step S101 are finely ground . After the fine grinding, a binder is added, granulated and pressed to obtain a blank. The binder is preferably polyvinyl acetate (PVA). The amount of binder added is 5% -8% of the mass of ceramic powders. When the particle size of the ceramic powder particles is larger, the addition amount of the binder is smaller. When the particle size of the ceramic powder particles is smaller, the addition amount of the binder is larger.

By selecting the appropriate doping modification and adjusting the appropriate Mg / Nb / Ti ratio, a ferroelectric ceramic material sintered at a temperature of 1200 ° C.-1250 ° C. can be obtained with a two-step synthesis process. Using special ferroelectric materials (PMN-PT relaxor ferroelectrics), the effect is achieved of conducting the electric field and at the same time blocking the conduction current. Since the impedance of a dielectric capacitor is inversely proportional to the dielectric constant, a ferroelectric material with high dielectric constant and nanopolar microdomains is being developed to reduce the voltage drop on the electrode sheet and to optimize the effect of the electrode sheet for conducting the electric field. At the same time, the dielectric response time of the polar microdomain is optimized and a low-loss material is developed to reduce the loss and prevent the electrode from heating up. The performance is summarized as follows: the material selected is ferroelectric PMN-PT material, in the frequency range from 1 KHz to 1 MHz, the relative dielectric constant is greater than 11500, and the dielectric loss is less than 0.05. To further ensure safety, the ceramic disk is resistant to high voltages under the action of an alternating electric field of 5 kV per millimeter and will not break. The material has high dielectric constant and high energy storage density properties, can be used to manufacture high energy storage density ceramic capacitors, and has good application prospects.

On the back of the electrode sheet body 301 a thermistor is arranged, the generator of the electric field 100 further comprising an alarm device, and wherein when the electrode sheet body 301 increases and exceeds a preset value, the electric field generator 100 the output intensity of the electric field is reduced or the output is blocked immediately, and the process is accompanied by an alarm message; to avoid excessive heat generation in the treated area, causing discomfort or burns to the patient.

In the electric field generator 100 an electrode temperature detection module is furthermore arranged, which detects the temperature of the electrode sheet body through the thermistor and feeds a corresponding temperature detection signal back to the control module of the generator of the electric field, if the temperature exceeds 41 degrees, the output of the generator of the electric field 100 reduced or blocked immediately.

For the substrate 302 A rag can be used with a pressure-sensitive adhesive on both sides, with one side of the rag attached to the Inside of the portable device and the other side on the electrode sheet body 301 is glued; and wherein the electrode sheet body 301 is coated with a conductive gel in which the salt is dissolved to improve its conductivity. On the outermost side of the field energy electrode patch 300 If a protective film is still in place, in use the protective film is removed to expose the conductive gel.

16 Figure 10 illustrates a detailed embodiment of the field energy electrode patch 300 represent, the substrate 302 medical tape, and being attached to the edge of the substrate 302 several notches 309 are provided which is suitable for forming an envelope on the head or other body parts of the patient, and wherein on the substrate 302 several positioning discs 304 are glued on, whereby it is the positioning disc 304 is a silicone positioning disk, the electrode sheet body 301 to attach, and being attached to the positioning disc 304 a plurality of positioning holes are provided in which the electrode sheet bodies 301 of ferroelectric ceramic material are glued, with the electrode sheet body on the flexible circuit board 305 are welded, and wherein the plurality of electrode sheet bodies 301 through the flexible circuit board 305 with an external line 306 are connected, being at the weld between the flexible circuit board 305 and the external line 306 a sleeve 307 is put on, and being for the sleeve 307 a silicone sleeve is used to prevent the weld point from hurting the human body. The external line 306 is with the line 107 connected.

To ensure good contact between the electrode sheet bodies 301 and to ensure the human body, the electrode sheet bodies protrude 301 0.1-0.2mm out of the positioning disc. So that the electrode sheet body 301 fit better to the head and other parts and make it easier for the patient to carry it, is on the positioning disc 304 a receiving slot 308 provided by the flexible circuit board 305 can go through.

There are several field energy electrode patches on the inside of the portable device 300 300 arranged; wherein the portable device is one or any combination of hats 200 , West 400 , Bras 500 and shorts 600 and wherein the portable device can further be a blanket, a scarf and a coat, etc.

The portable device is made of elastic fabric and can be wrapped on the human body, making the field energy electrode patch 300 fit closely to the human body. Using a highly elastic, skin-friendly fiber textile, the field energy electrode plasters 300 close to the human body (e.g. head, chest, etc.). At the same time, the human body does not feel strongly connected. The material is the same or similar to the material of the girdle, etc., and can be nylon, polyester fiber, etc.

The portable device can optionally be made from a handkerchief 001 be made with high elasticity, thereby it can be avoided that the portable device increases the burden on the user and causes other discomfort. For example, in summer and other high temperature seasons, the handheld device made of knitted cloth will not lead to overheating of the supporting part of the user.

The electric field generator 100 Outputs a low-intensity, low-frequency electrostatic wave, where the frequency intensity is 0-55Vpp, the electric field intensity is 0-5V / cm, and the modulation frequency is 50-500KHz.

Preferably, the maximum output voltage of the electric field generator is adjustable and has a range of 50 to 120Vpp, wherein the output waveform of the power supply device is the sine wave, the triangle wave and the square wave, and the output signal of the power supply device is sequentially outputted through at least four connections, and wherein the voltage is provided in at least 2 directions, and wherein the output time of each connection is adjustable in a range from 0.1 second to 10 seconds. The ability to break open the membrane and destroy other cell structures is improved by the application of a pulsed electric alternating current field with a frequency of about 50 kHz to 500 kHz; When this type of electric field is applied to the tissue, the force exerted on the intercellular organelles has a “hammering” effect, thereby applying innumerable force pulses (or blows) per second to the organelles, which causes the movement of organelles and cells Substances of different sizes from the two sub-cells to the bridge (or neck) are amplified, thereby increasing the possibility of a cell membrane rupture at the bridge position. The force exerted on the intracellular organelles also affects the organelles themselves and can cause the organelles to collapse or rupture.

As in 2 Shown is an electric field device for treating a brain tumor created by a connection between the electric field generator 100 and one cap 200 formed with a field energy electrode patch embedded inside. As in 3 depicted includes the hat 200 an upper tab located in the central portion 201 , one around the upper lobe 201 arranged anterior lobes 202 , a posterior lobe 203 , a left lobe 204 and a right lobe 205 . On the upper lobe 201 , the one around the upper lobe 201 arranged anterior lobes 202 , the posterior lobe 203 , the left lobe 204 and the right lobe 205 each is a field energy electrode patch 300 arranged, each field energy electrode patch 300 each through a line to the electric field generator 100 connected is. When using different field energy electrode patches 300 by inserting and pulling out the corresponding electrode connector 106 be connected to the electric field.

As in 6th shown, can after wearing the hat 200 on the head 002 the field energy electrode patch located at a corresponding position 300 be connected to the electric field in accordance with different locations of the brain tumor.

The field energy electrode patch in the hat 200 is used to treat intracranial tumors, the frequency of the electric field being 170-230KHz. The frequency of the electric field is preferably 200 kHz.

As in 7th Shown is an electric field device for treating the tumor created by a connection between the electric field generator 100 and a vest 400 with a field energy electrode patch embedded inside 300 educated. As in 8th pictured includes the vest 200 a dorsal flap 401 as well as a left lobe 402 and a right lobe 403 each on either side of the back lobe 401 are arranged. On the top and bottom of the back flap 401 each is a field energy electrode patch 300 arranged, the one on the upper part of the back flap 401 existing field energy electrode patches 300 of the vest part of the human body, while that of the lower part of the back flap 401 existing field energy electrode patches 300 corresponds to the organs at the waist of the human body. on the left lobe 402 and the right lobe 403 is also a field energy electrode patch 300 arranged. As in 8th and 9 shown is the field energy electrode patch 300 at a junction of the left lobe 402 and the right lobe 403 with the dorsal lobe 401 arranged, here correspond to the field energy electrode patches 300 the parts on either side of the trunk of the human body. When the field energy electrode patch 300 is moved outward, it corresponds to the chest cavity and lungs when it is adjusted upwards, while it corresponds to the abdominal organs such as the intestines, stomach, liver and other organs when it is adjusted downwards.

When the field energy electrode patch 300 in the vest 400 is used to treat colon tumors, the frequency of the electric field is 30-70 kHz, preferably 50 kHz. When used to treat small cell lung cancer, the frequency of the electric field is 170-230 KHz, preferably 200KHz. When used to treat non-small cell lung cancer, the frequency of the electric field is 120-170 KHz, preferably 150 KHz.

10 Fig. 13 shows a schematic representation of an electric field device for treating breast tumor produced by a connection between the electric field generator 100 and a bra 500 with a field energy electrode patch embedded inside 300 is formed as in 11 shown is the field energy electrode patch 300 on the inside of the spherical crown-shaped base 501 arranged, the electrode sheet body 301 placed around the mammary glands to effectively apply an electric field to the tumor cells in the mammary glands.

The field energy electrode patch 300 in the brassiere can be used for treating breast cancer, wherein the frequency of the electric field is 100-180 KHz, and the frequency of the electric field is preferably 120-150KHz.

12th Figure 3 shows a schematic representation of an electric field device for treating the tumor created by a connection between the electric field generator 100 and the shorts 600 with a field energy electrode patch embedded inside 300 is formed as in 13 pictured include the shorts 60 a posterior lobe 601 and one on each of the left and right sides of the posterior lobe 601 arranged left lobe 602 and right lobe 603 , being at an appropriate position of the posterior lobe 601 , of the left lobe 602 and the right lobe 603 one field energy electrode patch each 300 is arranged, and wherein the field energy electrode patch 30th correspond to the bladder, ovary and other parts of the human body.

The field energy electrode patch 300 is on the connecting part between the left lobe 602 as well as the right lobe 603 and the posterior lobe 601 arranged with the field energy electrode patch 300 after wearing are located on the two sides of the waist and hips of the human body; as in 14th As shown, the shorts have a higher waist shape with the field energy electrode patch 300 each on the left lobe 602 and the right lobe 603 and the positions are relatively high, and wherein after wearing the field energy electrode patches correspond to the two sides of the abdomen of the human body. When the field energy electrode patch 300 at relatively higher positions on the left and right sides of the posterior lobe 601 are arranged, correspond to the field energy electrode patches 300 after wearing the lateral back part of the waist of the human body.

When the field energy electrode patch in the shorts 600 is used to treat bladder tumors, the frequency of the electric field is 100-180KHz, preferably 130-150 KHz. When it is used for treating ovarian cancer, the frequency of the electric field is 170-230 KHz, preferably 200KHz.

1. 1. Stromversorgungsmanagementmodul:
   1. 1) Das Stromversorgungsmanagementmodul ist dazu ausgebildet, die über den Adapter eingegebene Stadtstromversorgung in die Gleichstromversorgung umzuwandeln, um sie jeweils für das Steuerhostmodul, das DC-DC-Modul und die wiederaufladbare Batterie bereitzustellen;
   2. 2) Das Stromversorgungsmanagementmodul ist dazu ausgebildet, die durch die wiederaufladbare Batterie ausgegebene DC-Stromversorgung jeweils für das Steuerhostmodul und das DC-DC-Modul umzuwandeln.
2. 2. DC-DC-Modul:
   • Das DC-DC-Modul ist dazu ausgebildet, die durch das Stromversorgungsmanagementmodul ausgegebene DC-Stromversorgung in die DC-Stromversorgung umzuwandeln und diese für das Leistungsverstärkermodul bereitzustellen.
3. 3. Wiederaufladbare Batterie:
   1. 1) Die Wiederaufladbare Batterie ist dazu ausgebildet, beim Anschluss ans Stromnetz die durch das Stromversorgungsmanagementmodul ausgegebene IDC-Leistung zu speichern;
   2. 2) Die Wiederaufladbare Batterie ist ferner dazu ausgebildet, wenn es nicht ans Stromnetz angeschlossen ist, die DC-Stromversorgung ans Stromversorgungsmanagementmodul auszugeben;
   3. 3) Dadurch, dass ein Spannungsrückkopplungssignal ans Steuerhostmodul übertragen wird, wird die Kapazität der wiederaufladbaren Batterie in Echtzeit überwacht;
   4. 4) Vorhandensein einer Batterieschutzfunktion, um die durch eine Überladung und Überentladung verursachten Batterieschäden zu verhindern und die Batterielebensdauer zu verlängern.

15th Figure 12 shows a more detailed schematic of an electric field generator 100 according to the present invention, wherein the electric field generator 100 comprises a power management module, a rechargeable battery, a control host module, a DC-DC module, a signal generation module, a power amplifier module, a power detection module, and a temperature sensing module.

1. 1. Power management module:
   1. 1) The power supply management module is configured to convert the city power supply input through the adapter into the DC power supply to provide it to the control host module, the DC-DC module and the rechargeable battery, respectively;
   2. 2) The power supply management module is configured to convert the DC power supply output by the rechargeable battery for the control host module and the DC-DC module, respectively.
2. 2. DC-DC module:
   • The DC-DC module is designed to convert the DC power supply output by the power supply management module into the DC power supply and to provide this for the power amplifier module.
3. 3. Rechargeable battery:
   1. 1) The rechargeable battery is designed to store the IDC power output by the power supply management module when connected to the power grid;
   2. 2) The rechargeable battery is also designed to output the DC power supply to the power supply management module when it is not connected to the power grid;
   3. 3) By transmitting a voltage feedback signal to the control host module, the capacity of the rechargeable battery is monitored in real time;
   4. 4) Existence of a battery protection function to prevent the battery damage caused by overcharge and overdischarge and to extend the battery life.

Claims (8)

Device for treating tumors of multiple organs based on an electric field, characterized in that it comprises: an electric field generator for outputting alternating current signals with adjustable voltage waveform, amplitude and frequency; a lead, one end of which is connected to the electric field generator and the other end to a field energy electrode patch; a field energy electrode patch comprising a flexible substrate and a plurality of electrode sheet bodies made of insulating capacitor materials arranged in an array on the substrate, the electrode sheet body being able to effectively excite the electric field and avoid generation of conduction current, and the electrode sheet body being connected to the lead; a portable device, wherein the plurality of field energy electrode patches are disposed on the inside of the portable device; and wherein the portable device comprises any one or any combination of hats, vests, bras and shorts. Device according to Claim 1 , characterized in that the portable device generally consists of medical nonwovens and other elastic materials, depending on the treatment position 1 to 100 individual electrodes are embedded and connected via a flexible circuit board to form an electrode array that is glued or wrapped on the human body, so that the field energy electrode patch fits closely to the human body. Device according to Claim 1 , characterized in that the output amplitude of the electric field generator is 0-120Vpp, the intensity of the electric field is 0-5V / cm and the modulation frequency is 50-500KHz. Device according to Claim 3 , characterized in that the maximum output voltage of the electric field generator is adjustable and has a range of 50 to 120Vpp, wherein the output waveform of the power supply device is the sine wave, the triangle wave and the square wave, and the output signal of the power supply device through at least four terminals sequentially is output, and wherein the voltage is provided in at least 2 directions, and wherein the output time of each connection is adjustable in a range from 0.1 second to 10 seconds. Device according to Claim 3 characterized in that field energy electrode patches are used in the hat for treating intracranial tumors, the frequency of the electric field being 170-230KHz; wherein the field energy electrode patch within the vest is used to treat tumors comprising: the colon tumor, the frequency of the electric field being 30-70 KHz; small cell lung cancer, where the frequency of the electric field is 170-230 KHz; non-small cell lung cancer, where the frequency of the electric field is 120-170 KHz; and wherein the field energy electrode patch in the brassiere is used for treating breast cancer, the frequency of the electric field being 100-180 KHz; wherein the field energy electrode patch within the shorts is used to treat the tumors comprising: bladder cancer, wherein the frequency of the electric field is 100-180 KHz; ovarian cancer, where the frequency of the electric field is 170-230 KHz. Device according to Claim 1 , characterized in that a thermistor is arranged on the rear side of the electrode sheet body, wherein when the electrode sheet body increases and exceeds a preset value, the generator of the electric field reduces the output or immediately blocks the output, and the process is accompanied by an alarm message is. Device according to Claim 1 , characterized in that the electrode sheet body is made of ceramic sheet having a high dielectric constant. Device according to Claim 7 , wherein the ceramic material has been produced in a process with the following steps: 1) Using a two-step solid phase process for the synthesis of Pb (1-1.5x) Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3, wherein the two-step solid phase process comprises: 1-1) using MgO and Nb2O5 as raw materials, heat holding for 2 hours at a temperature of 1000 ° C to 1200 ° C to synthesize MgNb2O6; 1-2) Using MgNb2O6, Pb3O4, TiO2, Bi2O3, CeO2 as raw materials, heat retention for 4 hours at a temperature of 820 ° C to 850 ° C to make the powders of Pb (1-1.5x) Bi0.5xCe0, 5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3 to synthesize; and wherein 0.002 × 0.04 and 0.05 y 0.1, and x and y are a number of moles; 2) Fine grinding of the powders of Pb (1-1.5x) Bi0.5xCe0.5x (Mg1 / 3Nb2 / 3) (1-y) TiyO3 synthesized in step 1), after the fine grinding a binder is added and granulated and pressed to get a blank. 3) removing the binder to remove the organics in the blank; 4) Sintering the blank to obtain a ferroelectric ceramic material.

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