DE102006050806A1 - Antimicrobial compositions and wound dressings - Google Patents

Abstract

A wound dressing and antimicrobial material are provided. The wound dressing comprises a carbonaceous material, a noble metal with which the carbonaceous material is applied, and optionally a resilient base layer, wherein the carbonaceous material is selected from a group consisting of activated carbon, graphite, carbon, and a combination thereof, while the Noble metal is selected from a group consisting of Ag, Au, Pd, Pt, Cu, Zn and a mixture of these. The antimicrobial composition is for external application to the skin and includes the above-mentioned carbonaceous material as well as the noble metal with which the carbonaceous material was applied.

Description

FIELD OF THE INVENTION

The The present invention relates to the use of a noble metal, coated on a carbonaceous material, in an antimicrobial Composition and an antimicrobial wound dressing. Especially For example, the present invention relates to an antimicrobial composition and a wound dressing containing a precious metal on activated carbon or porous Graphite is applied. Special collecting the present invention on and destroyed the microbes that are nearby the said composition or wound dressing, to prevent microbial infection.

BACKGROUND OF THE INVENTION

In In the past, antimicrobial drugs are directly on the injured body part been applied. Lately, depending on the type of wound medical wound dressings like medical associations, Wound dressings, bandages with gelatin film and wound plaster for covering the wound used. The wound is so isolated and protected inappropriate contact with the outside air, which prevents infections and relieves pain.

It is known that noble metals such as silver, gold, palladium, platinum, copper and zinc in wound dressings effectively kill microbes. The use of these precious metals in associations has also been revealed in numerous documents. For example, Robert Edward Burrell et al. ( US 6,692,773 B2 ) the use of a noble metal such as silver, gold, palladium or platinum or an alloy or compound of these in nanocrystalline form having a grain size of less than 100 nm, as a coating for a substance to produce a dressing with antiproliferative action. Widemire ( US 5,782,788 ) discloses the application of a layer of silver foil on a pad of gauze to prevent the proliferation of bacteria, viruses and fungi. Fabo ( US 5,340,363 ) discloses a dressing consisting of an outer absorbent layer and an inner porous water repellent layer woven of elastic fibers and surrounded by a soft water-repellent silicone or polyurethane gel, the gel being a carrier for an antibacterial agent (eg zinc), analgesic may serve as an active ingredient for stimulating wound healing.

Klippel et al. ( US 3,830,908 ) disclose the use of micronized allantoin as a carrier for a bactericidal or bacteriostatic ingredient (such as silver-citro-allantoinate). The composition is applied to the surface of a plastic vacuum splint or other dressing product to provide antibacterial activity depending on the molecular dissociation. McKnight et al. ( US 3,800,792 ) disclose a surgical dressing consisting of a layer of a tanned and re-tanned collagen foam film which is applied to a thick continuous layer of inert polymer. The collagen layer contains the finest parts of silver metal added by immersing the collagen film in Tollens reagent. Stowage water ( US 2,934,066 ) discloses a dressing of absorbent metal coated fibers, such as carded nonwoven coated with aluminum and reinforced by compressed cellulose, and polyamide fibers coated with vacuum deposited silver.

In In view of the above-described prior art, it becomes clear that antimicrobial precious metals are often used for wound healing be, especially in associations. However, the use of these precious metals is still concentrated on the precious metal alone and mostly on the precious metal in the form an alloy or compound. The use of a precious metal as a coating on a carbonaceous material is not disclosed. Furthermore, although by use in the state the technique can be achieved an antimicrobial effect, the Microbes only in "accidental" contact with the Killed precious metal. Out For this reason, the precious metals have only a "passive" antimicrobial Effect.

As is known to those of ordinary skill in the art, the above noble metals can counteract microbes only in the presence of moisture. Therefore, in practical use, the medium must always be moist. If necessary, water is added to create a humid environment. For example, according to US 6,692,773 B2 a nanocrystalline precious metal applied to a dressing for external application to the skin, a moist state must be maintained in the dressing, so that the precious metal unfolds the desired efficacy (see column 6, line 64 to column 7, line 17). Similarly disclosed US 6,692,773 B2 further, the benefits of an absorbent layer in the dressing that holds the moisture in it, thus activating the precious metal. (See said patent, column 5, lines 33 to 37). Such a need for moisture is also noted in other documents, such as the content that is available through the website http://www.burnsurgery.org/Modules/silver/images/section7b/Mid_partial_thickness3copy.jpg.

The present invention describes a another type of therapeutic application of a noble metal which has antimicrobial activity. In a preferred embodiment, the present invention can actively attract and kill microbes, effectively reducing or even preventing microbial infection.

SUMMARY OF THE INVENTION

To of the present invention may be the carbonaceous described therein Material in the form of a powder, a particle, a fiber or a slide exist unless otherwise specified.

One The aim of the present invention is to provide a wound dressing, a carbonaceous material, a carbonaceous material applied noble metal and, optionally, a resilient base layer includes. The carbonaceous material is selected from a group which made of activated carbon, graphite, carbon and a combination of these exists, and the precious metal is selected from a group that of silver, gold, palladium, platinum, copper, zinc and a combination consists of these. The dressing may optionally be (another) therapeutic contain active component (s).

One Another object of the present invention is to provide a Kits containing the wound dressing of the present invention and a fastener includes. The fastener may be any tool that attached to the wound dressing on the skin. For example, the fastener a dressing, a bandage or a wound dressing.

One Another object of the present invention is an antimicrobial Composition to the external To provide application on the skin based on carbon Material coated noble metal, wherein the carbonaceous material selected is made up of a group consisting of activated carbon, graphite, carbon and a combination of these, and the precious metal is selected from a group consisting of silver, gold, palladium, platinum, Copper, zinc and a combination of these. The named composition may optionally include other therapeutically active components.

In The present invention relates to the use of an activated carbon or porous Graphite is preferred as the carbonaceous material. It is believed, that the activated carbon / the porous Graphite on his / her surface Contracting microbes and absorbing them, due to the electrostatic interactions or Van der Waals forces between the microbes and the surface activated carbon / porous Graphites as well as due to the bioaffinity of the activated carbon / porous graphite. In contrast to the passive effect in the prior art in which the microbes only in "accidental" contact with the Destroyed precious metal and killed be, show the embodiments The present invention thus provides an active method of dressing and killing of Microbes in the environment of the precious metal to a better antimicrobial To provide effect. Furthermore is it in one embodiment, is not used in the activated carbon as the carbonaceous material necessary to add moisture. In other words, the present invention describes in comparison to the prior art, moisture and / or moisture containing component such as an absorbing layer for activation The precious metal requires a simpler way to get the desired one to achieve antimicrobial advantage.

BRIEF DESCRIPTION OF THE DRAWINGS

1 Figure 11 shows a schematic representation of an embodiment of the wound dressing of the present invention wherein the wound dressing is a wound dressing.

2 Figure 11 is a schematic representation of another embodiment of the wound dressing of the present invention wherein the wound dressing is a wound dressing.

3 FIG. 12 is a schematic representation of another embodiment of the wound dressing of the present invention wherein the wound dressing is made of gauze; FIG. 3A shows a partially enlarged front view of the gauze.

4 Fig. 3 shows a schematic representation of another further embodiment of the wound dressing of the present invention wherein the wound dressing is a sticking plaster.

5 shows a cross-sectional view along the line 5-5 out 4 ,

DESCRIPTION OF THE INVENTION

Of the Wound dressing of the present invention comprises a carbonaceous Material, a precious metal that coats on the carbonaceous material was, and optionally an elastic base layer. The elastic Base layer comprises a first surface and a second surface. The precious metal with the carbonaceous material is at least a part said first surface applied.

The present in the wound dressing of the present Invention containing elastic base layer may be porous or drug impermeable. If a gauze bandage or an adhesive plaster is desired, the elastic base accordingly consists of a porous material, preferably of a non-adhesive material. If wound dressing is desired, a drug-impermeable base should be used. Materials that are conventionally used as a wound dressing and that also meet the above-mentioned cellular or drug impermeable requirements can be used in the present invention. The porous base layer may be made, for example, but not limited to, from a woven fabric or from a nonwoven fabric consisting of one or more of the following materials: natural fiber, polyolefin fiber, polyester fiber, polyurethane fiber, polyamide fiber, polycellulose fiber and cotton fiber. Nonwoven fabric is preferred. Polymers suitable for preparing a drug-impermeable base include polyvinyl chloride, polyvinyl dichloride, polyolefin (eg, ethylene-vinyl acetate copolymer, polyethylene and polypropylene), polyurea and polyesters (eg, polyethylene terephthalate). The drug impermeable base may be a single polymer layer or a single polymer film, or a composite laminate consisting of multiple polymer layers.

The carbonaceous material in the wound dressing of the present invention Invention is selected from the group consisting of activated carbon, graphite, carbon and a combination of these. Activated carbon or porous graphite are favored. For example (but not limited to) activated carbon fiber, Coal in particle or powder form, porous graphite as elastic Graphite or expanded graphite and / or platelets by compression made of activated or graphitic carbon in powder or particle form were used. The precious metal is selected from a group consisting of silver, gold, palladium, platinum, copper, zinc and a combination thereof, preferably silver.

All suitable methods, such as immersion, thermocracking, electroplating, electroless metallization or vacuum metallization can be used to coat the precious metal on the carbonaceous material. About that In addition, the noble metal may be applied to the carbonaceous material in any known manner Material to be coated. To the precious metal ion, which antimicrobial activity shows to solve effectively, should be the size of the precious metal particles on the carbonaceous material not more than about 200 nm be, preferably not more than 100 nm and in the best case not more than 50 nm.

The Preparation of a silver-coated carbonaceous material is shown as an example to illustrate several methods for producing a noble metal coated carbonaceous Material according to the present Invention can be used.

Procedure I:

a. Immersion in a silver nitrate solution

A Activated carbon fiber is used for Immersed in a silver nitrate solution for 1 to 720 minutes to pick up the silver the surface to reduce the activated carbon fiber, followed by a drying step, to remove the water phase. The pH of the silver nitrate solution is maintained between 3 and 8. The drying step is in a temperature range between 25 ° C to 150 ° C performed.

b. High temperature thermal cracking

The Silver-containing activated carbon fiber is used in a controlled Temperature of 120 ° C up to 450 ° C for 5 to Placed in a high-temperature oven for 120 minutes for the silver on the surface of the Activated carbon fiber breaking into ultrafine metal particles. To the Oxidation or podsolation of the activated carbon fiber should be prevented the high temperature thermocracking preferably in a vacuum or be carried out in the presence of an inert gas such as nitrogen.

c. To wash

The thermocracked, high temperature, silver-containing activated carbon fiber is for Washed in water for 1 minute to 600 hours to remove the excess silver from the surface to remove the activated carbon fiber. After this step, the washed Activated carbon fiber burned to a silver-coated activated carbon fiber manufacture.

The silver-carrying activated carbon fiber produced by the process described above has a BET specific surface area of over 400 m / g, carbon content of over 50% by weight, silver content of over 0.001% by weight of the activated carbon fiber and a density of over 1, 8 g / m ³ . For the above-described method, an activated carbon fiber made of a material selected from a group consisting of polypropylene nitrile fiber, cellulose fiber, bitumen fiber, phenol fiber and a combination thereof may be used.

The relevant details of the above-described manufacturing process can be found in Taiwanese (ROC) Patent Publication No. 5,254,254. 0059115 ( TW 0059115 ). In addition, the preparation of the silver-carrying activated carbon fiber also be read in JP 10-99678 ; TA Oya, T. Wakahara, and S. Yoshida, Carbon, 31, 1243-1247, 1993 ; Fu, R., H. Zeng, and Y. Lu, "Studies on the Mechanisms of the Reaction of Activated Carbon Fibers with Oxidants," Carbon, 32 (4), 593-598 (1994). ; and Wang, YL, YZ Wan, XH Dong, GX Cheng, HM Tao, and TY Wen, "Preparation and Characterization of Antibacterial Viscose-based Activated Carbon Fiber Supporting Silver," Carbon, 36 (11), 1567-1571 (1998). , The above mentioned documents are included for reference.

Procedure II:

An electrochemical triode system is used wherein the auxiliary electrode is titanium-coated platinum, the working electrode is graphite and the reference electrode is reticulated silver wire. The reference electrode is arranged above the working electrode. An electrolytic solution is prepared by dissolving AgNO ₃ solids in water at a concentration of 0.001M. A graphite chip, an activated carbon fiber, a carbon fiber or a graphite fiber is dipped in the electrolytic solution and electroplated at an overpotential of -20mV in a pulsed galvanization manner. After 5 to 100 cycles, the surface of the graphite plate, the activated carbon fiber, the carbon fiber or the graphite fiber is coated with silver particles of a grain size of not more than 200 nm

Procedure III:

An electrochemical diode system is used, with a graphite plate being both cathode and anode. A graphite chip, activated carbon fiber, carbon fiber or graphite fiber is dipped in 0.001M of AgNO ₃ electrolyte solution and electroplated with an electron current of -5mA for 10 seconds. The surface of the graphite plate, the activated carbon fiber, the carbon fiber or the graphite fiber is coated with silver particles of a grain size of not more than 200 nm

If that with precious metal-carrying carbonaceous material that is present for the wound dressing When used in the form of fiber, it can be considered as Fiber, cloth, felt, tape or yarn can be used. Optionally, fabric fabrics (e.g., silver-carrying Activated carbon materials) or nonwovens made of carbon fibers or from a fiber mixture containing carbon fibers, or a carbon paper made of carbon fibers or a fiber blend, containing carbon fibers and an optional resin, directly for manufacturing of the wound dressing of the present invention. The Use of a base layer becomes unnecessary. In addition, the carbonaceous Material mixed in a polymer material to be like synthetic Provide one or more layers of the wound dressing.

If the base layer of the wound dressing is a porous base, the Precious metal coated carbonaceous material continuously or discontinuously on at least a portion of the first surface of the Base are applied. For example (but not exclusively) can the noble metal coated carbonaceous material having a first adhesive component are mixed, so that with the mixture the first surface The mixture is covered to the connection between the carbonaceous Material and the base to improve. Therefore, if the Mixture layer of the wound dressing in contact with the wound or the surrounding skin, an adhesive that does not irritate the skin, preferably a pressure-sensitive adhesive, better than the first adhesive. The first adhesive can also be applied to the first surface of the Base layer are applied, then the noble metal is coated carbonaceous material applied to the adhesive. If the carbonaceous material is a carbon pulp such as e.g. cloth is, can the carbon fiber layer and the base layer e.g. by ultrasonic welding together be connected to coat the two layers, or simply by The addition an additional one Adhesive layer that connects the two layers together. As a result, the wound dressing is made in the form of a sticking plaster.

If the base layer of the wound dressing is drug impermeable, For example, the noble metal-coated carbonaceous material can be used directly on at least a part of the first surface of the base as a material layer be applied from carbonaceous material. If accordingly the carbonaceous material is a carbon fiber, the carbon fiber can on at least a part of the first surface of the base as a fabric layer be applied. The carbon layer may be on the base layer by ultrasonic welding be applied. In this case, the carbon layer is made Carbon fiber and a natural or synthetic fiber. She can only Carbon fiber included. Optionally, an additional adhesive layer between the first surface the base and the layer of carbonaceous material used be used to connect the carbonaceous material layer with the first surface. Alternatively, the carbonaceous material layer may enter directly Contain adhesive. In this case, if the carbonaceous Material layer in contact with the wound or surrounding skin Preferably, an adhesive that does not irritate the skin, preferably a pressure-sensitive adhesive.

Pressure-sensitive adhesives known to be commonly used in wound dressings may be used in the present invention. For example, the pressure-sensitive adhesives disclosed in U.S. Pat US 4,675,009 . US 4,696,854 . US 5,536,263 . US 5,741,510 . US 5,972,377 and US Pat. No. 6,495,158 B1 disclosed. The above patents are attached to this document for reference. For example, but not exclusively, the pressure-sensitive adhesives that can be used in the present invention include the following pressure-sensitive adhesives for use in a percutaneous wound dressing: polyacrylate, siloxane, or polyisobutadiene.

Of the Wound dressing of the present invention may optionally include other therapeutic Active components include, for additional therapeutic benefits to grant. The therapeutically active component can either be directly in the Layer with the noble metal coated, carbonaceous material be incorporated or they can be individually in a separate Layer be present. If the therapeutically active component and the carbonaceous material is in separate drug layers, For example, the layer containing the carbonaceous material may intervene the base layer and the drug layer are placed. In this In the case, as mentioned above, the base layer may be a porous base layer and the carbonaceous material can be applied to the base become. Furthermore, the drug layer may also have a pressure-sensitive Adhesive component include that for a percutaneous wound dressing suitable is. As an alternative, the carbonaceous material inserted between the two drug layers (i.e., in the order Base layer, drug layer, layer of carbonaceous Material and drug layer). The therapeutically active component and the pressure-sensitive adhesive layer contained in the drug layers can exist be either the same or different.

each therapeutically active component for the healing of skin wounds can for the Wound dressing of the present invention can be used. For example (but not exclusively) includes the therapeutically active component responsible for the wound dressing can be used in the present invention, an antifungal Active substance such as erythromycin, tetracycline, clindamycin, cephalosporin, Acrisorcinol, haloprogin, iodochlorhydroxyquin, tolnaftate and triacetin, as well as drug components against injury, burn and scalding such as Centella asiatica, econazole nitrate, mafenide, mupirocin and povidone iodine.

optional For example, the wound dressing of the present invention also includes a Protective layer on the outer surface of the Material layer containing a pressure-sensitive adhesive for protection of the material (The material layer may be a drug layer, a layer made of carbonaceous material or a separate adhesive layer). The protective layer may be a single layer of material or two layers of material, partially overlapping, be. All known protective layers used in wound dressings can be for the present Invention can be used. For example (but not exclusively) you can Film consisting of one or more of the following materials be used as a protective layer: polyurethane, nylon, polyamide, Polycellulose, polyvinyl chloride, polyvinyldichloride, polyolefin (e.g. Ethylene-vinyl acetate copolymer, Polyethylene and polypropylene), polyurea and polyesters (e.g., polyethylene terephthalate).

The known technique used in the wound dressing of the present invention is briefly explained to the explanation of the present invention to facilitate. The technical characteristics and contents of the present Invention will be explained in more detail with reference to the drawings. However, they are the corresponding drawings are not drawn in actual proportion, since they only clarify the characteristics of the present invention should.

1 FIG. 11 is a side view of one embodiment of the wound dressing of the present invention wherein the wound dressing comprises a wound dressing (FIG. 1 ) for healing a wound. The wound dressing ( 1 ) contains a base layer ( 10 ), with a first surface ( 11 ) and a second surface ( 12 ), an antimicrobial layer ( 20 ) on said first surface, and a protective layer ( 40 ) on said antimicrobial layer ( 20 ). The antimicrobial layer ( 20 ) comprises a pressure-sensitive adhesive (not shown) and a silver-coated carbonaceous material ( 30 ) as well as optionally a therapeutically active component (not shown) for healing wounds from injuries, burns or scalds. The carbonaceous material may be activated carbon, graphite, carbon or a combination of these, preferably activated carbon, porous graphite or a combination thereof. Some examples include (but are not limited to) activated carbon fiber, particulate or powdered carbon, and / or porous graphite such as elastic graphite or expanded graphite. When using the wound dressing ( 1 ) the protective layer ( 40 ) of said antimicrobial layer ( 20 ) and then the wound dressing ( 1 ) with the side containing the antimicrobial layer ( 20 ), on the wound or injured body part.

2 shows a side view of a ande ren embodiment of the wound dressing of the present invention. The schematic wound dressing ( 1 ) contains a base layer ( 10 ), with a first surface ( 11 ) and a second surface ( 12 ), an antimicrobial layer ( 20 ) on said first surface ( 11 ), a medicinal layer ( 50 ) applied to said antimicrobial layer ( 20 ) and a protective layer ( 40 ) on said medicinal layer ( 50 ). The medicinal layer ( 50 ) includes a pressure-sensitive adhesive (not shown), a therapeutically active component (not shown) for healing wounds from burns and scalds. The antimicrobial layer ( 20 ) consists of a silver-containing carbonaceous material and may also contain an adhesive. The carbonaceous material may be activated carbon, graphite, carbon or a combination thereof; preferably activated carbon, porous graphite or a combination of these. Some examples include (but are not limited to) activated carbon fiber, powder or particulate coal and / or porous graphite such as elastic graphite or expanded graphite. When using the wound dressing ( 1 ) the protective layer ( 40 ) of said drug layer ( 50 ) and then the wound dressing ( 1 ) with the side containing the medicinal layer ( 50 ), on the wound or injured body part. Optionally, another drug layer is sandwiched between the base layer ( 10 ) and the antimicrobial layer ( 20 ) set.

3 FIG. 11 is a side view of another embodiment of the wound dressing of the present invention wherein the wound dressing is a gauze bandage (FIG. 100 ). 3A is a partially enlarged view of the gauze bandage ( 100 ). As in 3 and 3A shown, includes the gauze bandage ( 100 ) a base layer of fibrous material ( 110 ), which has a first surface ( 111 ) and a second surface ( 112 ) and an antimicrobial coating ( 120 ) applied to at least a portion of said first surface. The antimicrobial coating ( 120 ) contains a silver-carrying carbonaceous material (not shown) and a pressure-sensitive adhesive (not shown). The carbonaceous material may be activated carbon, graphite, carbon or a combination thereof; preferably activated carbon, porous graphite or a combination of these. Some examples include (but are not limited to) activated carbon fiber, powder or particulate coal and / or porous graphite such as elastic graphite or expanded graphite. In this embodiment, in which the silver-carrying carbonaceous material is carbon fiber, the carbon fiber may be incorporated directly into the fiber of the base layer (FIG. 110 ) are incorporated, thereby an adhesive or an additional fiber layer is no longer necessary.

4 FIG. 12 shows a schematic representation of another embodiment of the wound dressing of the present invention, wherein the wound dressing comprises a plaster ( 200 ). 5 shows a cross-sectional view along the line 5-5 4 , As shown in the 4 and 5 includes the adhesive plaster ( 200 ) a base layer ( 210 ), which has a first surface ( 211 ) and a second surface ( 212 ), a pressure-sensitive adhesive ( 220 ) located on said first surface ( 210 ), an antimicrobial fabric layer ( 230 ), preferably placed in the middle of the base view ( 21 ), and two protective layers ( 240 ), which partially overlap. The antimicrobial material layer ( 230 ) is a scrim layer containing a silver-carrying carbon fiber, preferably silver-carrying activated carbon fiber. Although the antimicrobial layer ( 230 ) is shown as a gauze, the antimicrobial layer may be a flexible carbonaceous material plate or a nonwoven fabric or fiber paper made of silver-carrying carbon fiber. Optionally, a drug layer (not shown), with another drug component for healing wounds from injuries, burns or scalds on the antimicrobial layer ( 230 ) to provide additional therapeutic effect.

In the wound dressing of the present invention wherein the noble metal on the activated carbon or the porous Graphite was applied, takes over Activated carbon / porous Graphite the task of activating the microbes near the wound dressing on their surface to absorb and accumulate. That on the activated carbon / porous graphite coated precious metal then passes over to the absorbed / accumulated To destroy microbes an aseptic condition for to create the wound, to promote the closure of the wound and to reduce the scarring. Besides, it is in the case in the activated carbon as a carrier for the precious metal used, not necessary, liquid to activate the Add precious metal, there the activated carbon absorbs moisture (usually from 5 to 20% by weight). With this simpler method, the present invention also provides the desired antimicrobial advantage.

The The present invention provides a kit consisting of the wound dressing this invention and a fastener consists. Every element, that the federation locally can attach, can be used as a fastener. To the Example (but not exclusive) the fastener may be a bandage, a bandage or a Be wound dressing.

The present invention also describes an antimicrobial composition for topical application to the skin. The together The invention relates to a carbonaceous material and an effective amount of a noble metal with which the carbonaceous material has been coated. The carbonaceous material is selected from a group consisting of activated carbon, graphite, carbon and a combination thereof, preferably activated carbon, porous graphite or a combination thereof. Some examples include (but are not limited to) activated carbon fiber, particulate or powdered carbon, porous graphite such as elastic graphite or expanded graphite. The noble metal is selected from a group consisting of silver, gold, palladium, platinum, copper, zinc and a combination thereof. Preferably, the noble metal is silver.

In The composition of the present invention is the amount of Precious metal with which the carbonaceous material is applied will, not critical, as long as the amount is the desired antimicrobial Effect shows. In terms of the weight of the precious metal itself is the amount typically between 0.0001 to 30% by weight, preferably between 0.01 and 10% by weight. the total weight of the composition. To the noble metal ion, which shows antimicrobial activity, to solve effectively should the grain size of the precious metal particles on the carbonaceous material not more than about 200 nm be, preferably not more than 100 nm and in the best case not more than 50 nm.

optional contains the composition of the present invention also a therapeutically active component in a therapeutically effective Amount. For example (but not exclusively) include the therapeutic active components, an antimicrobial agent, an antifungal agent Active ingredient or other therapeutic components for wounds from injury, burns or scalding. For example (but not exclusive) the composition of the present invention may optionally contain erythromycin, Tetracycline, clindamycione, cephalosporin, triclosan, phenoxy-isopropanol, Chlorhexidine glutonate, povidone iodine, acrisorcinol, haloprogin, iodochlorohydroxyquin, Tolnaftate, triacetin, Centella asiatica, econazole nitrate, mafenide, Mupirocin and / or povidone iodine included.

In addition to the active components, the composition of the present invention may also contain non-toxic, pharmaceutically-acceptable and skin-friendly carriers, thinners and excipients suitable for external application to the skin. Carriers, diluents and binders and the standard dosages for known pharmaceutically active substances can be found in US 6,692,773 B2 be read. The contents are attached to this document as a reference.

The Composition to the external Application on the skin can be in different dosage forms such as a gel, a paste, an ointment, a cream, a Emulsion and a suspension. The one coated with a precious metal Carbonaceous material can be pharmaceutically approved carriers, diluents and binders and other optional active components aseptic conditions are mixed to the desired dosage form manufacture. For example (but not exclusively) will be a suitable thickening or gelling agent to an aqueous or oily Base added, to make a face mask, ointment or cream. Water can for the watery Base are used. Depending on the inherent properties of the base can Aluminum stearate and hydrogenated lanolin used as thickener become. Strength, Tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, Talc or a mixture of these can be used as a binder be to the composition of the present invention in the Dosage form of a paste, an ointment, a cream or a To produce gels.

It It should be noted that the biggest difference between the The present invention and the prior art is that the noble metal, which has an antimicrobial property, in the present invention in the form of a carbonaceous one Material coated precious metal is used. By the use of activated carbon due to their ability to self To absorb moisture, the composition of the present Invention activate the precious metal for the antimicrobial advantage to use without adding moisture. In addition, the present improves Invention by the use of activated carbon / porous graphite as a carbonaceous material due to their ability to microbes In addition, the present invention also has the "passive" property known in the art was reached, in which the precious metal the microbes only on contact kills. That is, the present invention actively kills microbes. Out For this reason, the present invention is suitable for use in situations known in the art in which the precious metals externally be applied on the skin to kill microbes and reduce their growth for better antimicrobial benefits to grant.

Although the present invention has been disclosed above, the disclosure is not limited to the present invention. One of ordinary skill in the art may make changes or modifications without departing from the spirit and scope of the present invention. Consequently, the scope of the present invention is based on the attached claims.

Claims (21)

A wound dressing containing a carbonaceous material and a noble metal supported on the carbonaceous material was, wherein the carbonaceous material of a Group selected is made of activated carbon, graphite, coal and a combination of this consists. The dressing according to claim 1, wherein the carbonaceous material is selected from a group, made of activated carbon, porous Graphite and a combination of these consists. The dressing according to claim 2, wherein the porous Graphite selected from a group is made of elastic graphite, expanded graphite and a Combination consists of these. The wound dressing according to claim 1, wherein said Is precious metal silver and has a grain size of not more than 200 nm having. The wound dressing of claim 1, further comprising a flexible base layer having a first surface and a second surface, wherein said noble metal included carbonaceous material applied at least a portion of said first surface becomes. The wound dressing of claim 5, wherein the precious metal includes Carbonaceous material with a first adhesive on the first surface attached becomes. The dressing according to claim 5, the moreover having a second adhesive which is on the carbonaceous Material was applied. The dressing according to claim 6, the moreover having a second adhesive which is on the carbonaceous Material was applied. The dressing according to claim 1, the moreover has a therapeutically active component. The wound dressing according to claim 9, wherein said therapeutically active component is selected from a group from erythromycin, tetracycline, clindamycin, cephalosporin, acrisorcinol, Haloprogin, iodochlorhydroxyquin, tolnaftate, triacetin, Centella asiatica, econazole nitrate, mafenide, mupirocin, povidone iodine and one Combination of these. The dressing according to claim 1, wherein the dressing of woven, nonwoven or synthetic Skin exists. The dressing according to claim 1, wherein the carbonaceous material is selected from a group, made of powder, particles, fiber, platelets and a combination consists of these. A kit comprising the wound dressing of claim 1 and a fastener includes. The kit according to claim 13, wherein the fastener, a bandage, a bandage or a Wound pad is. An antimicrobial composition for the external Application on the skin containing a carbonaceous material and an effective amount of a noble metal with which the carbonaceous Material is applied, wherein said carbonaceous Material selected from a group is made of activated carbon, graphite, coal and a combination of this consists and said precious metal is selected from a group, made of silver, gold, palladium, platinum, copper, zinc and a Combination consists of these. The antimicrobial composition according to claim 15, wherein the carbonaceous material is selected from a group, made of activated carbon, porous Graphite and a combination of these consists. The antimicrobial composition according to claim 16, the porous one Graphite selected is made from a group consisting of elastic graphite, expanded Graphite and a combination of these consists. The antimicrobial composition according to claim 17, wherein said noble metal is silver and a grain size of not has more than 200 nm. The antimicrobial composition according to claim 15, the moreover has a therapeutically active component. The antimicrobial composition according to claim 19, wherein the therapeutically active component of a group selected consisting of erythromycin, tetracycline, clindamycin, cephalosporin, Acrisorcinol, haloprogin, iodochlorhydroxyquin, tolnaftate, triacetin, Centella asiatica, econazole nitrate, mafenide, mupirocin, povidone iodine and a combination of these. The antimicrobial composition according to claim 20 for use in a face mask.