CN203943772U - Biodegradable magnesium alloy blood vessel rack - Google Patents
Biodegradable magnesium alloy blood vessel rack Download PDFInfo
- Publication number
- CN203943772U CN203943772U CN201420229060.6U CN201420229060U CN203943772U CN 203943772 U CN203943772 U CN 203943772U CN 201420229060 U CN201420229060 U CN 201420229060U CN 203943772 U CN203943772 U CN 203943772U
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- connecting rod
- magnesium alloy
- blood vessel
- vessel rack
- straight
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- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 40
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 23
- 238000013461 design Methods 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 8
- 239000000956 alloy Substances 0.000 claims description 4
- 230000007797 corrosion Effects 0.000 abstract description 8
- 238000005260 corrosion Methods 0.000 abstract description 8
- 230000015556 catabolic process Effects 0.000 description 7
- 238000006731 degradation reaction Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000137 annealing Methods 0.000 description 3
- 208000037803 restenosis Diseases 0.000 description 3
- 229910001021 Ferroalloy Inorganic materials 0.000 description 2
- 230000004323 axial length Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Abstract
This utility model provides a kind of Biodegradable magnesium alloy blood vessel rack, described intravascular stent entirety is pipe net structure, comprise multiple main unit and connecting rod, wherein, described multiple main unit is uniformly distributed along the axial and circumferential directions, adjacent body connects by connecting rod between unit, and the connecting rod between the adjacent body unit of middle part is asymmetric N-type structure, and the connecting rod between the adjacent body unit at both ends is straight-bar structure.Biodegradable magnesium alloy blood vessel rack of the present utility model, there is high radial support intensity, good submissive performance, low radially rebound degree and axially cripetura rate, also have lower residual stress, makes support in human body, can realize homogeneous corrosion degraded.
Description
Technical field
This utility model relates to technical field of medical instruments, is specifically related to a kind of Biodegradable magnesium alloy blood vessel rack.
Background technology
Stent is one of main method for the treatment of coronary heart disease, from there is starting to be just subject to concern widely.The bare metal stent of support from starting most, bracket for eluting medicament finally, then develop till now Biodegradable scaffold rapidly, be all round the restenosis problem that solves blood vessel.
Effectively reduce from birth again the restenosis rate of blood vessel although bracket for eluting medicament can suppress smooth muscle cell by the release of anti-proliferative drugs, but still have the risk that advanced thrombus occurs.Biodegradable stent is got involved product as support of new generation, mainly contains three kinds: high molecular polymer support, ferroalloy support and magnesium alloy bracket.Although polymeric stent has good biocompatibility, support mechanical property is lower, and the time of degradation in vivo is longer.Although ferroalloy support has good mechanical property, degradation speed is too slow.Magnesium alloy bracket not only has good mechanical property and biocompatibility, and degradation rate is obviously accelerated compared with retort stand, degradation time approaches the required 4-6 of clinical medicine month most, magnesium alloy catabolite is the necessary material of body metabolism simultaneously, there is good biological safety, so get involved field at following support, magnesium alloy bracket has broad prospects.
At present, also few about the report of magnesium alloy bracket structural design, existing patent emphasis is mainly to obtain higher radial support intensity, good submissive performance etc.
Patent publication No. be in the patent of invention of CN103110465A, disclose moderate, the good radial support power of a kind of metal coverage rate, compliance good, be out of shape uniform supporting structure.Patent publication No. is that in the patent of invention of CN202724051, disclosed magnesium alloy bracket has excellent support power, compliance and fatigue strength.The common ground of these two Patent designs is the mechanical properties that are conceived to support, although can obtain good mechanical performance, does not consider the most important corrosion degradation problem of magnesium alloy bracket.
The corrosion degradation problem of magnesium alloy bracket is mainly relevant with two aspects: material and residual stress.Selecting a kind of magnesium alloy materials that can realize homogeneous corrosion is basis, and the residual stress distribution of support holding through overvoltage, after dilatating and deformable is evenly that support is realized the evenly essential condition of degraded.
Utility model content
Main purpose of the present utility model is in order to solve the inhomogeneous problem of existing magnesium alloy bracket corrosion degraded, design the mechanical property requirements that a kind of supporting structure can meet support, also can make support residual stress distribution is even holding through overvoltage, after dilatating and deformable simultaneously, degrades in endovascular homogeneous corrosion thereby realize support.
This utility model is achieved through the following technical solutions:
A kind of Biodegradable magnesium alloy blood vessel rack, described intravascular stent entirety is pipe net structure, comprise multiple main unit and connecting rod, wherein, described multiple main unit is uniformly distributed along the axial and circumferential directions, adjacent body connects by connecting rod between unit, and the connecting rod between the adjacent body unit of middle part is asymmetric N-type structure, and the connecting rod between the adjacent body unit at both ends is straight-bar structure.
Preferably, each main unit is wavy shaped configuration, and wherein, the top of the waves of described wavy shaped configuration is arc part, between adjacent arc part, connects by straight-bar position.
Preferably, described arc part is overstriking structural design.
Preferably, between described arcuate structure and straight-bar position, connect by gradual change type structure.
Preferably, described straight-bar structure connecting rod distributes along continuous uniform in circumferential direction, and described asymmetric N-type structure connecting rod is upwards spaced apart in week.
Preferably, described asymmetric N-type structure connecting rod is spaced apart in circumferential equal intervals.
Preferably, described intravascular stent adopts Mg-Nd-Zn-Zr magnesium alloy material.
The Biodegradable magnesium alloy blood vessel rack that this utility model provides, adopts Mg-Nd-Zn-Zr magnesium alloy, implants in order to the non-degradable support that thorough solution is traditional the restenosis problem causing after lesion vessels.Its operation principle is, before blood vessel endothelium completes, magnesium alloy bracket can support blood vessels, and then gradually degraded until disappear.Described magnesium alloy blood vessel rack is pipe net structure, comprise main unit and connecting rod, main unit presents waveform, arc part is taked to the design of overstriking, this is conducive to strengthen the deformability of arc part, between arc part and straight-bar position, adopt gradual change type structural transition, the stress of arc part can be transmitted toward straight-bar position gradually, reduce the stress concentration degree of support.Main unit in axial direction distributes, between the adjacent main unit of mid portion, connect with asymmetric N-type structure connecting rod, can effectively improve the submissive performance of support, the main unit at two ends connects with straight-bar structure connecting rod, " Os Canitis " phenomenon that can effectively suppress to occur in support process of expansion.Biodegradable magnesium alloy blood vessel rack of the present utility model, there is high radial support intensity, good submissive performance, low radially rebound degree and axially cripetura rate, also have lower residual stress, makes support in human body, can realize homogeneous corrosion degraded.
This utility model, compared with existing magnesium alloy bracket, has the following advantages:
The Biodegradable magnesium alloy blood vessel rack that this utility model provides, its main unit adopts wavy shaped configuration, comprises arch section and straight bar part, and this contributes to the pressure of support to hold distortion, holds size thereby obtain less pressure.
Suitably increase the size of arc part, strengthen the deformability of support at arc part, also contribute to improve the radial support power of support simultaneously.
Arc part is connected by gradual change type structure with straight-bar position, and the distortional stress of arc part can be transmitted toward straight-bar position gradually, realizes being uniformly distributed of residual stress, thereby is conducive to realize the homogeneous corrosion degraded of support.
Intravascular stent two ends adopt the connecting rod form of straight-bar, and are uniformly distributed circumferentially, and this design can effectively reduce the adverse effect of " dog bone " effect to support performance that support produces in the time of balloon expandable.
Intravascular stent middle part adopts asymmetric N-type structure connecting rod, upwards presents spaced apartly in week, is conducive to support and expands to obtain good submissive performance.
Brief description of the drawings
By reading the detailed description of non-limiting example being done with reference to the following drawings, it is more obvious that other features, objects and advantages of the present utility model will become:
Fig. 1 is flat deployable structure schematic diagram of the present utility model;
Fig. 2 is main unit partial enlarged drawing of the present utility model;
Fig. 3 is asymmetric N-type structure connecting rod of the present utility model;
In figure: 1 is main unit, 11 is arc part, and 12 is straight-bar position, and 13 is gradual change type structure, and 2 is asymmetric N-type structure connecting rod, and 3 is straight-bar structure connecting rod.
Detailed description of the invention
Below embodiment of the present utility model is elaborated: the present embodiment is implemented under taking technical solutions of the utility model as prerequisite, provided detailed embodiment and concrete operating process.It should be pointed out that to those skilled in the art, without departing from the concept of the premise utility, can also make some distortion and improvement, these all belong to protection domain of the present utility model.
Please refer to Fig. 1 to Fig. 3.
The present embodiment provides a kind of Biodegradable magnesium alloy blood vessel rack, described intravascular stent entirety is pipe net structure, comprise multiple main unit and connecting rod, wherein, described multiple main unit is uniformly distributed along the axial and circumferential directions, adjacent body connects by connecting rod between unit, and the connecting rod between the adjacent body unit of middle part is asymmetric N-type structure, and the connecting rod between the adjacent body unit at both ends is straight-bar structure.
Further, each main unit is wavy shaped configuration, and wherein, the top of the waves of described wavy shaped configuration is arc part, between adjacent arc part, connects by straight-bar position.
Further, described arc part is overstriking structural design.
Further, between described arcuate structure and straight-bar position, connect by gradual change type structure.
Further, described straight-bar structure connecting rod distributes along continuous uniform in circumferential direction, and described asymmetric N-type structure connecting rod is upwards spaced apart in week.
Further, described asymmetric N-type structure connecting rod is spaced apart in circumferential equal intervals.
Further, described intravascular stent adopts Mg-Nd-Zn-Zr magnesium alloy material.
Below in conjunction with accompanying drawing and specific experiment example, the present embodiment is elaborated.
Experimental example one
The preparation of magnesium alloy pipe
The preparation technology of the magnesium alloy pipe that this experimental example provides is: the Mg-Nd-Zn-Zr magnesium alloy ingot that (1) is 300mm by diameter of phi 90mm length at 400 DEG C is squeezed into diameter of phi 6-8mm, the pipe of wall thickness 0.5-1mm, after at 350 DEG C, anneal 30 minutes, remove extrusion process stress; (2) by the pipe of diameter of phi 6-8mm, wall thickness 0.5-1mm after the combination processing technique of multi-pass rolling, drawing, obtaining outside dimension is Φ 1-4mm, wall thickness 0.1-0.2mm support cutting magnesium alloy capillary tubes.Every rolling, drawing a time, carry out stress relief annealing one time, and annealing process is 350 DEG C, 30 minutes.
Go out pipe network type support by tubing by cut, support is carried out to ultrasonic anti-dandruff, pickling and electrochemical polishing treatment, then carry out stress relief annealing processing.In vitro, support is pressed and held and expand, the mechanical property of measurement bracket can obtain, and the radial support intensity of support is 100-130KPa, and axial cripetura rate and radially rebound degree are 3%-5%.In-vitro simulated vivo degradation experiment demonstration, it is 4-6 month that support provides the time of effective radial support power.
After pressing and holding sacculus, there is resilience in magnesium alloy bracket, come off in course of conveying for fear of support, and after the support after pressure is held carries out blow process, the anti-de-power of carrying of test bracket.When the maximum of displacement support during at 0-5mm is anti-, de-to carry power be 2.3N, and testing the maximum of omnidistance medium-height trestle, anti-de-to carry power be 3.5N.
Experimental example two
In conjunction with Fig. 1, this experimental example embodiment is described, the support of this experimental example embodiment is pipe net structure, is made up of multiple main unit 1 and connecting rod 2,3.Main unit 1 is uniformly distributed along the axial and circumferential directions, and main unit 1 is wavy shaped configuration, between arcuate structure 11, connects by straight-bar.Arc part 11 in main unit 1 is carried out to overstriking design, and the arc part 11 in main unit 1 is connected with gradual change type structure 13 with straight-bar position 12.Adjacent body connects by connecting rod between unit, and middle part connecting rod 2 is asymmetric N-type structure, and the connecting rod 3 at support two ends is straight-bar structure.The straight-bar structure connecting rod 3 at support two ends distributes along continuous uniform in circumferential direction, and the asymmetric N-type connecting rod 2 of middle part is upwards spaced apart in week.
Experimental example three
The support external diameter of this experimental example embodiment is 1-4mm, and cradling piece width is 0.1-0.2mm, and wall thickness is 0.1-0.2mm, and the axial length of support is 10-50mm.
Experimental example four
In conjunction with Fig. 2, this experimental example embodiment is described, the arc part 11 of this experimental example embodiment and the width at straight-bar position 12 are 0.1-0.2mm, and wherein, the size of arc part 11 is than the large 0.01-0.02mm of the size at straight-bar position 12.
Experimental example five
In conjunction with Fig. 1 and Fig. 3, this experimental example embodiment is described, the axial length of the asymmetric N-type structure connecting rod 2 of this experimental example embodiment and the straight-bar structure connecting rod 3 at support two ends is 0.5-1.0mm.Straight-bar structure connecting rod 3 is in upwards continuous distribution of week, and asymmetric N-type structure connecting rod 2 is spaced apart.
Experimental example six
In conjunction with Fig. 1, this experimental example embodiment is described, the rack body unit 1 of this experimental example embodiment is upwards being distributed with 6 week, and concrete distribution number can be determined by tube outer diameter, and the number that generally distributes is 4-8.
Experimental example seven
In conjunction with Fig. 1, this experimental example embodiment is described, the length at the lesion vessels position that the number that the rack body unit 1 of this experimental example embodiment distributes vertically can be implanted according to support is determined.
The Biodegradable magnesium alloy blood vessel rack that the present embodiment provides, comprises main unit and connecting rod.Main unit is uniformly distributed along the axial and circumferential directions, and main unit is wavy shaped configuration, between the arc part of wavy shaped configuration, connects by straight-bar position.Arc part in main unit is carried out to overstriking design, and the arc part in main unit is connected with gradual change type structure with straight-bar position.Adjacent body connects by connecting rod between unit, and middle part connecting rod is asymmetric N-type structure, and the connecting rod at support two ends is straight-bar structure.The straight-bar structure connecting rod at support two ends distributes along continuous uniform in circumferential direction, and the asymmetric N-type structure connecting rod of middle part is upwards spaced apart in week.
Above specific embodiment of the utility model is described.It will be appreciated that, this utility model is not limited to above-mentioned specific implementations, and those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present utility model.
Claims (7)
1. a Biodegradable magnesium alloy blood vessel rack, it is characterized in that: described intravascular stent entirety is pipe net structure, comprise multiple main unit and connecting rod, wherein, described multiple main unit is uniformly distributed along the axial and circumferential directions, adjacent body connects by connecting rod between unit, and the connecting rod between the adjacent body unit of middle part is asymmetric N-type structure, and the connecting rod between the adjacent body unit at both ends is straight-bar structure.
2. Biodegradable magnesium alloy blood vessel rack according to claim 1, it is characterized in that: each main unit is wavy shaped configuration, wherein, the top of the waves of described wavy shaped configuration is arc part, between adjacent arc part, connects by straight-bar position.
3. Biodegradable magnesium alloy blood vessel rack according to claim 2, is characterized in that: described arc part is overstriking structural design.
4. Biodegradable magnesium alloy blood vessel rack according to claim 2, is characterized in that: between described arcuate structure and straight-bar position, connect by gradual change type structure.
5. Biodegradable magnesium alloy blood vessel rack according to claim 1, is characterized in that: described straight-bar structure connecting rod distributes along continuous uniform in circumferential direction, and described asymmetric N-type structure connecting rod is upwards spaced apart in week.
6. Biodegradable magnesium alloy blood vessel rack according to claim 5, is characterized in that: described asymmetric N-type structure connecting rod is spaced apart in circumferential equal intervals.
7. according to the Biodegradable magnesium alloy blood vessel rack described in any one in claim 1 to 6, it is characterized in that: described intravascular stent adopts Mg-Nd-Zn-Zr magnesium alloy material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420229060.6U CN203943772U (en) | 2014-05-06 | 2014-05-06 | Biodegradable magnesium alloy blood vessel rack |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420229060.6U CN203943772U (en) | 2014-05-06 | 2014-05-06 | Biodegradable magnesium alloy blood vessel rack |
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| Publication Number | Publication Date |
|---|---|
| CN203943772U true CN203943772U (en) | 2014-11-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420229060.6U Expired - Lifetime CN203943772U (en) | 2014-05-06 | 2014-05-06 | Biodegradable magnesium alloy blood vessel rack |
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| Country | Link |
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| CN (1) | CN203943772U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693176A (en) * | 2017-09-29 | 2018-02-16 | 翎秀生物科技（上海）有限公司 | The intranasal support of balloon-expandable |
| CN109893295A (en) * | 2019-03-26 | 2019-06-18 | 北京航空航天大学 | A kind of negative poisson's ratio degradable blood vessel bracket structure |
| CN112754739A (en) * | 2019-11-04 | 2021-05-07 | 上海微创医疗器械（集团）有限公司 | Support frame |
| CN113069256A (en) * | 2021-03-26 | 2021-07-06 | 珠海通桥医疗科技有限公司 | Intracranial flexible closed loop stent |
-
2014
- 2014-05-06 CN CN201420229060.6U patent/CN203943772U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693176A (en) * | 2017-09-29 | 2018-02-16 | 翎秀生物科技（上海）有限公司 | The intranasal support of balloon-expandable |
| CN107693176B (en) * | 2017-09-29 | 2021-01-05 | 依奈德医疗技术（上海）有限公司 | Sacculus expanding type nasal internal support |
| CN109893295A (en) * | 2019-03-26 | 2019-06-18 | 北京航空航天大学 | A kind of negative poisson's ratio degradable blood vessel bracket structure |
| CN112754739A (en) * | 2019-11-04 | 2021-05-07 | 上海微创医疗器械（集团）有限公司 | Support frame |
| CN113069256A (en) * | 2021-03-26 | 2021-07-06 | 珠海通桥医疗科技有限公司 | Intracranial flexible closed loop stent |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HUCHUANG MEDICAL TECHNOLOGY (SHANGHAI) CO., LTD. Free format text: FORMER OWNER: SHANGHAI JIAO TONG UNIVERSITY Effective date: 20150414 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200240 MINHANG, SHANGHAI TO: 201506 JINSHAN, SHANGHAI |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150414 Address after: 201506 Shanghai Jinshan Industrial Zone Ting Wei Road No. 4, building 1428, room 6558 Patentee after: Shanghai Medical Technology (Shanghai) Co., Ltd. Address before: 200240 Dongchuan Road, Shanghai, No. 800, No. Patentee before: Shanghai Jiao Tong University |