CN117856831A - Medium-distance wireless biosensing system - Google Patents
Medium-distance wireless biosensing system Download PDFInfo
- Publication number
- CN117856831A CN117856831A CN202311773783.2A CN202311773783A CN117856831A CN 117856831 A CN117856831 A CN 117856831A CN 202311773783 A CN202311773783 A CN 202311773783A CN 117856831 A CN117856831 A CN 117856831A
- Authority
- CN
- China
- Prior art keywords
- circuit
- sensing circuit
- resonant frequency
- sensing
- reading circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000008878 coupling Effects 0.000 claims abstract description 21
- 238000010168 coupling process Methods 0.000 claims abstract description 21
- 238000005859 coupling reaction Methods 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 19
- 230000001939 inductive effect Effects 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 42
- 230000008859 change Effects 0.000 claims description 17
- 239000004020 conductor Substances 0.000 claims description 16
- 239000003989 dielectric material Substances 0.000 claims description 14
- 239000003990 capacitor Substances 0.000 claims description 13
- 238000005538 encapsulation Methods 0.000 claims description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 239000004642 Polyimide Substances 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 125000005456 glyceride group Chemical group 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 229920001721 polyimide Polymers 0.000 claims description 4
- 239000004626 polylactic acid Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910021389 graphene Inorganic materials 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 239000005022 packaging material Substances 0.000 claims 2
- 238000004891 communication Methods 0.000 abstract description 13
- 231100000419 toxicity Toxicity 0.000 abstract description 5
- 230000001988 toxicity Effects 0.000 abstract description 5
- 230000008569 process Effects 0.000 description 17
- 238000004590 computer program Methods 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000005297 material degradation process Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 1
- 229910002601 GaN Inorganic materials 0.000 description 1
- JMASRVWKEDWRBT-UHFFFAOYSA-N Gallium nitride Chemical compound [Ga]#N JMASRVWKEDWRBT-UHFFFAOYSA-N 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000036724 intravesical pressure Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000011819 refractory material Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000010897 surface acoustic wave method Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Abstract
The invention provides a medium-distance wireless biosensing system, and relates to the technical field of biosensing. The system of the invention comprises: the sensing circuit comprises an inductance, a capacitance and a resistance; the reading circuit and the sensing circuit meet the inductive weak coupling relation, and the inductive coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05. The wireless biological sensing system does not depend on a chip or a battery to realize wireless sensing, so that the wireless biological sensing system does not depend on a difficult-to-degrade material, and can select a degradable material without biological toxicity; the communication distance between the reading circuit and the sensing circuit can reach the same magnitude or a magnitude larger than the inductance size of the sensing circuit.
Description
Technical Field
The embodiment of the invention relates to the technical field of biological sensing, in particular to a medium-distance wireless biological sensing system.
Background
Implantable wireless biosensors are the most technically challenging biosensors, which are critical for accurate medical treatment. The device can be placed in a human body to continuously monitor physiological data, and provides important basis for accurately evaluating physical health condition and disease progression so as to guide a treatment scheme, improve the life quality of patients and reduce death rate. In the most ideal case, the circuit and the mechanical structure of the implanted wireless biosensor should be as simple as possible, without a battery, the communication distance can reach tens of centimeters and can penetrate the human body, and no recalibration is needed after the human body moves. In addition, for certain monitoring tasks that only need to be operated for a certain period of time, the implantable wireless biosensor should also be safely and non-toxic to degrade completely after completion of the task.
In the related art, wireless biosensors generally use a rigid integrated circuit chip, such as a Near Field Communication (NFC) or Radio Frequency Identification (RFID) chip, a microprocessor, or an analog-to-digital converter (ADC), and thus are difficult to degrade in vivo, and may affect device flexibility. Furthermore, some chips contain thousands of transistors, and their high power consumption typically results in reduced sensitivity (due to the power-sensitivity tradeoff in the ADC), significant heat generation, and reduced communication distance. To avoid the use of chips, researchers have proposed chipless wireless electronic skins based on inductive-capacitive (LC) resonance. However, the measurement results in this sensing mode are very sensitive to position changes between the reading coil and the sensing circuit, and the communication distance is also very short. Wireless sensing systems based on space-Time (PT) symmetry significantly improve the sensitivity coefficient and communication distance, however, their systems require fine tuning and the measurement results are still susceptible to positional variations between the read coil and the sensing circuit. In the related art, a chipless radio skin based on a surface acoustic wave sensor is prepared by integrating a gallium nitride ultrathin single crystal piezoelectric film on a flexible patch, and compared with the previous LC resonance chipless radio skin, the chipless radio skin has higher sensitivity, but the energy transmission efficiency is still not high, so that the communication distance is also shorter, and in addition, if the implanted body has weak toxicity.
It follows that currently common wireless biosensors have at least one of the following drawbacks: 1) The communication distance is short, and the measurement result is sensitive to the position change between the reading coil and the sensing circuit; 2) Depending on other more difficult degradation materials.
Disclosure of Invention
The embodiment of the invention provides a medium-distance wireless biosensing system, which at least partially solves the problems existing in the related art.
A first aspect of an embodiment of the present invention provides a medium-range wireless biosensing system, the system comprising: the sensing circuit comprises an inductance, a capacitance and a resistance; the inductance coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05;
the control method of the system is realized by the following steps:
during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close;
when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, an extreme value occurs in the phase difference between the voltage and the current of the high-frequency power supply;
based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s ；
Tuning based on the sensing circuitVibration frequency omega s And determining a reading of the biological signal to be measured according to a predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit.
Optionally, an inductive coupling coefficient between the reading circuit and the sensing circuit is greater than or equal to 0.0001.
Optionally, the high-frequency power supply, the adjustable capacitor and the inductor of the reading circuit are connected in series or in parallel.
Optionally, during sensing, the high frequency power supply frequency ω 1 Always with the resonant frequency omega of the reading circuit r And maintaining the offset of the fixed proportion, wherein the offset proportion is more than or equal to 0.1% and less than or equal to 2%.
Optionally, the number of times of changing the adjustable capacitance value of the reading circuit is 10 times or more, so that the resonance frequency ω of the reading circuit corresponding to the phase difference extremum of the high frequency power supply voltage and current r Is captured and the captured frequency bin meets a preset accuracy requirement.
Optionally, the adjustable capacitor is realized by piezoelectric driving the electrode plate spacing of the capacitor, or realized by a voltage control capacitor chip.
Optionally, the resonant frequency ω of the sensing circuit s 0.5 MHz or more and 100 MHz or less;
optionally, the sensing circuit is physically soft, highly deformable, and the inductance of the sensing circuit is a curvilinear stretchable structure.
Optionally, the sensing circuit physically includes a conductive material, a dielectric material, and an encapsulation material, the conductive material forming an inductance and a resistance, the conductive material forming a capacitance with the dielectric material, the encapsulation material being used for insulation and protection;
wherein the conductive material comprises: one or more of copper, gold, graphene, magnesium, and zinc;
the dielectric material includes: one or more of polyimide, polyethylene terephthalate, and polylactic acid;
the encapsulation material comprises: polydimethyl siloxane and/or polysebacic acid glyceride.
Optionally, the biological signal to be measured comprises strain, curvature, pressure, temperature, PH value, ion concentration; the biosignal affects the resonant frequency of the sensing circuit by affecting the inductive geometry, the capacitive geometry, and the dielectric coefficient of the capacitive dielectric material of the sensing circuit.
The second aspect of the embodiment of the present invention further provides a method for controlling the medium-distance wireless biosensing system, where the method is used for controlling the medium-distance wireless biosensing system in the first aspect, and the method includes:
during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close;
when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, an extreme value occurs in the phase difference between the voltage and the current of the high-frequency power supply;
based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s ；
Based on the resonant frequency omega of the sensing circuit s And determining a reading of the biological signal to be measured according to a predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit.
Optionally, the high frequency power supply frequency ω 1 Always with the resonant frequency omega of the reading circuit r And maintaining the offset of the fixed proportion, wherein the offset proportion is more than or equal to 0.1% and less than or equal to 2%.
Optionally, the number of times of changing the adjustable capacitance value of the reading circuit is 10 times or more, so that the resonance frequency ω of the reading circuit corresponding to the phase difference extremum of the high frequency power supply voltage and current r Frequency of (2)The intervals are captured, and the captured frequency intervals meet preset precision requirements.
Optionally, the resonant frequency ω of the sensing circuit s 0.5 MHz or more and 100 MHz or less.
Optionally, the biological signal to be measured comprises strain, curvature, pressure, temperature, PH value, ion concentration; the biosignal affects the resonant frequency of the sensing circuit by affecting the inductive geometry, the capacitive geometry, and the dielectric coefficient of the capacitive dielectric material of the sensing circuit.
A third aspect of the embodiments of the present invention provides a computer-readable storage medium having stored thereon a computer program which, when executed by a processor, implements the steps of the medium range wireless biosensing system control method according to the second aspect of the present invention.
The medium-distance wireless biosensing system provided by the embodiment of the invention does not depend on a chip or a battery to realize wireless sensing, so that the medium-distance wireless biosensing system provided by the embodiment of the invention does not depend on a difficult-to-degrade material, and can select a degradable material without biological toxicity; in the medium-distance wireless biological sensing system provided by the embodiment of the invention, the inductance coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05, and the control method of the system is realized by adopting the following steps: during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close; when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, strong resonance of the system is caused, and the phase difference between the voltage and the current of the high-frequency power supply is extreme; based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s The method comprises the steps of carrying out a first treatment on the surface of the Based on the resonant frequency omega of the sensing circuit s And predetermined biological signals and transmissions to be measuredAnd determining the corresponding relation between the resonant frequencies of the sensing circuits and the reading of the biological signals to be measured. Thus, the communication distance between the reading circuit and the sensing circuit may be the same order of magnitude or higher than the sensing circuit inductance size.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments of the present invention will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 shows a schematic circuit structure of a medium-distance wireless biosensing system according to an embodiment of the present invention;
FIG. 2 is a flow chart showing steps of a method for controlling a medium-distance wireless biosensing system according to an embodiment of the present invention;
FIG. 3 is a graph showing the variation of the phase difference between the power supply voltage and the current obtained in an exemplary embodiment according to an embodiment of the present invention with the resonant frequency of the reading circuit;
fig. 4 shows a plot of phase versus frequency derivatives of an exemplary embodiment provided by an embodiment of the present invention at different coupling coefficients and read circuit resonant frequencies.
Detailed Description
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
At present, common biological sensing systems all depend on chips or batteries, so that the common biological sensing systems depend on nondegradable materials and are easy to generate biological toxicity, or the measurement results of the current biological sensing systems are very sensitive to the position change between a reading coil and a sensing circuit, the communication distance is very short, and the common biological sensing systems can only reach the same magnitude of the inductance size of the sensing circuit, so that the application range of the common biological sensing systems is limited and cannot be applied to internal organs of organisms.
Based onThe embodiment of the invention aims to provide a wireless sensing system which does not depend on refractory materials and can realize medium-distance biological signal measurement. Specifically, as shown in fig. 1, a schematic structural diagram of a medium-distance wireless biosensing system provided by an embodiment of the present invention is shown, where the medium-distance wireless biosensing system provided by the embodiment of the present invention includes: the left part of the reading circuit and the sensing circuit in fig. 1 is the reading circuit, and comprises an adjustable capacitor C r Inductance L r Resistance R r And a high frequency power supply, the sensing circuit includes an inductance L s Capacitance C s And resistance R s The method comprises the steps of carrying out a first treatment on the surface of the The reading circuit and the sensing circuit meet the inductive weak coupling relation; and the inductance coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05.
In the embodiment of the present invention, the control method of the system is implemented by adopting the following steps S1 to S4, as shown in fig. 2, which shows a step flowchart of the control method of the medium-distance wireless biosensing system provided in the embodiment of the present invention, and specifically, the method includes:
s1, in the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close.
S2, when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, the phase difference between the voltage and the current of the high-frequency power supply is extremely large.
S3, based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s 。
S4, based on the resonance frequency omega of the sensing circuit s And determining a reading of the biological signal to be measured according to a predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit.
In the embodiment of the invention, the biological signals to be measured can comprise strain (including muscle strain, ligament strain, bone strain and the like), curvature (soft tissue bending deformation), pressure (including intra-abdominal pressure, intra-vesical pressure, intra-osseous pressure and the like), temperature (local organ temperature), PH value, ion concentration and the like. These signals can affect the resonant frequency of the sensing circuit by affecting the inductive geometry, capacitive geometry, and dielectric coefficient of the capacitive dielectric material of the sensing circuit.
In the embodiment of the invention, the control method of the medium-distance wireless biosensing system can be executed by a preset program to control the resonant frequency omega of the sensing circuit s A read is performed.
In the embodiment of the invention, the biological signals to be measured can be calibrated in advance based on the medium-distance wireless biological sensing system, and the resonance frequency omega of the medium-distance wireless biological sensing system can be determined s And each corresponding relation between the biological signals to be measured, and pre-storing each corresponding relation in the preset program, when in actual use, the biological signals to be measured can be selected currently, and the resonant frequency omega of the sensing circuit can be read out s And then, directly determining the reading of the biological signal to be measured according to the corresponding relation.
For example, the pressure can be calibrated in advance based on the medium-distance wireless biosensing system, and the corresponding resonant frequency omega under different pressures can be determined s To determine the resonant frequency omega of the mid-range wireless biosensing system s And the correspondence between pressures, referred to as pressure correspondence. The strain can be calibrated based on the medium-distance wireless biosensing system, and the corresponding resonant frequency omega under different strains can be determined s To determine the resonant frequency omega of the mid-range wireless biosensing system s And the strain, is referred to as strain correspondence. And storing the corresponding relation between the pressure and the strain into the preset program. In actual measurement, a pressure measurement mode is selected, and the preset program can be used for controlling the current resonant frequency omega s And the pressure correspondence determines a reading of the currently measured pressure.
In the embodiment of the invention, the inductance coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05, so that the measured biological signals are insensitive to the position change (including the distance and the angle) between the sensing circuit and the reading circuit, and the biological signals do not need to be calibrated again after the biological activities. And, the inductance coupling between the reading circuit and the sensing circuit is more than or equal to 0.0001 to keep higher resolution, otherwise the resolution is very low, and the signal is easily submerged by noise.
In the embodiment of the invention, the inductance coupling coefficient is regulated and controlled by the distance between the inductance of the reading circuit and the inductance of the sensing circuit, so in the embodiment of the invention, the inductance coupling coefficient between the reading circuit and the sensing circuit is between 0.0001 and 0.05, and the measurable distance between the corresponding reading circuit and the sensing circuit is a medium distance, and under the condition of not adopting superconducting materials, the inductance size of the sensing circuit is usually between the same magnitude and tens times.
In the embodiment of the present invention, in the step S1, the high-frequency power supply frequency ω 1 Always with the resonant frequency omega of the reading circuit r And maintaining the offset of the fixed proportion, wherein the offset proportion is more than or equal to 0.1% and less than or equal to 2%.
In the embodiment of the invention, the frequency omega of the high-frequency power supply 1 Always with the resonant frequency omega of the reading circuit r The small offset of the fixed proportion is kept to keep the system stable, and in the embodiment of the invention, the proposed offset proportion is beneficial to the system stability, and the resolution of the system is reduced due to the excessive offset.
In the embodiment of the present invention, in the step S1, the number of times of successively changing the adjustable capacitance value of the reading circuit is 10 times or more, so that the resonance frequency ω of the reading circuit corresponding to the phase difference extremum of the high-frequency power supply voltage and the current r Is captured and the captured frequency bin meets a preset accuracy requirement.
In the embodiment of the invention, the adjustable capacitance value of the reading circuit can be changed gradually to change the resonant frequency omega of the reading circuit when data reading is carried out (namely in the sensing process) r At the same time correspondingly changeHigh frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Similarly, when the resonant frequency ω of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, three frequencies (high-frequency power supply frequency ω 1 Resonant frequency omega of reading circuit r And the resonant frequency omega of the sensing circuit s ) Near, strong resonance of the system is induced, and the phase difference between the voltage and the current of the high-frequency power supply has an extreme value.
For example, the adjustable capacitance of the read circuit may be set to 90pF, corresponding to the resonant frequency ω of one read circuit r And adjusts the frequency omega of the high-frequency power supply 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Similarly, the adjustable capacitance of the reading circuit is changed to 100pF, i.e. the resonant frequency omega of the reading circuit is correspondingly changed r Adjusting the frequency omega of the high-frequency power supply 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Similarly, and by analogy, the adjustable capacitance value of the reading circuit is changed for more than 10 times successively, so that the phase difference extreme value of the high-frequency power supply voltage and the high-frequency power supply current is captured.
In the practical application process, the resonant frequency of the sensing circuit can be read in real time by the reading circuit, and the resonant frequency of the sensing circuit can be measured and read by the reading circuit when a user needs to measure.
In the embodiment of the invention, the sensing process refers to: the resonant frequency of the sensing circuit is read by a read circuit.
In the embodiment of the invention, in the reading process, the adjustable capacitance value can be controlled to be gradually changed by more than 10 points so as to capture the resonant frequency omega of the reading circuit corresponding to the phase difference extreme value of the high-frequency power supply voltage and the current r To determine the resonant frequency of the sensing circuit. In the embodiment of the invention, the resonant frequency omega of the reading circuit is changed by changing the adjustable capacitance value every time r And correspondingly adjust the high frequency power supply frequencyRate omega 1 After that, the phase difference between the high-frequency power supply voltage and the current, and the resonance frequency omega of the reading circuit can be determined r Relationship between them. In practical application, simply speaking, a change curve of the phase difference of the power supply voltage and the current along with the resonant frequency of the reading circuit can be drawn, and the point at which the extreme value of the phase difference of the high-frequency power supply voltage and the current appears can be captured based on the curve, so that the resonant frequency of the sensing circuit can be determined.
In the embodiment of the invention, in order to improve the resolution of the system, the adjustable capacitance value can be controlled to be changed successively more times (for example, tens times and hundreds times) so as to more accurately determine the point at which the extreme value of the phase difference between the high-frequency power supply voltage and the current appears, thereby more accurately determining the resonant frequency of the sensing circuit.
In the embodiment of the invention, in order to increase the reading speed, the number of times of gradually changing the adjustable capacitance value of the reading circuit is not too large in the sensing process.
In the embodiment of the invention, the resonant frequency omega of the sensing circuit s 0.5 MHz or more and 100 MHz or less. If the resonant frequency is too small, the circuit size is larger, if the resonant frequency is too large, the system is easily affected by organisms and environment, and the conductors in the circuit generate more obvious skin effect and proximity effect, so that the resistance is increased, and the communication distance is reduced. The smaller the resistance of the sensing circuit, the better, and no additional configuration can be made, using the resistance of the conductor itself used for the inductor.
In the embodiment of the invention, the biological signal can cause the change of the capacitance or inductance of the sensing circuit, so that the resonant frequency omega of the sensing circuit s Changes are made to determine the resonant frequency omega of the sensing circuit by the reading circuit s The biological signal to be measured can be further determined.
In the embodiment of the invention, the high-frequency power supply, the adjustable capacitor and the inductor of the reading circuit can be connected in series or in parallel.
In the embodiment of the invention, the adjustable capacitor can be realized by driving the distance between the capacitor plates by piezoelectricity, and a voltage control capacitor chip can also be selected.
In the embodiment of the invention, the smaller the resistance of the sensing circuit is, the better the resistance is, and no additional configuration is needed, and the resistance of the conductor used by the inductor of the sensing circuit is only adopted.
In an embodiment of the present invention, the sensing circuit is physically soft and highly deformable, and the inductance of the sensing circuit is a curved stretchable structure.
In particular, the sensing circuit may be physically flexible and highly deformable for mechanical adaptation to the living being, and may be specifically designed according to practical needs. For example, the inductor can be a curve-shaped stretchable structure, the stretchable inductor can reflect the strain if the designed capacitance is basically unchanged, and the sensor is suitable for a strain sensor, and is more suitable for measuring biological signals of other physical quantities if the designed capacitance is more sensitive to the change of the inductance.
In an embodiment of the invention, the sensing circuit physically comprises a conductive material, a dielectric material and an encapsulation material, wherein the conductive material forms an inductance and a resistance, the conductive material and the dielectric material form a capacitance together, and the encapsulation material is used for insulation and protection.
In an embodiment of the present invention, the conductive material may include: copper, gold, graphene, magnesium, and zinc.
Magnesium and zinc are among others degradable materials that can be used in situations where material degradation is required.
In an embodiment of the present invention, the dielectric material may include: one or more of Polyimide (PI), polyethylene terephthalate (PET), and polylactic acid (PLA).
Among them, polylactic acid (PLA) is a degradable material that can be used in a scenario where material degradation is required.
In an embodiment of the present invention, the encapsulation material may include: polydimethylsiloxane (PDMS) and/or polysebacic acid glyceride (PGS).
Among them, polysebacic acid glyceride (PGS) is a degradable material that can be used in situations where material degradation is required.
In the embodiment of the invention, the resonant frequency omega of the sensing circuit s Between 0.5 mhz and 100 mhz. If the resonant frequency is too small, the circuit size is larger, if the resonant frequency is too large, the system is easily affected by organisms and environment, and the conductors in the circuit generate more obvious skin effect and proximity effect, so that the resistance is increased, and the communication distance is reduced.
In an embodiment of the present invention, there is also provided an exemplary embodiment in which the reading circuit includes an adjustable capacitance C r Inductance L r =30μh, resistance R r =200kΩ and high frequency power supply (which can be provided by impedance analyzer), the sensing circuit includes inductance L s =4μh, capacitance C s =340 pF and resistor R s =1Ω. The high-frequency power supply, the adjustable capacitor and the inductor of the reading circuit are connected in parallel. Before the sensing circuit is uncoupled, the voltage value applied to the adjustable capacitor of the reading circuit and the adjustable capacitor/resonant frequency omega are calibrated r Is a relationship of (3). The inductance coupling coefficient between the reading circuit and the sensing circuit is 0.002, and during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While varying the high frequency power supply frequency omega 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Proximity (high frequency power supply frequency omega) 1 Always with the resonant frequency omega of the reading circuit r A small offset of a fixed proportion is maintained, in this example embodiment, the offset proportion is positive 0.5%). The phase difference between the high frequency power supply voltage and current is measured by an impedance analyzer. When the resonant frequency omega of the circuit is read r Changing to the resonant frequency omega of the sensing circuit s Near the sensor, strong resonance is caused, and the phase difference between the voltage and the current of the high-frequency power supply can be extreme, so that the resonance frequency omega of the sensing circuit is obtained s And further, the biological signal to be measured can be calculated. As shown in fig. 3, which shows a variation curve of the power supply voltage and current phase difference obtained in the exemplary embodiment of the present invention with the resonant frequency of the reading circuit. From fig. 3, it can be seen that the distinct extreme points and the corresponding frequency ranges, and thusTo determine the resonant frequency omega of the sensing circuit based on the frequency interval corresponding to the extreme point s . It should be noted that, the process does not need to find the extreme point accurately, as long as the found extreme point corresponds to the frequency interval to meet the actual accuracy requirement, for example, if the measurement accuracy of 5% of the measuring range is required, the adjustable capacitance value needs to be changed by more than 20 points successively; if measurement accuracy of 1% range is required, the adjustable capacitance value needs to be changed by more than 100 points. Furthermore, due to the high frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r The small offset of fixed proportion is kept, and fig. 3 can also be drawn as a change curve of the phase difference of the power supply voltage and the current along with the high-frequency power supply frequency of the reading circuit, and the high-frequency power supply frequency is utilized for corresponding capture, namely the resonance frequency omega of the sensing circuit is determined based on the frequency interval corresponding to the extreme point s Essentially the same as the resonant frequency with the read circuit.
FIG. 4 is a plot of phase versus frequency derivatives at different coupling coefficients and read circuit resonant frequencies for an exemplary embodiment of the present invention. As can be seen from fig. 4, the inductance coupling coefficient between the sensing circuit and the sensing circuit is less than 0.05, so that the measured biological signal is insensitive to the change of position (including distance and angle) between the sensing circuit and the sensing circuit, that is, the biological signal does not need to be recalibrated after being active. The inductive coupling coefficient should be greater than 0.0001 considering the measurement device error, otherwise the resolution is extremely low and the signal is easily swamped by noise. The inductance coupling coefficient is regulated and controlled by the distance between the inductance of the reading circuit and the inductance of the sensing circuit, so that the corresponding distance between 0.0001 and 0.05 of the inductance coupling coefficient is a medium distance which is between the same magnitude and tens of times of the size of the inductance of the sensing circuit.
The medium-distance wireless biosensing system provided by the embodiment of the invention does not depend on a chip or a battery to realize wireless sensing, so that the medium-distance wireless biosensing system provided by the embodiment of the invention does not depend on a difficult-to-degrade material, and can select a degradable material without biological toxicity; in the medium-distance wireless biological sensing system provided by the embodiment of the invention, the inductance coupling coefficient between the reading circuit and the sensing circuit is small0.05, the control method of the system is realized by the following steps: during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close; when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, strong resonance of the system is caused, and the phase difference between the voltage and the current of the high-frequency power supply is extreme; based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s The method comprises the steps of carrying out a first treatment on the surface of the Based on the resonant frequency omega of the sensing circuit s And determining the reading of the biological signal to be measured according to the predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit, so that the communication distance between the reading circuit and the sensing circuit can reach between the same magnitude and tens of times of the inductance size of the sensing circuit.
Based on the same inventive concept, the embodiment of the invention also provides a control method of the medium-distance wireless biosensing system, which is used for controlling the medium-distance wireless biosensing system in the above embodiment, and comprises the following steps:
during the sensing process, the adjustable capacitance value of the reading circuit is gradually changed to change the resonant frequency omega of the reading circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close;
when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, an extreme value occurs in the phase difference between the voltage and the current of the high-frequency power supply; based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s ；
Based on the resonant frequency omega of the sensing circuit s And determining a reading of the biological signal to be measured according to a predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit.
Optionally, the high frequency power supply frequency ω 1 Always with the resonant frequency omega of the reading circuit r And maintaining the offset of the fixed proportion, wherein the offset proportion is more than or equal to 0.1% and less than or equal to 2%.
Optionally, the number of times of changing the adjustable capacitance value of the reading circuit is 10 times or more, so that the resonance frequency ω of the reading circuit corresponding to the phase difference extremum of the high frequency power supply voltage and current r Is captured and the captured frequency bin meets a preset accuracy requirement.
Optionally, the resonant frequency ω of the sensing circuit s 0.5 MHz or more and 100 MHz or less.
Optionally, the biological signal to be measured comprises strain, curvature, pressure, temperature, PH value, ion concentration; the biosignal affects the resonant frequency of the sensing circuit by affecting the inductive geometry, the capacitive geometry, and the dielectric coefficient of the capacitive dielectric material of the sensing circuit.
Based on the same inventive concept, the embodiments of the present invention further provide a computer readable storage medium having a computer program stored thereon, which when executed by a processor, implements the steps in the medium-range wireless biosensing system control method described in any of the above embodiments.
In this specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by differences from other embodiments, and identical and similar parts between the embodiments are all enough to be referred to each other.
It will be apparent to those skilled in the art that embodiments of the present invention may be provided as a method, apparatus, or computer program product. Accordingly, embodiments of the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, embodiments of the invention may take the form of a computer program product on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, etc.) having computer-usable program code embodied therein.
Embodiments of the present invention are described with reference to flowchart illustrations and/or block diagrams of methods, terminal devices (apparatus), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable terminal device to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable terminal device, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable terminal device to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable terminal device to cause a series of operational steps to be performed on the computer or other programmable terminal device to produce a computer implemented process such that the instructions which execute on the computer or other programmable terminal device provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiment and all such alterations and modifications as fall within the scope of the embodiments of the invention.
Finally, it is further noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article or terminal device comprising the element.
The above detailed description of the medium-distance wireless biosensing system, the control method and the storage medium provided by the invention applies specific examples to illustrate the principle and the implementation of the invention, and the above examples are only used for helping to understand the method and the core idea of the invention; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in accordance with the ideas of the present invention, the present description should not be construed as limiting the present invention in view of the above.
Claims (10)
1. A medium range wireless biosensing system, said system comprising: the sensing circuit comprises an inductance, a capacitance and a resistance; the inductance coupling coefficient between the reading circuit and the sensing circuit is less than or equal to 0.05;
the control method of the system is realized by the following steps:
during sensing, the adjustable capacitance value of the reading circuit is changed gradually to change readingTaking the resonant frequency omega of the circuit r While correspondingly changing the high-frequency power supply frequency omega of the reading circuit 1 So that the high-frequency power supply frequency omega 1 Always with the resonant frequency omega of the reading circuit r Close;
when the resonant frequency omega of the reading circuit r Changing to the resonant frequency omega of the sensing circuit s In the vicinity, an extreme value occurs in the phase difference between the voltage and the current of the high-frequency power supply;
based on the resonance frequency omega of the reading circuit corresponding to the extremum r Determining the resonant frequency omega of the sensing circuit in the frequency range s ；
Based on the resonant frequency omega of the sensing circuit s And determining a reading of the biological signal to be measured according to a predetermined corresponding relation between the biological signal to be measured and the resonant frequency of the sensing circuit.
2. The medium range wireless biosensing system of claim 1, wherein an inductive coupling coefficient between said reading circuit and sensing circuit is greater than or equal to 0.0001.
3. The medium-range wireless biosensing system of claim 1, wherein a series connection or a parallel connection is provided among a high-frequency power supply, an adjustable capacitor and an inductance of the reading circuit.
4. The medium range wireless biosensing system of claim 1, wherein during sensing, said high frequency power supply frequency ω 1 Always with the resonant frequency omega of the reading circuit r And maintaining the offset of the fixed proportion, wherein the offset proportion is more than or equal to 0.1% and less than or equal to 2%.
5. The medium-range wireless biosensing system of claim 1, wherein the number of times of successively changing the adjustable capacitance value of the reading circuit is 10 times or more, so that the reading of the high-frequency power supply voltage corresponding to the phase difference extremum of the currentTaking the resonant frequency omega of the circuit r Is captured and the captured frequency bin meets a preset accuracy requirement.
6. The medium range wireless biosensing system of claim 1, wherein said adjustable capacitance is implemented by piezoelectric driven capacitance plate spacing or by a voltage controlled capacitance chip.
7. The medium range wireless biosensing system of claim 1, wherein a resonant frequency ω of the sensing circuit s And 0.5 MHz or more and 100 MHz or less.
8. The medium range wireless biosensing system of claim 1, wherein said sensing circuit is physically soft, highly deformable, and an inductance of said sensing circuit is a curvilinear stretchable structure.
9. The medium range wireless biosensing system of claim 1, wherein said sensing circuitry physically comprises conductive material, dielectric material and packaging material, said conductive material forming inductance and resistance, conductive material forming capacitance with dielectric material, packaging material for insulation and protection;
wherein the conductive material comprises: one or more of copper, gold, graphene, magnesium, and zinc;
the dielectric material includes: one or more of polyimide, polyethylene terephthalate, and polylactic acid;
the encapsulation material comprises: polydimethyl siloxane and/or polysebacic acid glyceride.
10. The medium range wireless biosensing system of claim 1, wherein said biosignal to be measured comprises strain, curvature, pressure, temperature, PH, ion concentration; the biosignal affects the resonant frequency of the sensing circuit by affecting the inductive geometry, the capacitive geometry, and the dielectric coefficient of the capacitive dielectric material of the sensing circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311773783.2A CN117856831A (en) | 2023-12-21 | 2023-12-21 | Medium-distance wireless biosensing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311773783.2A CN117856831A (en) | 2023-12-21 | 2023-12-21 | Medium-distance wireless biosensing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117856831A true CN117856831A (en) | 2024-04-09 |
Family
ID=90542689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311773783.2A Pending CN117856831A (en) | 2023-12-21 | 2023-12-21 | Medium-distance wireless biosensing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117856831A (en) |
-
2023
- 2023-12-21 CN CN202311773783.2A patent/CN117856831A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107106122B (en) | Wearable ultrasonic device for transmitting change signals in human or animal body | |
| US8603000B2 (en) | Method and apparatus for measuring blood volume | |
| US9364362B2 (en) | Implantable device system | |
| CN104605862B (en) | For handling the method and system of the glucose data measured from tool person with diabetes | |
| US20190254559A1 (en) | Implantable Sensor and Method for Such Sensor | |
| US8926496B2 (en) | Implantable device system | |
| RU2011153773A (en) | NON-INVASIVE BLOOD METABOLITES CONTROL | |
| JP2010525901A5 (en) | ||
| JP2015511843A5 (en) | ||
| Wang et al. | A novel intracranial pressure readout circuit for passive wireless LC sensor | |
| WO2008021226A1 (en) | Platform for detection of tissue structure change | |
| WO2016176590A1 (en) | Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction | |
| US20150196225A1 (en) | Health Monitoring System | |
| CN106901702A (en) | Quantitative pulse wave monitoring device based on the quick sensing element of flexible force | |
| WO2014096973A2 (en) | Systems and methods for internal analyte sensing | |
| Olivo et al. | A study of multi-layer spiral inductors for remote powering of implantable sensors | |
| WO2011143316A1 (en) | Device and method for measuring pressure exerted on a surface | |
| CN117856831A (en) | Medium-distance wireless biosensing system | |
| US11428588B2 (en) | Fully-passive pressure sensors and methods for their use | |
| CN111432713A (en) | Biotelemetry device capable of being ingested and implanted in a body | |
| Mandal et al. | A wireless implantable microsystem for real-time bladder volume monitoring | |
| KR20100036697A (en) | Implantable blood pressure testing apparatus in body and receiving system | |
| Khan et al. | Effect of temperature variation on remote pressure readout in wirelessly powered intracranial pressure monitoring system | |
| Moiz et al. | An embedded multichannel telemetry unit for bone strain monitoring | |
| Rosa et al. | Imaging from the implantable side: Ultrasonic-powered EIT system for surgical site infection detection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |