CN114324510A - Flexible sensor, soft intelligent dressing, preparation method and application thereof - Google Patents
Flexible sensor, soft intelligent dressing, preparation method and application thereof Download PDFInfo
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- CN114324510A CN114324510A CN202111382279.0A CN202111382279A CN114324510A CN 114324510 A CN114324510 A CN 114324510A CN 202111382279 A CN202111382279 A CN 202111382279A CN 114324510 A CN114324510 A CN 114324510A
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Abstract
The flexible sensor and the flexible intelligent dressing provided by the application integrate the pH working electrode, the temperature-sensitive resistor and the medicine release electrode for electrically controlled medicine release, so that the flexible sensor and the flexible intelligent dressing can be attached to a chronic wound surface, continuously monitor the pH and the temperature of the local environment of the wound surface in real time, further control the infection condition of the wound surface, and timely carry out medicine administration treatment on the infection condition through the electrically controlled medicine release, thereby realizing an intelligent treatment scheme for monitoring the wound to a certain extent.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a flexible sensor, a soft intelligent dressing, a preparation method and application thereof.
Background
The chronic wound is commonly seen in various clinical departments, has complex etiology and long course of disease, is a great problem in the new century, has obvious negative effects on the life quality of patients, causes medical burden to society due to high dressing change cost, and is difficult to heal due to infection, and the wound which is difficult to heal can be infected at the same time.
The main problems of the existing detection of chronic wounds are as follows: currently, most similar works focus on the embodiment of a sensing function for the selection and processing of a substrate for detecting a chronic wound surface, but the flexibility of a substrate and the application property of the wound surface are neglected, the modulus of the selected material is usually higher and is general with the application property of the skin, and the preparation process of a flexible electrode is more complex; in addition, it is difficult to fabricate sensors for high accuracy and high sensitivity temperature monitoring on flexible stretchable substrates due to the nature of the polymer itself. In the past, rigid devices such as temperature sensor chips and the like are integrated on Polyimide (PI) substrates, and have high modulus and poor skin adhesion. And is not stretchable, which greatly limits practical applications.
Disclosure of Invention
In view of this, it is necessary to provide a flexible sensor, a flexible intelligent dressing, and a preparation method and an application thereof, for solving the problems existing in the prior art that a flexible electronic device substrate is too hard and is not suitable for a wound surface.
In order to solve the above problems, the following technical solutions are adopted in the present application:
the application provides a flexible sensor, flexible sensor includes pH working electrode, reference electrode, temperature sensitive resistance and medicine release electrode, pH working electrode is used for the pH of detection environment, the reference electrode is used for providing the electrode of reference comparison, temperature sensitive resistance is used for detecting the temperature of environment, medicine release electrode can release the medicine under the effect of voltage.
In some of these embodiments, the pH working electrode comprises polyaniline.
In some of these embodiments, the reference electrode comprises Ag/AgCl ink.
In some of these embodiments, the temperature sensitive resistor is a 0805 type temperature sensitive resistor.
In some of these embodiments, the drug delivery electrode comprises polypyrrole and cefazolin sodium.
In addition, the application also provides a preparation method of the flexible sensor, which comprises the following steps:
providing a substrate mask plate;
preparing a substrate film on the substrate mask plate;
depositing a flexible circuit on the base film;
preparing the pH working electrode and the reference electrode on the flexible circuit;
preparing the temperature-sensitive resistor on the flexible circuit;
and preparing the medicament release electrode on the flexible circuit.
In addition, this application still provides a soft intelligent dressing, including flexible dressing and set up in flexible sensor on the dressing, flexible sensor laminating is on the surface of a wound, flexible sensor includes pH working electrode, reference electrode, temperature sensitive resistance and releases the medicine electrode, pH working electrode is used for the pH of detection environment, reference electrode is used for providing the electrode of reference comparison, temperature sensitive resistance is used for detecting the temperature of environment, it can release the medicine under the effect of voltage to release the medicine electrode.
Further, the application also provides a preparation method of the soft intelligent dressing, which comprises the following steps: the flexible sensor is disposed on a soft dressing.
Further, this application still provides one kind soft intelligent dressing's application, will soft intelligent dressing's flexible sensor laminating is on the surface of a wound.
This application adopts above-mentioned technical scheme, its beneficial effect as follows:
the flexible sensor and the flexible intelligent dressing provided by the application integrate the pH working electrode, the temperature-sensitive resistor and the medicine release electrode for electrically controlled medicine release, so that the flexible sensor and the flexible intelligent dressing can be attached to a chronic wound surface, continuously monitor the pH and the temperature of the local environment of the wound surface in real time, further control the infection condition of the wound surface, and timely carry out medicine administration treatment on the infection condition through the electrically controlled medicine release, thereby realizing an intelligent treatment scheme for monitoring the wound to a certain extent.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments of the present application or the prior art will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a flexible sensor provided in embodiment 1 of the present application.
Fig. 2 is a flowchart of a process for preparing a flexible sensor according to embodiment 2 of the present application.
Fig. 3 is a schematic structural diagram of a mask blank provided in embodiment 2 of the present application.
Fig. 4 is a schematic structural diagram of a soft and smart dressing provided in example 3 of the present application.
Detailed Description
Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present application and should not be construed as limiting the present application.
In the description of the present application, it is to be understood that the terms "upper", "lower", "horizontal", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing the present application and simplifying the description, and do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments.
Example 1
Referring to fig. 1, a schematic structural diagram of a flexible sensor according to an embodiment of the present disclosure includes: a pH working electrode 110, a reference electrode 120, a temperature sensitive resistor 130 and a drug release electrode 140.
The pH working electrode 110 is used to detect the pH of the environment.
In some of these embodiments, the pH working electrode comprises polyaniline.
The reference electrode 120 is used to provide an electrode for reference comparison.
In some of these embodiments, the reference electrode 120 comprises Ag/AgCl ink.
The temperature sensitive resistor 130 is used for detecting the temperature of the environment.
In some of these embodiments, the temperature sensitive resistor is a 0805 type temperature sensitive resistor.
The drug release electrode 140 can release drugs under the action of voltage.
In some of these embodiments, the drug delivery electrode 140 comprises polypyrrole and cefazolin sodium.
The flexible sensor provided by the above embodiment 1 of the present application integrates pH sensing, temperature sensing, and an electronically controlled drug release micro flexible sensor array, so that the flexible sensor array can be attached to a chronic wound surface, continuously monitor the pH and temperature of the local environment of the wound surface in real time, and further control the infection condition of the wound surface, and the electronically controlled drug release can timely perform drug administration treatment on the infection condition, thereby implementing an intelligent treatment scheme of wound monitoring to a certain extent.
Example 2
Referring to fig. 2, the present application further provides a method for manufacturing the flexible sensor, including the following steps:
step S110: a substrate mask is provided.
It can be understood that, in practice, a corresponding substrate mask plate may be designed according to the position distribution of each sensor region and the lead on the substrate, please refer to fig. 3, which is a schematic structural diagram of the mask plate.
Step S120: and preparing a substrate film on the substrate mask plate.
In some of the examples, Ecoflex substrate films with a thickness of 200um were prepared by spin coating.
Step S130: depositing a flexible circuit on the base film.
In some embodiments, gold having a thickness of 200nm distributed according to the mask plate is deposited as a flexible circuit on the mask plate for deposition designed in step S110 and the Ecoflex substrate film prepared in step S120 by a thermal evaporation apparatus.
Step S140: and preparing the pH working electrode and the reference electrode on the flexible circuit.
In some of these embodiments, polyaniline is deposited on the flex circuit by electrochemical deposition and dried naturally at room temperature as the working electrode of the core of the pH sensor; Ag/AgCl ink with the thickness of 0.5mm is coated on a pH reference area prepared by a flexible circuit by a coating method and is used as a reference electrode of the pH sensor.
Step S150: and preparing the temperature-sensitive resistor on the flexible circuit.
In some embodiments, 0805 type temperature-sensitive resistors with ultra-small volume are adopted and distributed in a sensing area according to sensor pins, and are connected with gold wires in a flexible circuit in a matched liquid metal manner to form a complete sensing circuit.
Step S160: and preparing the medicament release electrode on the flexible circuit.
In some of these examples, polypyrrole (Pyy) and cefazolin sodium were used to prepare the working electrode of the drug release electrode that can be controlled electrically, and the reference electrode was the ink mentioned in step S140 above, and a voltage of-0.5 v was applied to release the drug due to the positive and negative charges.
Furthermore, a PI flexible circuit is connected with a rear-end data processing and transmitting module and the like to form complete sensor measurement, and a data circuit can be acquired.
The method for manufacturing the flexible sensor provided in embodiment 2 of the present application can measure multiple parameters in a small area, including pH, temperature of a local microenvironment of a chronic wound surface, and electronically controlled drug release, and the flexible circuit is manufactured on the flexible substrate by a simple method, and the introduction of the liquid metal is used as both the circuit and the interface to realize the combination and coexistence of flexibility and hardness, including the combination of the rigid temperature sensor and the flexible substrate, so that the requirements of flexible attachment to the wound surface and allowing wound surface penetrating fluid to pass through the substrate are considered while the supporting function of the substrate is ensured. The preparation method is simple and feasible.
Example 3
Referring to fig. 4, the present application further provides a flexible smart dressing, which includes a flexible dressing 310 and a flexible sensor 320 disposed on the flexible dressing 310. The flexible sensor is attached to the wound surface.
The detailed structure and the manufacturing method of the flexible sensor 320 can refer to embodiments 1 and 2, and are not described herein.
The soft intelligent dressing provided by the embodiment 3 of the application comprises the flexible sensor, and the flexible sensor integrates the pH working electrode, the temperature sensitive resistor and the drug release electrode for electrically controlled drug release, so that the dressing can be attached to a chronic wound surface, the pH and the temperature of the local environment of the wound surface can be continuously monitored in real time, the infection condition of the wound surface can be controlled, the drug delivery treatment can be timely carried out on the infection condition through the electrically controlled drug release, and the intelligent treatment scheme for wound monitoring can be realized to a certain extent.
Further, the application also provides a preparation method of the soft intelligent dressing, which comprises the following steps: the flexible sensor is arranged on the soft dressing, and the preparation process is simple.
The application provides a soft intelligent dressing will the flexible sensor laminating of soft intelligent dressing is on the surface of a wound, and applicable in the characteristics of chronic surface of a wound semi-open, permeable surface of a wound penetrant and the miniature sensing array of a plurality of important indexes of integrated detection to the problem that the flexible electronic equipment substrate of preparation is too hard under the solution prior art, is inapplicable to the surface of a wound.
The foregoing is considered as illustrative only of the preferred embodiments of the invention, and is presented only for the purpose of illustrating the principles of the invention and not in any way to limit its scope. Any modifications, equivalents and improvements made within the spirit and principles of the present application and other embodiments of the present application without the exercise of inventive faculty will occur to those skilled in the art and are intended to be included within the scope of the present application.
Claims (9)
1. The flexible sensor is characterized by comprising a pH working electrode, a reference electrode, a temperature-sensitive resistor and a medicine releasing electrode, wherein the pH working electrode is used for detecting the pH of the environment, the reference electrode is used for providing a reference comparison electrode, the temperature-sensitive resistor is used for detecting the temperature of the environment, and the medicine releasing electrode can release medicines under the action of voltage.
2. The flexible sensor of claim 1, wherein the pH working electrode comprises polyaniline.
3. The flexible sensor of claim 1, wherein the reference electrode comprises Ag/AgCl ink.
4. The flexible sensor of claim 1, wherein the temperature-sensitive resistor is a 0805 type temperature-sensitive resistor.
5. The flexible sensor of claim 1, wherein the drug release electrode comprises polypyrrole and cefazolin sodium.
6. A method of making a flexible sensor according to claim 1, comprising the steps of:
providing a substrate mask plate;
preparing a substrate film on the substrate mask plate;
depositing a flexible circuit on the base film;
preparing the pH working electrode and the reference electrode on the flexible circuit;
preparing the temperature-sensitive resistor on the flexible circuit;
and preparing the medicament release electrode on the flexible circuit.
7. The flexible sensor is attached to a wound surface and comprises a pH working electrode, a reference electrode, a temperature-sensitive resistor and a drug release electrode, wherein the pH working electrode is used for detecting the pH of the environment, the reference electrode is used for providing an electrode for reference comparison, the temperature-sensitive resistor is used for detecting the temperature of the environment, and the drug release electrode can release drugs under the action of voltage.
8. A method of making a flexible smart dressing as claimed in claim 7, comprising the steps of: the flexible sensor is disposed on a soft dressing.
9. Use of a flexible smart dressing according to claim 7, wherein the flexible sensors of the flexible smart dressing are applied to the wound bed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111382279.0A CN114324510A (en) | 2021-11-22 | 2021-11-22 | Flexible sensor, soft intelligent dressing, preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111382279.0A CN114324510A (en) | 2021-11-22 | 2021-11-22 | Flexible sensor, soft intelligent dressing, preparation method and application thereof |
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| CN114324510A true CN114324510A (en) | 2022-04-12 |
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| CN202111382279.0A Pending CN114324510A (en) | 2021-11-22 | 2021-11-22 | Flexible sensor, soft intelligent dressing, preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
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| CN101249064A (en) * | 2008-03-28 | 2008-08-27 | 厦门大学 | Preparation of sulphonation aluminum phthalocyanine medicament chip taking polypyrole as medicament carrier |
| US20090194427A1 (en) * | 2003-12-31 | 2009-08-06 | Shen-Kan Hsiung | Using polypyrrole as the contrast ph detector to fabricate a whole solid-state ph sensing device |
| CN110201296A (en) * | 2019-05-20 | 2019-09-06 | 北京化工大学 | A kind of conducting polymer microneedle patch and preparation method thereof for controlled drug release |
| US20200061379A1 (en) * | 2018-08-24 | 2020-02-27 | The United States Government As Represented By The Department Of Veterans Affairs | Devices, systems, and methods for remotely monitoring and treating wounds or wound infections |
| CN110974171A (en) * | 2019-12-13 | 2020-04-10 | 深圳先进技术研究院 | Wound surface monitoring device, preparation method thereof and wound surface dressing assembly |
| CN111888641A (en) * | 2019-05-06 | 2020-11-06 | 上海敬巽信息科技有限公司 | Iontophoretic drug delivery device |
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2021
- 2021-11-22 CN CN202111382279.0A patent/CN114324510A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090194427A1 (en) * | 2003-12-31 | 2009-08-06 | Shen-Kan Hsiung | Using polypyrrole as the contrast ph detector to fabricate a whole solid-state ph sensing device |
| CN101249064A (en) * | 2008-03-28 | 2008-08-27 | 厦门大学 | Preparation of sulphonation aluminum phthalocyanine medicament chip taking polypyrole as medicament carrier |
| US20200061379A1 (en) * | 2018-08-24 | 2020-02-27 | The United States Government As Represented By The Department Of Veterans Affairs | Devices, systems, and methods for remotely monitoring and treating wounds or wound infections |
| CN111888641A (en) * | 2019-05-06 | 2020-11-06 | 上海敬巽信息科技有限公司 | Iontophoretic drug delivery device |
| CN110201296A (en) * | 2019-05-20 | 2019-09-06 | 北京化工大学 | A kind of conducting polymer microneedle patch and preparation method thereof for controlled drug release |
| CN110974171A (en) * | 2019-12-13 | 2020-04-10 | 深圳先进技术研究院 | Wound surface monitoring device, preparation method thereof and wound surface dressing assembly |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
| CN115645149B (en) * | 2022-12-14 | 2024-01-23 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
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