CN108498856A - A kind of customized wound dressing and preparation method thereof - Google Patents
A kind of customized wound dressing and preparation method thereof Download PDFInfo
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- CN108498856A CN108498856A CN201810501279.XA CN201810501279A CN108498856A CN 108498856 A CN108498856 A CN 108498856A CN 201810501279 A CN201810501279 A CN 201810501279A CN 108498856 A CN108498856 A CN 108498856A
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- dressing
- wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a kind of customized wound dressings, include the Dressing substrate being made of porous water-absorbing material, the microchannel for liquid communication is equipped in the Dressing substrate, which has outlet and the entrance being arranged on the Dressing substrate.The present invention discloses the preparation methods of above-mentioned wound dressing.Dressing inner passage can lead to nutrient solution, and the waste liquid absorbed from site of injury is taken away while being cells with nutrient, be conducive to the recovery of wound.Indwelling interface in dressing can easily carry out nutrition perfusion and change liquid, keep the active environment conducive to wound healing, accelerate to restore, and do not influence the daily action of patient.
Description
Technical field
The invention belongs to field of medical article technology, it is specifically related to a kind of customized wound dressing and its making side
Method.
Background technology
Medical dressing major function is covering, protection damaged skin, while providing the environment for contributing to wound healing.Tradition
Mainly using natural fibrous materials class dressing such as degreasing cotton gauze, meche, cotton balls and cotton films, wound can be made to dry, had
It is physically isolated function；But exists and exudate is formed a scab, cause wound adhesion, when dressing causes pain and new wound, Yi Jixi
The problems such as bacterium grows, moisturizing and anthemorrhagic performance are bad.
As a kind of Medical dressing, gel surface is smooth for gel-like dressing, and good biocompatibility, water absorbing capacity is strong,
Aquation repeatedly can occur when being contacted with tissue, in the moisture absorption to dressing in tissue, can the continuous absorption surface of a wound ooze
Go out object, then form gel, when replacement will not adhesion.Aerogel dressing can closely be binded with the surface of a wound of out-of-flatness, reduce bacterium
The chance of growth prevents trauma surface infestation, and new vessels is accelerated to generate, and promotes epithelial cell growth.
Currently, most of gel-like medical dressing lead to dressing all without the custom-shaped for various wounds on the market
Fitting effect decline.In addition most of gel-like medical dressing do not actively promote the removal waste fluid of wound recovery, logical nutrition etc.
Functional structure largely limits the sepage absorbability of dressing, while it is outer that the histocyte of wound can not be given to provide
Boundary's nutrition slows down the resume speed of wound.
Invention content
In order to overcome deficiency existing for wound dressing in background technology, the present invention provides a kind of customized wounds to apply
Material, is more bonded with wound, there is covering wound, antibacterial, promotion wound healing and other effects.
Invention also provides a kind of production methods of customized wound dressing, and this method step is simple, embodiment party
Just.
A kind of customized wound dressing includes the Dressing substrate being made of porous water-absorbing material, the Dressing substrate
The interior microchannel being equipped with for liquid communication, the microchannel have outlet and the entrance being arranged on the Dressing substrate.
The present invention, as Dressing substrate, is applied on wound using porous water-absorbing material, can absorb sepage, reduces wound
Bacteria breed, further speed up the wound healing of wound.
Preferably, there is the moulding surface structure consistent with corresponding wound after the Dressing substrate water suction.Using the technical side
Case can more to be bonded between dressing and wound, and extraneous foul or bacterium is avoided to invade wound.Meanwhile using with it is right
The moulding surface structure that wound is consistent is answered, the fitting effect of dressing is further improved.
Preferably, the water imbibition freeze-dried material is gel freeze-dried material.When using the dressing, sepage is absorbed, just
It can restore gel state, will not generate adhesion between wound, when dismounting, secondary injury will not be brought to wound.
Gel like material of the present invention can be polysaccharide, gelatin, matrigel, GelMA (gelatin-methyl methacrylate
Ester) blend between glue, alginate and above-mentioned gel rubber material.After Dressing substrate being made using these above-mentioned gel rubber materials,
Lyophilized technique can be used Dressing substrate is lyophilized, be porous structure after freeze-drying, is suitble to preserve, pastes and then apply in wound
On, after absorbing sepage, gel state can be restored automatically.As further preferred, the gel rubber material is alginate；Or institute
State the mixture that gel rubber material is GelMA glue and alginate.Using above-mentioned gel mixture, GelMA (gelatin-had both been remained
Methyl methacrylate) biocompatibility good advantage, in turn ensure the mechanical property of gel-in-matrix.The present invention passes through more
The mixing of kind gel in specific proportions, can reach preferable biocompatibility and mechanical performance, can be used as the biology of embedded cell
The base material of viable skin chip.
When using alginate material, using the sodium alginate aqueous solution and quality that mass concentration is 1%-4%
The calcium chloride water of a concentration of 2%-4% carries out print value using coaxial extruder head and obtains, inside extruder head and above-mentioned calcium chloride
Solution is connected, and outside extruder head is connected with the sodium alginate aqueous solution of 1%-4%.
When selecting the mixed gel of GelMA glue and alginate, can by GelMA (gelatin-methyl methacrylate) with match
The mass concentration set be 2%-4% sodium alginate aqueous solution by mixing, the matter of the mixed solution sodium alginate ensured
Amount volume ratio is 1%-2%, and the mass volume ratio of GelMA is 5%-15%.Finally pass through photocuring or molten by calcium chloride
Liquid cures.
Preferably, in the interior growth factor for containing antibacterial anti-infective material, promoting wound healing of the Dressing substrate
It is one or two kinds of.Using the technical solution, bacterium infection can be prevented, enhances wound healing, is inhaled in combination with the Dressing substrate
There is this special tectonic of the moulding surface structure consistent with corresponding wound after water, wound and antibacterial anti-infective material can be further increased
The contact area for expecting, promoting the growth factor of wound healing, further promotes wound healing.
Antibacterial anti-infective material of the present invention can be nano silver, zinc, chitosan, honey, chitin and above-mentioned
The blend of storeroom.In the material phase for preparing making skin chip, antibacterial anti-infective material can be mixed with gel rubber material.
It, can be by antibacterial anti-infective material such as when the mixed gel or alginate that select GelMA glue and alginate are as gel
Material is mixed with GelMA glue with the aqueous solution of the mixed solution of alginate or sodium alginate.If antibacterial anti-infective material selection
Nano silver, then in mixed solution, the addition of nano silver is 1-50mg/L.If antibacterial anti-infective material is chitosan, mix
In solution, the addition of chitosan is 1-5% (mass percent).
Preferably, the growth factor of the promotion wound healing is selected from following one or more：Epidermal growth
The factor, fibroblast growth factor, platelet derived growth factor, human vascular endothelial growth factor, transforming growth because
Son, bone morphogenetic protein etc..
Preferably, the outlet and inlet are equipped with indwelling connector.Preferably, the dressing perfusion interface of the present invention is adopted
With the indwelling quick coupling of medical infusion.After dressing is at the wound coverage, perfusing hole be connected to external liquid pumping device, progress dressing
The cycle of interior liquid and replacement.After pump liquid reaches metering, you can disconnect, indwelling interface is left, until changing liquid next time
It is again coupled to, does not during which influence the daily action of patient.For there is particular/special requirement, wearable miniature pump liquid dress can be added
It sets, reaches the function of changing liquid in real time.
A method of the customized wound dressing described in any of the above-described technical solution is made, is included the following steps：
(1) according to the true form of patient wound, the threedimensional model of corresponding wound dressing is established；
(2) prepare the material of making wound dressing；
(3) method for fast mfg is utilized to make the wound dressing with the microchannel for liquid communication；
It is selectable to enter step (4)：
(4) dressing made is lyophilized, obtains the wound dressing；
Wherein step (1) and step (2) are limited without sequencing.
Preferably, the method for fast mfg is selected from 3D printing method, sacrificial layer manufactures pouring procedure.It is of the present invention
Inside there is the dressing structure of pipeline the techniques such as can be poured by 3D printing increasing material manufacturing, sacrificial layer manufacture and be made.Inside dressing
Pipeline be used for after dressing wound coverage to being passed through liquid inside dressing.The liquid being passed through can be debridement liquid, take away dressing
The sepage absorbed from site of injury, improves the sepage absorbability of dressing.Can also be cell nutrient solution, it will by way of infiltration
Nutrient delivery can also be that various drugs are used for accelerating the surface of a wound to the neonatal cell of site of injury, the recovery healing of acceleration of wound
Healing.
When selecting 3D printing method, in step (1), after the threedimensional model for establishing wound dressing, by calculating machine-cut
Piece software is completed, to the slice of threedimensional model, to finally obtain the 3D printing path data of skin chip, pass through existing 3D printing
Equipment is printed；For example for printing microtube structure, the coaxial inside and outside double nozzle structures being nested may be used and carry out
Directly print.When selecting sacrificial layer to manufacture pouring procedure, in step (1), according to the threedimensional model of structure, mold and sacrificial is made
The making of domestic animal layer material.
According to the present invention, dressing materials matrix is made of gel like material, and is hindered containing antibacterial anti-infective material and promotion
The growth factor of mouth healing.There is the pipeline for liquid communication inside dressing, and there are the fluids of plug type at dressing both ends
Perfusion inlet and outlet, dressing has covering wound, antibacterial, promotion wound healing and other effects, and process is simple, ring
It protects.
When using dressing of the invention, it is only necessary to which the dressing that storage will be lyophilized is covered on wound.It certainly can be according to reality
Border needs, and first can carry out moisture absorption processing to freeze-drying dressing, water may be used and carry out moisture absorption, or liquid medicine can be used, disinfectant etc.
Moisture absorption is carried out to dressing, then is covered on wound.
The present invention compared with prior art, has the advantage that：
(1) shape of dressing is customizable, is bonded shape of wound.
(2) Dressing substrate is made of gel, good biocompatibility, is not adhered skin, reduces the pain at patient trauma, and
Wet environment can be provided for wound site, be conducive to the growth of site of injury neonatal cell.
(3) contain anti-infective antibacterial material in dressing, inhibit the bacteria breed of site of injury.The growth factor included accelerates wound
The healing of mouth.
(4) pipeline configuration is included in stratiform dressing, on the one hand can takes away dressing by way of leading to liquid into pipeline
In absorbed sepage, improve the sepage absorbability of dressing, on the other hand can be by cell nutrient solution by way of infiltration
It is transferred to the histocyte of wound, is conducive to the growth of cell, accelerating wound healing.
(5) perfusing hole is connected to the connector of indwelling function, and after using intermittent feed flow, dressing can be filled with external pump liquid
Separation is set, does not influence the daily action of patient.It can quickly be connect with liquid pumping device by indwelling connector to when feed flow next time, side
Just practical.
Description of the drawings
Fig. 1 is the wound dressing schematic diagram of the built-in channel of the present invention.
Specific implementation mode
To better illustrate the present invention, assigns and further illustrating below by example.
Embodiment 1, the customizable alginate nano Ag wound active dressing with inner passage that the present invention provides a kind of
And preparation method, it includes the following steps：
(1) dressing display model and path are established：It is built according to the true form of patient wound by 3 d modeling software
The threedimensional model of vertical dressing.By computer Slice Software, continuous dressing 3D printing path is generated.
(2) printed material is prepared：A certain amount of biochemical grade sodium alginate powder is weighed, radiation sterilization half in the UV lamp is put
Hour, sodium alginate powder and deionized water are mixed by the mass ratio of 1%-4%, magnetic stirrer stirs 24 hours, temperature
Degree is set as 60 DEG C, rotating speed 120rpm.It is to be mixed uniformly after obtain mass concentration be 1%-4% sodium alginate aqueous solution.
And be sufficiently mixed sodium alginate aqueous solution and proper amount of nano silver-colored (1-50mg/L) as antibacterial material, incorporation is directed to wound site
The growth factor of cell is uniformly mixed.
(3) calcium chloride cross-linked material is prepared：A certain amount of biochemical grade calcium chloride powder is weighed, irradiation in the UV lamp is put and goes out
Bacterium half an hour is mixed calcium chloride powder and deionized water by the mass ratio of 2%-4%, and magnetic stirrer stirs 1 hour, temperature
Degree is set as 25 DEG C, rotating speed 120rpm.It is to be mixed uniformly after obtain mass concentration be 2%-4% calcium chloride water.
(4) 3D printing sodium alginate wound dressing：Printer extruder head uses coaxial extruder head, inside extruder head and step
(3) calcium chloride solution prepared in is connected, and outside extruder head is connected with the mixing material prepared in step (2).When printing, chlorination
Calcium is 1 with the logical liquid speed ratio for mixing dressing:1.Since inner passage is connected with calcium chloride solution, the sodium alginate with external channel
Matrix will produce cross-linking reaction, and inner passage is formed in the bar printed.Calcium chloride solution is supported as internal simultaneously
Material prevents collapsing for inner passage.Using 3D printer above-mentioned material is pressed the company generated in step (1) on collecting board
Continuous path is printed as the dressing of custom-shaped, after dressing molding, continues to print a distance, pouring liquid mouth is reserved in side.
Finally the dressing that printing is completed is placed in the calcium chloride solution of a concentration of 2%-4% and is crosslinked, and is connected at perfusing hole
Portable indwelling interface, completes the making of dressing.
After the dressing is overlying on wound, the alginate matrix of customization can be bonded wound, and flap coverage absorbs sepage, and
Moist healing environment is provided.The nano silver adulterated in dressing can be in the form of sustained release, and slow release plays antibacterial in wound
Effect.Growth factor promotes site of injury to correspond to the growth of cell, accelerating wound healing equally in the form of sustained release.Furthermore, it is possible to
It is passed through cell nutrient solution from reserved perfusing hole, absorbed sepage in dressing on the one hand can be taken away, improve the sepage of dressing
On the other hand cell nutrient solution can be transferred to the histocyte of wound by way of infiltration, is conducive to by absorbability
The growth of neonatal cell, accelerating wound healing.The continuous pump liquid of external liquid pumping device can be connect by perfusing hole whenever necessary, also may be used
In such a way that liquid is changed in the intermittent timing of selection, the nutrient solution being pumped into is replaced into the waste liquid in channel.Change patient after the completion of liquid
Interface is extracted, to liquid pumping device is connected again when changing liquid next time, does not during which interfere with normal life.
When high-volume makes, the dressing made can be subjected to frozen dried, facilitate storage, it, can be through before actual use
Cross simple moisture absorption processing, you can be directly covered on wound use.
Embodiment 2, the present invention provides a kind of customizable alginate-GelMA wound dressings and system with inner passage
Preparation Method, it includes the following steps：
(1) dressing display model and path are established：It is built according to the true form of patient wound by 3 d modeling software
The threedimensional model of vertical dressing and dressing internal channel.
(2) channel sacrificial layer holder is prepared：Using water-soluble material, dressing inner passage is prepared according to first step model
Holder.
(3) sodium alginate-GelMA solution is prepared：A certain amount of biochemical grade sodium alginate powder is weighed, is put in the UV lamp
Radiation sterilization half an hour is mixed sodium alginate powder and deionized water by the mass ratio of 2%-4%, magnetic stirrer stirring
24 hours, temperature setting was 60 DEG C, rotating speed 120rpm.It is to be mixed uniformly after obtain mass concentration be 2%-4% alginic acid
Sodium water solution.GelMA (gelatin-methyl methacrylate) is ensured to obtain with the sodium alginate aqueous solution configured by mixing
The mass percent of mixed solution sodium alginate be 1%-2%, the mass percent of GelMA is 5%-15%, and mixes shell
For glycan (mass percent 1%-2%) with for the growth factor (mass percent 1%-2%) of wound site cell, mixing is equal
It is even, the base material for being suitable for cell growth adherency is made.
(4) wound dressing is molded：Sodium alginate-GelMA the solution that will be prepared, pours the mold in the holder containing sacrificial layer
In, using the ultraviolet light of 365nm wavelength, sodium alginate-GelMA mixed matrixs are started to cure by ultraviolet light stimulus.It is auxiliary
After molding is fully cured in material, dressing is soaked in deionized water, dissolves internal pipeline sacrificial layer material, and in the discrepancy in channel
Mouth end connects indwelling interface, completes the making of dressing.
Claims (10)
1. a kind of customized wound dressing, which is characterized in that include the Dressing substrate being made of porous water-absorbing material, it is described
The microchannel for liquid communication is equipped in Dressing substrate, which, which has, is arranged the outlet on the Dressing substrate and enters
Mouthful.
2. customized wound dressing according to claim 1, which is characterized in that have after Dressing substrate water suction with
The consistent moulding surface structure of corresponding wound.
3. customized wound dressing according to claim 1, which is characterized in that the porous water-absorbing material is gel
Freeze-dried material.
4. customized wound dressing according to claim 3, which is characterized in that the gel is selected from following at least one
Kind：Polysaccharide, gelatin, matrigel, GelMA glue, alginate.
5. customized wound dressing according to claim 1, which is characterized in that containing antibacterial anti-in the Dressing substrate
Infected material, one or both of the growth factor for promoting wound healing.
6. customized wound dressing according to claim 5, which is characterized in that the antibacterial anti-infective material is selected from
Following at least one：Nano silver, zinc, chitosan, honey, chitin.
7. customized wound dressing according to claim 5, which is characterized in that the growth of the promotion wound healing
The factor is selected from following one or more：Epithelical cell growth factor, fibroblast growth factor, platelet derived growth because
Son, human vascular endothelial growth factor, transforming growth factor, bone morphogenetic protein.
8. customized wound dressing according to claim 1, which is characterized in that the outlet and inlet are equipped with indwelling
Connector.
9. a kind of method making the customized wound dressing of claim 1-8 any one of them, which is characterized in that including such as
Lower step：
(1) according to the true form of patient wound, the threedimensional model of corresponding wound dressing is established；
(2) prepare the material of making wound dressing；
(3) method for fast mfg is utilized to make the wound dressing with the microchannel for liquid communication；
It is selectable to enter step (4)：
(4) dressing made is lyophilized, obtains the wound dressing；
Wherein step (1) and step (2) are limited without sequencing.
10. the method according to claim 9 for making customized wound dressing, which is characterized in that the quick manufacture
Method is selected from 3D printing method, sacrificial layer manufactures pouring procedure.
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| CN201810501279.XA CN108498856A (en) | 2018-05-23 | 2018-05-23 | A kind of customized wound dressing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810501279.XA CN108498856A (en) | 2018-05-23 | 2018-05-23 | A kind of customized wound dressing and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731130A (en) * | 2018-11-14 | 2019-05-10 | 华中科技大学同济医学院附属协和医院 | A kind of method that low-temperature biological 3D printing technique prepares hydrogel Wound dressing |
| CN110664541A (en) * | 2019-09-25 | 2020-01-10 | 北京科技大学 | Preparation method of 3D-printed wound customized band-aid |
| CN110947021A (en) * | 2019-12-17 | 2020-04-03 | 山东朱氏药业集团有限公司 | Preparation method of degradable wound dressing and batching equipment of dressing |
| CN112717191A (en) * | 2021-01-08 | 2021-04-30 | 齐齐哈尔大学 | Preparation method of customizable and functional dressing |
| CN113144272A (en) * | 2021-02-07 | 2021-07-23 | 南京鼓楼医院 | Shape-adjustable hydrogel patch for wound repair and preparation method thereof |
| CN113144283A (en) * | 2021-04-26 | 2021-07-23 | 广东海洋大学 | TSCP-GelMA hydrogel for promoting wound healing and preparation and application thereof |
| CN114404666A (en) * | 2022-01-28 | 2022-04-29 | 南京鼓楼医院 | In-situ printing support for wound repair and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102387765A (en) * | 2009-04-30 | 2012-03-21 | 罗曼-劳氏股份有限公司 | Film for covering a wound |
| CN102781380A (en) * | 2010-03-11 | 2012-11-14 | 凯希特许有限公司 | Dressings, systems and methods for treating a tissue site |
| CN103895226A (en) * | 2014-03-24 | 2014-07-02 | 浙江大学 | 3D-printing-based machining method of three-dimensional micro-fluidic chip and printing device |
| US20160184495A1 (en) * | 2014-12-30 | 2016-06-30 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Surface pump and dressing comprising a surface pump |
| CN105778126A (en) * | 2016-03-31 | 2016-07-20 | 中国人民解放军军事医学科学院野战输血研究所 | Genipin cross-linked biogel as well as preparation method and application thereof |
| CN107693483A (en) * | 2017-11-02 | 2018-02-16 | 巴斯特医药科技（常州）有限公司 | Long-acting controlled release composite membrane and its preparation method with gel state pressure transmission key-course |
-
2018
- 2018-05-23 CN CN201810501279.XA patent/CN108498856A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102387765A (en) * | 2009-04-30 | 2012-03-21 | 罗曼-劳氏股份有限公司 | Film for covering a wound |
| CN102781380A (en) * | 2010-03-11 | 2012-11-14 | 凯希特许有限公司 | Dressings, systems and methods for treating a tissue site |
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