CN106963358A - A kind of embedded nerve electrode based on carbon nano tube line - Google Patents
A kind of embedded nerve electrode based on carbon nano tube line Download PDFInfo
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Abstract
The invention discloses a kind of embedded nerve electrode based on carbon nano tube line, it is related to medical instruments field, including expose portion and insulated part, the expose portion is with the insulated part from same CNT line electrode, the CNT line electrode of the expose portion is directly exposed, and the CNT line electrode of the insulated part is wrapped up by insulating barrier；The expose portion is used for the record of electroneurographic signal or carries out electro photoluminescence to nerve fiber.The nerve electrode size of the disclosure of the invention is small, and with flexible structure and closely with neuronal contacts, this set can reduce the mechanical damage caused to nerve fiber, be advantageously implemented et al. Ke steady in a long-term.The carbon nano-tube material that nerve electrode is used has the advantages that electric charge injectability is high, the electroneurographic signal that can either realize high s/n ratio using the nerve electrode of small-size carbon nanotube line is recorded, local nerve electro photoluminescence can be realized again, improve the spatial selectivity of nerve electrode electro photoluminescence.
Description
Technical field
The present invention relates to medical instruments field, more particularly to a kind of embedded nerve electrode based on carbon nano tube line.
Background technology
As biological nervous system and the physical channel of artificial electron's equipment, the performance of embedded nerve electrode is directly determined
The collection of biological neural electric signal and the long-term reliability of nerve electric stimulation.The design consideration of nerve electrode mainly includes
The biocompatibility of material and the repeatability of biological safety, the mechanics of electrode and electrochemical stability and manufacture craft etc..
Using polymer, platinum, iridium or silicon more than traditional embedded nerve electrode for periphery and central nervous tissue
Material, although can realize the function of electrode, it can be difficult to accomplishing high-biocompatibility, flexibility (i.e. low mechanical damage
Property), the unification of high s/n ratio and high electric charge injectability.Wherein, the problem of flexibility of electrode is one huge, flexibility is greatly
Influence the relative motion between electrode and nerve fibre, flexible higher, the relative motion between electrode and nerve fibre of electrode
Fewer, the mechanical damage caused is smaller, is conducive to the regeneration of nerve fiber and improves the signal to noise ratio of nerve signal.Electrode is thinner,
Bending modulus is smaller then flexible better；It is general but electrode thickness is influenceed by material electrochemical properties itself and engineering properties
Logical material is meticulous is easily broken off and can improve impedance, is unfavorable for electrode and implements electro photoluminescence.Therefore, develop have concurrently superior flexibility,
The novel electrode of electrochemical properties and biocompatibility is to realize the key that electroneurographic signal steady in a long-term is recorded or stimulated.
Through the literature search discovery to prior art, Cutrone et al. is in Journal of Neural Engineering
" the A three-dimensional self-opening delivered on (neural engineering periodical, 12 (2015) 016016)
Intraneural peripheral interface (SELINE) " (the peripheral nerve interface of three-dimensional self-retaining), this article is proposed
A kind of nerve electrode being fixed in peripheral nerve beam based on polyimide material.Specific design thinking is：Pass through width
For 150 μm of structure, width is fixed in peripheral nerve beam for 360 μm of electrod-array in body.The substrate of the electrod-array
Material is polyimides, and gold is used as electrode material.Its deficiency is：Organism is during free movement, because polyamides is sub-
The flexibility of amido bottom material is not enough, therefore the electrod-array will be caused directly to cause the machinery of the nerve fibre in nerve tract to damage
Wound, it is impossible to realize that permanently effective electroneurographic signal is recorded or stimulated.Simultaneously as gold injects as the electric charge of electrode material
Ability, when as stimulating electrode, easily occurs electrochemical corrosion, it is impossible to for a long time as stimulating electrode.
The content of the invention
In view of the drawbacks described above of prior art, the technical problems to be solved by the invention are that existing nerve electrode is difficult to
There are high-biocompatibility, low mechanical damage, high s/n ratio and high electric charge injectability simultaneously, it is impossible to realize permanently effective pair
The problem of bioelectrical signals are acquired with output.
In view of the drawbacks described above of prior art, the present invention provides a kind of embedded nerve based on carbon nano tube line
Pole, including expose portion 1 and insulated part 2, the expose portion 1 is with the insulated part 2 from same CNT
Line electrode, the CNT line electrode of the expose portion 1 directly exposes, the CNT line electrode quilt of the insulated part 2
Insulating barrier is wrapped up；The expose portion 1 is used for the record of electroneurographic signal or carries out electro photoluminescence to nerve.
Further, the material of the nerve electrode is carbon nano tube line, a diameter of 100nm- of the carbon nano tube line
100μm。
Further, the carbon nano tube line is drawn by a plurality of a diameter of 0.1nm-10nm single-root carbon nano-tube and formed.
Further, the carbon nano tube line electrode length scope of the expose portion 1 is 1 μm of -1mm.
Further, the insulating layer material of the insulated part 2 is c-type Parylene (Parylene-C) or medical
Silica gel (Silicone).
Further, the thickness of insulating layer of the insulated part 2 is 1 μm -5 μm.
Further, the nerve scaffold carrier of the embedded nerve electrode is the cuspidated rigid solid structure of tool, such as
Tungsten filament, stainless steel wire.
Further, the recording mode of the embedded nerve electrode is that differential type is recorded or non-differential type record, institute
The differential record that differential type record refers to realize the electroneurographic signal of two passages by two adjacent CNT line electrodes is stated,
The ambient noise interference of common mode is eliminated, signal to noise ratio is improved.
Further, the embedded nerve electrode is single-channel electrodes or multi-channel electrode.
Further, the stimulation mode of the embedded nerve electrode be monopole electro photoluminescence or bipolar electro photoluminescence, it is described
Monopole electro photoluminescence refers to that reclaiming electrode (return electrode) size is more than stimulating electrode size, and electric apart from stimulating
Stimulation mode of the pole more than 1 centimetre, one loop of the recovery electrode and stimulating electrode formation；The bipolar electro photoluminescence is referred to
The stimulation mode that two distances are used in conjunction with tens microns to several millimeters of stimulating electrode.
Further, the embedded nerve electrode can be used in periphery or central nervous system tissue.
Further, the implantation of the embedded nerve electrode refers to that the expose portion 1 is completely disposed at peripheral nerve
In beam or inside central nervous tissue.
Compared with prior art, the present invention has the advantages that：
1st, the material that the nerve electrode that provides of the present invention is used is carbon nano tube line, and carbon nano tube line has superior soft
Property, i.e., composite bending modulus is very low；Under minimum diameter, the significantly larger than metal such as platinum, iridium is realized god by the flexibility of carbon nano tube line
Through being brought into close contact between electrode and nerve fiber, be implanted into after the nerve electrode it is long-term in body using being difficult to cause nerve fiber
Mechanical damage.
2nd, the CNT wire material that the nerve electrode that the present invention is provided is used has superior tensile strength, in carbon nanometer
In the case that pipeline diameter is suitable with nerve fibre, such as at 10 μm, do not pulled apart by bio-tissue internal force.
3rd, the chemical property for the CNT wire material that the nerve electrode that the present invention is provided is used is good, with very high electricity
Lotus injectability, is that can realize that effective electric charge is transmitted using small-size carbon nanotube line electrode, so as to improve electro photoluminescence
Spatial selectivity, and ensure the persistence and validity of electro photoluminescence.
4th, by the present invention in that realizing the differential record of electroneurographic signal with two passage carbon nano tube line electricity, reduce biological
The influence of the ambient noise caused in body and motion process, so as to further improve the signal to noise ratio of record nerve signal.
5th, the implantation carrier of carbon nano tube line nerve electrode of the present invention is that have cuspidated rigid solid structure, such as tungsten filament,
The damage caused in implantation process to nerve fiber can be significantly reduced.
The technique effect of the design of the present invention, concrete structure and generation is described further below with reference to accompanying drawing, with
It is fully understood from the purpose of the present invention, feature and effect.
Brief description of the drawings
Fig. 1 show the schematic diagram that a kind of preferred embodiment of the present invention is used in peripheral nerve beam；
A kind of preferred embodiment that Fig. 2 show the present invention is used in cortex and the schematic diagram of deep brain position；
Wherein, the blood vessel in 1- expose portions, 2- insulated parts, 3- nerve cords, 4- nerve tracts, 5- nerve cords, 6- brains
Cortex, 7- Basal ganglias, 8- cerebellums, 9- central sulcuses, 10- oblongata.
Embodiment
Below in conjunction with accompanying drawing to a kind of preferred reality of the embedded nerve electrode based on carbon nano tube line of the present invention
Example is applied to be described in detail, but the present invention is not limited in the embodiment.Thoroughly understand in order that the public has to the present invention,
Concrete details is described in detail in present invention below preferred embodiment.
Embodiment 1
As shown in figure 1, two embedded nerve electrodes based on carbon nano tube line are implanted to the same of peripheral nerve dry 3
In peripheral nerve beam 4, for recording the peripheral nerve fiber electric signal under motion state and carrying out part to periphery nerve tract 4
Electro photoluminescence.Wherein, the embedded nerve electrode based on carbon nano tube line includes expose portion 1 and insulated part 2, expose portion
1 derives from same CNT line electrode with insulated part 2, and the CNT line electrode of expose portion 1 directly exposes, insulation
The CNT line electrode of part 2 is wrapped up by insulating barrier；Expose portion 1 is used for the record of electric signal or nerve is entered to assassinate
Swash.
Embedded nerve electrode material is carbon nano tube line, a diameter of 10 μm of carbon nano tube line.The carbon nano tube line by
A plurality of 0.1nm-10nm single-root carbon nano-tube draws and formed.The carbon nano tube line electrode length scope of expose portion 1 is 1 μm-
500μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel (Silicone).
The thickness of insulating layer of insulated part 2 is 1 μm -5 μm.
The recording mode of embedded nerve electrode records for differential type, and differential type record refers to receive by two adjacent carbon
Mitron line electrode realizes the differential record of the electroneurographic signal of two passages, eliminates the ambient noise interference of common mode, improves signal to noise ratio.
Embedded nerve electrode uses multi-channel electrode, and the stimulation mode of nerve electrode is two close stimulation electricity
Bipolar electro photoluminescence between pole, bipolar electro photoluminescence refers to the stimulation mode that two close stimulating electrodes are used in conjunction with.
The implant site of embedded nerve electrode include but is not limited to ulnar nerve, nervus radialis, median nerve, sciatic nerve and
Its branch；The carrier of nerve electrode is tungsten filament in the present embodiment, and electrode implantation process is：Carrier carries embedded nerve electrode and worn
Saturating perineurium, is pierced into inside nerve fiber；Carrier is withdrawn from, embedded nerve electrode is stayed in inside nerve tract, neuroelectricity
The implantation of pole refers to that expose portion 1 is completely disposed in peripheral nerve beam 4 or inside central nervous tissue, because carrier is tool
Cuspidated rigid solid structure, the implantation of nerve electrode is to nerve cord 3, the damage that the blood vessel 5 in nerve tract 4 or nerve cord is caused
Wound is smaller.
Embodiment 2
As shown in Fig. 2 two adjacent CNT line electrodes are implanted to cortex respectively, electricity is carried out to the nerve of brain
The nerve electric stimulation of the differential record of signal or part；Neural electrical activity for recording motor cortex, or realize to body sense
Feel that cortex, visual cortex carry out electro photoluminescence, realize somatesthesia or visual feedback.Wherein, the implantation based on carbon nano tube line
Formula nerve electrode includes expose portion 1 and insulated part 2, and expose portion 1 is with insulated part 2 from same carbon nano tube line
Electrode, the CNT line electrode of expose portion 1 is directly exposed, and the CNT line electrode of insulated part 2 is wrapped up by insulating barrier；
Expose portion 1 is used for the record of electroneurographic signal or carries out electro photoluminescence to nerve.
The material of embedded nerve electrode is carbon nano tube line, a diameter of 10 μm of carbon nano tube line.The carbon nano tube line
Drawn and formed by a plurality of a diameter of 0.1nm-5nm single-root carbon nano-tube.The carbon nano tube line electrode length scope of expose portion 1
It is 1 μm -5 μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel
(Silicone) polymer of good biocompatibility such as.The thickness of insulating layer of insulated part 2 is 2 μm -4 μm.
The recording mode of embedded nerve electrode records for differential type, and differential type record refers to receive by two adjacent carbon
Mitron line electrode realizes the differential record of the electroneurographic signal of two passages, eliminates the ambient noise interference of common mode, improves signal to noise ratio.
Embedded nerve electrode uses multi-channel electrode, and the stimulation mode of nerve electrode is two close stimulation electricity
Bipolar electro photoluminescence between pole, bipolar electro photoluminescence refers to the stimulation mode that two close stimulating electrodes are used in conjunction with.
The implant site of embedded nerve electrode includes but is not limited to the load of nerve electrode in cerebral cortex 6, the present embodiment
Tool is tungsten filament, and electrode implantation process is：Carrier carries embedded nerve electrode and penetrates perineurium, is pierced into cerebral nerve tissue
It is internal；Carrier is withdrawn from, embedded nerve electrode is stayed in inside cerebral nerve, the implantation of nerve electrode refers to expose portion 1
It is completely disposed inside brain cortex neural, such as cerebral cortex 6, because carrier is the cuspidated rigid solid structure of tool, neuroelectricity
The damage that the implantation of pole is caused to brain neuroblastoma or cerebral vessels is smaller.
Embodiment 3
As shown in Fig. 2 two adjacent CNT line electrodes are implanted to brain deep layer respectively, the god for carrying out deep brain
Through electric signal record or electrical stimulation regulation and control.Wherein, the embedded nerve electrode based on carbon nano tube line includes expose portion 1
With insulated part 2, expose portion 1 is with insulated part 2 from same CNT line electrode, the carbon nanometer of expose portion 1
Pipeline electrode is directly exposed, and the CNT line electrode of insulated part 2 is wrapped up by insulating barrier；Expose portion 1 is used for neural telecommunications
Number record or to nerve carry out electro photoluminescence.
The material of embedded nerve electrode is carbon nano tube line, a diameter of 10 μm of carbon nano tube line.The carbon nano tube line
Drawn and formed by a plurality of a diameter of 5nm-10nm single-root carbon nano-tube.The carbon nano tube line electrode length scope of expose portion 1
It is 1 μm -500 μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel
(Silicone).The thickness of insulating layer of insulated part 2 is 3 μm -5 μm.
The recording mode of embedded nerve electrode records for non-differential type.
Embedded nerve electrode uses single-channel electrodes, and the stimulation mode of nerve electrode is monopole electro photoluminescence, monopole
Electro photoluminescence refers to it being to reclaim electrode (return electrode) size to be more than stimulating electrode size, and apart from stimulating electrode
Stimulation mode more than 1 centimetre, and reclaim one loop of electrode and stimulating electrode formation.
The implant site of embedded nerve electrode includes but is not limited to Basal ganglia 7, cerebellum 8, central sulcus 9 or oblongata 10；
The carrier of nerve electrode is tungsten filament in the present embodiment, and electrode implantation process is：Carrier carries embedded nerve electrode and penetrates nerve
Film, is pierced into inside nerve fiber；Carrier is withdrawn from, embedded nerve electrode is stayed in inside nerve tract, the implantation of nerve electrode
Refer to that expose portion 1 is completely disposed inside brain neuroblastoma, such as Basal ganglia 7, cerebellum 8, central sulcus 9 or oblongata 10, due to carrying
Tool is the cuspidated rigid solid structure of tool, the damage that the implantation of nerve electrode is caused to brain neuroblastoma or cerebral vessels compared with
It is small.
Preferred embodiment of the invention described in detail above.It should be appreciated that one of ordinary skill in the art without
Need creative work just can make many modifications and variations according to the design of the present invention.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical scheme, all should be in the protection domain being defined in the patent claims.
Claims (10)
1. a kind of embedded nerve electrode based on carbon nano tube line, it is characterised in that including expose portion (1) and insulated part
(2), the expose portion (1) derives from same CNT line electrode, the expose portion with the insulated part (2)
(1) CNT line electrode is directly exposed, and the CNT line electrode of the insulated part (2) is wrapped up by insulating barrier；It is described
Expose portion (1) is used for the record of electroneurographic signal or carries out electro photoluminescence to nerve.
2. the embedded nerve electrode as described in claim 1 based on carbon nano tube line, it is characterised in that the neuroelectricity
The material of pole is carbon nano tube line, a diameter of 100nm-100 μm of the carbon nano tube line.
3. the embedded nerve electrode as described in claim 2 based on carbon nano tube line, it is characterised in that the carbon nanometer
Pipeline is drawn by a plurality of a diameter of 0.1nm-10nm single-root carbon nano-tube and formed.
4. the embedded nerve electrode as described in claim 1 based on carbon nano tube line, it is characterised in that the exposed portion
The carbon nano tube line electrode length scope for dividing (1) is 1 μm of -1mm.
5. the embedded nerve electrode as described in claim 1 based on carbon nano tube line, it is characterised in that the insulation division
The insulating layer material for dividing (2) is c-type Parylene or medical silica-gel.
6. the embedded nerve electrode as described in claim 5 based on carbon nano tube line, it is characterised in that the insulation division
The thickness of insulating layer for dividing (2) is 1 μm -5 μm.
7. the embedded nerve electrode as described in claim 1 based on carbon nano tube line, it is characterised in that the implanted
The nerve scaffold carrier of nerve electrode is the cuspidated rigid solid structure of tool, such as tungsten filament, stainless steel wire.
8. the embedded nerve electrode based on carbon nano tube line as any one of claim 1-7, it is characterised in that institute
The recording mode of embedded nerve electrode is stated to record for differential type or non-differential type record.
9. the embedded nerve electrode based on carbon nano tube line as any one of claim 1-7, it is characterised in that institute
It is single-channel electrodes or multi-channel electrode array to state embedded nerve electrode.
10. the embedded nerve electrode based on carbon nano tube line as any one of claim 1-7, it is characterised in that
The stimulation mode of the embedded nerve electrode is monopole electro photoluminescence or bipolar electro photoluminescence.
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| CN201710244916.5A CN106963358A (en) | 2017-04-14 | 2017-04-14 | A kind of embedded nerve electrode based on carbon nano tube line |
| CN201810771411.9A CN108904972A (en) | 2017-04-14 | 2017-04-14 | A kind of embedded nerve electrode based on carbon nano tube line |
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| CN108744268A (en) * | 2018-03-29 | 2018-11-06 | 北京大学 | Application of the flexible and transparent carbon nanotube nerve electrode array in neural photoelectricity interface |
| CN110545720A (en) * | 2019-07-17 | 2019-12-06 | 诺尔医疗（深圳）有限公司 | anti-bending intracranial electrode manufacturing method, intracranial deep electrode and electroencephalograph |
| CN110721402A (en) * | 2018-07-16 | 2020-01-24 | 上海交通大学 | Implanted nerve electrode system |
| CN110841186A (en) * | 2019-11-19 | 2020-02-28 | 华中科技大学 | Implanted peripheral nerve electrode |
| CN112004573A (en) * | 2018-04-27 | 2020-11-27 | 普雷塞斯股份公司 | Electrode body and electrode arrangement for an electrode arrangement for electrical stimulation and method for producing an electrode arrangement |
| CN114177472A (en) * | 2021-11-30 | 2022-03-15 | 中国人民解放军总医院第四医学中心 | Implanted electrical stimulation sensing feedback system applied to lower limb artificial limb |
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