CN106581769A - Functionalized nano biological ceramic coating and preparation process thereof - Google Patents
Functionalized nano biological ceramic coating and preparation process thereof Download PDFInfo
- Publication number
- CN106581769A CN106581769A CN201611127049.9A CN201611127049A CN106581769A CN 106581769 A CN106581769 A CN 106581769A CN 201611127049 A CN201611127049 A CN 201611127049A CN 106581769 A CN106581769 A CN 106581769A
- Authority
- CN
- China
- Prior art keywords
- parts
- ceramic coating
- functionalized nano
- hours
- implantation material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a functionalized nano biological ceramic coating and a preparation process thereof. The functionalized nano biological ceramic coating is prepared from the following components: tricalcium phosphate, chromium sulfate, strontium fluorapatite, aluminum chloride, sodium metatitantate, ammonium molybdate, silica gel, chitosan fibers, carbon molecular sieve-220, carboxymethyl chitin, polyhydroxybutyric acid, acetylglutamic acid, tartaric acid, cellulose acetate, 3-acrylamide dopamine, methyl salicylate, eucalyptol, urea, span-80 and distilled water. The biological ceramic coating provided by the invention is significantly high in bonding intensity with an implant, and the maximum bearing load of the biological ceramic coating reaches 105-127N or above, so that a demand on the mechanical performance of the coating of the implant is satisfied; and in addition, the coating is excellent in biocompatibility, and the coating is capable of promoting the adhesion and growth of osteoblast, accelerating repair and healing rates and shortening a healing cycle.
Description
Technical field
The invention belongs to medical material tech field, more particularly to a kind of functionalized nano bio-ceramic coating and its preparation
Technique.
Background technology
Bio-medical material is to carry out diagnosis and treatment for organism, repair and replace its disease damage tissue, organ or promote its property
The new High-tech Material of energy.With the important breakthrough of the continuous progress and crucial science and technology of Novel medical technology, biological material
Material has been increasingly becoming global scientist and related scholar falls over each other one of focus material of research and development.
Titanium and titanium alloy implant are widely used in Bone Defect Repari in bio-medical material at present, yet with its own
Biologically inert, affect knitting rate.Generally, power is implanted in order to improve titanium and titanium alloy implant, often to which
Surface coating modification.Bio-ceramic coating can be promoted knitting, and be had due to its good biocompatibility
Good wearability, corrosion resistance and hardness, are titanium and the preferable coating material of titanium alloy implant.Additionally, can also be by changing
The composition composition for becoming ceramic coating is capable of achieving ceramic coating functionalization, uses flexibly, but generally ceramic coating and metal base
Bond strength need further to improve.
The content of the invention
For this purpose, the present invention provides a kind of functionalized nano bio-ceramic coating and its preparation technology, solve in prior art
At least one technical problem.
For this purpose, the present invention provides a kind of functionalized nano bio-ceramic coating, it is prepared from by the component of following weight portion：
Tricalcium phosphate 15-27 parts, chromic sulfate 3-9 parts, fluorophosphoric acid strontium 1-4 parts, aluminum chloride 1-6 parts, meta-titanium perborate 1.3-2.8 parts, molybdic acid
Ammonium 0.6-1.5 parts, Silica hydrogel 0.3-2 parts, chitin fiber 0.5-1.7 parts, -220 1-3 parts of carbon molecular sieve, carboxymethyl chitin
1.2-3.8 parts, poly butyric 0.3-1.2 parts, acetylglutamate 0.8-2 parts, tartaric acid 0.6-2.4 parts, cellulose acetate
1.1-3 parts, 3- acrylamido dopamine 0.4-1.5 parts, methyl salicylate 0.1-0.7 parts, eucalyptol 0.1-0.5 parts, carbamide
0.8-1.7 parts, Arlacel-80 0.3-1.4 parts, distilled water 64-77 parts.
An embodiment of the invention, wherein, the Silica hydrogel be aminopropyl silicone oil, terminal hydroxy group methyl-silicone oil,
One or more in methyl vinyl silicon oil.
An embodiment of the invention, wherein, it is prepared from by the component of following weight portion：Tricalcium phosphate 17-
26 parts, chromic sulfate 3.4-8.6 parts, fluorophosphoric acid strontium 1.2-3.7 parts, aluminum chloride 1.6-5.4 parts, meta-titanium perborate 1.4-2.6 parts, molybdic acid
Ammonium 0.8-1.2 parts, Silica hydrogel 0.4-1.7 parts, chitin fiber 0.6-1.5 parts, -220 1.3-2.6 parts of carbon molecular sieve, carboxymethyl
Chitin 1.4-3.5 parts, poly butyric 0.4-1 parts, acetylglutamate 0.9-1.8 parts, tartaric acid 0.8-2.2 parts, acetic acid are fine
Dimension element 1.5-2.8 parts, 3- acrylamido dopamine 0.6-1.3 parts, methyl salicylate 0.2-0.6 parts, eucalyptol 0.1-0.4
Part, carbamide 0.9-1.4 parts, Arlacel-80 0.5-1.2 parts, distilled water 68-75 parts.
For this purpose, the present invention provides a kind of preparation technology of functionalized nano bio-ceramic coating, comprise the steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 2-8 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 60-80 DEG C is heated to, 20-40 minutes are stirred, is processed in adding step 1 afterwards
Implantation material, at 50-60 DEG C soak 2-5 hours, be then transferred in reactor, at 110-130 DEG C react 2-24 it is little
When, take out, clean and air-dry, be obtained and process implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, after standing 1-5 hours at 80-100 DEG C
Take out, be obtained and process implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and is placed in step 3,5-24 hours are reacted at 160-180 DEG C, is taken out, cleaned and air-dry,
Functionalized nano bio-ceramic coating is obtained.
An embodiment of the invention, wherein, in the step 2, hydrothermal reaction condition is：React at 115 DEG C
10 hours.
An embodiment of the invention, wherein, in the step 3, reaction condition is：3 are stood at 85 DEG C little
When.
An embodiment of the invention, wherein, in the step 4, hydrothermal reaction condition is：React at 175 DEG C
8 hours.
Beneficial effects of the present invention are：
The bio-ceramic coating that the present invention is provided is significantly improved with the bond strength of implantation body, and its value reaches 53.8-62.8MPa, and
The maximum of ball disk-type friction test is born load and is up to 105-127N, meets the mechanical property requirements of the coating of implant, and
The coating has good biocompatibility, can promote osteoblastic adhesion and growth, accelerates healing speed, and shortening is healed
The conjunction cycle.
Specific embodiment
With reference to embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention, but not
For limiting the scope of the present invention.
Embodiment 1
A kind of functionalized nano bio-ceramic coating, is prepared from by the component of following weight portion：15 parts of tricalcium phosphate, chromic sulfate
3 parts, 1 part of fluorophosphoric acid strontium, 1 part of aluminum chloride, 1.3 parts of meta-titanium perborate, 0.6 part of ammonium molybdate, 0.3 part of Silica hydrogel, chitin fiber 0.5
Part, -220 1 parts of carbon molecular sieve, 1.2 parts of carboxymethyl chitin, 0.3 part of poly butyric, 0.8 part of acetylglutamate, tartaric acid
0.6 part, 1.1 parts of cellulose acetate, 0.4 part of 3- acrylamidos dopamine, 0.1 part of methyl salicylate, 0.1 part of eucalyptol, urine
0.8 part of element, 0.3 part of Arlacel-80,64 parts of distilled water.
Wherein, the Silica hydrogel is aminopropyl silicone oil.
A kind of preparation technology of functionalized nano bio-ceramic coating, comprises the steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 2 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 60 DEG C are heated to, is stirred 20 minutes, is added the implantation processed in step 1 afterwards
Material, soaks 2 hours at 50 DEG C, is then transferred in reactor, reacts 2 hours at 130 DEG C, takes out, and cleans and air-dries,
It is obtained and processes implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, taken out after standing 1 hour at 80 DEG C,
It is obtained and processes implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and be placed in step 3, reacted 5 hours at 160 DEG C, take out, clean and air-dry, that is, be obtained
Functionalized nano bio-ceramic coating.
Embodiment 2
A kind of functionalized nano bio-ceramic coating, is prepared from by the component of following weight portion：27 parts of tricalcium phosphate, chromic sulfate
9 parts, 4 parts of fluorophosphoric acid strontium, 6 parts of aluminum chloride, 2.8 parts of meta-titanium perborate, 1.5 parts of ammonium molybdate, 2 parts of Silica hydrogel, chitin fiber 1.7
Part, -220 3 parts of carbon molecular sieve, 3.8 parts of carboxymethyl chitin, 1.2 parts of poly butyric, 2 parts of acetylglutamate, tartaric acid 2.4
Part, 3 parts of cellulose acetate, 1.5 parts of 3- acrylamidos dopamine, 0.7 part of methyl salicylate, 0.5 part of eucalyptol, carbamide 1.7
Part, 1.4 parts of Arlacel-80,77 parts of distilled water.
Wherein, the Silica hydrogel is terminal hydroxy group methyl-silicone oil and the mixture of methyl vinyl silicon oil, both mass ratioes
For 2:3.
A kind of preparation technology of functionalized nano bio-ceramic coating, comprises the steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 8 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 80 DEG C are heated to, is stirred 40 minutes, is added the implantation processed in step 1 afterwards
Material, soaks 5 hours at 60 DEG C, is then transferred in reactor, reacts 24 hours under 110, takes out, and cleans and air-dries,
It is obtained and processes implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, taken out after standing 5 hours at 100 DEG C,
It is obtained and processes implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and be placed in step 3, reacted 24 hours at 180 DEG C, take out, clean and air-dry, that is, be obtained
Functionalized nano bio-ceramic coating.
Embodiment 3
A kind of functionalized nano bio-ceramic coating, is prepared from by the component of following weight portion：17 parts of tricalcium phosphate, chromic sulfate
3.4 parts, 1.2 parts of fluorophosphoric acid strontium, 1.6 parts of aluminum chloride, 1.4 parts of meta-titanium perborate, 0.8 part of ammonium molybdate, 0.4 part of Silica hydrogel, shitosan
0.6 part of fiber, -220 1.3 parts of carbon molecular sieve, 1.4 parts of carboxymethyl chitin, 0.4 part of poly butyric, acetylglutamate 0.9
Part, 0.8 part of tartaric acid, 1.5 parts of cellulose acetate, 0.6 part of 3- acrylamidos dopamine, 0.2 part of methyl salicylate, eucalyptol
0.1 part, 0.9 part of carbamide, 0.5 part of Arlacel-80,68 parts of distilled water.
Wherein, the Silica hydrogel is aminopropyl silicone oil and the mixture of terminal hydroxy group methyl-silicone oil, and the mass ratio of both is
1:4。
A kind of preparation technology of functionalized nano bio-ceramic coating, comprises the steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 6 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 75 DEG C are heated to, is stirred 35 minutes, is added the implantation processed in step 1 afterwards
Material, soaks 4 hours at 55 DEG C, is then transferred in reactor, reacts 10 hours at 115 DEG C, takes out, and cleans and wind
It is dry, it is obtained and processes implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, taken out after standing 3 hours at 85 DEG C,
It is obtained and processes implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and be placed in step 3, reacted 8 hours at 175 DEG C, take out, clean and air-dry, that is, be obtained
Functionalized nano bio-ceramic coating.
Embodiment 4
A kind of functionalized nano bio-ceramic coating, is prepared from by the component of following weight portion：26 parts of tricalcium phosphate, chromic sulfate
8.6 parts, 3.7 parts of fluorophosphoric acid strontium, 5.4 parts of aluminum chloride, 2.6 parts of meta-titanium perborate, 1.2 parts of ammonium molybdate, 1.7 parts of Silica hydrogel, shitosan
1.5 parts of fiber, -220 2.6 parts of carbon molecular sieve, 3.5 parts of carboxymethyl chitin, 1 part of poly butyric, 1.8 parts of acetylglutamate,
2.2 parts of tartaric acid, 2.8 parts of cellulose acetate, 1.3 parts of 3- acrylamidos dopamine, 0.6 part of methyl salicylate, eucalyptol 0.4
Part, 1.4 parts of carbamide, 1.2 parts of Arlacel-80,75 parts of distilled water.
Wherein, mixture of the Silica hydrogel for aminopropyl silicone oil, terminal hydroxy group methyl-silicone oil and methyl vinyl silicon oil, and
The mass ratio of three is 3:1:1.
A kind of preparation technology of functionalized nano bio-ceramic coating, comprises the steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 7 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 75 DEG C are heated to, is stirred 28 minutes, is added the implantation processed in step 1 afterwards
Material, soaks 4 hours at 58 DEG C, is then transferred in reactor, reacts 10 hours at 115 DEG C, takes out, and cleans and wind
It is dry, it is obtained and processes implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, taken out after standing 3 hours at 85 DEG C,
It is obtained and processes implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and be placed in step 3, reacted 8 hours at 175 DEG C, take out, clean and air-dry, that is, be obtained
Functionalized nano bio-ceramic coating.
Comparative example 1
In place of this comparative example and the difference of embodiment 1 it is：Not comprising Silica hydrogel, carbon molecular sieve -220 and meta-titanium perborate.
Comparative example 2
In place of this comparative example and the difference of embodiment 1 it is：Not comprising chitin fiber, 3- acrylamidos dopamine and Oleum Eucalypti
Essence.
Performance test
Below the properties of the bio-ceramic coating prepared by above example and comparative example are tested, its method of testing
Carried out using the testing standard of the industry, DCO result is as shown in the table：
| Bond strength/MPa（Scarification） | Maximum bears load/N（Ball disk-type friction is tested, 60 min） | OD values（Osteoblasts cultivation 3 days） | |
| Embodiment 1 | 53.8 | 105 | 0.973±0.012 |
| Embodiment 2 | 55.7 | 112 | 0.965±0.021 |
| Embodiment 3 | 57.2 | 117 | 0.982±0.016 |
| Embodiment 4 | 60.5 | 124 | 0.996±0.018 |
| Embodiment 5 | 62.8 | 127 | 1.021±0.014 |
| Comparative example 1 | 46.7 | 91 | 0.935±0.019 |
| Comparative example 2 | 42.4 | 94 | 0.918±0.013 |
From above test result, the bio-ceramic coating that the present invention is provided is significantly improved with the bond strength of implantation body, its
Value is born load and is up to 105-127N up to 53.8-62.8MPa, and the maximum of ball disk-type friction test, meets the coating of implant
Mechanical property requirements, and the coating has good biocompatibility, can promote osteoblastic adhesion and growth, accelerates
Healing speed, shortens healing cycle.
Claims (7)
1. a kind of functionalized nano bio-ceramic coating, it is characterised in that be prepared from by the component of following weight portion：Phosphoric acid
DFP 15-27 parts, chromic sulfate 3-9 parts, fluorophosphoric acid strontium 1-4 parts, aluminum chloride 1-6 parts, meta-titanium perborate 1.3-2.8 parts, ammonium molybdate
0.6-1.5 parts, Silica hydrogel 0.3-2 parts, chitin fiber 0.5-1.7 parts, -220 1-3 parts of carbon molecular sieve, carboxymethyl chitin
1.2-3.8 parts, poly butyric 0.3-1.2 parts, acetylglutamate 0.8-2 parts, tartaric acid 0.6-2.4 parts, cellulose acetate
1.1-3 parts, 3- acrylamido dopamine 0.4-1.5 parts, methyl salicylate 0.1-0.7 parts, eucalyptol 0.1-0.5 parts, carbamide
0.8-1.7 parts, Arlacel-80 0.3-1.4 parts, distilled water 64-77 parts.
2. functionalized nano bio-ceramic coating according to claim 1, it is characterised in that the Silica hydrogel is aminopropyl
One or more in silicone oil, terminal hydroxy group methyl-silicone oil, methyl vinyl silicon oil.
3. functionalized nano bio-ceramic coating according to claim 1, it is characterised in that by the group of following weight portion
Divide and be prepared from：Tricalcium phosphate 17-26 parts, chromic sulfate 3.4-8.6 parts, fluorophosphoric acid strontium 1.2-3.7 parts, aluminum chloride 1.6-5.4 parts,
Meta-titanium perborate 1.4-2.6 parts, ammonium molybdate 0.8-1.2 parts, Silica hydrogel 0.4-1.7 parts, chitin fiber 0.6-1.5 parts, carbon molecule
Sieve -220 1.3-2.6 parts, carboxymethyl chitin 1.4-3.5 parts, poly butyric 0.4-1 parts, acetylglutamate 0.9-1.8 parts,
Tartaric acid 0.8-2.2 parts, cellulose acetate 1.5-2.8 parts, 3- acrylamido dopamine 0.6-1.3 parts, methyl salicylate
0.2-0.6 parts, eucalyptol 0.1-0.4 parts, carbamide 0.9-1.4 parts, Arlacel-80 0.5-1.2 parts, distilled water 68-75 parts.
4. the preparation technology of a kind of functionalized nano bio-ceramic coating according to claim 1, it is characterised in that include
Following steps：
Step 1, will implantation material first carry out corona treatment, then by Jing process implantation material add carboxymethyl chitin
In acetylglutamate, 2-8 hours are stood, take out and clean and dry up, it is standby；
Step 2, by Arlacel-80, Silica hydrogel, methyl salicylate, poly butyric and eucalyptol add half distilled water in, then
Chitin fiber and carbon molecular sieve -220 are added, 60-80 DEG C is heated to, 20-40 minutes are stirred, is processed in adding step 1 afterwards
Implantation material, at 50-60 DEG C soak 2-5 hours, be then transferred in reactor, at 110-130 DEG C react 2-24 it is little
When, take out, clean and air-dry, be obtained and process implantation material M, it is standby；
Step 3, by tricalcium phosphate, chromic sulfate, fluorophosphoric acid strontium, aluminum chloride, meta-titanium perborate, ammonium molybdate, 3- acrylamido DOPA
Amine and remaining distilled water mix homogeneously, process implantation material M in being subsequently adding step 2, after standing 1-5 hours at 80-100 DEG C
Take out, be obtained and process implantation material N；
Step 4, carbamide, cellulose acetate and tartaric acid are added in step 3 in solution, be uniformly mixed, be subsequently transferred to
In reactor, implantation material will be processed and is placed in step 3,5-24 hours are reacted at 160-180 DEG C, is taken out, cleaned and air-dry,
Functionalized nano bio-ceramic coating is obtained.
5. the preparation technology of functionalized nano bio-ceramic coating according to claim 4, it is characterised in that the step
In 2, hydrothermal reaction condition is：React 10 hours at 115 DEG C.
6. the preparation technology of functionalized nano bio-ceramic coating according to claim 5, it is characterised in that the step
In 3, reaction condition is：3 hours are stood at 85 DEG C.
7. the preparation technology of functionalized nano bio-ceramic coating according to claim 6, it is characterised in that the step
In 4, hydrothermal reaction condition is：React 8 hours at 175 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611127049.9A CN106581769A (en) | 2016-12-09 | 2016-12-09 | Functionalized nano biological ceramic coating and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611127049.9A CN106581769A (en) | 2016-12-09 | 2016-12-09 | Functionalized nano biological ceramic coating and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106581769A true CN106581769A (en) | 2017-04-26 |
Family
ID=58597915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611127049.9A Pending CN106581769A (en) | 2016-12-09 | 2016-12-09 | Functionalized nano biological ceramic coating and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106581769A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107353767A (en) * | 2017-06-30 | 2017-11-17 | 南宁东印时代广告有限公司 | Ceramic coating |
| CN109453426A (en) * | 2018-09-03 | 2019-03-12 | 北京化工大学 | A kind of Bone Defect Repari bioactive ceramics fibrous composite scaffold and preparation method thereof |
| CN110386814A (en) * | 2019-09-03 | 2019-10-29 | 长沙华脉新材料有限公司 | A kind of Specialty bio ceramic material and preparation method thereof for 3D printing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| CN101381881A (en) * | 2007-09-05 | 2009-03-11 | 西南交通大学 | Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition |
| CN101785879A (en) * | 2010-01-26 | 2010-07-28 | 广东省人民医院 | Degradable airway stent and application thereof |
| CN102552973A (en) * | 2012-02-17 | 2012-07-11 | 浙江海圣医疗器械有限公司 | Medical degradable and absorbable Mg-Sr-Ca series magnesium alloy implant and preparation method thereof |
| CN105339017A (en) * | 2013-05-02 | 2016-02-17 | 奥齿泰有限责任公司 | Method for treating surface of implant |
-
2016
- 2016-12-09 CN CN201611127049.9A patent/CN106581769A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| CN101381881A (en) * | 2007-09-05 | 2009-03-11 | 西南交通大学 | Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition |
| CN101785879A (en) * | 2010-01-26 | 2010-07-28 | 广东省人民医院 | Degradable airway stent and application thereof |
| CN102552973A (en) * | 2012-02-17 | 2012-07-11 | 浙江海圣医疗器械有限公司 | Medical degradable and absorbable Mg-Sr-Ca series magnesium alloy implant and preparation method thereof |
| CN105339017A (en) * | 2013-05-02 | 2016-02-17 | 奥齿泰有限责任公司 | Method for treating surface of implant |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107353767A (en) * | 2017-06-30 | 2017-11-17 | 南宁东印时代广告有限公司 | Ceramic coating |
| CN109453426A (en) * | 2018-09-03 | 2019-03-12 | 北京化工大学 | A kind of Bone Defect Repari bioactive ceramics fibrous composite scaffold and preparation method thereof |
| CN110386814A (en) * | 2019-09-03 | 2019-10-29 | 长沙华脉新材料有限公司 | A kind of Specialty bio ceramic material and preparation method thereof for 3D printing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wang et al. | Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation | |
| CN106581769A (en) | Functionalized nano biological ceramic coating and preparation process thereof | |
| Cui et al. | Controllable growth of hydroxyapatite on electrospun poly (dl-lactide) fibers grafted with chitosan as potential tissue engineering scaffolds | |
| EP1796753B1 (en) | Hyaluronic acid coated bone implant device | |
| CN102008752B (en) | Porous biphasic calcium phosphate biological scaffold with nano hydroxyapatite coating and preparation method thereof | |
| CN109355057A (en) | A kind of bionical tissue adhesive of poly-amino acid-based mussel and preparation method thereof | |
| Zheng et al. | Phosphorylated chitosan to promote biomimetic mineralization of type I collagen as a strategy for dentin repair and bone tissue engineering | |
| US20210038760A1 (en) | Biomimetic bone composite material, a preparation method and uses thereof | |
| CN100408114C (en) | Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation | |
| CN105268026A (en) | Method for preparing chitosan/graphene oxide/nano-hydroxyapatite three-dimensional porous composite scaffold material | |
| Zheng et al. | Surface Modification of Poly (ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti‐Inflammation, Angiogenesis, Osteogenic Properties | |
| CN114272436B (en) | Surface chemical modification method for dental implant combined with alveolar bone and application | |
| Agarwal et al. | Enhanced corrosion resistance and cytocompatibility of biomimetic hyaluronic acid functionalised silane coating on AZ31 Mg alloy for orthopaedic applications | |
| WO2023087830A1 (en) | Surface coating capable of degrading magnesium and magnesium alloy, and preparation method therefor | |
| Wang et al. | Preparation of phytic acid/silane hybrid coating on magnesium alloy and its corrosion resistance in simulated body fluid | |
| CN113398329B (en) | Surface modification method of polyether-ether-ketone artificial skeleton | |
| CN108219360B (en) | Medical polyether-ether-ketone composite material and preparation method thereof | |
| CN106806939B (en) | Bone repair material and preparation method and application thereof | |
| KR20120036687A (en) | Preparation method of microsphere carrier of calcium phosphate cement with collagen | |
| CN108714245B (en) | A kind of preparation method of the sustainable hydrogel for inducing cartilage differentiation and being connect with bone substrate | |
| WO2024066040A1 (en) | Zinc oxide/zinc phosphate nanorod composite antibacterial coating and preparation method therefor and use thereof | |
| CN110180024B (en) | Composite stent and preparation method thereof | |
| CN104532213B (en) | Preparation method of medical implant material surface function atom doped molecular sieve layer | |
| CN104117095A (en) | Method for preparing strontium/fibroin bionic coating modified artificial ligament | |
| CN111298199B (en) | Temporary implant for orthopedics department and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170426 |
|
| WD01 | Invention patent application deemed withdrawn after publication |