CN106139229A - A kind of novel antibacterial aerogel dressing and preparation method thereof - Google Patents
A kind of novel antibacterial aerogel dressing and preparation method thereof Download PDFInfo
- Publication number
- CN106139229A CN106139229A CN201510158347.3A CN201510158347A CN106139229A CN 106139229 A CN106139229 A CN 106139229A CN 201510158347 A CN201510158347 A CN 201510158347A CN 106139229 A CN106139229 A CN 106139229A
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- China
- Prior art keywords
- wound
- ethyl hydroxybenzoate
- propylene glycol
- liquid
- chitosan
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Abstract
The present invention relates to a kind of novel antibacterial aerogel dressing and preparation method thereof, according to mass percent, including: chitosan: 1-5%；Carbomer: 0.5-5%；Propylene glycol: 0.5-20%；Ethyl hydroxybenzoate: 0.02-0.1%；Triethanolamine: 0.2-0.7%；Ketone peptide: 0.1-0.4%；Deionized water: 70-95%, the present invention uses chitosan as antibacterial, can effective Antibacterial activity, and combine antiseptic and inhibiting bacteria function agent ethyl hydroxybenzoate, it is effectively improved local wound microenvironment, ethyl hydroxybenzoate is stronger to the fungistatic effect of fungus, ethyl hydroxybenzoate coordinates the propylene glycol of low concentration, can strengthen antisepsis, and propylene glycol can absorb a large amount of wound dissolution fluid as wetting agent and keep wound moist, will not adhesion wound, alleviate patient pain, it addition, ketone peptide is a kind of good consolidant, wound healing time can be shortened, promote that wound preferably heals.
Description
Technical field
The present invention relates to medical material tech field, particularly relate to a kind of novel antibacterial hydrogel and apply
Material and preparation method thereof.
Background technology
Medical dressing is the medical material that a class covers for various wounds, wound surface temporarily
Material, can make wound exempt from antibacterial infect and the impact of other foeign element, play protection wound,
The effect of wound surface, degreasing cotton gauze, as a kind of traditional dressing, plays at medicine and hygiene fields
Important function, but degreasing cotton gauze liquid absorption is big not, and easily glue with skin wound tissue
Even, it is easily destroyed epithelium and the granulation tissue of new life when changing dressings, causes bleeding, wound is caused
Secondary injury, making Principle of Pain, degreasing cotton gauze be replaced becomes market trend, current city
More and more using aerogel dressing on field, aerogel dressing is the three-dimensional containing certain moisture
The swelling body of reticular polymer, has good water absorption and biocompatibility, hydrogel table
Surface tension between face and ambient water solution is low, it is possible to reduce to the absorption of protein in body fluid
Effect, aerogel dressing has good moisture-vapor transmission and suitable gas percent of pass, energy
Closely fit with irregular wound surface and do not stick together, reduce bacteria breed, and be easily changed,
It addition, the thermal capacity of aerogel dressing itself is big, wound there is is cooling effect, wound can be alleviated
Pain, at present, aerogel dressing is conducted extensive research by Chinese scholars, but state
Interior development is relatively slow, and also have greatly improved in terms of research and development of products space.
Summary of the invention
For the present situation of above-mentioned prior art, the technical problem to be solved is to provide
One can shorten wound healing time, alleviates patient pain, improves the novel anti-of local wound microenvironment
Bacterium aerogel dressing and preparation method thereof.
The present invention solves the technical scheme that above-mentioned technical problem used: a kind of novel antibacterial water
Gel dressing, according to mass percent, including:
Chitosan: 1-5%；
Carbomer: 0.5-5%；
Propylene glycol: 0.5-20%；
Ethyl hydroxybenzoate: 0.02-0.1%；
Triethanolamine: 0.2-0.7%；
Ketone peptide: 0.1-0.4%；
Deionized water: 70-95%.
The preparation method of a kind of novel antibacterial aerogel dressing, comprises the following steps:
A, being dissolved in deionized water by chitosan, temperature controls between 55-65 degree, fully
Stirring is allowed to dissolve, and obtains first liquid；
B, carbomer is dissolved in deionized water swelling, and is sufficiently stirred for being allowed to dissolve, obtains
Second liquid；
C, the second liquid of step (b) is slowly added in the first liquid of step (a)
It is sufficiently stirred for, mixing；
D, in the liquid of step (c), it is sequentially added into propylene glycol, ethyl hydroxybenzoate, ketone peptide,
And it is sufficiently stirred for mixing, add triethanolamine and PH is adjusted between 5.5-7；
After e, stirring eliminate bubble, obtain product.
Compared with prior art, it is an advantage of the current invention that: the present invention uses chitosan as killing
Microbial inoculum, can effective Antibacterial activity, and combine antiseptic and inhibiting bacteria function agent ethyl hydroxybenzoate, effectively change
Kind local wound microenvironment, ethyl hydroxybenzoate is relatively strong to the fungistatic effect of fungus, and ethyl hydroxybenzoate coordinates
The propylene glycol of low concentration, can strengthen antisepsis, and propylene glycol can absorb greatly as wetting agent
Amount wound dissolution fluid also keeps wound moist, will not adhesion wound, alleviate patient pain, it addition,
Ketone peptide is a kind of good consolidant, can shorten wound healing time, promotes that wound is more preferable
Healing, reduces cicatrix, and this product adjusts the order of material mixing during configuration and strictly controls
The temperature of prepared material so that product safety is stable.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, and following example are right
The explanation of the present invention and the invention is not limited in following example.
A kind of novel antibacterial aerogel dressing, according to mass percent, including:
Chitosan: 1-5%；
Carbomer: 0.5-5%；
Propylene glycol: 0.5-20%；
Ethyl hydroxybenzoate: 0.02-0.1%；
Triethanolamine: 0.2-0.7%；
Ketone peptide: 0.1-0.4%；
Deionized water: 70-95%.
Wherein, chitosan is antibacterial, can be with Antibacterial activity, and chitosan also has fast
The function of short stopping blood, carbomer is high molecular weight water soluble polymer, good stability, has thickening to hang
Floating grade acts on, and ethyl hydroxybenzoate is as antiseptic and inhibiting bacteria function agent, relatively strong to the inhibition of fungus, and
And ethyl hydroxybenzoate coordinates the propylene glycol of low concentration, antisepsis is higher, and propylene glycol is as moisturizing
Agent can absorb a large amount of wound dissolution fluid and keep wound moist, will not adhesion wound, alleviate trouble
Person's pain, ketone peptide is a kind of good consolidant, can shorten wound healing time, promotes wound
Mouthful preferably healing, reduces cicatrix, triethanolamine as nertralizer, by with the carboxylic such as carbomer
Base neutralizes, and forms stable macromolecular structure, reaches the application effect of thickening and moisturizing.
The preparation method of a kind of novel antibacterial aerogel dressing, comprises the following steps:
A, being dissolved in deionized water by chitosan, temperature controls between 55-65 degree, fully
Stirring is allowed to dissolve, and obtains first liquid；
B, carbomer is dissolved in deionized water swelling, and is sufficiently stirred for being allowed to dissolve, obtains
Second liquid；
C, the second liquid of step (b) is slowly added in the first liquid of step (a)
It is sufficiently stirred for, mixing；
D, in the liquid of step (c), it is sequentially added into propylene glycol, ethyl hydroxybenzoate, ketone peptide,
And it is sufficiently stirred for mixing, add triethanolamine and PH is adjusted between 5.5-7；
After e, stirring eliminate bubble, obtain product.
The present invention use chitosan as antibacterial, can effective Antibacterial activity, and combine anti-
Rotten antibacterial ethyl hydroxybenzoate, is effectively improved local wound microenvironment, and fungus is pressed down by ethyl hydroxybenzoate
Bacterium effect is relatively strong, and ethyl hydroxybenzoate coordinates the propylene glycol of low concentration, can strengthen antisepsis,
Propylene glycol can absorb a large amount of wound dissolution fluid as wetting agent and keep wound moist, will not glue
Even wound, alleviates patient pain, it addition, ketone peptide is a kind of good consolidant, can shorten
Wound healing time, promotes that wound preferably heals, reduces cicatrix, this product is in configuration process
The order of middle adjustment material mixing the temperature of strict control of material so that product safety are stable.
Last it is noted that above example is only in order to illustrate technical scheme, and
Non-to its restriction；Although the present invention being described in detail with reference to previous embodiment, ability
Territory it will be appreciated by the skilled person that it still can be to the technical side described in foregoing embodiments
Case is modified, or replaces wherein portion of techniques feature on an equal basis；And these amendment or
Person replaces, and does not make the essence of appropriate technical solution depart from various embodiments of the present invention technical scheme
Spirit and scope.
Claims (2)
1. a novel antibacterial aerogel dressing, it is characterised in that according to mass percent,
Including:
Chitosan: 1-5%；
Carbomer: 0.5-5%；
Propylene glycol: 0.5-20%；
Ethyl hydroxybenzoate: 0.02-0.1%；
Triethanolamine: 0.2-0.7%；
Ketone peptide: 0.1-0.4%；
Deionized water: 70-95%.
2. the preparation method of a novel antibacterial aerogel dressing, it is characterised in that include following
Step:
A, being dissolved in deionized water by chitosan, temperature controls between 55-65 degree, fully
Stirring is allowed to dissolve, and obtains first liquid；
B, carbomer is dissolved in deionized water swelling, and is sufficiently stirred for being allowed to dissolve, obtains
Second liquid；
C, the second liquid of step (b) is slowly added in the first liquid of step (a)
It is sufficiently stirred for, mixing；
D, in the liquid of step (c), it is sequentially added into propylene glycol, ethyl hydroxybenzoate, ketone peptide,
And it is sufficiently stirred for mixing, add triethanolamine and PH is adjusted between 5.5-7；
After e, stirring eliminate bubble, obtain product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510158347.3A CN106139229A (en) | 2015-04-02 | 2015-04-02 | A kind of novel antibacterial aerogel dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510158347.3A CN106139229A (en) | 2015-04-02 | 2015-04-02 | A kind of novel antibacterial aerogel dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106139229A true CN106139229A (en) | 2016-11-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510158347.3A Pending CN106139229A (en) | 2015-04-02 | 2015-04-02 | A kind of novel antibacterial aerogel dressing and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN106139229A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692191A (en) * | 2017-01-25 | 2017-05-24 | 天津嘉氏堂科技有限公司 | Wound surface protection composition and preparation method thereof |
| CN107951945A (en) * | 2017-11-14 | 2018-04-24 | 汕头大学医学院第附属医院 | External application Chinese medicine gel dressing and preparation method thereof |
| CN115444811A (en) * | 2022-05-31 | 2022-12-09 | 海南海药本草生物科技有限公司 | External borneol camphor oil preparation for treating burns and scalds and preparation method thereof |
-
2015
- 2015-04-02 CN CN201510158347.3A patent/CN106139229A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692191A (en) * | 2017-01-25 | 2017-05-24 | 天津嘉氏堂科技有限公司 | Wound surface protection composition and preparation method thereof |
| CN107951945A (en) * | 2017-11-14 | 2018-04-24 | 汕头大学医学院第附属医院 | External application Chinese medicine gel dressing and preparation method thereof |
| CN115444811A (en) * | 2022-05-31 | 2022-12-09 | 海南海药本草生物科技有限公司 | External borneol camphor oil preparation for treating burns and scalds and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |
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| WD01 | Invention patent application deemed withdrawn after publication |