CN106110371A - A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber wound dressing - Google Patents
A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber wound dressing Download PDFInfo
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- CN106110371A CN106110371A CN201610567875.9A CN201610567875A CN106110371A CN 106110371 A CN106110371 A CN 106110371A CN 201610567875 A CN201610567875 A CN 201610567875A CN 106110371 A CN106110371 A CN 106110371A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0092—Electro-spinning characterised by the electro-spinning apparatus characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2371/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/04—Alginic acid; Derivatives thereof
Abstract
The preparation method of a kind of high-hydroscopicity sodium alginate composite nano fiber Wound dressing, sodium alginate, water-soluble polymer, cross-linking agent are dissolved in water and alcohol mixture by described method, prepare spinning solution；Utilizing electrostatic spinning technique to prepare sodium alginate composite nano fiber, then heating crosslinks reaction, it is thus achieved that high-hydroscopicity sodium alginate composite nano fiber Wound dressing.Described method includes: the preparation of (1) spinning solution；(2) electrospun nanofibers；(3) nanofiber crosslinking Treatment prepares high-absorbable sodium alginate composite nano fiber.The present invention uses special process to prepare high-hydroscopicity sodium alginate composite nano fiber Wound dressing, overcome brittle, ventilative, the shortcoming of moisture sorption effect difference that existing alginic acid fibre medical dressing exists, can be various skin wound and different repairing phases provide multi-functional wound dressings there is sterilization, stop blooding, relieve the pain, reduce the effects such as infection also wound healing.
Description
Technical field
The present invention relates to the preparation method of a kind of high-hydroscopicity sodium alginate composite nano fiber wound dressing, belong to medical treatment and defend
Green material technical field.
Background technology
Medical wounded surface dressing is that a class is in order to cover skin ulcer, wound or other important biomolecule medical materials damaged, its research
With a development always hot issue.Traditional Wound dressing mainly includes common plant fiber, carboxymethyl cellulose class, shell
Polysaccharide etc., but generally there is product category and function singleness, be formed without the problems such as series of products, functional defect.Closely
A large amount of basic research about wound surface and clinical treatment demonstrate in decades provides suitable moist environment to be conducive to into wound surface
The healing of wound.Novel absorbent dressing can keep the moistening healing that can promote again wound of wound surface.At present, new pattern compress is being sent out
Reaching country and use the most universal, domestic the most gradually beginning is applied in the treatment of various wound surface.
Nanofiber has less diameter and bigger specific surface area, thus tool has been widely used.Utilize Nanowire
The non-woven fabrics made of dimension has the feature of highly-breathable, adds nanofiber and has big surface area, is commonly used to make medical
Dressing is to promote that wound restores.For relatively conventional dressing, nanofiber dressing is for significant performance advantage.Including good
Hemostasis and absorbency, nanofiber dressing comprises substantial amounts of micropore and higher surface area, it is possible to accelerate hemostasis, water absorption rate
17.9%～213% can also be reached, and the water absorption rate of conventional film dressing is only capable of reaching 2.3%；The porous of nanofiber dressing
Structure so that it is have good breathability, is of value to the Repiration of cell；It addition, the slight void of nanofiber dressing is also
Antibacterial infected wound, nanofiber dressing can be stoped to have good skin attachement, wound is played covering and protection is made
With；Nanofiber dressing also has multifunctionality, can realize the wound of difference in functionality by adding vitamin, cell growth factor etc.
Hinder dressing.
Sodium alginate is the polysaccharide material refined from seaweed plants.When alginic acid fibre acts on wound-contacting layer,
Its interphase interaction with wound and produce sodium alginate, calcium alginate gel.This gel has hydrophilic, and can make oxygen
Gas by and antibacterial can not pass through.Owing to sodium alginate nano fiber is in the potential using value of biomedical sector, in recent years
Cause the dense research interest of people.Notification number CN100443126 discloses a kind of Nanowire with sodium alginate as substrate
Dimensional scaffold material and preparation method thereof, with sodium alginate as substrate, introduces polyethylene glycol oxide or polyvinyl alcohol passes through electrostatic spinning
Method be prepared for sodium alginate nano fiber timbering material.Notification number CN101230150 discloses a kind of pure sodium alginate and receives
The preparation method of rice fiber film material, introduces a kind of solvent type highly polar modifying agent-many in the aqueous solution of sodium alginate
Hydroxy compounds glycerol, effectively regulates sodium alginate aqueous solution by the highly polar and low surface tension of this compound etc.
Physical property, thus realize sodium alginate soln from spinning spinnable transformation, and obtain uniform and smooth pure sodium alginate
Micro/nano fibrous membrane material.Xie Hong etc. are with calcium chloride/ethanol solution that mass fraction is 3% as cross-linking agent, to being loaded with hydrochloric acid
The polyvinyl alcohol of Moxifloxacin/sodium alginate electrostatic spinning nano fiber cross-links, drug-loading fibre in drug release in vitro grind
Study carefully result to show: along with the increase of crosslinking time, drug releasing rate slows down.Conclude employing calcium chloride/anhydrous second
Alcoholic solution is that the water-fast and swelling behavior of the polyvinyl alcohol/sodium alginate electrostatic spinning fiber of cross-linking agent modification is good, will be more suitable for
In the dressing with the wound healing and having transudate of feeling embarrassed.Sodium alginate and Polyethylene Glycol (PEG) are blended by ice filling ice etc., dissolve
In water, it is prepared for sodium alginate composite nano fiber through electrospinning process.
Prepare sodium alginate nano fiber above with respect to method of electrostatic spinning and only have studied the preliminary medicine of technical process and material
Thing release performance, has no about the absorptive research of material, it is true that as Novel wound dressing, water absorption is that it is the heaviest
The property data wanted, it is thus achieved that the sodium alginate nano fiber of high-hydroscopicity can keep wound surface wet environment, is expected in wound
Face dressing obtains applications well.
Summary of the invention
It is an object of the invention to, possess high-specific surface area and porosity to prepare, high water suction, moisture holding capacity, good
Biocompatibility and the wound dressing materials of anthemorrhagic performance, the open a kind of high-hydroscopicity sodium alginate composite Nano of the present invention is fine
The preparation method of dimension wound dressing.
Realize technical scheme as follows:
The preparation method of a kind of high-hydroscopicity sodium alginate composite nano fiber Wound dressing, described method is by sodium alginate, water
Soluble polymer, cross-linking agent is dissolved in water and alcohol mixture, prepares spinning solution；Electrostatic spinning technique is utilized to prepare Sargassum
Acid sodium composite nano fiber, then heating crosslinks reaction, it is thus achieved that high-hydroscopicity sodium alginate composite nano fiber wound surface applies
Material.
The preparation method step of the present invention a kind of high-hydroscopicity sodium alginate composite nano fiber Wound dressing is as follows:
(1) preparation of solution
Sodium alginate and water-soluble polymer and cross-linking agent are dissolved in water and alcohol mixture, are made into spinning of homogeneous transparent
Silk solution.Wherein the content of sodium alginate is between 0.5%-4% (wt/v), and preferably 1%-2%, water-soluble polymer content is at 4%-
Between 12% (wt/v), preferably 6%-9%, content of crosslinking agent is the 0.2%-10% (wt/w) of raw material components, preferably 0.5%-5%, water and
Ethanol volume ratio between 10:0-5:5, preferably 9:1-7:3.
Described water-soluble polymer can be polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol oxide, Polyethylene Glycol, bright
One or more of glue, chitosan, collagen protein etc..
Described cross-linking agent includes glycidyl methacrylate, Ethylene glycol dimethacrylate, hydroxyethyl methacrylate
One or more of ethyl ester, Hydroxypropyl methacrylate etc..
(2) electrospun nanofibers
Electrostatic spinning process is: by molten for the mixture containing sodium alginate and water-soluble polymer and cross-linking agent of step (1)
Liquid loads in the device for storing liquid of constant temperature, device for storing liquid connection traffic pump, and device for storing liquid is connected with spinning head by four fluorine tube, adjusts
Distance between spinning head and the catcher of ground connection, opens high voltage power supply, turn-on flow rate pump, and injection stream is mapped to certain translational speed
Catcher on, obtain sodium alginate composite nano-fiber membrane material.
Described electrospinning device is mainly by high voltage power supply, charging gear, injection apparatus, collection device four part group
Becoming, voltage is between 15KV-40KV, and solution flow rate is between 0.3ml/h-9ml/h, and receiving range is between 5cm-25cm.Institute
The sodium alginate composite nano-fiber membrane material of preparation is vacuum dried 2 days in vacuum drying oven.
(3) nanofiber crosslinking Treatment prepares high-absorbable sodium alginate composite nano fiber
Crosslink material processes technique: be placed in by the sodium alginate composite nano-fiber membrane material containing cross-linking agent of step (2)
In air dry oven, regulation temperature crosslink processes 7-24 hour, and temperature, between 50 DEG C-120 DEG C, obtains high-absorbable alginic acid
Sodium composite nano fiber.
The porous sodium alginate nano fiber of the present invention have high specific surface area and porosity and excellence water suction and
Water retention property, can use as Medical wounded surface dressing.
Compared with prior art, the invention has the beneficial effects as follows: the present invention provides a kind of and uses electrospinning process to combine
Thermal crosslinking treatment combination technique is prepared high-hydroscopicity sodium alginate composite nano fiber Wound dressing and is had high-specific surface area and hole
Gap rate and the water suction of excellence and water retention property, it is possible to time, provide good wet environment for wound healing acceleration.The present invention adopts
It is water and alcohol mixture with the solvent used in electrospinning process, there is environment-protecting asepsis, be beneficial to obtain thickness and absorb up to
The weight of 14 times of water of own wt, and under 37 ° of C, moisture holding capacity is up to the feature of 24 little uniform nanofibers.The present invention
Use special process to prepare high-hydroscopicity sodium alginate composite nano fiber Wound dressing, overcome existing alginic acid fibre medical
Brittle, ventilative, the shortcoming of moisture sorption effect difference that dressing exists, can be that various skin wound provides multi-functional with different repairing phases
Wound dressing, has sterilization, stops blooding, relieves the pain, reduces infection the effect such as wound healing.The material preparation process of the present invention
Simply, process conditions are controlled, and material structure and performance are easily controlled.The high-hydroscopicity sodium alginate composite nano fiber of preparation can
Use as Wound dressing.
Accompanying drawing explanation
Fig. 1 is high-hydroscopicity sodium alginate composite nano fiber preparation flow figure；
Fig. 2 is high-hydroscopicity sodium alginate composite nano fiber stereoscan photograph.
Detailed description of the invention
Embodiment 1
Weigh 1 gram of sodium alginate and 8 grams of PVA add 100ml deionized waters and ethanol mixture (water and ethanol volume ratio 9:
1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 1 gram of glycidyl methacrylate, continues
Continuous stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid in device for storing liquid, utilize electrostatic spinning apparatus system
Standby sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Prepared
Sodium alginate composite nano-fiber membrane material be vacuum dried in vacuum drying oven 2 days.Then proceed in air dry oven,
Crosslinking Treatment 24h at 100 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches certainly
14 times of heavy sensation of the body amount.
Embodiment 2
Weigh 1 gram of sodium alginate and 8 grams of PVA add 100ml deionized waters and ethanol mixture (water and ethanol volume ratio 8:
2), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 0.5 gram of glycidyl methacrylate,
Continue stirring reaction 2h, be cooled to room temperature and obtain transparent spinning liquid, spinning liquid is loaded in device for storing liquid, utilize electrostatic spinning apparatus
Prepare sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Made
Standby sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then proceed in air dry oven,
Crosslinking Treatment 24h at 120 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches certainly
12 times of heavy sensation of the body amount.
Embodiment 3
Weigh 1 gram of sodium alginate and 10 grams of PEO add 100ml deionized waters and ethanol mixture (water and ethanol volume ratio 9:
1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 0.5 gram of glycidyl methacrylate,
Continue stirring reaction 2h, be cooled to room temperature and obtain transparent spinning liquid, spinning liquid is loaded in device for storing liquid, utilize electrostatic spinning apparatus
Prepare sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Made
Standby sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then proceed in air dry oven,
Crosslinking Treatment 24h at 120 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches certainly
10 times of heavy sensation of the body amount.
Embodiment 4
Weigh 1 gram of sodium alginate and 8 grams of PVA add 100ml deionized waters and ethanol mixture (water and ethanol volume ratio 9:
1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 1 gram of hydroxyethyl methylacrylate, continues to stir
Mix reaction 2h, be cooled to room temperature and obtain transparent spinning liquid, spinning liquid is loaded in device for storing liquid, utilize electrostatic spinning apparatus preparation sea
Sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Prepared sea
Sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then proceed in air dry oven, 100 DEG C
Lower crosslinking Treatment 24h, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches own wt
16 times.
Embodiment 5
Weigh 1 gram of sodium alginate and 10 grams of PEO add 100ml deionized waters and ethanol mixture (water and ethanol volume ratio 9:
1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 1 gram of hydroxyethyl methylacrylate, continues to stir
Mix reaction 2h, be cooled to room temperature and obtain transparent spinning liquid, spinning liquid is loaded in device for storing liquid, utilize electrostatic spinning apparatus preparation sea
Sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Prepared sea
Sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then proceed in air dry oven, 100 DEG C
Lower crosslinking Treatment 24h, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches own wt
17 times.
Embodiment 6
Weigh 1 gram of sodium alginate and 10 grams of Polyethylene Glycol add 100ml deionized water and mixture (water and the ethanol volume of ethanol
Than 8:2), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 1 gram of Hydroxypropyl methacrylate, continues
Continuous stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid in device for storing liquid, utilize electrostatic spinning apparatus system
Standby sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.Prepared
Sodium alginate composite nano-fiber membrane material be vacuum dried in vacuum drying oven 2 days.Then proceed in air dry oven,
Crosslinking Treatment 24h at 120 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption reaches certainly
14 times of heavy sensation of the body amount.
Embodiment 7
Weigh 1 gram of sodium alginate, 0.5 gram of gelatin and 8 grams of PVA and add 100ml deionized water and mixture (water and the ethanol of ethanol
Volume ratio 9:1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 1 gram of hydroxyethyl methacrylate second
Ester, continues stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid in device for storing liquid, utilize electrostatic spinning
Device prepares sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance 10cm.
Prepared sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then forced air drying is proceeded to
In case, crosslinking Treatment 24h at 80 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material liquid absorption
Reach 15 times of own wt.
Embodiment 8
Weigh 1 gram of sodium alginate, 0.5 gram of gelatin and 10 grams of PEO and add 100ml deionized water and mixture (water and the second of ethanol
Alcohol volume ratio 8:2), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 0.5 gram of methacrylic acid contracting
Water glyceride, continues stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid in device for storing liquid, utilize quiet
Electric spinning device prepares sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance
10cm.Prepared sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then air blast is proceeded to
In drying baker, crosslinking Treatment 24h at 80 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material is inhaled
Liquid measure reaches 13 times of own wt.
Embodiment 9
Weigh 1 gram of sodium alginate, 1 gram of gelatin and 8 grams of PVA and add 100ml deionized water and mixture (water and the ethanol body of ethanol
Long-pending than 9:1), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 0.5 gram of Glycidyl methacrylate sweet
Grease, continues stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid in device for storing liquid, utilize Static Spinning
Silk device prepares sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution flow rate 3ml/h, distance
10cm.Prepared sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.Then air blast is proceeded to
In drying baker, crosslinking Treatment 24h at 100 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Prepared material is inhaled
Liquid measure reaches 15 times of own wt.
Embodiment 10
Weigh 0.5 gram of sodium alginate, 0.5 gram of chitosan and 10 grams of PEO, 2 grams of glacial acetic acids, add 100ml deionized water and ethanol
Mixture (water and ethanol volume ratio 8:2), under 80 DEG C of water-baths magnetic agitation 2h dissolve formed clear solution, be subsequently adding
0.5 gram of glycidyl methacrylate, continues stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, loaded by spinning liquid
In device for storing liquid, electrostatic spinning apparatus is utilized to prepare sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV,
Solution flow rate 3ml/h, distance 10cm.Prepared sodium alginate composite nano-fiber membrane material vacuum in vacuum drying oven is done
Dry 2 days.Then proceed in air dry oven, crosslinking Treatment 24h at 100 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite Nano is fine
Dimension film.Prepared material liquid absorption reaches 12 times of own wt.
Embodiment 11
Weigh 1 gram of sodium alginate, 0.5 gram of chitosan and 10 grams of PEO, 2 grams of glacial acetic acids, addition 100ml deionized water and ethanol
Mixture (water and ethanol volume ratio 8:2), under 80 DEG C of water-baths, magnetic agitation 2h is dissolved and is formed clear solution, is subsequently adding 0.5
Gram methacrylic acid contracting hydroxyl ethyl ester, continues stirring reaction 2h, is cooled to room temperature and obtains transparent spinning liquid, spinning liquid loads liquid storage dress
In putting, electrostatic spinning apparatus is utilized to prepare sodium alginate composite nano-fiber membrane material.Spinning condition: voltage 30KV, solution stream
Speed 3ml/h, distance 10cm.Prepared sodium alginate composite nano-fiber membrane material is vacuum dried 2 days in vacuum drying oven.
Then proceed in air dry oven, crosslinking Treatment 24h at 120 DEG C, it is thus achieved that high-hydroscopicity sodium alginate composite nano-fiber membrane.Institute
The material liquid absorption of preparation reaches 15 times of own wt.
Claims (4)
1. a preparation method for high-hydroscopicity sodium alginate composite nano fiber Wound dressing, described method by sodium alginate,
Water-soluble polymer, cross-linking agent is dissolved in water and alcohol mixture, prepares spinning solution；Utilize electrostatic spinning technique preparation sea
Sodium alginate composite nano fiber, then heating crosslinks reaction, it is thus achieved that high-hydroscopicity sodium alginate composite nano fiber wound surface
Dressing；
The step of described method is as follows:
(1) preparation of spinning solution
Sodium alginate and water-soluble polymer and cross-linking agent are dissolved in water and alcohol mixture, are made into spinning of homogeneous transparent
Silk solution；Wherein the content of sodium alginate is 0.5%-4% (wt/v), and water-soluble polymer content is 4%-12% (wt/v), crosslinking
Agent content is the 0.2%-10% (wt/v) of raw material components, and water and ethanol volume ratio are 10:0-5:5；
(2) electrospun nanofibers
Electrostatic spinning process is: by molten for the mixture containing sodium alginate and water-soluble polymer and cross-linking agent of step (1)
Liquid loads in the device for storing liquid of constant temperature, device for storing liquid connection traffic pump, and device for storing liquid is connected with spinning head by four fluorine tube, adjusts
Distance between spinning head and the catcher of ground connection, opens high voltage power supply, turn-on flow rate pump, and injection stream is mapped to certain translational speed
Catcher on, obtain sodium alginate composite nano-fiber membrane material；
Described electrospinning device includes high voltage power supply, charging gear, injection apparatus and collection device, and voltage is 15KV-40KV,
Solution flow rate is 0.3ml/h-9ml/h, and receiving range is 5cm-25cm；Prepared sodium alginate composite nano-fiber membrane material
Vacuum drying oven is vacuum dried 2 days；
(3) nanofiber crosslinking Treatment prepares high-absorbable sodium alginate composite nano fiber
Crosslink material processes technique: be placed in by the sodium alginate composite nano-fiber membrane material containing cross-linking agent of step (2)
In air dry oven, regulation temperature crosslink processes 7-24 hour, and temperature, between 50 DEG C-120 DEG C, obtains high-absorbable alginic acid
Sodium composite nano fiber.
A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber Wound dressing, its
Being characterised by, in the preparation of described step (1) solution, the content of sodium alginate is 1%-2%, and water-soluble polymer content is 6%-
9%, content of crosslinking agent is the 0.5%-5% of raw material components, and water and ethanol volume ratio are 9:1-7:3.
A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber Wound dressing, its
Being characterised by, described water-soluble polymer can be polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol oxide, Polyethylene Glycol, bright
Glue, chitosan, collagen protein one or more.
A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber Wound dressing, its
Being characterised by, described cross-linking agent includes glycidyl methacrylate, Ethylene glycol dimethacrylate, hydroxyethyl methacrylate
Ethyl ester, Hydroxypropyl methacrylate one or more.
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Cited By (18)
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| CN107737366A (en) * | 2017-09-30 | 2018-02-27 | 广东泰宝医疗科技股份有限公司 | A kind of modified sodium alginate electrospinning fibre haemostatic membrane and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006049666A1 (en) * | 2006-10-18 | 2008-04-30 | Carl Freudenberg Kg | Producing polymer fibers for the manufacture of cleaning, hygiene or medical products comprises electrospinning a colloidal dispersion of a water-insoluble polymer |
| CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
| CN104436281A (en) * | 2014-12-06 | 2015-03-25 | 江西省科学院应用化学研究所 | Preparation method of porous sodium alginate nano-fiber wound dressing |
-
2016
- 2016-07-19 CN CN201610567875.9A patent/CN106110371A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006049666A1 (en) * | 2006-10-18 | 2008-04-30 | Carl Freudenberg Kg | Producing polymer fibers for the manufacture of cleaning, hygiene or medical products comprises electrospinning a colloidal dispersion of a water-insoluble polymer |
| CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
| CN104436281A (en) * | 2014-12-06 | 2015-03-25 | 江西省科学院应用化学研究所 | Preparation method of porous sodium alginate nano-fiber wound dressing |
Non-Patent Citations (1)
| Title |
|---|
| 段久芳: "《天然高分子材料》", 31 March 2016, 华中科技大学出版社 * |
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