CN105726178A - Intravascular stent and preparation method and application thereof - Google Patents
Intravascular stent and preparation method and application thereof Download PDFInfo
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- CN105726178A CN105726178A CN201610268908.XA CN201610268908A CN105726178A CN 105726178 A CN105726178 A CN 105726178A CN 201610268908 A CN201610268908 A CN 201610268908A CN 105726178 A CN105726178 A CN 105726178A
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- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 229920002988 biodegradable polymer Polymers 0.000 claims description 5
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- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 abstract description 8
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Abstract
The invention relates to an intravascular stent and a preparation method and application thereof. The intravascular stent comprises a positioning section, a central supporting section and a tail-end supporting section. The positioning section comprises a plurality of first repeat single parts, the central supporting section comprises at least two central supporting units and at least one first connection unit, and each central supporting unit comprises a plurality of second repeat single parts. The tail-end supporting section comprises at least two tail-end supporting units and at least one second connection unit, and each tail-end supporting unit comprises a plurality of third repeat single parts. The first repeat single parts are not as many as the second repeat single parts, a supporting force of the central supporting section is larger than that of the tail-end supporting section, and a plane formed by the front ends of the first repeat single parts are intersected with the axis of the intravascular stent. The intravascular stent is effective in supporting and positioning, less in harms to vein walls and capable of effectively avoiding formation of thrombi.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of intravascular stent, its preparation method and application.
Background technology
Venous disease is most commonly seen in vascular surgery disease, and especially deep vein thrombosis of lower extremity and lower limb great saphenous varicose vein are more common.And having in the reason that both diseases are formed is caused by iliac vein compression greatly.Detection of iliac vein compression syndrome (iliacveincompressionsyndrome, IVCS) mean that iliac vein is oppressed by iliac artery, cause intracavity adhesion, narrow or inaccessible, thus there is the syndrome of range of clinical symptom, also known as May Thurner, Cockett syndrome.Detection of iliac vein compression syndrome incidence rate is 20%～34%.
Solving compression of vein to perform the operation in treatment, owing to needs enter abdomen operation, wound is relatively big, and patient is difficult to accept always always, therefore less in the operation number of cases of China's report.Cause that a lot of patient's lower extremity swelling and distension cannot solve, have some patients, because the blood stasis of blood is stagnant, phlebothrombosis occurs.Development from eighties of last century the nineties interventional technique, domestic begin through balloon expandable, the method of stent endoprosthesis solves iliac vein compression, through the clinical treatment of nearly 20 years, the method of interventional therapy is accepted by vascular surgery circle, simultaneously because wound is little, patient also can accept, and now domestic have a lot of hospital to carry out this work.Also have a lot of doctors that this technology is used for the patient of iliac vein thrombosis sequela simultaneously.Along with being significantly increased of clinical disease number of cases, and the arterial bracket that the clinical bore of use always is bigger at present treats the patient of detection of iliac vein compression syndrome, thus occurring in that an important problem, namely in support, the probability of secondary thrombus is higher, this is little with arterial bracket mesh, and the structure of iliac vein causes that arterial bracket must stretch into postcava 1-1.5 centimetre, and its support force does not cause designed by vein.
At present, the research report display of lot of domestic and foreign, less with the support that detection of iliac vein compression syndrome designs for indication.Domestic have can be taken off self-inflated bone vein support (utility model: 201520126120.6) effectively prevention deep vein thrombosis of lower extremity and come off the pulmonary infarction caused, after completing therapeutic purposes, can take out through jugular vein or femoral vein approach and avoid support Preserving time to produce complication.The latticed webmaster being coiled into for treating the narrow support of iliac vein (utility model: 201320053442.3) to be woven by nickel-titanium metal silk, webmaster front tube actinal surface is inclined-plane, the angle of inclined-plane and webmaster section is 40 degree, webmaster has the labelling circle of ellipse, it is achieved accurate positioning.But these bone vein supports yet suffer from some problems: be not all suitable for recovering bone venous blood flow state and increasing blood flow, and be easily caused the formation of thrombosis, thus be necessary to carry out research and development and the applied research of novel bone vein support.
Summary of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, intravascular stent, its preparation method and application that a kind of structure is different are provided, this intravascular stent has and is not easily formed thrombosis, histocompatibility is good, the support force of vein suitably and is not affected blood flow, simple in construction, easy to operate, accurate positioning, it is possible to meet the needs to iliac vein treatment in clinic.
For solving above technical problem, the present invention adopts the following technical scheme that
It is an object of the present invention to provide a kind of intravascular stent, it can change to the expansion state of the second cross-sectional diameter having had extended from the compressive state with the first cross-sectional diameter,
Described intravascular stent includes the location section, central support section and the end support section that are sequentially connected with on the axis direction of described intravascular stent,
Described location section includes circumferentially distributed multiple first repeated monomers along described intravascular stent,
Described central support section includes at least two central supporting unit and at least one the first connection unit that adjoin one another on the axis direction of described intravascular stent, described central supporting unit includes circumferentially distributed multiple second repeated monomers along described intravascular stent
Described end support section includes at least two end support unit and at least one the second connection unit that adjoin one another on the axis direction of described intravascular stent, described end support unit includes the circumferentially distributed multiple the third repeating monomers along described intravascular stent
The number of the first described repeated monomer is different from the number of the second described repeated monomer, the support force of described central support section more than the support force of described end support section, the axes intersect of the plane that the leading section of multiple the first described repeated monomers is formed and described intravascular stent.
According to an embodiment of the invention, the number of the first described repeated monomer is less than the number of the second described repeated monomer.
Preferably, the number of the second described repeated monomer is 2 ~ 4 times of the number of the first described repeated monomer.
Preferably, the number of the first described repeated monomer is 4 to 10.
Further, the leading section of described central support section is connected to the first developing cell.
According to a preferred aspect of the present invention, the leading section of the second repeated monomer of described central support section is connected to the first developing cell, and the number of the first developing cell can equal can not also wait with the number of the first described repeated monomer.
In the present invention, the first repeated monomer can be connected with the second repeated monomer, it is also possible to is connected unit with first and is connected.
According to an embodiment of the invention, the described bearing of trend of location section is 0 ° ~ 60 ° with the angle of the axis direction of described intravascular stent.
Preferably, when the described bearing of trend of location section is 0 ° with the angle of the axis direction of described intravascular stent, described intravascular stent is substantially in cylinder；When the described bearing of trend of location section has angle with the axis direction of described intravascular stent, described location section extends away from the direction of the axis of described intravascular stent towards leading section gradually from the one end being connected with described central support section.
According to a preferred aspect of the present invention, the leading section of the first described repeated monomer is fillet, and the circular arc inner radius of fillet is be more than or equal to 0.1mm.
According to an embodiment of the invention, the length of the first described repeated monomer is 5 ~ 15mm, it is preferred to 10 ~ 15mm；The length of described central support section and described end support section independently be 30 ~ 60mm, it is preferred to 30 ~ 40mm；The thickness of described intravascular stent is 0.1 ~ 0.3mm.
According to an embodiment of the invention, the length of the second described repeated monomer and described the third repeating monomer independently be 1 ~ 7mm, it is preferred to 2 ~ 5mm.
Preferably, the rearward end of described end support section is connected to multiple second developing cell.It is further preferable that the number of the second described developing cell is 3 to 10.
According to a specific embodiment of the present invention, described first connects unit and includes circumferentially distributed multiple first connectors along described intravascular stent, described second connects unit and includes circumferentially distributed multiple second connectors along described intravascular stent, the number of the no more than second described repeated monomer of number of the first described connector, the number of the no more than described the third repeating monomer of number of the second described connector, the number of the second described repeated monomer is equal with the number of the third repeating monomer.
It is further preferable that 2 ~ 3 times that the number of the second described repeated monomer in each described central supporting unit is the first described connector number in each the first described connection unit.
It is further preferable that 2 ~ 3 times that the number of the described the third repeating monomer in each described end support unit is the second described connector number in each the second described connection unit.
In the present invention, described central support section can be connected unit by first with described end support section and be connected with end support unit, it would however also be possible to employ central supporting unit and second connects unit and is connected.
Preferably, the width of second connector described in width ratio of the first described connector is wide by 10% ~ 30%, and the width of the second described connector is 0.1 ~ 0.3mm.
In the present invention, the width of the first described connector is equal with the width of the first described repeated monomer.
In the present invention, the width of the second described repeated monomer and the width of described the third repeating monomer can adopt regular width, such as 0.1 ~ 0.3mm.
In the present invention, the material of described intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.
In the present invention, plane and the angle of the axis of described intravascular stent that the leading section of multiple the first described repeated monomers is formed are 45 ° ~ 89 °, it is preferred to 45 ° ~ 80 °, more preferably 55 ° ~ 75 °.
The preparation method that it is a further object to provide a kind of above-mentioned intravascular stent, carries out cut by material according to the path on support Design drawing, then processes obtain described intravascular stent through pickling, electrochemical process.
Certainly, the intravascular stent of the present invention can also adopt additive method to be prepared, for instance, weave or welding.
3rd purpose of the present invention is to provide a kind of stent delivery system, its above-mentioned intravascular stent.
4th purpose of the present invention is to provide a kind of above-mentioned intravascular stent purposes in bifurcated vessels.
Preferably, the present invention provides a kind of above-mentioned intravascular stent purposes in iliac vein.
The present invention is defined as the front of intravascular stent positioning side, section place, is defined as the rear of intravascular stent with side, end support section place.
In the present invention, the angle of definition is the angle less than 90 ° formed between straight line and plane or straight line and straight line.
The total length of the intravascular stent in the present invention refers to the leading section the longest vertical dimension to the second developing cell of the first repeated monomer.The length of the first repeated monomer, the second repeated monomer and the third repeating monomer refers to the leading section vertical dimension to rearward end of each repeated monomer.Central support section refers to that the first developing cell is to the vertical dimension between the leading section of end support section.The length of end support section refers to that the rearward end of central support section is to the vertical dimension between the second developing cell.
Due to the enforcement of technique scheme, the present invention compared with prior art has the advantage that
The intravascular stent of the present invention is particularly well-suited to iliac vein, the support effect of iliac vein is good and the injury of wall of vein is little, it is possible to be prevented effectively from intravascular stent and implant the formation of secondary thrombus in after-poppet, in addition, the intravascular stent of the present invention can be good at positioning in iliac vein, improves the accuracy of release, easy and simple to handle, the simple in construction of the intravascular stent of the present invention, convenient for production, cost is low, thus having important practical significance and good potential applicability in clinical practice.
Accompanying drawing explanation
Fig. 1 is the schematic diagram (bearing of trend of location section is consistent with the axis direction of intravascular stent) that the intravascular stent of the present invention is implanted in iliac vein；
Fig. 2 is the structural representation that the intravascular stent of embodiment 1 is launched into plane；
Fig. 3 is the intravascular stent axonometric chart (bearing of trend of location section is consistent with the axis direction of intravascular stent) at expansion state of embodiment 1；
Fig. 4 is the intravascular stent axonometric chart (location section is horn mouth shape) at expansion state of embodiment 1；
Fig. 5 is the enlarged drawing of the second connector；
Fig. 6 is the enlarged drawing of the first connector；
Fig. 7 is the enlarged drawing of the first repeated monomer；
Fig. 8 is the structural representation that the intravascular stent of embodiment 2 is launched into plane；
Fig. 9 is the intravascular stent axonometric chart (bearing of trend of location section is consistent with the axis direction of intravascular stent) at expansion state of embodiment 2；
Figure 10 is the intravascular stent axonometric chart (location section is horn mouth shape) at expansion state of embodiment 2；Figure 11 is the schematic diagram (location section is horn mouth shape) that the intravascular stent of embodiment 1 is implanted in iliac vein；
Figure 12 is the schematic diagram (bearing of trend of location section is consistent with the axis direction of intravascular stent) that the intravascular stent of embodiment 2 is implanted in iliac vein；
Figure 13 is the schematic diagram (location section is horn mouth shape) that the intravascular stent of embodiment 2 is implanted in iliac vein；
Wherein: 1, location section；11, the first repeated monomer；2, central support section；21, central supporting unit；211, the second repeated monomer；22, first connects unit；221, the first connector；3, end support section；31, end support unit；311, the third repeating monomer；32, second connects unit；321, the second connector；4, the first developing cell；5, the second developing cell；β is the angle of the plane that formed of the leading section of the first repeated monomer and the axis of intravascular stent；W1 is the width of the first connector；W2 is the width of the second connector；W3 is the width of the first repeated monomer；W4 is the width of the second repeated monomer；W5 is the width of the third repeating monomer；L1 is the length of the first repeated monomer；L2 is the length of central support section；L3 is the length of end support section；L4 is the length of the second repeated monomer；L5 is the length of the third repeating monomer；L6 is the intravascular stent total length when expansion state.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described in detail, but the present invention is not limited to following example.
The intravascular stent of the present invention is primarily adapted for use in bifurcated vessels, is particularly well-suited in iliac vein (such as Fig. 1).In the process that intravascular stent is implanted iliac vein, intravascular stent is arranged in the carrier of stent delivery system, now, intravascular stent is in compressive state, after intravascular stent is delivered to correct position by carrier, release intravascular stent, intravascular stent expands outwardly to expansion state, thus iliac vein is played a supporting role, intravascular stent has the first cross section when compressive state, there is the second cross section when expansion state state, and, the diameter of the first cross section is less than the diameter of the second cross section.In the present invention, the first cross section and the cross section that the second cross section is central support section 2, and the axis perpendicular of this cross section and intravascular stent.In the present embodiment, the external diameter of the second cross section is 10 ~ 20mm, it is preferred to 12 ~ 16mm.
The material of intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.Rustless steel can adopt SUS-316L rustless steel etc..Memorial alloy can adopt Ni-Ti alloy, Cu-Al-Mn alloy etc..Cochrome can adopt CoCr-L605 cochrome etc..Biodegradable metals is a kind of metal that can decompose in human body, for instance pure magnesium, magnesium alloy, pure iron and ferroalloy etc..Biodegradable polymer can be polylactic acid, polyglycolic acid, poly-(lactic acid-6-caprolactone), gathers Biodegradable polymerics such as (glycolic-6-caprolactones).In addition, it is possible in vivo in degradable metal, coat a kind of biodegradable polymer material and be used as the material of intravascular stent.
The intravascular stent of the present invention can utilize laser engraving one-shot forming.The production process of laser engraving: first, utilizes CAM to create cutting path based on support Design drawing；Secondly, metal or macromolecular material are carried out cut；Finally, improve surface smoothness through overpickling and electrochemical process, make each edge shape mellow and full.
As shown in Figures 2 and 3, intravascular stent includes the location section 1, central support section 2 and the end support section 3 that are sequentially connected with from front to back on the axis direction of intravascular stent.
Location section 1 includes circumferentially distributed multiple first repeated monomers 11 along intravascular stent.
Central support section 2 includes at least two central supporting unit 21 and at least one the first connection unit 22 that adjoin one another on the axis direction of intravascular stent, central supporting unit 21 includes circumferentially distributed multiple second repeated monomers 211 along intravascular stent, and first connects unit 22 includes circumferentially distributed multiple first connectors 221 along intravascular stent.The number of no more than second repeated monomer 211 of number of the first connector 221, it is preferable that the number of the second repeated monomer 211 in each central supporting unit 21 is each first connect the first connector 221 number in unit 22 2 ~ 3 times.
End support section 3 includes at least two end support unit 31 and at least one the second connection unit 32 that adjoin one another on the axis direction of intravascular stent, end support unit 31 includes the circumferentially distributed multiple the third repeating monomers 311 along intravascular stent, and second connects unit 32 includes circumferentially distributed multiple second connectors 321 along intravascular stent.The number of the no more than the third repeating monomer 311 of number of the second connector 321, it is preferable that the number of the third repeating monomer 311 in each end support unit 31 is each second connect the second connector 321 number in unit 32 2 ~ 3 times.
First repeated monomer the 11, second repeated monomer 211 in the present invention, the structure of the third repeating monomer 311 can be able to be formed the arbitrary shape in hole, for instance V-type, grid type, rhombus etc..First connector 221 and second connector 321 distribution mode on whole intravascular stent can be arbitrary, for instance form of straight lines, V-type, W type, S type, N-type etc..
In the present invention, the leading section of central support section 2 is connected to the first developing cell 4, in the present embodiment, the leading section of the second repeated monomer 211 of central support section 2 is connected to the first developing cell 4, the setting of the first developing cell 4 makes intravascular stent can be good at realizing location, facilitates doctor to find point of release accurately.
In the present embodiment, the rearward end of the first repeated monomer 11 is connected with the leading section of the second repeated monomer 211.
In the present invention, the number of the first repeated monomer 11 is 4 to 10, and the number of the first developing cell 4 is equal or different with the number of the first repeated monomer 11.
In the present invention, central support section 2 can be connected unit 22 by first with end support section 3 and be connected with end support unit 31, central supporting unit 21 can also be adopted to be connected unit 32 with second be connected, namely, connector between central support section 2 and end support section 3 can be the first connector 221, it is also possible to be the second connector 321.When connector between central support section 2 and end support section 3 is the first connector 221, the number that central supporting unit 21 connects unit 22 with first is identical.
In the present invention, the rearward end of end support section 3 is connected to multiple second developing cell 5, and the number of the second developing cell 5 is 3 to 10, and, the number of the second developing cell 5 is equal with the number of the first developing cell 4.In the present embodiment, the second developing cell 5 can be connected with end support unit 31, or be connected unit 32 with second and be connected, and the second developing cell 5 is uniformly distributed along the circumference of intravascular stent.
In the present invention, the number of the first repeated monomer 11 is different from the number of the second repeated monomer 211, and the number of the second repeated monomer 211 is equal with the number of the third repeating monomer 311.Preferably, the number of the first repeated monomer 11 is less than the number of the second repeated monomer 211, in the present embodiment, the number of the second repeated monomer 211 is 2 ~ 4 times of the number of the first repeated monomer 11, thus ensureing that the aperture that the first repeated monomer 11 is formed is bigger, after as shown in Figure 1 intravascular stent being implanted iliac vein, when location section 1 extends postcava, it is possible to avoid because the aperture of intravascular stent is less of causing the formation of thrombosis and avoiding location section 1 that the blood flow of opposite iliac vein is impacted.
In the present embodiment, the bearing of trend of location section 1 is 0 ° ~ 60 ° with the angle of the axis direction of intravascular stent.As it is shown on figure 3, the bearing of trend of location section 1 is consistent with the axis direction of intravascular stent, namely angle is 0 °, and now, intravascular stent is substantially cylinder type when expansion state.As shown in Figure 4, angle is there is in the bearing of trend of location section 1 with the axis direction of intravascular stent, and, location section 1 extends away from the direction of the axis of intravascular stent towards leading section gradually from the one end being connected with central support section 2, and namely location section 1 is in the horn mouth shape expanded outwardly gradually from back to front.
In the present invention, the support force of central support section 2 is more than the support force of end support section 3, it is ensured that reduce the damage to wall of vein of the end support section 3 of intravascular stent while the central support section 2 of the intravascular stent support force to iliac vein.The present invention adopt the width W1 of the first connector 221 width W2 wide 10% ~ 30% than the second connector 321 to realize the support force support force more than end support section 3 of central support section 2, it is of course also possible to adopt other modes to realize the support force support force more than end support section 3 of central support section 2.In the present embodiment, the width W2(of the second connector 321 is as shown in Figure 5) it is 0.1 ~ 0.3mm.
The width W1(of the first connector 221 is as shown in Figure 6) with the width W3(of the first repeated monomer 11 as shown in Figure 7) equal.The width W4(of the second repeated monomer 211 is as shown in Figure 6) and the third repeating monomer 311 width W5(as shown in Figure 5) regular width can be adopted, for instance 0.1 ~ 0.3mm.
In the present embodiment, the thickness 0.1 ~ 0.3mm(of intravascular stent is not shown), the thickness of intravascular stent refers to the external diameter of the cross section of intravascular stent and the difference of internal diameter.
In the present embodiment, the leading section circular arc inner radius of the first repeated monomer 11 is not shown more than 0.1mm(), thus decreasing the intravascular stent stimulation to blood vessel.
In the present embodiment, the length L1 of the first repeated monomer 11 is 5 ~ 15mm, it is preferred to 10 ~ 15mm, and the length of the first repeated monomer 11 is long, can cause that the leading section of the first repeated monomer 11 touches the blood vessel wall on opposite and causes the adverse effects such as the stimulation to blood vessel；The length of the first repeated monomer 11 is too short, then can affect intravascular stent location in iliac vein so that intravascular stent cannot stably be implanted in desired location.
The length L2 of the central support section 2 and length L3 of end support section 3 independently be 30 ~ 60mm, it is preferred to 30 ~ 40mm, and the length L4 of the second repeated monomer 211 and length L5 of the third repeating monomer 311 independently be 1 ~ 7mm, it is preferred to 2 ~ 5mm.That is, central support section 2 generally comprises 8 central supporting unit 21, and end support section 3 generally comprises 8 end support unit 31, and certainly, the number of central supporting unit 21 and end support unit 31 can also be adjusted according to actual needs.
The intravascular stent of the present invention total length L 6 when expansion state is 50 ~ 120mm, it is preferred to 60 ~ 100mm.
Embodiment 1 is identical with the foregoing of embodiment 2, difference only with: in embodiment 1, the axis perpendicular of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent, as shown in Figures 2 and 3.In embodiment 2, the axes intersect of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent, and the angle β of the axis of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent is 45 ° ~ 89 °, as shown in Figures 8 to 10, wherein, in Fig. 8 to 10, the angle β of the axis of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent is 70 °, in embodiment 2, the length of the first repeated monomer 11 gradually changes, but, its length range should within the length range of the first repeated monomer 11 of above-mentioned restriction.
Above the present invention is described in detail; its object is to allow the personage being familiar with this art will appreciate that present disclosure and to be carried out; can not limit the scope of the invention with this; and the invention is not restricted to the embodiments described; the equivalence that all spirit according to the present invention are made changes or modifies, and all should be encompassed within protection scope of the present invention。
Claims (15)
1. an intravascular stent, it can change to the expansion state of the second cross-sectional diameter having had extended from the compressive state with the first cross-sectional diameter, it is characterised in that:
Described intravascular stent includes the location section (1), central support section (2) and the end support section (3) that are sequentially connected with on the axis direction of described intravascular stent,
Described location section (1) includes circumferentially distributed multiple first repeated monomers (11) along described intravascular stent,
Described central support section (2) includes at least two central supporting unit (21) and at least one the first connection unit (22) that adjoin one another on the axis direction of described intravascular stent, described central supporting unit (21) includes circumferentially distributed multiple second repeated monomers (211) along described intravascular stent
Described end support section (3) includes at least two end support unit (31) and at least one the second connection unit (32) that adjoin one another on the axis direction of described intravascular stent, described end support unit (31) includes the circumferentially distributed multiple the third repeating monomers (311) along described intravascular stent
The number of described the first repeated monomer (11) is different from the number of described the second repeated monomer (211), the support force of described central support section (2) more than the support force of described end support section (3), the axes intersect of the plane that the leading section of multiple described the first repeated monomers (11) is formed and described intravascular stent.
2. intravascular stent according to claim 1, it is characterised in that: the number of described the first repeated monomer (11) is less than the number of described the second repeated monomer (211).
3. intravascular stent according to claim 2, it is characterised in that: the number of described the second repeated monomer (211) is 2 ~ 4 times of the number of described the first repeated monomer (11), and the number of described the first repeated monomer (11) is 4 to 10.
4. intravascular stent according to claim 1, it is characterised in that: the leading section of described central support section (2) is connected to the first developing cell (4).
5. intravascular stent according to claim 1, it is characterised in that: the angle of the bearing of trend of described location section (1) and the axis direction of described intravascular stent is 0 ° ~ 60 °.
6. intravascular stent according to claim 1, it is characterised in that: the leading section of described the first repeated monomer (11) is fillet, and the circular arc inner radius of fillet is be more than or equal to 0.1mm.
7. intravascular stent according to claim 1, it is characterized in that: the length of described the first repeated monomer (11) is 5 ~ 15mm, the length of described central support section (2) and described end support section (3) independently be 30 ~ 60mm, and the thickness of described intravascular stent is 0.1 ~ 0.3mm.
8. intravascular stent according to claim 1, it is characterised in that: the rearward end of described end support section (3) is connected to multiple second developing cell (5), and the number of described the second developing cell (5) is 3 to 10.
9. intravascular stent according to claim 1, it is characterized in that: described first connects unit (22) and include circumferentially distributed multiple first connectors (221) along described intravascular stent, described second connects unit (32) and includes circumferentially distributed multiple second connectors (321) along described intravascular stent, the number of no more than described second repeated monomer (211) of number of described the first connector (221), the number of the no more than described the third repeating monomer (311) of number of described the second connector (321), the number of described the second repeated monomer (211) is equal with the number of described the third repeating monomer (311).
10. intravascular stent according to claim 9, it is characterised in that: the width of second connector (321) described in width ratio of described the first connector (221) is wide by 10% ~ 30%, and the width of described the second connector (321) is 0.1 ~ 0.3mm.
11. intravascular stent according to claim 1, it is characterised in that: the material of described intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.
12. intravascular stent according to claim 1, it is characterised in that: plane and the angle of the axis of described intravascular stent that the leading section of multiple described the first repeated monomers (11) is formed are 45 ° ~ 89 °.
13. the preparation method of the intravascular stent as according to any one of claim 1 to 12, it is characterised in that: material is carried out cut according to the path on support Design drawing, then processes obtain described intravascular stent through pickling, electrochemical process.
14. the purposes that the intravascular stent as according to any one of claim 1 to 12 is in bifurcated vessels.
15. the purposes that the intravascular stent as according to any one of claim 1 to 12 is in iliac vein.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610268908.XA CN105726178B (en) | 2016-04-27 | 2016-04-27 | A kind of intravascular stent, its preparation method and application |
| US15/737,365 US10695201B2 (en) | 2016-04-27 | 2016-07-11 | Intravascular stent, preparation method and use thereof |
| EP16900039.5A EP3449878A4 (en) | 2016-04-27 | 2016-07-11 | Vascular stent, preparation method therefor, and application thereof |
| PCT/CN2016/089590 WO2017185529A1 (en) | 2016-04-27 | 2016-07-11 | Vascular stent, preparation method therefor, and application thereof |
| US16/878,320 US11471309B2 (en) | 2016-04-27 | 2020-05-19 | Intravascular stent, preparation method and use thereof |
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| CN201610268908.XA CN105726178B (en) | 2016-04-27 | 2016-04-27 | A kind of intravascular stent, its preparation method and application |
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| CN105726178B (en) | 2017-12-22 |
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