CN103736146B - Method for preparing silver-loaded non-woven fabric - Google Patents
Method for preparing silver-loaded non-woven fabric Download PDFInfo
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- CN103736146B CN103736146B CN201310713195.XA CN201310713195A CN103736146B CN 103736146 B CN103736146 B CN 103736146B CN 201310713195 A CN201310713195 A CN 201310713195A CN 103736146 B CN103736146 B CN 103736146B
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- China
- Prior art keywords
- silver
- fibers
- fiber
- woven fabric
- calcium alginate
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 28
- 239000004332 silver Substances 0.000 title claims abstract description 28
- 239000004745 nonwoven fabric Substances 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title abstract description 5
- 239000000835 fiber Substances 0.000 claims abstract description 23
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 12
- 229920000615 alginic acid Polymers 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000648 calcium alginate Substances 0.000 claims abstract description 10
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 10
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 10
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000009960 carding Methods 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 6
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 4
- 238000001467 acupuncture Methods 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract description 5
- 229940072056 alginate Drugs 0.000 abstract description 5
- 229920001817 Agar Polymers 0.000 abstract 1
- 239000008272 agar Substances 0.000 abstract 1
- -1 silver ions Chemical class 0.000 abstract 1
- 238000009987 spinning Methods 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 18
- 208000027418 Wounds and injury Diseases 0.000 description 18
- 241000894006 Bacteria Species 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 241000195493 Cryptophyta Species 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 230000001427 coherent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 208000018875 hypoxemia Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000012984 antibiotic solution Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Abstract
The invention discloses a method for preparing a silver-loaded non-woven fabric. The method comprises the following steps: carding 1kg of an alginate base material into orderly fibers by a carding machine; immersing into a silver solution with the concentration of 1,600ug/ml in a mass ratio of 1:8, properly stirring, and taking out until the silver ions are sufficiently enriched onto the fibers; centrifugally drying in a spinning manner for 4-8 minutes by using a spin-dryer until the fibers are in a dry state, and dehydrating for 3-5 minutes with 95 percent ethanol; baking with a drier to obtain fluffy and soft agar fibers; uniformly mixing the baked calcium alginate silver fibers and pure calcium alginate staple fibers in a ratio of 1:1; opening, needling and slitting to obtain silver-loaded medical non-woven fabric with silver content of about 12,000mg/g.
Description
Technical field
The present invention relates to a kind of preparation method of silver-loaded non-woven fabric.
Background technology
Wound healing is the premise of body function rehabilitation after wound, therefore quickening wound healing research is particularly important, wherein
Development to Wound dressing is one of focus of research.New pattern compress is also referred to as active dressing or revolutionary dressing.1962
Doctor Winter is in animal（Pig）Experiment in obtain.WINTET has found that speed of wound healing is than sudden and violent under closed moist environment
It is exposed to the air drying surface of a wound fast again.So as to establish the theoretical foundation using the process surface of a wound of new pattern compress.Until eight
The ten's were just born the moisture retention bearing hydrocolloid dressing of the first generation.The nineties are generated various with the development of material technology
The dressing of not same-action is had according to the different phase of wound.Alginate dressing is the algae albumen extracted in natural precious palm fibre algae
Acid, is the insoluble polysaccharide of fibre types element, and a kind of calcium salt is converted in manufacturing process, is being contacted with wound exudate
When, can be exchanged by interionic, make indissolubility alginates calcium be changed into soluble mosanom, and calcium is discharged, with extremely strong
Absorbability, can absorb quite with the liquid of 20 times of own wt, which ensure that wound wet union environment, extend the dressing time,
The slough self-dissolving in wound, the calcium ion in alginates is set to form one layer of network gel in wound surface and contribute to promoting simultaneously
Enter hemostasis.As calcium alginate dressings application clinically, the time of wound repair are shortened, wound infection rate is reduced, and
And cure rate is improve, and mitigate patient's pain, patient medical funds are correspondingly saved, especially the patient of chronic ulcer can be in
Front yard dressing, increased the compliance of patient.Because silver has suction-operated to the microorganism in liquid, microorganism is by silver absorption
Afterwards, play respiratory enzyme and just lose effect, microorganism will be dead rapidly.Using forward position nanometer technology by silver nanoparticle, make
Sterilizing ability of the silver under nm regime generates qualitative leap, and few Nano Silver can produce powerful bactericidal action, will receive
Meter Yin is added in product, and the product for itself not having anti-microbial property produces new technical ability, and this has in itself be to product
One kind is lifted.At present domestic enterprise set foot in calcium alginate dressings enterprise it is less, being related to carry just more counting on one's fingers for silver-colored alginate dressing can
Number, according to medicine equipment certification database displaying is registered, and such certification is mostly foreign enterprise to be owned.
The content of the invention
The invention provides a kind of preparation method of silver-loaded non-woven fabric, it will be applied using the powerful bactericidal action of Nano Silver
The killing bacteria grown such as time or wound in material, so as to effectively prevent cross-infection.
Present invention employs technical scheme below：A kind of preparation method of silver-loaded non-woven fabric, it is comprised the following steps：Will
1kg alginates base material carding machines are carded to coherent fiber, then with 1：8 mass ratio is impregnated into concentration 1600ug/ml
Silver-colored solution in, in good time stirring, treats that silver ion is fully enriched on fiber, takes out, drier centrifuge dripping 4min ~ 8min as
Drying regime, then with 95% ethanol dehydration 3min ~ 5min, drying machine drying, the alginate fibre of fluffy softness is obtained, by what is dried
Calcium alginate silver fiber and pure calcium alginate chopped fiber are according to 1:1 uniform mixing, carries out shredding, and acupuncture, cutting obtain silver content
The load silver medical adhesive-bonded fabric of about 12000mg/g.
The time of described drier centrifuge dripping is 4min as drying regime.The described ethanol dehydration 3min of use 95%.
The invention has the advantages that：After employing above technical scheme, the present invention not only has high-hygroscopicity, algae
The absorbable 11 times of liquid equivalent to own wt of hydrochlorate medical films, and with hemostatic：Alginates medical films contact wound
Sepage discharges Ca2+, can promote the formation of thrombokinase, accelerates blood clotting process, while also having into colloidality：Absorb wound
, there is Na+/Ca2+ ion exchanges in mouth diffusate, in wound surface one layer of stable network gel is formed with sepage.For wound battalion
Make a microenvironment beneficial to tissue growth（Micro- acid, anaerobic or hypoxemia, appropriateness moistening）, promote wound healing：It is micro- acid, anaerobic or
Hypoxemia, appropriateness moistening wound climate promote growth factor release, stimulate cellular proliferation, improve epidermal cell power of regeneration and
Signaling, promotes wound healing.The present invention has biocidal property：1., good airproof performance, makes wound with extraneous bacterium isolation； ②、
Harmful bacteria is fixed on fibrous inside, and silver ion effectively inhibits harmful bacteria to breed and reduce the machine that bacterium contacts with the surface of a wound
Meeting；3., moistening, the environmental benefits of micro- acid play a role in neutrophil leucocyte, strengthen local bactericidal ability, reduce infection and occur
Rate.The present invention can reduce scar and be formed：Due to, not damaged non-stimulated to the surface of a wound, so scar forms few.
Specific embodiment
Technical scheme is further illustrated below by embodiment.
Embodiment one, a kind of preparation method of silver-loaded non-woven fabric of the invention, it is comprised the following steps：By 1kg alginic acid alkali
Timber-used carding machine is carded to coherent fiber, then with 1：8 mass ratio is impregnated in the silver-colored solution of concentration 1600ug/ml,
In good time stirring, treats that silver ion is fully enriched on fiber, takes out, drier centrifuge dripping 4min as drying regime, then with 95%
Ethanol dehydration 3min, drying machine drying obtains the alginate fibre of fluffy softness, by the calcium alginate silver fiber dried and pure marine alga
Sour calcium chopped fiber is according to 1:1 uniform mixing, carries out shredding, and acupuncture, cutting obtain the load silver doctor that silver content is about 12000mg/g
Use non-woven fabrics.
The silver-ion antibiotic solution that the present invention is adopted, its combination silver-loaded non-woven fabric antibacterial action is determined as follows：Antibiotic fabric
12000ppm containing antimicrobial agent concentration, test is mainly gram-positive bacteria, such as staphylococcus aureus from bacterial classification；Holland type is cloudy
Property bacterium, such as EHEC；And Candida albicans, culture medium is using nutrient broth medium and nutrient agar.
Antibiotic fabric antibacterial test method：The succusions of GB/T 20944.3
Test result is as follows：
| EHEC | Staphylococcus aureus | Candida albicans | |
| Sterilizing rate | 97.5% | 99.1% | 100% |
Alginates, gauze, gel rubber material, foam and its any combination are covered in the dressing that the base material of the present invention is constituted, this
Bar shaped dressing, rope shape dressing, patch shape dressing and its any combination are covered in the dressing that bright base material is constituted, what base material of the present invention was constituted
Homogeneous individual layer, multilayer, rope shape, patch shape and its any combination are covered in dressing.The concentration of Nano Silver of the present invention and the amount of base material
In certain functional relation, Nano silver solution is adsorbed onto to some extent on base material.
Claims (1)
1. a kind of preparation method of silver-loaded non-woven fabric, it is comprised the following steps：1kg alginates base material carding machines have been carded to
The fiber of orderliness, then with 1：8 mass ratio is impregnated in the silver-colored solution of concentration 1600ug/ml, and in good time stirring, treats that silver ion fills
Separating/enriching takes out on fiber, drier centrifuge dripping 4min as drying regime, then with 95% ethanol dehydration 3min, dryer
Drying, obtains the calcium alginate silver fiber of fluffy softness, and the calcium alginate silver fiber dried and pure calcium alginate chopped fiber are pressed
According to 1:1 uniform mixing, carries out shredding, and acupuncture, cutting obtain the load silver medical adhesive-bonded fabric that silver content is 12000mg/g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310713195.XA CN103736146B (en) | 2013-12-22 | 2013-12-22 | Method for preparing silver-loaded non-woven fabric |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310713195.XA CN103736146B (en) | 2013-12-22 | 2013-12-22 | Method for preparing silver-loaded non-woven fabric |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103736146A CN103736146A (en) | 2014-04-23 |
| CN103736146B true CN103736146B (en) | 2017-04-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310713195.XA Active CN103736146B (en) | 2013-12-22 | 2013-12-22 | Method for preparing silver-loaded non-woven fabric |
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| Country | Link |
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| CN (1) | CN103736146B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104179033B (en) * | 2014-08-01 | 2016-07-20 | 陕西科技大学 | A kind of cell-phone cover production method of functional synthetic leather |
| CN105463700A (en) * | 2015-12-18 | 2016-04-06 | 厦门百美特生物材料科技有限公司 | Spunlace alginate dressing |
| CN107899061A (en) * | 2017-11-13 | 2018-04-13 | 广东泰宝医疗科技股份有限公司 | A kind of alginates wound repair dressing and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9400994D0 (en) * | 1994-01-20 | 1994-03-16 | Bristol Myers Squibb Co | Wound dressing |
| CN1935268A (en) * | 2006-10-18 | 2007-03-28 | 上海川本卫生材料有限公司 | Nano silver calcium alginate antibacterial dressing |
| CN101721734A (en) * | 2008-10-22 | 2010-06-09 | 威海威高创新有限公司 | Medical calcium alginate antiseptic dressing and preparation method thereof |
| CN102505461A (en) * | 2011-10-28 | 2012-06-20 | 褚省吾 | Preparation method for silver-loaded calcium alginate fiber or silver-loaded medical non-woven fabric |
| GB2504872B (en) * | 2011-11-01 | 2015-07-01 | Brightwake Ltd | Wound dressings, and yarn useful therein |
| CN103074703A (en) * | 2012-12-03 | 2013-05-01 | 佛山市优特医疗科技有限公司 | Antibacterial silver-containing fiber wound dressing and preparation method thereof |
-
2013
- 2013-12-22 CN CN201310713195.XA patent/CN103736146B/en active Active
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| Publication number | Publication date |
|---|---|
| CN103736146A (en) | 2014-04-23 |
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Effective date of registration: 20171214 Address after: 225321 Taizhou, Jiangsu Port Industrial Park, Far East Avenue, No. 8 Patentee after: ROOSIN MEDICAL CO., LTD. Address before: 225321 Taizhou, Jiangsu Port Industrial Park, Far East Avenue, No. 8 Patentee before: Chu Jiamian |
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Denomination of invention: A method of preparing non-woven fabric with silver Effective date of registration: 20201116 Granted publication date: 20170412 Pledgee: Bank of Nanjing Co., Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT Co.,Ltd. Registration number: Y2020980008040 |
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Date of cancellation: 20211227 Granted publication date: 20170412 Pledgee: Bank of Nanjing Co., Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2020980008040 |
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Denomination of invention: A preparation method of silver loaded non-woven fabric Effective date of registration: 20211229 Granted publication date: 20170412 Pledgee: Bank of Nanjing Co., Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2021980016868 |
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