CN101613075B - Method for constructing virtual channel for restricting liquid drop movement - Google Patents
Method for constructing virtual channel for restricting liquid drop movement Download PDFInfo
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- CN101613075B CN101613075B CN2009100234592A CN200910023459A CN101613075B CN 101613075 B CN101613075 B CN 101613075B CN 2009100234592 A CN2009100234592 A CN 2009100234592A CN 200910023459 A CN200910023459 A CN 200910023459A CN 101613075 B CN101613075 B CN 101613075B
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- liquid drop
- virtual channel
- drop movement
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Abstract
The invention discloses a method for constructing a virtual channel for restricting liquid drop movement. A liquid channel is constructed on the basis of a super-hydrophobic structure design without an actual groove or solid wall. The method is used for building two microstructure regions respectively provided with a higher energy rampart and a lower energy rampart through a surface microstructure design so that the liquid drop movement is restricted in a virtual channel enclosed by the energy ramparts. The method reduces the hysteresis resistance born by a micro liquid chip in liquid drop movement, lowers the requirement on a driving device in the micro liquid chip, reduces the mass loss of liquid drops in the transportation and analysis process, improves the analysis and detection efficiency and the accuracy of the micro liquid chip to a micro sample and saves resources.
Description
Technical field
The design that the present invention relates to the miniflow pipeline is used, and belongs to the micro-fluidic chip technical field, particularly a kind of building method of virtual channel for restricting liquid drop movement.
Background technology
Micro-fluidic chip (microfluidic), claim chip lab (lab-on-a-chip) again, be sample preparation, reaction designed in chemistry and the field such as biology, separate and basic operation unit such as detection is integrated in a kind of technology platform on the chip of more than square centimeters (even littler).It mainly forms network by microchannel, runs through whole system with controlled fluid.In recent years, micro-fluidic chip development with the form of discontinuous drop as controlled fluid, and than traditional continuous fluid, this class individual droplets volume is little, and the face body is than big, and the relatively hot transmission is very fast; Separate between drop, not diffusion, recirculation is beneficial to rapid mixing in the drop, is desirable chemical reaction container.Therefore, how designing microchannel is beneficial to the control of drop and transports become key problem in technology.
The tradition microchannel mainly is to construct groove by Micrometer-Nanometer Processing Technologies such as photoetching and etchings to form passage on material substrate, and the inner wall smooth degree requires very high.But because this class channel form is limit (closed), drop contact area with the surface of solids in passage is very big, and the hysteresis effect of drop is very obvious and can cause mass loss in transport process, therefore will effectively control liquid drop movement and just compare difficulty.Also have scholar's Applied Surface Chemistry to modify design surface to distribute and control liquid drop movement, but the greatest problem that these class methods exist is the biochemical compatible of drop inner analysis material and face finish material, unfavorable to the reaction control of liquid in the fluid channel.
Based on the super hydrophobic surface of coarse structure, for harmless the transporting of liquid in the microchannel provides possibility.Because the contact area of super hydrophobic surface and drop is less, the suffered viscosity resistance of drop will be very little, makes drop more easily move, even can realize that the harmless of liquid transports.Simultaneously, by the design surface micro-structural, the free energy barrier of layout surface distributes easily, with the only freely-movable in the zone of design in advance of control drop, has the liquid drop movement of higher free energy barrier distributed areas then to be restricted at other.
Summary of the invention
The building method that the purpose of this invention is to provide a kind of tunnel of restricting liquid drop movement, the structure of flow channel for liquids designs based on super-drainage structure, does not need actual groove or solid wall.Suffered hysteresis resistance when this method has reduced liquid drop movement in the micro flow chip, reduced requirement to drive unit in the micro flow chip, reduced simultaneously drop transport, mass loss in the analytic process, improved analyzing and testing efficient and the accuracy of micro flow chip, saved resource micro sample.
The objective of the invention is to realize in the following way: a kind of tunnel of restricting liquid drop movement may further comprise the steps:
1) on base material, makes up with Micrometer-Nanometer Processing Technologies such as etchings by photoetching and have the wide a of different parallel groove micro-structurals, the zone of micro-structural spacing b and microstructure height h.Wherein, make up micro-structural width a
1=1～10 μ m, micro-structural spacing b
1=15～25 μ m, the parallel groove of microstructure height h=20～40 μ m is as the energy barrier zone of restricting liquid drop movement;
2) make up micro-structural width a
2=1～25 μ m (a
2＞a
1), micro-structural spacing b
2=1～25 μ m (b
2＜b
1), the parallel groove of microstructure height h=20～40 μ m is as the tunnel zone that transports drop;
3) tunnel peak width L=500 μ m～1000 μ m, energy barrier peak width L '＞800 μ m, transport droplet size V=2～20 μ l, energy barrier zone with above-mentioned structure surrounds the tunnel zone that drop transports, drop is limited in the passage flows, and can not go beyond energy barrier zone;
If base material intrinsic contact angle＜90 °, the hydrophobic coating of one deck modified making up on the later surface of micro-structural, the silicon fluoride surface modifier F8261 (C of the genus chemical inert material of producing as German goldschmidt chemical corporation
8F
13H
4Si (OCH
2CH
3)
3).
Can arrange on energy barrier zone that many tunnel zones are to be built into channel network.
Described hydrophobic coating material is the silicon fluoride surface modifier.
The present invention is applied to microchannel with the super hydrophobic surface design theory, constructed microchannel both sides do not have traditional solid wall form, come restricting liquid drop but utilize the theoretical foundation of microstructure design to come from by the higher rough region of energy barrier, as there being a stifled invisible wall (energy barrier) to block drop, make liquid drop movement only limit to the tunnel zone that is surrounded by the energy barrier; Even drop is not dropped in tunnel position accurately, also can produce unbalanced laplace pressure and make drop move to the low zone of energy barrier from the high zone of energy barrier automatically owing to it is inner, the realization drop is accurately located.This microchannel has reduced the contact area of the drop and the surface of solids as much as possible, significantly reduces the hysteresis power that drop is subjected in transport process, reduces the adhesion loss of drop.In addition, the contact area of drop and gas is multiplied, and promptly the gas liquid reaction area is multiplied, and improves detection sensitivity and speed, and this is for need be to the field of gas fast detecting, and is as the microsensor of real-time monitoring gas componant, significant.
Description of drawings
Fig. 1 is that micro-structural of the present invention is arranged schematic diagram.
Fig. 2 is the actual effect figure of virtual channel for restricting liquid drop movement of the present invention;
Fig. 3 realizes the actual effect figure of location automatically for drop on the tunnel of the present invention;
Below in conjunction with example content of the present invention is described further.
The specific embodiment
As shown in Figure 1, a kind of tunnel micro-structural of restricting liquid drop movement is arranged schematic diagram, makes up micro-structural width a from the teeth outwards by micro-structural process technologies such as photoetching and etchings
1=1～10 μ m, micro-structural spacing b
1=15～25 μ m, the parallel groove of microstructure height h=20～40 μ m is as the energy barrier zone 1 of restricting liquid drop movement; Simultaneously, make up micro-structural width a
2=1～25 μ m (a
2＞a
1), micro-structural spacing b
2=1～25 μ m (b
2＜b
1), the parallel groove of microstructure height h=20～40 μ m is as the tunnel zone 2 that transports drop.Tunnel width L=500 μ m～1000 μ m, barrier peak width L '＞800 μ m.When droplet size by V
1Increase to V
2The time, liquid-drop contact angle CA
1Remain unchanged, so the drop three-phase line of contact will move outward, until tunnel zone 2 and energy barrier zone 1 intersection; When droplet size by V
2Increase to V
3The time, liquid-drop contact angle will be by CA
1Be converted to CA gradually
2(CA
2＞CA
1), and that three-phase line of contact will keep will be motionless.The free energy barrier in barrier zone 1 is greater than the free energy barrier in tunnel zone 2, and therefore, drop will be gone beyond the barrier zone just must overcome a very big energy barrier, is not having to be difficult to generation under the auxiliary situation of outside energy.More than several factors make drop be limited in the tunnel zone.
Fig. 2 is a kind of tunnel actual effect figure of restricting liquid drop movement, and it makes up micro-structural by the lithography process technology and obtains on the smooth surface of silicon base material.Because therefore silicon base material intrinsic contact angle＜90 ° is making up the hydrophobic coating of modification one deck on the later surface of micro-structural.Concrete grammar is as follows: micro-structural is made up the silicon base material sample ultrasonic cleaning finish, dry the back and immerse that to be furnished with mass concentration be 2% F8261 (German goldschmidt chemical corporation
) alcoholic solution two hours, take out and put into the heating in vacuum case, be heated to 130 ℃, be incubated one hour, obtain final sample.Volume is placed microstructure area at the drop of 2～20 μ l scopes, can see that drop can be limited in the tunnel zone 2 that is surrounded by energy barrier zone 1 very effectively.
Fig. 3 is that drop is realized the actual effect figure of location automatically on tunnel, when drop is not dropped in accurately tunnel zone 2, drop is inner can to produce unbalanced laplace pressure owing to the coarse structure on surface is different, impel drop to move to the low tunnel zone 2 of energy barrier from the high energy barrier zone 1 of energy barrier automatically, the final accurately location of realizing.
Claims (4)
1. the building method of a virtual channel for restricting liquid drop movement is characterized in that:
1) by photoetching be etched on the base material and make up micro-structural width a
1=1～10 μ m, micro-structural spacing b
1=15～25 μ m, the parallel groove of microstructure height h=20～40 μ m is as the energy barrier zone of restricting liquid drop movement.
2) make up micro-structural width a
2, 1≤a
1＜a
2≤ 25 μ m, micro-structural spacing b
2, 1≤b
2＜b
1≤ 25 μ m, the parallel groove of microstructure height h=20～40 μ m is as the tunnel that transports drop;
3) tunnel width L=500 μ m～1000 μ m, energy barrier peak width L '＞800 μ m, transport droplet size V=2～20 μ l, surround the tunnel that drop transports, drop is limited in the tunnel flows with the energy barrier zone of above-mentioned structure.
2. the building method of a kind of virtual channel for restricting liquid drop movement according to claim 1 is characterized in that, if base material intrinsic contact angle＜90 °, on the micro-structure surface behind the structure, modify the hydrophobic coating of one deck.
3. the building method of a kind of virtual channel for restricting liquid drop movement according to claim 2 is characterized in that, described hydrophobic coating material is the silicon fluoride surface modifier.
4. the building method of a kind of virtual channel for restricting liquid drop movement according to claim 1 is characterized in that, makes up many tunnels simultaneously and forms channel network.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100234592A CN101613075B (en) | 2009-07-28 | 2009-07-28 | Method for constructing virtual channel for restricting liquid drop movement |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100234592A CN101613075B (en) | 2009-07-28 | 2009-07-28 | Method for constructing virtual channel for restricting liquid drop movement |
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| CN101613075A CN101613075A (en) | 2009-12-30 |
| CN101613075B true CN101613075B (en) | 2011-06-01 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106861781B (en) * | 2017-04-10 | 2023-04-11 | 黑龙江科技大学 | Micro-channel preparation method for reducing fluid resistance based on surface nano-bubbles |
| CN107513495B (en) * | 2017-09-01 | 2020-07-31 | 中国科学院苏州生物医学工程技术研究所 | Multi-channel droplet detection chip for nucleic acid detection |
| CN108107918B (en) * | 2018-01-11 | 2023-11-17 | 广州航海学院 | Device and method for controlling movement direction of liquid drop |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1534312A (en) * | 2003-03-31 | 2004-10-06 | 朗迅科技公司 | Method and device for controlling liquid motion on surface of ultrafine structure or microstructure |
| CN1658972A (en) * | 2002-06-07 | 2005-08-24 | 阿米克股份公司 | Micro fluidic structures |
| CN1760112A (en) * | 2005-11-22 | 2006-04-19 | 华中科技大学 | Super hydrophobic surface possessing dual microtexture and preparation method |
| CN1805833A (en) * | 2003-04-15 | 2006-07-19 | 安堤格里斯公司 | Ultraphobic surfaces |
-
2009
- 2009-07-28 CN CN2009100234592A patent/CN101613075B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1658972A (en) * | 2002-06-07 | 2005-08-24 | 阿米克股份公司 | Micro fluidic structures |
| CN1534312A (en) * | 2003-03-31 | 2004-10-06 | 朗迅科技公司 | Method and device for controlling liquid motion on surface of ultrafine structure or microstructure |
| CN1805833A (en) * | 2003-04-15 | 2006-07-19 | 安堤格里斯公司 | Ultraphobic surfaces |
| CN1760112A (en) * | 2005-11-22 | 2006-04-19 | 华中科技大学 | Super hydrophobic surface possessing dual microtexture and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| JP特开2009-155733A 2009.07.16 |
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