CH668179A5 - DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF. - Google Patents

DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF. Download PDF

Info

Publication number
CH668179A5
CH668179A5 CH672/85A CH67285A CH668179A5 CH 668179 A5 CH668179 A5 CH 668179A5 CH 672/85 A CH672/85 A CH 672/85A CH 67285 A CH67285 A CH 67285A CH 668179 A5 CH668179 A5 CH 668179A5
Authority
CH
Switzerland
Prior art keywords
layer
weight
parts
layer film
polyurethane elastomer
Prior art date
Application number
CH672/85A
Other languages
German (de)
Inventor
Popov Stefan Dobrev
Vazbazov Nikola Dr Alexandrov
Tchervenkov Yordan Dr M Ivanov
Ivanova Todorka Stefanova
Tashev Venelin Angelov
Komarov Nikolay Tzanev
Original Assignee
Tpo Pharmachim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tpo Pharmachim filed Critical Tpo Pharmachim
Publication of CH668179A5 publication Critical patent/CH668179A5/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F15/00—Auxiliary appliances for wound dressings; Dispensing containers for dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F13/534—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84—Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00119—Wound bandages elastic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00157—Wound bandages for burns or skin transplants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00246—Wound bandages in a special way pervious to air or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00519—Plasters use for treating burn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F2013/530802—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium characterized by the foam or sponge other than superabsorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F13/534—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
    • A61F2013/53445—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad from several sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Description

Aufgabe der Erfindung ist es, einen provisorischen Erio satz menschlicher Haut zur Behandlung von grossen Wundflächen zu erarbeiten, welcher nicht vor 24 — 48 Stunden ausgewechselt werden muss, keine sekundären Infektionen zu-lässt, sowie zu einer 100%igen Transplantation von Leichen-und eigener Haut verhelfen und die Exsudate und das nekro-15 tische Gewebe adsorbieren soll. The object of the invention is to develop a provisional erio set of human skin for the treatment of large wound areas, which does not have to be replaced before 24-48 hours, does not allow secondary infections, and for a 100% transplantation of corpses and one's own Help skin and adsorb the exudates and necrotic tissue.

Diese Aufgabe wird mittels einem Zweischicht-Folienumschlag der eingangs genannten Art erfindungsgemäss dadurch gelöst, dass die untere Schicht aus porösem Schaumstoff mit 70 bis 90% offenen Poren besteht und die obere 20 Schicht ein mikroporöses Polyurethan-Elastomer mit einem Molekülgewicht über 15 000 darstellt, wobei der ganze Umschlag mit einer 0,01 bis 15 %igen Zetylpyridinbromid-Lösung imprägniert ist. This object is achieved according to the invention by means of a two-layer film wrapping of the type mentioned at the outset in that the lower layer consists of porous foam with 70 to 90% open pores and the upper 20 layer is a microporous polyurethane elastomer with a molecular weight of more than 15,000, where the entire envelope is impregnated with a 0.01 to 15% zetylpyridine bromide solution.

Eine zweckmässige Weiterausgestaltung des erfindungs-25 gemässen Zweischicht-Folienumschlages ist Gegenstand der Ansprüche 2 und 3. An expedient further development of the two-layer film envelope according to the invention is the subject of claims 2 and 3.

Gegenstand der Erfindung ist ferner ein Verfahren zur Herstellung eines Zweischicht-Folienumschlages nach Anspruch 1, welches dadurch gekennzeichnet ist, dass man die 30 obere Polyurethan-Elastomer-Schicht aus einer Polyurethan-Lösung in organischen Lösungsmitteln, wie Dimethylformamid, Äthylmethylketon, Toluol und Zellulose-Azetobutyrat, herstellt. The invention further relates to a method for producing a two-layer film envelope according to claim 1, which is characterized in that the upper polyurethane elastomer layer is made from a polyurethane solution in organic solvents such as dimethylformamide, ethyl methyl ketone, toluene and cellulose. Acetobutyrate.

Dabei ist es zweckmässig, wenn man zur Herstellung des 35 Polyurethan-Elastomers von einer Polymerlösung ausgeht, welche folgende Zusammensetzung aufweist: It is expedient here to start with a polymer solution which has the following composition in order to produce the polyurethane elastomer:

BESCHREIBUNG DESCRIPTION

Die Erfindung betrifft einen Zweischicht-Folienumschlag zum provisorischen Ersatz der menschlichen Haut, welcher zum Bedecken grosser, vorwiegend durch Verbrennen verursachter Wundflächen dient und mit einer unteren Schicht aus porösem Schaumstoff und einer oberen Schicht aus mikroporösem synthetischem Material versehen ist, sowie ein Verfahren zur Herstellung dieses Zweischicht-Folienum-schlages. The invention relates to a two-layer film cover for the temporary replacement of human skin, which is used to cover large wound areas, mainly caused by burning, and is provided with a lower layer of porous foam and an upper layer of microporous synthetic material, and a method for producing the same Two-layer film envelope.

Es ist bekannt, dass bei der Behandlung grosser Brandwundflächen die offene Wunde mit grossen Müllverbänden bedeckt wird, welche mit Silbernitrat, Unguenta und anderen Flüssigkeiten getränkt sind. Diese Verbände werden des öfteren gewechselt, weil sie keine Barriere für die pathogenen Mikroorganismen sind. Auf diese Weise ist die Wunde nicht von sekundären Infektionen geschützt, es treten oft Komplikationen ein und in schweren Fällen ist die Sterblichkeit gross. Dieses Verfahren löst das Hauptproblem, eine schnelle Wiederherstellung der Ganzheit der Haut des Kranken, nicht, da die nachfolgende Hauttransplantation in den meisten Fällen erfolglos ist. It is known that when treating large burned areas, the open wound is covered with large garbage dressings, which are saturated with silver nitrate, unguenta and other liquids. These dressings are changed frequently because they are not a barrier to the pathogenic microorganisms. In this way, the wound is not protected from secondary infections, complications often occur and mortality is high in severe cases. This procedure does not solve the main problem, a quick restoration of the wholeness of the patient's skin, since the subsequent skin graft is unsuccessful in most cases.

Bekannt ist weiter die Behandlung grosser Wundflächen, bei welcher als provisorischer Ersatz menschlicher Haut ein Zweischicht-Umschlag benutzt wird, dessen untere Schicht ein poröser Schaumstoff darstellt und die obere Schicht eine mikroporöse synthetische Materia ist. Dieser Umschlag wird auf die Wundfläche aufgelegt und alle 2—4 Stunden gewechselt. Also known is the treatment of large wound areas, in which a two-layer cover is used as a temporary replacement of human skin, the lower layer of which is a porous foam and the upper layer is a microporous synthetic material. This envelope is placed on the wound surface and changed every 2-4 hours.

Die Nachteile dieses Zweischicht-Umschlages bestehen darin, dass der Verband sehr oft gewechselt werden muss, The disadvantages of this two-layer cover are that the dressing has to be changed very often,

Polyurethan-Elastomer Dimethylformamid 40 Methyläthylketon Toluol Polyurethane elastomer dimethylformamide 40 methyl ethyl ketone toluene

Zellulose-Azetobutyrat Cellulose acetobutyrate

20 Gewichtsteile 40 Gewichtsteile 20 Gewichtsteile 18 Gewichtsteile 2 Gewichtsteile 20 parts by weight 40 parts by weight 20 parts by weight 18 parts by weight 2 parts by weight

Die Vorteile des erfindungsgemässen provisorischen Er-45 satzes menschlicher Haut bestehen im folgenden: The advantages of the provisional replacement of human skin according to the invention are as follows:

Der Verband wird in einem Zeitraum von 24 — 48 Stunden gewechselt, wodurch die Wunde nicht traumatisiert wird und steril bleibt. Er absorbiert und inaktiviert alle Exsudate und nekrotischen Gewebe. Er verhindert den Verlust geweb-50 licher Flüssigkeiten, d.h. die Dehydratation der Wundflächen und des menschlichen Körpers. Beschleunigt die Granulierung der Wunden und gewährleistet eine 100%ige Über(Ver-)pflanzung der Transplantanten. The dressing is changed over a period of 24-48 hours, which means that the wound is not traumatized and remains sterile. It absorbs and inactivates all exudates and necrotic tissue. It prevents the loss of tissue fluids, i.e. the dehydration of the wound surfaces and the human body. Accelerates the granulation of the wounds and ensures 100% transplantation of the transplants.

Anhand der nachstehenden beispielsweisen Ausführung 55 wird die Erfindung näher erläutert. The invention is explained in more detail using the exemplary embodiment 55 below.

Der zweischichtige Folien-Umschlag besteht aus einer unteren Schicht, welche ein poröser Schaumstoff darstellt, der aus elastischem Schaumpolyurethan vom Äther- oder Estertyp besteht, 70—90% offene Poren enthält und einer 60 oberen (Oberflächen-)Schicht, die mikroporös ist, eine Dicke von 0,1—0,5 mm aufweist, sowie elastisch und widerstandsfähig gegenüber chemischen Reagenzien ist. Die Polymerlösung von der das Polyurethan-Elastomer mit einem Molekülgewicht über 15 000 hergestellt wird, weist folgende Zu-65 sammensetzung auf: The two-layer film envelope consists of a lower layer, which is a porous foam, which consists of elastic foam polyurethane of the ether or ester type, contains 70-90% open pores and a 60 upper (surface) layer, which is microporous, one Thickness of 0.1-0.5 mm, as well as elastic and resistant to chemical reagents. The polymer solution from which the polyurethane elastomer with a molecular weight of more than 15,000 is produced has the following composition:

Polyurethan-Elastomer Dimethylformamid Polyurethane elastomer dimethylformamide

20 Gewichtsteile 40 Gewichtsteile 20 parts by weight 40 parts by weight

3 3rd

668179 668179

Methyläthylketon 20 Gewichtsteile Methyl ethyl ketone 20 parts by weight

Toluol 18 Gewichtsteile Toluene 18 parts by weight

Zellulose-Azetobutyrat 2 Gewichtsteile Cellulose acetobutyrate 2 parts by weight

Der provisorische Ersatz menschlicher Haut wird nach der sogenannten übertragbaren Methode des Auftragens hergestellt. Die Bildung der oberen Schicht erfolgt durch Ra-kel-Auftragung auf einen Träger mit adhäsiver Oberfläche, ein «feuchtes» Aufbringen ohne Zwischenklebstofif auf die Polymerlösung, eine Folie von Schaumstoff und Ausscheidung des Lösemittels durch Verdampfung in einer Kammer mit Heissluftheizung. Das hergestellte «Tuch» wird automatisch in 10/25 oder 12/40 cm grosse Stücke geschnitten, mit einer 0,01 — 15%igen Zetylpyridinbromid-Lösung imprägniert, danach getrocknet und in hermetisch verschlossenen Polyurethan-Papierbeuteln verpackt. The temporary replacement of human skin is made using the so-called transferable method of application. The upper layer is formed by a Rakel application on a carrier with an adhesive surface, a "wet" application without an intermediate adhesive onto the polymer solution, a film of foam and the solvent is eliminated by evaporation in a chamber with hot air heating. The «cloth» produced is automatically cut into 10/25 or 12/40 cm pieces, impregnated with a 0.01 - 15% zetylpyridine bromide solution, then dried and packed in hermetically sealed polyurethane paper bags.

Der als provisorische Ersatz menschlicher Haut dienende Zweischicht-Folienumschlag wird klinisch zur Behandlung von grossen Wundflächen folgenderweise angewandt: The two-layer film cover, which serves as a temporary replacement for human skin, is used clinically to treat large wound areas as follows:

Jede «Folie» des provisorischen Ersatzes menschlicher Haut wird mit steriler physiologischer Lösung befeuchtet und auf die Wundfläche geklebt. So werden die Folien dicht aneinander aufgelegt bis die Wundfläche völlig bedeckt ist. Ein zusätzlicher Verband wird nicht gemacht. Der provisorische Ersatz bleibt auf der Wunde während einer Zeitdauer von 24 bis 48 Stunden, am besten 48 Stunden; während dieser Zeit werden die Exsudate und das nekrotische Gewebe adsorbiert. Die Wunden sind rein und steril. Nachdem die «Folien» abgenommen werden, sind die Wunden zum Transplantieren von Leichen- oder eigener Haut bereit. Each “film” of the temporary replacement of human skin is moistened with sterile physiological solution and stuck to the wound surface. So the foils are placed close together until the wound area is completely covered. An additional bandage is not made. The temporary replacement remains on the wound for a period of 24 to 48 hours, preferably 48 hours; during this time the exudates and necrotic tissue are adsorbed. The wounds are clean and sterile. After the "foils" have been removed, the wounds are ready for transplanting corpse or own skin.

In den Kliniken angewandt, gibt der erfmdungsgemässe Zweischicht-Folienumschlag sehr gute Resultate. When used in clinics, the two-layer film wrapping according to the invention gives very good results.

5 5

10 10th

15 15

20 20th

25 25th

30 30th

35 35

40 40

45 45

50 50

55 55

60 60

65 65

Claims (6)

668179 668179 PATENTANSPRÜCHE PATENT CLAIMS 1. Zweischicht-Folienumschlag zum provisorischen Ersatz menschlicher Haut mit einer unteren Schicht aus porösem Schaumstoff und einer oberen Schicht aus mikroporösem synthetischem Material, dadurch gekennzeichnet, dass die untere Schicht aus porösem Schaumstoff mit 70 bis 90% offenen Poren besteht und die obere Schicht ein mikroporöses Polyurethan-Elastomer mit einem Molekülgewicht über 15 000 darstellt, wobei der ganze Umschlag mit einer 0,01 bis 15%igen Zetylpyridinbromid-Lösung imprägniert ist. 1. Two-layer film cover for the temporary replacement of human skin with a lower layer of porous foam and an upper layer of microporous synthetic material, characterized in that the lower layer consists of porous foam with 70 to 90% open pores and the upper layer is a microporous Represents polyurethane elastomer with a molecular weight above 15,000, the entire envelope is impregnated with a 0.01 to 15% solution of zetylpyridine bromide. 2. Zweischicht-Folienumschlag nach Anspruch 1, dadurch gekennzeichnet, dass die untere Schicht eine solche aus elastischem Schaumpolyurethan vom Äther- oder Estertyp ist. 2. Two-layer film envelope according to claim 1, characterized in that the lower layer is one made of elastic foam polyurethane of the ether or ester type. 3. Zweischicht-Folienumschlag nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die obere Schicht 0,1 bis 3. Two-layer film envelope according to claim 1 or 2, characterized in that the upper layer 0.1 to 0,5 mm dick und von grosser Elastizität ist. 0.5 mm thick and of great elasticity. 4. Verfahren zur Herstellung eines Zweischicht-Folienumschlages nach Anspruch 1, dadurch gekennzeichnet, dass man die obere Polyurethan-Elastomer-Schicht aus einer Polyurethan-Lösung in organischen Lösungsmitteln herstellt. 4. A method for producing a two-layer film envelope according to claim 1, characterized in that the upper polyurethane elastomer layer is produced from a polyurethane solution in organic solvents. 5. Verfahren nach Anspruch 4, dadurch gekennzeichnet, dass man als organisches Lösungsmittel Dimethylformamid, Äthylmethylketon, Toluol oder Zellulose-Azebutyrat verwendet. 5. The method according to claim 4, characterized in that the organic solvent used is dimethylformamide, ethyl methyl ketone, toluene or cellulose azebutyrate. 6. Verfahren nach Anspruch 4, dadurch gekennzeichnet, dass man zur Herstellung des Polyurethan-Elastomers von einer Polymerlösung ausgeht, welches folgende Zusammensetzung aufweist: 6. The method according to claim 4, characterized in that one starts with a polymer solution for producing the polyurethane elastomer, which has the following composition: Polyurethan-Elastomer Dimethylformamid Methyläthylketon Toluol Polyurethane elastomer dimethylformamide methyl ethyl ketone toluene Zellulose-Azetobutyrat Cellulose acetobutyrate 20 Gewichtsteile 40 Gewichtsteile 20 Gewichtsteile 18 Gewichtsteile 2 Gewichtsteile demzufolge die Wunde zusätzlich traumatisiert wird; die untere mikroporöse Schicht nimmt zwar die Exsudate auf, 20 parts by weight 40 parts by weight 20 parts by weight 18 parts by weight 2 parts by weight consequently the wound is additionally traumatized; the lower microporous layer absorbs the exudates, doch sie besitzt keine antiseptischen Eigenschaften, wodurch sekundäre Infektionen, zufolge des adsorbierten Exsudats s auftreten. Wenn der Umschlag nicht rechtzeitig gewechselt wird, kann es zu einer ziemlich starken Blutung kommen, was einen ungünstigen Einfluss auf die weitere Behandlung der Wunde hat. however, it has no antiseptic properties, which leads to secondary infections due to the adsorbed exudate. If the envelope is not changed in time, there may be fairly heavy bleeding, which will adversely affect further treatment of the wound.
CH672/85A 1985-02-13 1985-02-14 DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF. CH668179A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08503654A GB2170713B (en) 1985-02-13 1985-02-13 Human skin substitute for temporary use

Publications (1)

Publication Number Publication Date
CH668179A5 true CH668179A5 (en) 1988-12-15

Family

ID=10574398

Family Applications (1)

Application Number Title Priority Date Filing Date
CH672/85A CH668179A5 (en) 1985-02-13 1985-02-14 DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF.

Country Status (4)

Country Link
CH (1) CH668179A5 (en)
DE (1) DE3505853A1 (en)
FR (1) FR2577133A1 (en)
GB (1) GB2170713B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2577133A1 (en) * 1985-02-13 1986-08-14 Tpo Pharmachim TEMPORARY SUCCEDANE OF HUMAN SKIN
DE3751254D1 (en) * 1986-10-31 1995-05-24 Nippon Zeon Co Wound dressing.
NL8801741A (en) * 1988-07-08 1990-02-01 Utermoehlen Nv ART SKIN.
NL8902237A (en) * 1989-09-06 1991-04-02 Hc Implants Bv ART SKIN.
GB2267427A (en) * 1992-06-05 1993-12-08 Isabel Maria Reis Treating burns
EP1493452B1 (en) * 2003-06-18 2010-02-03 Corpura B.V. Antimicrobially active flexible hydrophilic polyurethane foam
DE102004061406A1 (en) 2004-12-21 2006-07-06 Bayer Innovation Gmbh Infection-resistant polyurethane foams, process for their preparation and use in antiseptic-treated wound dressings
GB0606661D0 (en) 2006-04-03 2006-05-10 Brightwake Ltd Improvements relating to dressings
PT2268483T (en) * 2008-02-27 2018-07-10 Basf Se Multi-layer composite materials comprising a foam layer, corresponding method of production and use thereof
GB2493960B (en) 2011-08-25 2013-09-18 Brightwake Ltd Non-adherent wound dressing
WO2013074526A2 (en) 2011-11-15 2013-05-23 Byocoat Enterprises, Inc. Antimicrobial compositions and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2103590C3 (en) * 1970-01-28 1974-05-16 Parke, Davis & Co., Detroit, Mich. (V.St.A.) Medical wound dressing
DE2140491A1 (en) * 1971-08-12 1973-02-22 Pawlowa Bactericidal compsns - contg a quaternary base, a filmogenic polymer and a solvent
BE789739A (en) * 1971-10-05 1973-04-05 Lock Peter M SURGICAL DRESSING
US3849238A (en) * 1972-04-07 1974-11-19 S Ronel Artificial skin
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US3972328A (en) * 1975-07-28 1976-08-03 E. R. Squibb & Sons, Inc. Surgical bandage
DE2845686A1 (en) * 1977-07-28 1979-04-05 Schwarzheide Synthesewerk Veb METHOD OF MANUFACTURING A MEDICAL Wound Dressing
DE3035037A1 (en) * 1980-09-17 1982-04-22 Fa. Carl Freudenberg, 6940 Weinheim Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances
GB2102012B (en) * 1981-07-02 1984-11-21 Peter Maurice Lock Wound dressing material
FR2524304B1 (en) * 1982-03-31 1985-06-14 Delalande Sa ARTIFICIAL SKIN
DE3302984C2 (en) * 1983-01-29 1986-05-22 Sorbexx GmbH Gesellschaft für Adsorptionstechnik und Verbundstoffe, 8586 Gefrees Wound cover material in sheet form
FR2577133A1 (en) * 1985-02-13 1986-08-14 Tpo Pharmachim TEMPORARY SUCCEDANE OF HUMAN SKIN

Also Published As

Publication number Publication date
GB2170713B (en) 1988-10-05
GB8503654D0 (en) 1985-03-13
FR2577133A1 (en) 1986-08-14
DE3505853A1 (en) 1986-08-21
GB2170713A (en) 1986-08-13

Similar Documents

Publication Publication Date Title
DE69434125T2 (en) Hydrogelwundverband
DE19901134C2 (en) dressing material
DE19631421C2 (en) Antimicrobial wound dressings
DE69826484T2 (en) IMPROVED WOUND ASSOCIATION
DE69919957T2 (en) Plaster, arrangement consisting of a plaster and a container, and method
EP0040378B1 (en) Mixture for medical semi-rigid supporting bandages, medical bandages obtained therewith and method of making them
EP2520258B1 (en) Expansible wound dressing
DE2248813A1 (en) ARTICLE IN FOAM POLYURETHANE AND METHOD FOR ITS PRODUCTION
DE4026153C2 (en)
DE1642155A1 (en) Wound closure agents
DE2651089B2 (en) Self-curing material for support bandages
DE3011664A1 (en) Wound bandage
EP2711033A1 (en) System for wound treatment
CH668179A5 (en) DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF.
DE2305998A1 (en) NEW DEODORIZING TAPES BASED ON PERIODIC ACID
DE2103590C3 (en) Medical wound dressing
EP0238839A2 (en) Wound covering having a high absorption capacity, based on a polysaccharide as the carrier of a non-immobilized enzyme with a therapeutic activity
DE3302984C2 (en) Wound cover material in sheet form
EP0485374B1 (en) Dressing comprising a microporous plastic base layer and a liquid-absorbant layer applied thereto
DE3203225A1 (en) Germinating bandage
CH615099A5 (en)
DD272414A5 (en) METHOD FOR PRODUCING A MEDICAMENT PREPARED FOR WOUND HEALING
EP2711029A1 (en) Wound dressing
EP3842075B1 (en) Siloxane-containing wound dressing
DD252950A3 (en) MEDICAL WOUND ASSOCIATION

Legal Events

Date Code Title Description
PL Patent ceased