CA1176929A - Urodynamic catheter - Google Patents

Urodynamic catheter

Info

Publication number
CA1176929A
CA1176929A CA000407302A CA407302A CA1176929A CA 1176929 A CA1176929 A CA 1176929A CA 000407302 A CA000407302 A CA 000407302A CA 407302 A CA407302 A CA 407302A CA 1176929 A CA1176929 A CA 1176929A
Authority
CA
Canada
Prior art keywords
tube
distance
catheter
opening
leading end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000407302A
Other languages
French (fr)
Inventor
Henry Jarczyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UROTEK Inc
Original Assignee
UROTEK Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UROTEK Inc filed Critical UROTEK Inc
Priority to CA000407302A priority Critical patent/CA1176929A/en
Priority to GB08317948A priority patent/GB2123300B/en
Priority to DE19833324747 priority patent/DE3324747A1/en
Priority to FR8311754A priority patent/FR2530149B1/en
Priority to JP58127047A priority patent/JPS5922561A/en
Application granted granted Critical
Publication of CA1176929A publication Critical patent/CA1176929A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M2025/004Multi-lumen catheters with stationary elements characterized by lumina being arranged circumferentially

Abstract

ABSTRACT OF THE DISCLOSURE
There is provided a urodynamic catheter which includes a tube having at least three lumens, each communicating with openings spaced at different distances from the closed leading end of the tube. In a further embodiment, an additional lumen is provided in the tube, communicating with the interior of a balloon which is attached to the tube and located between the second and third openings, measured away from the leading end.

Description

` - -URODYNAMIC CATHETER
This invention relates generally to the medical field of Urodynamic studies, and has to do particularly with the construction of an improved urodynamic catheter adapted to conduct urodynamic tests on the lower urinary tract.
BACKGOUND OF THIS INVENTION
. _ Urodynamic tests are diagnostic procedures, the purpose of which is to assess the physiologic properties of the lower urinary tract, i.e. the bladder and urethra.
The urinary bladder and the urethra work together as a unit to serve the double purpose of collecting and conveying urine. The bladder is composed mostly of small muscles which are to a large degree under voluntary control. Muscle bundles run in different directions and from layer to layer.
The adaptation of the bladder to the changing urine volume is mainly due to the viscal-elastic property of the organ. The bladder wall, in a healthy individual, is able to expand without any significant increase in tension as the bladder fills with urine. One of the 25 major urodynamic tests involves filling the bladder with a saline solution, and simultaneously measuring the intravesical pressure. The plot of pressure against volume of contents during this filling is called a cystometrogram, and the early portion of this graphical 30 representation of pressure against volume is substantially flat in a healthy individual. When the -~ 2 1176~2~

individual is instructed to void, or when the urge to void arises automatically, the pressure inside the bladder increases.
Another standard urodynamic test is called the urethral pressure profile (UPP). This test is typically carried out by inserting a catheter having a side opening and a lumen communicating with that opening. A dilute saline solution is pumped into the lumen and out through the side opening at a fixed rate, while the catheter is steadily withdrawn from the urethra at a substantially constant speed. A plot of the back pressure in the line between the pump and the side opening, against the physical distance of the opening along the urethra, yields the UPP. Typically, as the opening passes a-location of constriction, whether normal or abnormal, theback pressure rises, and appears as a spike or hump in the graphical representation of pressure against distance.
Another factor related to the test just 20 mentioned is the functional profile length, which is basically the length of the urethra over which the pressure profile is taken.
One of the important parameters derived from the urethral pressure profile test (UPP) is what is 25 called the maximum urethral closure pressure, which is the difference between the maximum pressure derived by the UPP test and the intravesical pressure of the bladder.
Prior patents of interest to this subject 30 matter are as follows:
U.S. Pat No. 4,136,681, issued Jan. 30, 1979, to Edward H. Hon U.S. Pat No. 168,703, issued Jan. 30, 1979, to Kenneth Kenigsberg 35 U.S. Pat No. 4,191,196, issued issued Mar. 4, 1980, to Bradley et al U.S. Pat No. 4,217,911, issued May 5, 1981, to Terry N.
Layton .~;

.. . .

,-- 3 117~Z9 U.S. Pat No. 4,252,131, issued Feb. 24, 1981, to Hon et al U.S. Pat No. 4,006,735, issued Feb. 8, 1977, to Hittman et al U.S. Pat No. 4,023,562, issued May 17, 1977, to Hynecek et al U.S. Pat No. 3,480,003, issued Nov. 25, 1969, to N.A.
Crites U.S. Pat No. 4,265,243, issued May 5, 1981, to Glenn N.
10 Taylor U.S. Pat No. 4,301,811, issued Nov. 24, 1981, to Terry N.
Layton U.S. Pat No. 3,437,088, issued April 8, 1969, to L. J.
Bielinski U.S. Pat Uo. 4,214,593, issued July 29, 1980, to Imbruce et al GENERAL DESCRIPTION OF THIS INVENTION
It is an aspect of this invention to provide an improved urodynamic catheter which can be utilized for carrying out all of the tests described above.
More particularly, this invention provides a urodynamic catheter which includes a tube having at least three lumens and a closed leading end. A first one of 25 the lumens communicates with a first side opening in the tube spaced a first distance from the leading end. A
second lumen communicates with a second opening spaced a second distance from the leading end, the second distance being greater than the ~irst distance. A third lumen 30 communicates with a third side opening in the tube spaced a third distance from the leading end, the third distance being greater than the second distance.
In a variation of the catheter, a fourth lumen is provided in the tube, which communicates with the 35 interior of an inflatable balloon attached to the tube and located ~etween the second and third openings.
GENERAL DESCPIPTION OF THE DRAWINGS
Two embodiments of this invention are ; illustrated in the accompanying drawings, in which like ~ 4 ~1769Z9 numerals denote like parts throughout the several views, and in which:
Figure 1 is a partly ~roken away elevational view of a first embodiment of the urodynamic catheter of this invention;
Figure 2 is a partly broken away elevational view of a second embodiment thereof;
Figure 3 is an enlarged sectional view taken at the line 3-3 in figure 1; and Figure 4 is an enlarg d sectional view taken at the line 4-4 in figure 2.
DETAILED DESCRIPTION OF THE DRAWINGS
Attention is first directed to Figure 1, which shows a catheter 10 which includes a tube 12 and four internal passageways or lumens 14, 15, 16 and 17, as can be seen in Figure 3. One of the lumens, that numbered 16 in Figure 3, communicates through a bore hole 20 with a first side opening 22 which is spaced back from the leading end 24 of the tube 12. The distance from the leading end 24 through the opening 22, in the embodiment illustrated, is approximately 7 mm. The opening 22 and the lumen 16 are intended to be used for bladder filling, and therefore the opening 22 should be located reasonably close to the leading end 24 of the catheter. The actual leading end 24 is capped by a closure member 26 which is heat sealed or otherwise affixed to the cut end of the tube 12, in order to close all lumens. As can be seen the closure end 26 is rounded, for ease of insertion.
The closure member itself has a length of about 3 mm, leaving approximately 4 mm between the actual cut end of the tube and the location of the opening 22. It is to be understood that this particular distance could vary, but that it is of advantage to have the filling opening 22 located as close as possible to the leading end 24. A
second one of the lumens, that numbered 15 in Figure 3, communicates through a bore with a second side opening 28 in the tube 12. The purpose of the lumen 15 and the side opening 28 is to monitor the intravesical pressure as the ` bladder is being filled through the opening 22. This 11~ 2~

allows the cystometrogram to be plotted, this being a plot of intravesical pressure (pressure within the bladder) against volume of bladder contents. A third lumen, that numbered 14 in Figure 3, communicates though a bore hole with a third side opening 30 which is spaced further back from the leading end 2~.
The opening 30 is used to monitor closure pressure during cystometry. The location of the opening 30 will vary due to the different location of the urethral sphincter in ma~e and female patients.
In addition, the side opening 30 and its associated lumen 14 are used to establish the urethral pressure profile (UPP), which determines compliance along the urethra wall. As previously described, a constant infeed of saline solution (0.9~ NaCl) is applied through the opening where the UPP is being determined, and the back pressure is measured and plotted against longitudinal position along the urethra.
The last lumen, numbered 17 in Figure 3 communicates through the bore with the interior of a balloon 32. The balloon is made of expandible material and is adapted to assume a substantial spherical shape when inflated. The balloon 32 includes two collars 34 and 35 through which the tube 12 passes, and which are 25 heat sealed or otherwise affixed to the tube 12 in a liquid-tight manner. When deflated, the balloon 32 lies closely adjacent the tube 12, so as not to interfere with insertion or withdrawal of the catheter. When the balloon 32 is inflated, by providing pressurized liquid 30 though the lumen 17, it prevents the catheter from falling out during the investigation, and also allows cystometric examination in the standing position or during certaln exercises for detecting urinary incontinance (stress incontinance~.
It will be understood that during the UPP test, the balloon 32 would be deflated and collapsed against the tube 12.
At the outer or non-insertion end of 37 of the tube 1~, there is a connection with a plurality of smaller single-lumen tubes 39, which form the connections to the various pumps, gages, etc. which are used for the urodynamic tests described. The connection is normally made by suppling a small coupling member in which are embedded four small-diameter hollow pins, each one being adapted to fit snugly within one of the lumens of the tube 12 at one end, and within the single lumen of one of the tubes 39 at the other end. Once these connections have been made, a sleeve 41 is fitted around the connector and heated sealed or otherwise fixed in place.
The construction of this connecting location is conventional, and need not be described or illustrated in detail.
Although not illustrated in Figure 1, the tube 12 has a plurality of markings at regular spacings along its length, particularly for use during the UPP test.
Typically, these markings would be located at 1 cm intervals.
Attention is now directed to Figure 2, which shows a modified form of the catheter of this invention, differing from that of Fig. 1 primarily in the absence of the balloon 32 and the absence of the side opening ~communicating with the interior of the balloon. A~o~er ~ difference relates to the location of the opening ~
25 which in Figure 2 is closer to the leading end 24 than is the opening 30 to the leading end 24 in Figure 1.
However, as previously mentioned, the location of the side openings 30 (30a) will vary depending upon the sex of the patient, and the preference of the end user.
The remaining openings in Figure 2 are identified by the same numerals as in Figure 1.
It will be understood that the tube 12 for the Figure 2 embodiment would typically be a three lumen tube such as is shown at 44 in Figure 4. The lumens are 35 identified by the numerals 46, 47 and 48. However, there is no reason why a four-lumen tube could not be utilized for the Figure 2 embodiment, with only three of the lumens active, and the other lumen being closed. It will ; be understood, in a general way, that a tube for use with . - . . .

, 7 1~769Z9 this invention needs to have at least a number of lumens corresponding to the opening, (including the opening for the balloon _f a balloon is present), but that additional lumens could be provided, and simply not utilized.
It will be evident from the foregoing description how the two embodiments of the catheter of this invention may be utilized for establishing the parameters described under the heading "Bac~ground of This Invention". It will further be understood that the lumen communicating with the opening 30 (30a) can be utilized to monitor closure pressure during cystometry.
In ~igure 2, a series of marker positions S0 have been drawn adjacent to the tube 12, to show the locations of longitudinally spaced marks used during the lS UPP test It is desirable to givè an approximate idea of suitable or satisfactory dimensions for the spacings of the various openings, although these are not given with any intention to be limiting. In a satisfactory catheter constructed in accordance with Figure 1, the opening 22 is located 7 mm away from the leading end 24, and the spacing between openings 22 and 28 is approximately 1 cm.
Thus, the distance from the leading end 24 to the opening 28 is approximately triple the distance from the leading 25 end 24 to the opening 22. From the opening 22 to the opening 30, a suitable distance is approximately 8 cm, with the balloon 32 being located somewhat closer to the opening 30 than to the opening 28.
For the catheter of Figure 2, the opening 22 30 may again be located about 7 mm from the leading end 24a and the spacing between the openings 22 and 28 may be about 1 cm. The distance from the opening 22 to the opening 30a may be about 7 cm. Again, these distances may vary, particularly due to the fact that the position 35 of the opening 30 (30a) depends somewhat on the sex Gf the patient and the preference of the individual examlner .

~ 8 11769Z~
Each lumen may have a diameter in the range of about 0.8 mm, and the tube itself may have a diameter of aroun-i 3.3 mm.
While specific embodiments of this invention have been illustrated in the accompanying drawings and described in the foregoing disclosure, it will be apparent to those skilled in the art that changes and modifications may be made therein without departing from the essence of this invention as set forth in the appended claims.

Claims (10)

CLAIMS:
1. A urodynamic catheter comprising:
a tube having at least four lumens and a closed leading end, a first one of said lumens communicating with a first side opening in the tube spaced a first distance from said leading end, a second one of said lumens communicating with a second side opening in the tube spaced a second distance from said leading end, said second distance being greater than said first distance, a third one of said lumens communicating with a third side opening in the tube, spaced a third distance from said leading end, said third distance being greater than said second distance, a fourth one of said lumens communicating with the interior of an inflatable balloon attached to the tube, the balloon being located between said second and third openings.
2. The catheter claimed in claim 1, in which said second distance is about triple said first distance.
3. The catheter claimed in claim 1 or claim 2, in which said third distance is between about 4 and 5.5 times as great as said second distance.
4. The catheter claimed in claim 1, in which the ratio or said first, second and third distances is substantially 1:3:12.5.
5. The catheter claimed in claim 1, in which the ratio of said first, second and third distances is substantially 1:3:11.
6. The catheter claimed in claim 4 or claim 5, in which said first distance is substantially 0.7 cm.
7. The catheter claimed in claim 1 or claim 5, in which said balloon is centered at a location along the tube which lies closer to said third opening than to said second opening.
8. The catheter claimed in claim 1, claim 2 or claim 3, in which said leading end is closed by a rounded closure member which seals all lumens.
9. The catheter claimed in claim 1, claim 2 or claim 3, further including markings at regular intervals along said tube.
10. The catheter claimed in claim 1, claim 2 or claim 3, further including markings at regular intervals of 1 cm along said tube.
CA000407302A 1982-07-14 1982-07-14 Urodynamic catheter Expired CA1176929A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA000407302A CA1176929A (en) 1982-07-14 1982-07-14 Urodynamic catheter
GB08317948A GB2123300B (en) 1982-07-14 1983-07-01 Urodynamic catheter
DE19833324747 DE3324747A1 (en) 1982-07-14 1983-07-08 URODYNAMIC CATHETER
FR8311754A FR2530149B1 (en) 1982-07-14 1983-07-13 URETRAL CATHETER INTENDED IN PARTICULAR FOR CYSTOMETRIC EXAMINATIONS
JP58127047A JPS5922561A (en) 1982-07-14 1983-07-14 Urine dynamical cathetel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000407302A CA1176929A (en) 1982-07-14 1982-07-14 Urodynamic catheter

Publications (1)

Publication Number Publication Date
CA1176929A true CA1176929A (en) 1984-10-30

Family

ID=4123221

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000407302A Expired CA1176929A (en) 1982-07-14 1982-07-14 Urodynamic catheter

Country Status (5)

Country Link
JP (1) JPS5922561A (en)
CA (1) CA1176929A (en)
DE (1) DE3324747A1 (en)
FR (1) FR2530149B1 (en)
GB (1) GB2123300B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225071A (en) * 1983-06-03 1984-12-18 日本シヤ−ウツド株式会社 Catheter
JPS6092502U (en) * 1983-11-28 1985-06-24 土田 正義 Urethral pressure detection device
DE3406294A1 (en) * 1984-02-22 1985-09-05 Hubmann, Max, Dr., 8520 Erlangen Catheter
DE8407894U1 (en) * 1984-03-15 1984-09-06 Richard Wolf Gmbh, 7134 Knittlingen DILATATOR FOR WIDING INPUT CHANNELS OF THE KIDNEY
US4921483A (en) * 1985-12-19 1990-05-01 Leocor, Inc. Angioplasty catheter
US4777951A (en) * 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
DE3810408A1 (en) * 1988-03-26 1989-10-12 Thomas Lang Duodenal probe
US4927418A (en) * 1989-01-09 1990-05-22 Advanced Cardiovascular Systems, Inc. Catheter for uniform distribution of therapeutic fluids
JP2517329Y2 (en) * 1990-03-16 1996-11-20 日本ゼオン株式会社 Pacing catheter
IT1272800B (en) * 1994-09-02 1997-06-30 Mauro Dimitri DRAINAGE CATHETER FOR CONTINENT URINARY NEO-BLADDS MADE WITH THE USE OF THE INTESTINE OR STOMACH
US5688237A (en) * 1995-05-04 1997-11-18 Cedars-Sinai Medical Center Implantable catheter and method of use
US5980483A (en) * 1996-05-21 1999-11-09 Dimitri; Mauro Drainage catheter for continent urinary neo-bladders
DE19947907A1 (en) * 1999-10-06 2001-04-19 Thomas Wolffgram Catheter for the combined examination of the left ventricle and the right and left coronary arteries
US7112177B2 (en) 2003-03-04 2006-09-26 Wolfe Tory Medical, Inc. Apparatus for monitoring intra-abdominal pressure
AU2003901057A0 (en) * 2003-03-10 2003-03-20 Zsolt Balosh Intra-abdominal urinary catheter pressure monitor
AU2004218771B2 (en) * 2003-03-10 2010-03-25 Abviser Medical, Llc Intra-abdominal pressure monitoring uninary catheter
AU2004324086A1 (en) 2004-10-11 2006-04-20 Abviser Medical, Llc Intra-abdominal pressure monitoring device and method
FR2881658B1 (en) * 2005-02-08 2007-04-27 Peters Surgical Soc Par Action PROBE FOR URODYNAMIC EXAMINATION
DE102011106676A1 (en) * 2011-07-05 2013-03-14 Eberhard-Karls-Universität Tübingen Universitätsklinikum Intrajugular Balloon Catheter
US11819644B2 (en) * 2019-10-16 2023-11-21 Cjmi, Llc Method and apparatus for treating genitourinary problems

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1212249B (en) * 1964-03-23 1966-03-10 Franz Josef Stuecker Dr Device for tamponade and secretion pressure determination of intestinal fistulas
US3394705A (en) * 1965-10-22 1968-07-30 Daniel J. Abramson Drainage balloon catheter having means for antiseptic treatment of the urethra
FR1537010A (en) * 1966-06-16 1968-08-23 Respiratory probe
US3437088A (en) * 1966-12-01 1969-04-08 Leonard J Bielinski Apparatus for measuring motility of body organs
US3480003A (en) * 1967-02-03 1969-11-25 Battelle Development Corp Apparatus for measuring esophageal motility
US4006735A (en) * 1974-07-16 1977-02-08 Hittman Corporation Pressure sensor apparatus
US4023562A (en) * 1975-09-02 1977-05-17 Case Western Reserve University Miniature pressure transducer for medical use and assembly method
US4136681A (en) * 1976-02-17 1979-01-30 American Home Products Corporation Catheter for measuring intrauterine pressure
US4191196A (en) * 1976-06-15 1980-03-04 American Medical Systems, Inc. Profilometry method and apparatus
DE2632280A1 (en) * 1976-07-17 1978-01-19 Hoechst Ag UROLOGICAL CATHETER
US4168703A (en) * 1977-07-18 1979-09-25 Kenneth Kenigsberg Gastroesophageal reflux diagnostic tool
DE2734247C2 (en) * 1977-07-29 1984-07-19 Fresenius AG, 6380 Bad Homburg Device for continuous chemical analysis in the living body
DE2737855A1 (en) * 1977-08-23 1979-03-08 Edgar Gindele Bladder drainage catheter with inflatable tip - has channel for irrigating urinary tract, and outer end which is forked to receive tube coupling
US4252131A (en) * 1978-04-17 1981-02-24 American Home Products Corporation Catheter for measuring intrauterine pressure
US4214593A (en) * 1978-09-18 1980-07-29 Mallinckrodt, Inc. Esophageal pressure monitoring device
US4301811A (en) * 1978-10-27 1981-11-24 The Kendall Company Cystometry system
US4217911A (en) * 1978-10-27 1980-08-19 The Kendall Company Cystometry system
US4265243A (en) * 1979-04-04 1981-05-05 The Kendall Company Collection container with siphon assembly
US4328806A (en) * 1980-06-18 1982-05-11 American Hospital Supply Corporation Catheter with trans-luminal gas pathway
EP0044804A1 (en) * 1980-07-21 1982-01-27 Barsom, Shafik, Dr. med. Urethral catheter

Also Published As

Publication number Publication date
GB2123300A (en) 1984-02-01
GB2123300B (en) 1986-01-02
GB8317948D0 (en) 1983-08-03
JPS5922561A (en) 1984-02-04
DE3324747A1 (en) 1984-02-16
JPH0344783B2 (en) 1991-07-09
FR2530149A1 (en) 1984-01-20
FR2530149B1 (en) 1988-04-29

Similar Documents

Publication Publication Date Title
US4538621A (en) Urodynamic catheter
CA1176929A (en) Urodynamic catheter
US4809710A (en) Multilumen manometer catheter
US5385563A (en) Urodynamic catheter
US6719709B2 (en) Diagnostic urethral assembly and method
US4407301A (en) Disc membrane catheter for performing cystometrograms and urethral profiles
DE60132557T2 (en) CATHETER FOR URODYNAMIC EXAMINATION AND METHOD FOR THE PRODUCTION THEREOF
US4723556A (en) Intracranial ventricular catheter assembly
EP1404222B1 (en) Urethral profiling device
US5207228A (en) Dual port thermodilution catheter
US5312343A (en) Device for segmental perfusion and aspiration of colon and rectum
EP2459058B1 (en) Systems and devices for assessment of body cavity pressures
US3825013A (en) Balloon catheter
JPH0337930B2 (en)
Wheatley et al. Anal pressure studies in spinal patients.
CN210750826U (en) Double-bag external urethral sphincter dilating tube
CN217696592U (en) Sacculus forced-out test instrument
Lahk et al. Balloon topography: a simple method of evaluating anal function
WO1986003957A1 (en) Installation for pressure measurement
DE3917179A1 (en) Catheter system for cardiological diagnosis
Ronen Measurements of urethral pressure profiles in the male horse
CN209848117U (en) Catheter
CN218852810U (en) Curvature-adjustable mapping catheter
DE4234640A1 (en) Rectal catheter with holding and protective balloons - has round, or slot-shaped holes in protective balloon for outflow of excessive water
DE102012012180A1 (en) Device for in-vivo measurement of oxygen partial pressure of intravascular fluid, has polarographic measurement unit for oxygen partial pressure measurement, which is arranged along catheter

Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry