AU2003295684A1 - Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids - Google Patents

Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids

Info

Publication number
AU2003295684A1
AU2003295684A1 AU2003295684A AU2003295684A AU2003295684A1 AU 2003295684 A1 AU2003295684 A1 AU 2003295684A1 AU 2003295684 A AU2003295684 A AU 2003295684A AU 2003295684 A AU2003295684 A AU 2003295684A AU 2003295684 A1 AU2003295684 A1 AU 2003295684A1
Authority
AU
Australia
Prior art keywords
pyrrol
dihydroxy
synthesis
heptanoic acids
heptanoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003295684A
Other versions
AU2003295684A8 (en
Inventor
Ben-Zion Dolitzky
Zvi Harel
Ramy Lidor-Hadas
Jakob Oren
Nurit Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of AU2003295684A1 publication Critical patent/AU2003295684A1/en
Publication of AU2003295684A8 publication Critical patent/AU2003295684A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
AU2003295684A 2002-11-15 2003-11-17 Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids Abandoned AU2003295684A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US42634202P 2002-11-15 2002-11-15
US60/426,342 2002-11-15
US46611403P 2003-04-29 2003-04-29
US60/466,114 2003-04-29
US48044003P 2003-06-23 2003-06-23
US60/480,440 2003-06-23
US48338103P 2003-06-27 2003-06-27
US60/483,381 2003-06-27
PCT/US2003/037026 WO2004046105A2 (en) 2002-11-15 2003-11-17 Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids

Publications (2)

Publication Number Publication Date
AU2003295684A1 true AU2003295684A1 (en) 2004-06-15
AU2003295684A8 AU2003295684A8 (en) 2004-06-15

Family

ID=32330042

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003295684A Abandoned AU2003295684A1 (en) 2002-11-15 2003-11-17 Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids

Country Status (3)

Country Link
EP (1) EP1480943A2 (en)
AU (1) AU2003295684A1 (en)
WO (1) WO2004046105A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20060197A1 (en) * 2005-03-14 2006-10-18 Pfizer Science & Tech Ltd Preparation of an atorvastatin intermediate
GB2424880A (en) * 2005-04-06 2006-10-11 Generics Crystalline forms of atorvastatin sodium, processes for their preparation and their use in inhibiting HMG-CoA reductase
SI22255A (en) * 2006-04-14 2007-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New polymorphs of statine salts and their application in pharmaceutical formulations
US20090081801A1 (en) * 2007-08-15 2009-03-26 Vinod Kumar Kansal Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
KR100850558B1 (en) * 2008-01-02 2008-08-06 조동옥 Process for preparing useful in synthesis of atorvastatin
CN103184248B (en) * 2011-12-29 2016-02-10 杭州师范大学 The method of the pyrrole ring analog derivative that a kind of Enzyme catalyzed synthesis N-replaces
CN102796036B (en) * 2012-09-12 2014-06-04 江苏阿尔法药业有限公司 Preparation method of atorvastatin calcium
US11970482B2 (en) 2018-01-09 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof
CN109232354A (en) * 2018-10-09 2019-01-18 河南师范大学 A kind of preparation method of high purity atorvastatin calcium raw material drug
CN109232353A (en) * 2018-10-09 2019-01-18 河南师范大学 A kind of preparation method of Atorvastatin calcium condensation product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
IT1237792B (en) * 1989-12-21 1993-06-17 Zambon Spa ACTIVE COMPOUNDS AS INHIBITORS OF THE HMG-COA REDUCTASE ENZYME
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
KR20040017278A (en) * 2001-07-06 2004-02-26 테바 파마슈티컬 인더스트리즈 리미티드 Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation

Also Published As

Publication number Publication date
WO2004046105A2 (en) 2004-06-03
EP1480943A2 (en) 2004-12-01
WO2004046105A3 (en) 2004-10-07
AU2003295684A8 (en) 2004-06-15

Similar Documents

Publication Publication Date Title
AU2003293632A1 (en) Phenethanolamine derivatives
AU2003225551A1 (en) Synthesis of 2h- and 13c- substituted dithianes
AU2002310583A1 (en) Fischer-tropsch synthesis process
AU2002360375A1 (en) Synthesis strategies based on the appropriate use of inductance effects
AU2003288023A1 (en) Process for the manufacture of 1,2-epoxy-3-chloropropane
AU2003248647A1 (en) Stereoselective synthesis of 1,2-disubstituted cycloalkyls
AU2003295684A1 (en) Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids
AU2003256264A1 (en) Carotenoid synthesis
AU2002333336A1 (en) Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof
AU2003250151A1 (en) Method for the synthesis of anthracycline-peptide conjugates
AU2003246963A1 (en) Synthesis of cyclohexanone derivatives
AU2003218176A1 (en) Asymetric synthesis of amino-pyrrolidinones
AU2002368502A1 (en) Process for the synthesis of 2-deoxy-d-glucose
AU2003282700A1 (en) Kavalactone product
AU2003224327A1 (en) Process for the synthesis of peptides
AU2003293079A1 (en) Modulation of jagged 1 expression
AU2003218407A1 (en) Synthesis of 2,6-dicarbonylpyridines
AU2003299746A1 (en) Total synthesis of daurichromenic acid
AU2003270143A1 (en) Improved methods for the synthesis of nucleic acids
AU2003217354A1 (en) Synthesis of sulfamidates
AU2003225642A1 (en) Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
AU2003250716A1 (en) Continuous production of couscous
AU2003251431A1 (en) Synthesis of discodermolide
AU2003228532A1 (en) Methods of use of the enzymes of mycothiol synthesis
AU2003255307A1 (en) Arylamides

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase